CN103608350B - 三唑并吡啶类化合物 - Google Patents

三唑并吡啶类化合物 Download PDF

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Publication number
CN103608350B
CN103608350B CN201280030682.XA CN201280030682A CN103608350B CN 103608350 B CN103608350 B CN 103608350B CN 201280030682 A CN201280030682 A CN 201280030682A CN 103608350 B CN103608350 B CN 103608350B
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CN
China
Prior art keywords
amino
phenyl
base
triazolo
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280030682.XA
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English (en)
Chinese (zh)
Other versions
CN103608350A (zh
Inventor
V.舒尔策
D.科泽蒙德
A.M.温格纳
G.西迈斯特
D.施特基希特
P.利瑙
H.席罗克
H.布里姆
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Bayer Pharma AG
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Bayer Pharma AG
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Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CN103608350A publication Critical patent/CN103608350A/zh
Application granted granted Critical
Publication of CN103608350B publication Critical patent/CN103608350B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280030682.XA 2011-04-21 2012-04-16 三唑并吡啶类化合物 Expired - Fee Related CN103608350B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11163342.6 2011-04-21
EP11163342 2011-04-21
EP11167872.8 2011-05-27
EP11167872 2011-05-27
PCT/EP2012/056914 WO2012143329A1 (en) 2011-04-21 2012-04-16 Triazolopyridines

Publications (2)

Publication Number Publication Date
CN103608350A CN103608350A (zh) 2014-02-26
CN103608350B true CN103608350B (zh) 2015-11-25

Family

ID=46124297

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280030682.XA Expired - Fee Related CN103608350B (zh) 2011-04-21 2012-04-16 三唑并吡啶类化合物

Country Status (39)

Country Link
US (1) US20140120087A1 (https=)
EP (1) EP2699575B1 (https=)
JP (1) JP5989091B2 (https=)
KR (1) KR20140025470A (https=)
CN (1) CN103608350B (https=)
AP (1) AP3491A (https=)
AR (1) AR086191A1 (https=)
AU (1) AU2012244859B2 (https=)
CA (1) CA2833657A1 (https=)
CL (1) CL2013003044A1 (https=)
CO (1) CO6801751A2 (https=)
CR (1) CR20130539A (https=)
CY (1) CY1116439T1 (https=)
DK (1) DK2699575T3 (https=)
DO (1) DOP2013000244A (https=)
EA (1) EA023766B1 (https=)
EC (1) ECSP13013011A (https=)
ES (1) ES2539265T3 (https=)
GT (1) GT201300254A (https=)
HR (1) HRP20150517T1 (https=)
HU (1) HUE025496T2 (https=)
IL (1) IL228704A0 (https=)
JO (1) JO3040B1 (https=)
MA (1) MA35049B1 (https=)
ME (1) ME02143B (https=)
MX (1) MX348783B (https=)
MY (1) MY164939A (https=)
PE (1) PE20141351A1 (https=)
PH (1) PH12013502169A1 (https=)
PL (1) PL2699575T3 (https=)
PT (1) PT2699575E (https=)
RS (1) RS54044B1 (https=)
SA (1) SA112330466B1 (https=)
SG (1) SG194003A1 (https=)
SI (1) SI2699575T1 (https=)
TW (1) TWI558703B (https=)
UY (1) UY34034A (https=)
WO (1) WO2012143329A1 (https=)
ZA (1) ZA201308707B (https=)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
UA111841C2 (uk) 2011-04-21 2016-06-24 Гіліад Сайєнсіз, Інк. Сполуки бензотіазолу та їх фармацевтичне застосування
UA112096C2 (uk) * 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
WO2013135612A1 (en) 2012-03-14 2013-09-19 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
SG11201408419QA (en) 2012-07-10 2015-01-29 Bayer Pharma AG Method for preparing substituted triazolopyridines
WO2014020041A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
HK1222849A1 (zh) * 2013-06-07 2017-07-14 Bayer Pharma Aktiengesellschaft 具有作爲mps-1抑制剂的活性的取代的三唑并吡啶类
CA2914516A1 (en) * 2013-06-07 2014-12-11 Bayer Pharma Aktiengesellschaft Substituted triazolopyridines
HK1219737A1 (zh) * 2013-06-10 2017-04-13 Bayer Pharma Aktiengesellschaft 用於治疗癌症的新化合物
TN2015000543A1 (en) * 2013-06-11 2017-04-06 Bayer Pharma AG Combinations for the treatment of cancer comprising a mps-1 kinase inhibitor and a mitotic inhibitor
AP2015008898A0 (en) 2013-06-11 2015-12-31 Bayer Pharma AG Prodrug derivatives of substituted triazolopyridines
EP2860177A3 (en) 2013-09-20 2015-06-10 Bayer Intellectual Property GmbH Synthesis of functionalized arenes
ES2966392T3 (es) 2015-04-17 2024-04-22 Crossfire Oncology Holding B V Biomarcadores pronósticos para quimioterapia inhibidora de TTK
AU2018233367B2 (en) * 2017-03-16 2021-08-12 Jiangsu Hengrui Medicine Co., Ltd. Heteroaryl[4,3-c]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
CA3137152A1 (en) 2019-04-18 2020-10-22 The Johns Hopkins University Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof
EP3994132A1 (en) 2019-07-03 2022-05-11 Sumitomo Dainippon Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (tnk1) inhibitors and uses thereof
AU2021362678A1 (en) 2020-10-13 2023-05-04 The Johns Hopkins University SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025821A1 (en) * 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
WO2009010530A1 (en) * 2007-07-18 2009-01-22 Novartis Ag Bicyclic heteroaryl compounds and their use as kinase inhibitors

Family Cites Families (12)

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US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
ATE413167T1 (de) 2004-08-17 2008-11-15 Galderma Res & Dev Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen
MX2010002115A (es) 2007-08-23 2010-06-01 Aztrazeneca Ab 2-anilinopurin-8-onas como inhibidores de ttk/mps1 para el tratamiento de trastornos .proliferativos.
CA2691448A1 (en) 2007-08-31 2009-03-05 Dominique Swinnen Triazolopyridine compounds and their use as ask inhibitors
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
AU2008328882A1 (en) * 2007-11-27 2009-06-04 Cellzome Limited Amino triazoles as PI3K inhibitors
SG173610A1 (en) 2009-02-13 2011-09-29 Fovea Pharmaceuticals Sa [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors
JP6168773B2 (ja) 2009-04-29 2017-07-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾキノキサリン
JP5728683B2 (ja) 2009-09-04 2015-06-03 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
UY33452A (es) * 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008025821A1 (en) * 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
WO2009010530A1 (en) * 2007-07-18 2009-01-22 Novartis Ag Bicyclic heteroaryl compounds and their use as kinase inhibitors

Also Published As

Publication number Publication date
CR20130539A (es) 2013-12-04
WO2012143329A1 (en) 2012-10-26
EA201301181A1 (ru) 2014-08-29
MX348783B (es) 2017-06-28
GT201300254A (es) 2015-09-01
CN103608350A (zh) 2014-02-26
CY1116439T1 (el) 2017-02-08
DK2699575T3 (da) 2015-06-22
HK1190398A1 (zh) 2014-07-04
ME02143B (me) 2015-10-20
PT2699575E (pt) 2015-07-29
MY164939A (en) 2018-02-15
SI2699575T1 (sl) 2015-10-30
PL2699575T3 (pl) 2015-08-31
UY34034A (es) 2012-11-30
TW201245194A (en) 2012-11-16
CO6801751A2 (es) 2013-11-29
PE20141351A1 (es) 2014-11-01
AP3491A (en) 2015-12-31
ES2539265T3 (es) 2015-06-29
US20140120087A1 (en) 2014-05-01
MA35049B1 (fr) 2014-04-03
RS54044B1 (sr) 2015-10-30
ZA201308707B (en) 2016-07-27
NZ616456A (en) 2015-09-25
JP2014511887A (ja) 2014-05-19
TWI558703B (zh) 2016-11-21
AP2013007182A0 (en) 2013-10-31
CL2013003044A1 (es) 2014-05-02
HRP20150517T1 (hr) 2015-06-19
EA023766B1 (ru) 2016-07-29
KR20140025470A (ko) 2014-03-04
PH12013502169A1 (en) 2014-01-13
EP2699575B1 (en) 2015-03-25
HUE025496T2 (en) 2016-04-28
CA2833657A1 (en) 2012-10-26
ECSP13013011A (es) 2013-12-31
DOP2013000244A (es) 2014-03-16
MX2013012289A (es) 2013-11-21
JP5989091B2 (ja) 2016-09-07
JO3040B1 (ar) 2016-09-05
SG194003A1 (en) 2013-11-29
EP2699575A1 (en) 2014-02-26
IL228704A0 (en) 2013-12-31
AR086191A1 (es) 2013-11-27
AU2012244859B2 (en) 2017-06-08
SA112330466B1 (ar) 2015-09-28
AU2012244859A1 (en) 2013-10-31

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