JO3040B1 - ترايازولوبيريدينات - Google Patents

ترايازولوبيريدينات

Info

Publication number
JO3040B1
JO3040B1 JOP/2012/0093A JOP20120093A JO3040B1 JO 3040 B1 JO3040 B1 JO 3040B1 JO P20120093 A JOP20120093 A JO P20120093A JO 3040 B1 JO3040 B1 JO 3040B1
Authority
JO
Jordan
Prior art keywords
compounds
triazolopyridines
prophylaxis
disease
preparing
Prior art date
Application number
JOP/2012/0093A
Other languages
English (en)
Inventor
Margret Wengner Antje
Siemeister Gerhard
Stöckigt Detlef
Kosemund Dirk
Schulze Volker
Lienau Philip
Schirok Hartmut
Briem Hans
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Application granted granted Critical
Publication of JO3040B1 publication Critical patent/JO3040B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات triazolopyridine من الصيغة العامة (I): (I) حيث R1، R2، R3، R4، وR5 كما هو موضح في الوصف وفي عناصر الحماية، بطرق لتحضير المركبات المذكورة، بتركيبات دوائية واتحادات تشمل المركبات المذكورة، باستخدام المركبات المذكورة لتصنيع تركيبة دوائية لمعالجة أو الوقاية من مرض، بالإضافة إلى مركبات وسطية مفيدة في تحضير المركبات المذكورة.
JOP/2012/0093A 2011-04-21 2012-04-18 ترايازولوبيريدينات JO3040B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11163342 2011-04-21
EP11167872 2011-05-27

Publications (1)

Publication Number Publication Date
JO3040B1 true JO3040B1 (ar) 2016-09-05

Family

ID=46124297

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0093A JO3040B1 (ar) 2011-04-21 2012-04-18 ترايازولوبيريدينات

Country Status (39)

Country Link
US (1) US20140120087A1 (ar)
EP (1) EP2699575B1 (ar)
JP (1) JP5989091B2 (ar)
KR (1) KR20140025470A (ar)
CN (1) CN103608350B (ar)
AP (1) AP3491A (ar)
AR (1) AR086191A1 (ar)
AU (1) AU2012244859B2 (ar)
CA (1) CA2833657A1 (ar)
CL (1) CL2013003044A1 (ar)
CO (1) CO6801751A2 (ar)
CR (1) CR20130539A (ar)
CY (1) CY1116439T1 (ar)
DK (1) DK2699575T3 (ar)
DO (1) DOP2013000244A (ar)
EA (1) EA023766B1 (ar)
EC (1) ECSP13013011A (ar)
ES (1) ES2539265T3 (ar)
GT (1) GT201300254A (ar)
HK (1) HK1190398A1 (ar)
HR (1) HRP20150517T1 (ar)
HU (1) HUE025496T2 (ar)
IL (1) IL228704A0 (ar)
JO (1) JO3040B1 (ar)
MA (1) MA35049B1 (ar)
ME (1) ME02143B (ar)
MX (1) MX348783B (ar)
MY (1) MY164939A (ar)
PE (1) PE20141351A1 (ar)
PL (1) PL2699575T3 (ar)
PT (1) PT2699575E (ar)
RS (1) RS54044B1 (ar)
SA (1) SA112330466B1 (ar)
SG (1) SG194003A1 (ar)
SI (1) SI2699575T1 (ar)
TW (1) TWI558703B (ar)
UY (1) UY34034A (ar)
WO (1) WO2012143329A1 (ar)
ZA (1) ZA201308707B (ar)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2015008931A0 (en) 2011-04-21 2015-12-31 Gilead Sciences Inc Benzothiazole compounds and their pharmaceutical use
UA112096C2 (uk) * 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
WO2013103738A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. Napthalene acetic acid derivatives against hiv infection
WO2013103724A1 (en) 2012-01-04 2013-07-11 Gilead Sciences, Inc. 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids
WO2013135612A1 (en) 2012-03-14 2013-09-19 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
KR20150040845A (ko) * 2012-07-10 2015-04-15 바이엘 파마 악티엔게젤샤프트 치환된 트리아졸로피리딘을 제조하는 방법
WO2014020041A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
CN105408332B (zh) * 2013-06-07 2017-05-10 拜耳制药股份公司 取代的三唑并吡啶类
CA2914521A1 (en) * 2013-06-07 2014-12-11 Bayer Pharma Aktiengesellschaft Substituted triazolopyridines having activity as mps-1 inhibitors
EP3008061A1 (en) * 2013-06-10 2016-04-20 Bayer Pharma Aktiengesellschaft Novel compounds for the treatment of cancer
WO2014198645A1 (en) * 2013-06-11 2014-12-18 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer comprising a mps-1 kinase inhibitor and a mitotic inhibitor
JP2016526534A (ja) 2013-06-11 2016-09-05 バイエル・ファルマ・アクティエンゲゼルシャフト 置換トリアゾロピリジンのプロドラッグ誘導体
EP2860177A3 (en) 2013-09-20 2015-06-10 Bayer Intellectual Property GmbH Synthesis of functionalized arenes
WO2016166255A1 (en) 2015-04-17 2016-10-20 Netherlands Translational Research Center B.V. Prognostic biomarkers for ttk inhibitor chemotherapy
UA125592C2 (uk) * 2017-03-16 2022-04-27 Джянгсу Хенгруй Медісін Ко., Лтд. ПОХІДНА ГЕТЕРОАРИЛ[4,3-c]ПІРИМІДИН-5-АМІНУ, СПОСІБ ЇЇ ОТРИМАННЯ ТА ЇЇ МЕДИЧНІ ЗАСТОСУВАННЯ
AU2020257301A1 (en) 2019-04-18 2021-11-11 The Johns Hopkins University Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof
AU2020300619A1 (en) 2019-07-03 2022-01-27 Sumitomo Pharma Oncology, Inc. Tyrosine kinase non-receptor 1 (TNK1) inhibitors and uses thereof

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US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
ES2315909T3 (es) 2004-08-17 2009-04-01 GALDERMA RESEARCH & DEVELOPMENT Nuevos compuestos bioaromaticos que son activadores de los receptores del tipo ppar y su utilizacion en composiciones cosmeticas y farmaceuticas.
SG174086A1 (en) * 2006-08-30 2011-09-29 Cellzome Ltd Triazole derivatives as kinase inhibitors
AU2008277628B2 (en) * 2007-07-18 2012-03-15 Novartis Ag Bicyclic heteroaryl compounds and their use as kinase inhibitors
MX2010002115A (es) 2007-08-23 2010-06-01 Aztrazeneca Ab 2-anilinopurin-8-onas como inhibidores de ttk/mps1 para el tratamiento de trastornos .proliferativos.
WO2009027283A1 (en) 2007-08-31 2009-03-05 Merck Serono S.A. Triazolopyridine compounds and their use as ask inhibitors
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
CN101952285A (zh) * 2007-11-27 2011-01-19 塞尔卓姆有限公司 作为pi3k抑制剂的氨基三唑
WO2010092041A1 (en) * 2009-02-13 2010-08-19 Fovea Pharmaceuticals Sa [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors
CN102413831B (zh) 2009-04-29 2014-06-04 拜耳知识产权有限责任公司 取代的咪唑并喹喔啉
CA2772790C (en) 2009-09-04 2017-06-27 Benjamin Bader Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
UY33452A (es) * 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas

Also Published As

Publication number Publication date
HUE025496T2 (en) 2016-04-28
ES2539265T3 (es) 2015-06-29
WO2012143329A1 (en) 2012-10-26
PT2699575E (pt) 2015-07-29
AP2013007182A0 (en) 2013-10-31
IL228704A0 (en) 2013-12-31
ME02143B (me) 2015-10-20
UY34034A (es) 2012-11-30
PE20141351A1 (es) 2014-11-01
CY1116439T1 (el) 2017-02-08
AR086191A1 (es) 2013-11-27
HK1190398A1 (zh) 2014-07-04
KR20140025470A (ko) 2014-03-04
MX348783B (es) 2017-06-28
JP5989091B2 (ja) 2016-09-07
SI2699575T1 (sl) 2015-10-30
CL2013003044A1 (es) 2014-05-02
EP2699575B1 (en) 2015-03-25
AU2012244859B2 (en) 2017-06-08
ZA201308707B (en) 2016-07-27
MX2013012289A (es) 2013-11-21
JP2014511887A (ja) 2014-05-19
MY164939A (en) 2018-02-15
NZ616456A (en) 2015-09-25
EA201301181A1 (ru) 2014-08-29
AP3491A (en) 2015-12-31
MA35049B1 (fr) 2014-04-03
TW201245194A (en) 2012-11-16
US20140120087A1 (en) 2014-05-01
EP2699575A1 (en) 2014-02-26
DK2699575T3 (da) 2015-06-22
SG194003A1 (en) 2013-11-29
ECSP13013011A (es) 2013-12-31
GT201300254A (es) 2015-09-01
CN103608350A (zh) 2014-02-26
EA023766B1 (ru) 2016-07-29
PL2699575T3 (pl) 2015-08-31
TWI558703B (zh) 2016-11-21
AU2012244859A1 (en) 2013-10-31
DOP2013000244A (es) 2014-03-16
CN103608350B (zh) 2015-11-25
CR20130539A (es) 2013-12-04
HRP20150517T1 (hr) 2015-06-19
CO6801751A2 (es) 2013-11-29
SA112330466B1 (ar) 2015-09-28
RS54044B1 (en) 2015-10-30
CA2833657A1 (en) 2012-10-26

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