CN103608019B - 抗肿瘤剂 - Google Patents

抗肿瘤剂 Download PDF

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Publication number
CN103608019B
CN103608019B CN201280025929.9A CN201280025929A CN103608019B CN 103608019 B CN103608019 B CN 103608019B CN 201280025929 A CN201280025929 A CN 201280025929A CN 103608019 B CN103608019 B CN 103608019B
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CN
China
Prior art keywords
compound
och
ddd
nmr
mannopyranoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280025929.9A
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English (en)
Chinese (zh)
Other versions
CN103608019A (zh
Inventor
杉浦丽子
村冈修
筒井望
喜多绫子
久能树
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kindai University
Original Assignee
Kindai University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kindai University filed Critical Kindai University
Publication of CN103608019A publication Critical patent/CN103608019A/zh
Application granted granted Critical
Publication of CN103608019B publication Critical patent/CN103608019B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280025929.9A 2011-05-27 2012-05-28 抗肿瘤剂 Expired - Fee Related CN103608019B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011-119797 2011-05-27
JP2011119797 2011-05-27
JP2012-097198 2012-04-20
JP2012097198 2012-04-20
PCT/JP2012/063686 WO2012165394A1 (ja) 2011-05-27 2012-05-28 抗腫瘍剤

Publications (2)

Publication Number Publication Date
CN103608019A CN103608019A (zh) 2014-02-26
CN103608019B true CN103608019B (zh) 2017-02-15

Family

ID=47259250

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280025929.9A Expired - Fee Related CN103608019B (zh) 2011-05-27 2012-05-28 抗肿瘤剂

Country Status (5)

Country Link
US (1) US9828406B2 (https=)
EP (1) EP2716293B1 (https=)
JP (2) JP6047309B2 (https=)
CN (1) CN103608019B (https=)
WO (1) WO2012165394A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9828406B2 (en) * 2011-05-27 2017-11-28 Kinki University Antitumor agent
CN105384785B (zh) * 2015-11-24 2018-06-19 中国人民解放军第二军医大学 含有半乳糖类脂肪酸衍生物的制备方法及其在医药领域的应用
US12257214B2 (en) 2021-06-02 2025-03-25 The Charlotte Mecklenburg Hospital Authority Compositions and methods comprising deoxy-pentitols

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008260715A (ja) * 2007-04-12 2008-10-30 National Institute Of Advanced Industrial & Technology マンノシルアルジトールリピッド及びその製造方法
JP2009126820A (ja) * 2007-11-22 2009-06-11 Toyobo Co Ltd 新規マンノシルエリスリトールリピッドおよびその製造方法
WO2011112889A2 (en) * 2010-03-12 2011-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0474590A3 (en) * 1990-08-13 1993-04-21 Ciba-Geigy Ag Taurine derivatives, process for their preparation and their use
AU683026B2 (en) 1992-10-22 1997-10-30 Kirin Pharma Kabushiki Kaisha Novel shingoglycolipid and use thereof
US6153736A (en) 1995-09-27 2000-11-28 The Liposome Company, Inc. Modified ether glyceroglycolipids
DE19802450A1 (de) * 1998-01-23 1999-07-29 Hoechst Marion Roussel De Gmbh Ustilipide, Verfahren zu deren Herstellung sowie deren Verwendung
DE60003794T2 (de) 1999-02-26 2004-06-17 Toyo Suisan Kaisha, Ltd. Sulforhamnosylacylglycerin-derivate und ihre verwendung als medikamente
GB0025437D0 (en) * 2000-10-17 2000-11-29 Unilever Plc Esters
DE10135098B4 (de) * 2001-07-11 2004-05-13 Schering Ag Verfahren zur Herstellung von peracylierten 1-O-Glycosiden
JP4370591B2 (ja) * 2001-07-31 2009-11-25 独立行政法人産業技術総合研究所 リポソームおよびそれからなる細胞への物質導入担体
JP2006504752A (ja) 2002-10-15 2006-02-09 ロレアル 乾燥皮膚の治療及び／又は予防における脂肪酸のアミド又は糖とのエステルの使用
JP4858946B2 (ja) * 2006-01-10 2012-01-18 独立行政法人産業技術総合研究所 乳化剤又は可溶化剤
GB0614034D0 (en) * 2006-07-14 2006-08-23 Iqur Ltd Antiviral compounds
US9828406B2 (en) * 2011-05-27 2017-11-28 Kinki University Antitumor agent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008260715A (ja) * 2007-04-12 2008-10-30 National Institute Of Advanced Industrial & Technology マンノシルアルジトールリピッド及びその製造方法
JP2009126820A (ja) * 2007-11-22 2009-06-11 Toyobo Co Ltd 新規マンノシルエリスリトールリピッドおよびその製造方法
WO2011112889A2 (en) * 2010-03-12 2011-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-MANNOSYLCERAMIDE AND STIMULATION OF NKT CELL ANTI-TUMOR IMMUNITY

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Mannosylerythritol Lipid Is a Potent Inducer of Apoptosis and Differentiation of Mouse Melanoma Cells in Culture1;Xiaoxian Zhao等;《CANCER RESEARCH》;19990115;第59卷;482-486页 *

Also Published As

Publication number Publication date
JP6307138B2 (ja) 2018-04-04
US20140121175A1 (en) 2014-05-01
EP2716293A4 (en) 2015-03-18
EP2716293A1 (en) 2014-04-09
JP2017036311A (ja) 2017-02-16
EP2716293B1 (en) 2017-09-06
JP6047309B2 (ja) 2016-12-21
JP2013237659A (ja) 2013-11-28
CN103608019A (zh) 2014-02-26
WO2012165394A1 (ja) 2012-12-06
US9828406B2 (en) 2017-11-28

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Granted publication date: 20170215