CN103599021B - Roselle extract as well as preparation method thereof and application thereof in whitening skincare cosmetics - Google Patents
Roselle extract as well as preparation method thereof and application thereof in whitening skincare cosmetics Download PDFInfo
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- CN103599021B CN103599021B CN201310568285.4A CN201310568285A CN103599021B CN 103599021 B CN103599021 B CN 103599021B CN 201310568285 A CN201310568285 A CN 201310568285A CN 103599021 B CN103599021 B CN 103599021B
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Abstract
The invention discloses a roselle extract as well as a preparation method and application thereof. The roselle extract is prepared through the following steps: adding roselle into deionized water or an ethyl acetate solvent; performing ultrasonic extraction at 25 DEG C for 15-30 minutes; filtering the liquid with a 0.45-micron microporous filtration membrane, and collecting the filtrate; performing vacuum rotary evaporation under a condition of controlling the vacuum degree at 0.094-0.096MPa to obtain a roselle extract concentrate; freeze-drying the concentrate to obtain the roselle extract. The application of the roselle extract as a whitening skincare agent and particularly in skin cosmetics is as follows: the roselle extract is added into the skin cosmetics at a mass ratio (roselle to skin cosmetics) of (0.01-10):100; moreover, the preparation process is simple and easy to implement, and the finally obtained skin cosmetics are natural and safe and have the characteristics of whitening capacity, oxidation resistance and the like.
Description
Technical field
The present invention relates to a kind of containing Hibiscus Sabdariffa Linn extract and preparation method thereof and its application in whitening and skin-protecting applies some make up.
Technical background
Hibiscus Sabdariffa Linn has another name called Calyx Hibisci Sabdariffae, is the annual herb plant of Malvaceae Hibiscus.Its calyx is rich in Ramulus Sambuci Williamsii three glucosides, protein, organic acid, several amino acids, and a large amount of natural complex and the mineral of needed by human body, as nutritions such as ferrum, calcium, phosphorus.Containing reducing sugar 5.7 grams in its every hectogram raw material; 2.37 grams, protein; Pectin 19.8 grams; Malic acid 3.3 grams; Tannin 1.09 grams; Anthocyanidin 14.5 grams; Vitamin 89 milligrams, in addition also containing 17 seed amino acids and polyhydric phenols, Furan Aldehydes, hydroxymethylfurans aldehyde such as human body institute required winter propylhomoserin, glutamic acid, proline, glycine, alanine, lysine, arginine.
The achievement in research of Modern Medical Field shows: Hibiscus Sabdariffa Linn protocatechuic acid (PCA) can promote the destruction of blood cell; Hibiscus Sabdariffa Linn extract (Rs) can suppress chemical substance (AOM) to cause the effect of colon canceration; The polyphenol (HPE) of Hibiscus Sabdariffa Linn can promote withering of stomach cancer cell; What the anthocyanidin (HAc) of Hibiscus Sabdariffa Linn can promote blood cell withers destruction; The extract of Hibiscus Sabdariffa Linn can increase the effect of glutathione (GSH) liver function protecting; The anthocyanidin (HAc) of Hibiscus Sabdariffa Linn can also suppress medicine to cause liver oxidative damage.Hibiscus Sabdariffa Linn extract can also regulate blood pressure, improving water flood.
Except having above-mentioned medical care effect, find after deliberation, Hibiscus Sabdariffa Linn extract also has good skin effect and stronger tryrosinase rejection ability, can be used for preparing whitening and skin-protecting agent safely and effectively.Apply a series of skins prepared by this whitening and skin-protecting agent to apply some make up there is preparation technology's simple possible, good, the natural safety of tryrosinase inhibition, the feature of Wheat Protein while whitening, Hibiscus Sabdariffa Linn extract of the present invention is a kind of whitening and skin-protecting composition of ideal natural plants.Have not yet to see its relevant whitening and skin-protecting effect and as whitening agent be applied to skin apply some make up in research report.
Summary of the invention
An object of the present invention is to provide a kind of whitening and skin-protecting agent and a kind of Hibiscus Sabdariffa Linn extract and preparation method thereof, and this whitening and skin-protecting agent is that pure natural, safety, tryrosinase inhibition are good, and has certain antioxidation and moistening effect.
Two of object of the present invention is to provide above-mentioned Hibiscus Sabdariffa Linn extract as the application of whitening and skin-protecting agent in whitening skin care product, namely provides a kind of cream frost, emulsion, disposable skin protection gel or cleansing milk containing above-mentioned Hibiscus Sabdariffa Linn extract.
Technical scheme of the present invention
A kind of Hibiscus Sabdariffa Linn extract, is prepared by a method comprising the following steps:
(1), add in deionized water or ethyl acetate solvent by dry for Hibiscus Sabdariffa Linn, the mass ratio controlling Hibiscus Sabdariffa Linn and deionized water or ethyl acetate solvent calculates, i.e. Hibiscus Sabdariffa Linn: deionized water or ethyl acetate solvent are obtain mixed liquor after 1:4-20 mixes;
The mixed liquor control temperature of gained is 25 DEG C, and power is 150W, and frequency is after carrying out supersound extraction 15-30min under the ultrasound condition of 40kHz, with 0.45 μm of filtering with microporous membrane;
(2) it is carry out rotary evaporation in vacuo under the condition of 0.094 ~ 0.096MPa that the filtrate obtained after, step (1) being filtered controls vacuum, obtain Hibiscus Sabdariffa Linn extract concentrated solution, be-55 DEG C of lyophilizations by the Hibiscus Sabdariffa Linn extract concentrated solution control temperature of gained again, obtain Hibiscus Sabdariffa Linn extract solid.
Above-mentioned a kind of Hibiscus Sabdariffa Linn extract is applied as whitening and skin-protecting agent, the present invention illustrates with its application in skins such as preparing cream frost, emulsion, disposable skin protection skin protection gel or cleansing milk applies some make up, but does not limit it as the application of whitening and skin-protecting agent in other skin-protection products.
Above-mentioned a kind of Hibiscus Sabdariffa Linn extract is as the application process of whitening and skin-protecting agent in the skins such as cream frost, emulsion, disposable skin protection skin protection gel or cleansing milk apply some make up, calculate in mass ratio, i.e. Hibiscus Sabdariffa Linn extract: cream frost, emulsion, disposable skin protection skin protection gel or cleansing milk are the ratio of 0.01 ~ 10:100, adds to Hibiscus Sabdariffa Linn extract in cream frost, emulsion, disposable skin protection skin protection gel or cleansing milk.
Cream frost containing above-mentioned Hibiscus Sabdariffa Linn extract, an emulsion, calculate by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.01-10%
Solid grease 1-15%
Liquid fat 1-10%
Emulsifying agent 1-10%
Wetting agent 0-10%
Rheology control agent 0-1%
Antiseptic 0.1-0.3%
Essence 0-1.0%
Antioxidant 0.02-0.10%
Surplus is deionized water;
Described solid grease is fatty acid, fatty alcohol or fatty glyceride;
Wherein said fatty acid is stearic acid, myristic acid, oleic acid or behenic acid;
Described fatty alcohol is oleyl alcohol, spermol, cetostearyl alcohol or two Lauryl Alcohols;
Described fatty glyceride is glyceryl monostearate, distearin or glyceryl tristearate;
Described liquid fat is the mixture of one or more compositions in white oil, Jojoba oil, dimethicone, Cyclomethicone, olive oil, Oleum Ricini, isopropyl palmitate, iso-octyl palmitate, isopropyl myristate, caprylic capric triglyceride, Semen Tritici aestivi germ oil, American Avocado Tree oil, almond oil, Oleum Cocois and Petiolus Trachycarpi oil;
Described emulsifying agent is the mixture of one or more compositions in polyoxyethylene stearyl alcohol ether, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerine monofatty ester and ethoxylated castor oil;
The mixture that wherein said polyoxyethylene stearyl alcohol ether is polyoxyethylene (2) stearic alcohol ether, polyoxyethylene (21) stearic alcohol ether or polyoxyethylene (2) stearic alcohol ether and polyoxyethylene (21) stearic alcohol ether form;
Described wetting agent is glycerol, 1,3 butylene glycol or hyaluronate sodium;
Described rheology control agent is hydroxyethyl-cellulose or card ripple;
Described antiseptic is the mixture of hydroxyphenyl methyl ester and hydroxyphenyl propyl ester composition, calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described essence is conventional perfume material mixture in cosmetics;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene (BHT) or vitamin E.
Above-mentioned is a kind of containing the protective skin cream of Hibiscus Sabdariffa Linn extract or the preparation method of emulsion, specifically comprises the steps:
(1), the oil phase of solid grease, liquid grease, emulsifying agent, antioxidant composition is heated to 65-90 DEG C of stirring and dissolving as A phase;
(2), Hibiscus Sabdariffa Linn extract, rheology control agent, wetting agent to be dissolved in deionized water and to be heated to 65-90 DEG C of insulation as B phase;
(3), under control homogenizer rotating speed is 10000-20000rpm/min condition, the B phase control of step (2) gained being added speed is that 50-100ml/min is joined in the A phase of step (1) gained, and continues homogenizing until A phase and B phase mix homogeneously with homogenizer;
(4), after step (3) A phase and B phase mix homogeneously, Temperature fall to 75 ~ 80 DEG C, carry out mechanical defoaming;
(5), step (4) froth breaking complete after Temperature fall to 45 DEG C time, add essence, antiseptic, continue mechanical agitation and stop to mix homogeneously and after naturally cooling to room temperature stirring, discharging, obtain a kind of protective skin cream containing Hibiscus Sabdariffa Linn extract or emulsion.
A disposable skin protection gel containing above-mentioned Hibiscus Sabdariffa Linn extract, calculates by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.01-10%
Liquid fat 1-10%
Emulsifying agent 1-10%
Wetting agent 0.05-10%
Rheology control agent 0-1%
Antiseptic 0.3%
Essence 0-1.0%
Antioxidant 0.02-0.10%
Surplus is deionized water;
Described liquid fat is the mixture of one or more compositions in white oil, dimethicone, Jojoba oil, Cyclomethicone, olive oil, Oleum Ricini, isopropyl palmitate, iso-octyl palmitate, isopropyl myristate, caprylic capric triglyceride, Semen Tritici aestivi germ oil, American Avocado Tree oil, almond oil, Oleum Cocois and Petiolus Trachycarpi oil;
Described emulsifying agent is the mixture of one or more compositions in polyoxyethylene stearyl alcohol ether, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerine monofatty ester and ethoxylated castor oil;
The mixture that wherein said polyoxyethylene stearyl alcohol ether is polyoxyethylene (2) stearic alcohol ether, polyoxyethylene (21) stearic alcohol ether or polyoxyethylene (2) stearic alcohol ether and polyoxyethylene (21) stearic alcohol ether form;
Described wetting agent is the mixture of one or more compositions in glycerol, 1,3 butylene glycol, hyaluronic acid, hyaluronate sodium and nicotiamide;
Described rheology control agent is hydroxyethyl-cellulose or card ripple;
Described antiseptic is the mixture that hydroxyphenyl methyl ester and hydroxyphenyl propyl ester form, and calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described essence is conventional perfume material mixture used for cosmetic;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene or vitamin E.
The preparation method of above-mentioned a kind of disposable skin protection gel containing Hibiscus Sabdariffa Linn extract, is characterized in that specifically comprising the steps:
(1), by deionized water add in beaker, start agitator, slowly poured in beaker by rheology control agent, it is for subsequent use that rheology control agent adds complete continuation stirring 15-20min;
(2), liquid fat, antioxidant and emulsifying agent Hybrid Heating are heated to 50 DEG C as oil phase and obtain oil phase;
(3), Hibiscus Sabdariffa Linn extract, wetting agent are joined in step (1) add in the deionized water after rheology control agent and be heated to 50 DEG C of mix homogeneously and obtain aqueous phase;
(4), the oil phase of step (2) gained is joined in the aqueous phase of step (3) gained, open homogenizer simultaneously, mixing speed is 10000-20000rpm/min, carry out emulsifying 3min, emulsifying terminates rear triethanolamine, sodium hydroxide or potassium hydroxide adjust ph be 6-7, continue to stir, control speed of agitator is 100-500rpm/min, during Temperature fall to 45 DEG C, add antiseptic, continue mechanical agitation to stop to mix homogeneously and after naturally cooling to room temperature stirring, discharging, obtains a kind of skin protection gel containing Hibiscus Sabdariffa Linn extract.
A cleansing milk containing above-mentioned Hibiscus Sabdariffa Linn extract, calculates by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.01-10%
Solid grease 1-35%
Surfactant 1-20%
Emulsifying agent 0.5-2%
Wetting agent 0.05-10%
Rheology control agent 0-1%
Antiseptic 0.1%
Essence 0-1.0%
Chelating agen 0.1%
It is 78-85% that alkali adds to degree of neutralization
Surplus is deionized water.
Wherein said solid grease is fatty acid, and described fatty acid is the mixture of one or more compositions in stearic acid, myristic acid, Palmic acid, lauric acid;
Described surfactant is the mixture of one or more compositions in anion, both sexes or non-ionic surface active agent;
Described anion surfactant is amino acids, sulfuric acid ester, phosphoric acid ester, sulfonic acid esters etc., is specially sodium lauroyl sarcosine salt, monoalkyl phosphoric acid esters, lauroyl N-methyltaurine sodium, lauryl sulphate acid triethanol ammonium, lauryl alcohol succinate disodium sulfonate;
Described amphoteric surfactant is cocamido propyl betaine;
Described non-ionic surface active agent is coconut monoethanol amide;
Described emulsifier polyoxyethylene stearic alcohol ether, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerine monofatty ester or ethoxylated castor oil;
Described wetting agent is glycerol, propylene glycol or 1,3 butylene glycol;
Described rheology control agent is hydroxyethyl-cellulose;
Described antiseptic is the mixture that hydroxyphenyl methyl ester and hydroxyphenyl propyl ester form, and calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described essence is conventional perfume material mixture used for cosmetic;
Described alkali is triethanolamine, sodium hydroxide or potassium hydroxide;
Wherein the computational methods of degree of neutralization are:
Degree of neutralization=(purity) ∕ (acid number of the consumption * fatty acid of fatty acid used in cleansing milk) of the consumption * alkali of alkali
The acid number of described fatty acid is:
Fatty acid: lauric acid, myristic acid, Palmic acid, stearic acid
Acid number: 280 250 218 197
The definition of acid number: in and the milligram number of potassium hydroxide needed for 1g fatty acid.
Described chelating agen is EDETATE SODIUM.
The preparation method of above-mentioned a kind of cleansing milk containing Hibiscus Sabdariffa Linn extract, specifically comprises the steps:
(1), by alkali join in deionized water and dissolve, then add wetting agent, rheology control agent, be heated to 75 DEG C, obtain aqueous phase;
(2), by solid grease, emulsifying agent be mixed and heated to 75 DEG C and stir and dissolve, obtain oil phase;
(3), first oil phase is put into emulsifying pot, open and stir, aqueous phase is joined oil phase fast, and control mixing speed is 10000-20000rpm/min;
(4), after aqueous phase added, hierarchy of control temperature 80-90 DEG C has been carried out saponification 30-60min;
(5), saponification adds surfactant after terminating, antiseptic, Hibiscus Sabdariffa Linn solution of extract, chelating agen is added when being cooled to 50-60 DEG C, be cooled to 40-45 DEG C again when can tie cream to system, keep 40-45 DEG C, controlling mixing speed is that 100-500rpm/min carries out stirring 30-60min, stirs the cleansing milk that both must contain Hibiscus Sabdariffa Linn extract after terminating.
Beneficial effect of the present invention
A kind of Hibiscus Sabdariffa Linn extract of the present invention, because it has whitening effect, therefore a kind of Hibiscus Sabdariffa Linn extract of the present invention is applied in during skin applies some make up as a kind of whitening and skin-protecting agent.
In addition, a kind of Hibiscus Sabdariffa Linn extract of the present invention and the skin containing this Hibiscus Sabdariffa Linn extract apply some make up, and its preparation technology's simple possible, is suitable for suitability for industrialized production.
Accompanying drawing explanation
Fig. 1, Hibiscus Sabdariffa Linn extract and vitamin C are to the curve chart of inhibitory activity against tyrosinase.
Detailed description of the invention
Also by reference to the accompanying drawings the present invention is set forth further below by embodiment, but do not limit the present invention.
embodiment 1
A kind of Hibiscus Sabdariffa Linn extract, prepare by the following method:
(1), add in deionized water by dry for Hibiscus Sabdariffa Linn, the mass ratio controlling Hibiscus Sabdariffa Linn and deionized water calculates, i.e. Hibiscus Sabdariffa Linn: deionized water is obtain mixed liquor after 1:10 mixes;
The mixed liquor control temperature of gained is 25 DEG C, and power is 150W, and frequency is after carrying out supersound extraction 15-30min under the ultrasound condition of 40kHz, with 0.45 μm of filtering with microporous membrane;
(2) it is carry out rotary evaporation in vacuo under the condition of 0.094-0.096MPa that the filtrate obtained after, step (1) being filtered controls vacuum, obtain Hibiscus Sabdariffa Linn extract concentrated solution, be-55 DEG C of lyophilizations by the Hibiscus Sabdariffa Linn extract concentrated solution control temperature of gained, obtain Hibiscus Sabdariffa Linn extract.
The Hibiscus Sabdariffa Linn extract of above-mentioned gained is carried out inhibition the effects to tryrosinase respectively, and its concrete steps are as follows:
(1), the extraction of tryrosinase:
Diced after potato decortication, put into the freezing 24h of-20 DEG C, refrigerator, get about 10g and put into beater, add 30mL phosphate buffer solution and pull an oar, then pour in beaker, be placed in refrigerator and leave standstill, require that refrigerator temperature is set in 0-5 DEG C;
(2), OD
1the test of value:
Get the TYR solution of 1.5mL and the phosphate buffer solution of 3.1mL, after 35-40 DEG C of water-bath 10min, add the supernatant of extract solution that 0.2mL prepared and 0.2mL Rhizoma Solani tuber osi extraction of substance.Put into the light absorption value that cuvette measures 475nm place after mixing, minute be the 1st, 2,3,4,5,6,7,8,12,15,18min;
(3), OD
2the test of value:
Get the TYR solution of 1.5mL and the phosphate buffer solution of 3.1mL, after 35-40 DEG C of water-bath 10min, add the supernatant of 0.2mL deionized water and 0.2mL Rhizoma Solani tuber osi extraction of substance, put into the light absorption value that cuvette measures 475nm place after mixing, minute be the 1st, 2,3,4,5,6,7,8,12,15,18min;
(4), OD
3the test of value:
Get the TYR solution of 1.5mL and the phosphate buffer solution of 3.1mL, after 35-40 DEG C of water-bath 10min, add extract solution and 0.2mL phosphate buffer solution that 0.2mL prepared.Put into the light absorption value that cuvette measures 475nm place after mixing, minute be the 1st, 2,3,4,5,6,7,8,12,15,18min;
(5), OD
4the test of value:
Get the TYR solution of 1.5mL and the phosphate buffer solution of 3.1mL, after 35-40 DEG C of water-bath 10min, add 0.2mL deionized water and 0.2mL phosphate buffer solution.Put into the light absorption value that cuvette measures 475nm place after mixing, minute be the 1st, 2,3,4,5,6,7,8,12,15,18min.
Test parallel three times, averaged, calculate now Hibiscus Sabdariffa Linn extract to tyrosinase inhibition rate, the computing formula of suppression ratio rate: suppression ratio (%)=[1-(OD
1-OD
3)/(OD
2-OD
4)] × 100%;
The curve that the extract seen in Fig. 1 tyrosinase inhibition rate curve of Hibiscus Sabdariffa Linn extract is corresponding, as can be seen from the curve that the extract of Fig. 1 is corresponding, when Hibiscus Sabdariffa Linn extract is increased to 6min to the suppression ratio of tyrosinase inhibition rate gradually from 12.5% during 1min 23.8%, and this value is on a declining curve after 10min, show that Hibiscus Sabdariffa Linn extract has good tryrosinase rejection ability thus, but the suppression time falls short of, may to be that effective ingredient concentration in Hibiscus Sabdariffa Linn extract is lower cause for this.
In sum, can show that Hibiscus Sabdariffa Linn extract has certain rejection ability to tryrosinase, indicating Hibiscus Sabdariffa Linn extract is thus a kind of safe and effective natural plant whitening composition, therefore can be used in skin-lightening cosmetic as whitening and skin-protecting agent.
comparative example 1
Compare with one of tyrosinase inhibitor conventional in prior art vitamin C, replace Hibiscus Sabdariffa Linn extract with vitamin C concentration (10mg/mL) under the same conditions, carry out suppression ratio the effects.
It the results are shown in Figure curve corresponding to Vc in 1, the curve that Vc is corresponding as can be seen from Fig. 1, during 2min, vitamin C is 17.5% to the suppression ratio of tryrosinase, then be increased to 35% after 18min gradually, indicate vitamin C thus, as conventional tyrosinase inhibitor, there is good whitening capability.
In sum, can draw under the same conditions, in the scope of 0-4min, the tyrosinase inhibition rate of the Hibiscus Sabdariffa Linn extract solution of 10mg/mL increases gradually, and it is suitable to solution suppression ratio with the vitamin C of 10mg/mL, after 10min, vitamin C continues to increase to suppression ratio, Hibiscus Sabdariffa Linn extract suppression ratio declines, illustrate that Hibiscus Sabdariffa Linn extract has certain whitening capability, and its effect is suitable with vitamin C in 2-9min time range, again having confirmed above-mentioned Hibiscus Sabdariffa Linn extract is a kind of safety, effective natural plant whitening composition, can be used in skin-lightening cosmetic as whitening and skin-protecting agent.
application Example 1
Using the Hibiscus Sabdariffa Linn extract of embodiment 1 gained as whitening and skin-protecting agent, preparing the application in protective skin cream, namely a kind of protective skin cream containing Hibiscus Sabdariffa Linn extract, calculates by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.02g (0.02%)
Solid grease 5g(5%)
Liquid fat 8g(8%)
Emulsifying agent 3.5g(3.5%)
Antiseptic 0.3g (0.3%)
Antioxidant 0.05g (0.05%)
Deionized water 83.13g(83.13%);
Described solid grease is the mixture of cetostearyl alcohol and glyceryl monostearate composition, calculates in mass ratio, i.e. cetostearyl alcohol: glyceryl monostearate is 4:1;
Described liquid fat is the mixture of white oil, dimethicone and Jojoba oil composition, calculates in mass ratio, i.e. white oil: dimethicone: Jojoba oil is 1:2:1;
Described emulsifying agent is the mixture that polyoxyethylene (2) stearic alcohol ether and polyoxyethylene (21) stearic alcohol ether form, and calculates in mass ratio, i.e. polyoxyethylene (2) stearic alcohol ether: polyoxyethylene (21) stearic alcohol ether is 1.5:2;
Described antiseptic is the mixture of hydroxyphenyl methyl ester and hydroxyphenyl propyl ester composition, calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene.
The preparation method of above-mentioned a kind of protective skin cream containing Hibiscus Sabdariffa Linn extract, specifically comprises the steps:
(1), polyoxyethylene (21) the stearic alcohol ether of polyoxyethylene (2) the stearic alcohol ether of the Jojoba oil of the glyceryl monostearate of the cetostearyl alcohol of 5g solid grease and 4g and 1g, 8g liquid grease and the white oil of 2g, the dimethicone of 4g and 2g, 3.5g emulsifying agent and 1.5g and 2g, the 0.05g antioxidant oil phase that is 2,6-di-tert-butyl hydroxy toluenes form are heated to 65-90 DEG C of stirring and dissolving and are incubated for subsequent use as A phase;
(2), the Hibiscus Sabdariffa Linn extract of 0.02g embodiment 1 gained to be dissolved in the deionized water of 83.13g and to be heated to 65-90 DEG C of insulation for subsequent use as B phase;
(3), under control homogenizer rotating speed is 10000-20000rpm/min condition, is that 50-100ml/min is joined in the A phase of step (1) gained by the B phase control drop rate of step (2) gained, continues homogenizing 3min with homogenizer simultaneously;
(4), after step (3) homogenizing 3min terminates, be cooled to 75 ~ 80 DEG C, using agitator instead, to control speed of agitator be that 100-500rpm/min carries out mechanical defoaming;
(5) when, step (4) mechanical defoaming is cooled to 45 DEG C after completing, add 0.3g antiseptic and 0.2g hydroxyphenyl methyl ester and 0.1g hydroxyphenyl propyl ester, continuing to control agitator speed is that 100-500rpm/min stirs, to be cooled being cooled to after room temperature stops stirring, discharging, obtains a kind of protective skin cream containing Hibiscus Sabdariffa Linn extract.
application Example 2
Using the Hibiscus Sabdariffa Linn extract of embodiment 1 gained as whitening and skin-protecting agent, the application in preparation emulsion, namely a kind of emulsion containing Hibiscus Sabdariffa Linn extract, calculates by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.02g(0.02%)
Solid grease 4g(4%)
Liquid fat 10g(10%)
Emulsifying agent 3.5g(3.5%)
Wetting agent 0.05g(0.05%)
Rheology control agent 0.2g(0.2%)
Antiseptic 0.3g(0.3%)
Antioxidant 0.05(0.05%)
Deionized water 81.88g(81.88%);
Described solid grease is the mixture of cetostearyl alcohol and stearic acid composition, calculates in mass ratio, i.e. cetostearyl alcohol: stearic acid is 3:1;
Described liquid fat is the mixture of isopropyl palmitate, dimethicone and Jojoba oil composition, calculates in mass ratio, i.e. isopropyl palmitate: dimethicone: Jojoba oil is 5:3:2;
Described emulsifying agent is the mixture that polyoxyethylene (2) stearic alcohol ether and polyoxyethylene (21) stearic alcohol ether form, and calculates in mass ratio, i.e. polyoxyethylene (2) stearic alcohol ether: polyoxyethylene (21) stearic alcohol ether is 1.5:2;
Described wetting agent is hyaluronate sodium;
Described rheology control agent is hydroxyethyl-cellulose;
Described antiseptic is the mixture of hydroxyphenyl methyl ester, hydroxyphenyl propyl ester composition, calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene.
The preparation method of above-mentioned a kind of emulsion containing Hibiscus Sabdariffa Linn extract, specifically comprises the steps:
(1), polyoxyethylene (21) the stearic alcohol ether of polyoxyethylene (2) the stearic alcohol ether of the Jojoba oil of the stearic acid of the cetostearyl alcohol of 4g solid grease and 3g and 1g, 10g liquid grease and the isopropyl palmitate of 5g, the dimethicone of 3g and 2g, 3.5g emulsifying agent and 1.5g and 2g, the 0.05g antioxidant oil phase that is 2,6-di-tert-butyl hydroxy toluenes form are heated to 65-90 DEG C of stirring and dissolving and are incubated for subsequent use as A phase;
(2), the Hibiscus Sabdariffa Linn extract of 0.02g embodiment 1 gained, 0.2g rheology control agent hydroxyethyl-cellulose, 0.05g wetting agent hyaluronate sodium to be dissolved in the deionized water of 81.88g and to be heated to 65-90 DEG C of insulation for subsequent use as B phase;
(3), under control homogenizer rotating speed is 10000-20000rpm/min condition, is that 50-100ml/min is joined in the A phase of step (1) gained by the B phase control drop rate of step (2) gained, continues homogenizing 3min with homogenizer simultaneously;
(4), after step (3) homogenizing 3min, be cooled to 75 ~ 80 DEG C, using agitator instead, to control speed of agitator be that 100-500rpm/min carries out mechanical defoaming;
(5) when, step (4) froth breaking is cooled to 45 DEG C after completing, add the hydroxyphenyl methyl ester of 0.3g antiseptic and 0.2g and the hydroxyphenyl propyl ester of 0.1g, continuing to control agitator speed is that 100-500rpm/min stirs, to be cooled being cooled to after room temperature stops stirring, discharging, obtains a kind of emulsion containing Hibiscus Sabdariffa Linn extract.
application Example 3
Using the Hibiscus Sabdariffa Linn extract of embodiment 1 gained as whitening and skin-protecting agent, the application in the disposable skin protection gel of preparation, namely a kind of disposable skin protection gel containing Hibiscus Sabdariffa Linn extract, calculates by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.02g (0.02%)
Liquid fat 3g(3%)
Emulsifying agent 1g(1%)
Wetting agent 3.05g(3.05%)
Rheology control agent 0.5g(0.5%)
Antiseptic 0.3g(0.3%)
Antioxidant 0.05g(0.05%)
Deionized water 92.08g(92.08%);
Described liquid fat is the mixture of dimethicone, Cyclomethicone composition, calculates in mass ratio, i.e. dimethicone: Cyclomethicone is 2:1;
Described emulsifying agent is polyoxyethylene sorbitan fatty acid ester-80;
Described wetting agent is the mixture of glycerol, 1,3 butylene glycol and hyaluronate sodium composition, calculates in mass ratio, i.e. glycerol: 1,3 butylene glycol: hyaluronate sodium is 1:2:0.05;
Described rheology control agent is card ripple;
Described antiseptic is the mixture of hydroxyphenyl methyl ester, hydroxyphenyl propyl ester composition, calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene.
The preparation method of above-mentioned a kind of disposable skin protection gel containing Hibiscus Sabdariffa Linn extract, specifically comprises the steps:
(1), add in beaker by 92.08g deionized water, start agitator, then 0.5g rheology control agent and card ripple are slowly poured in beaker, it is for subsequent use that rheology control agent adds complete continuation stirring 15-20min;
(2), 3g liquid fat and 2g dimethicone and 1g Cyclomethicone, 0.05g antioxidant i.e. 2,6-di-tert-butyl hydroxy toluenes and 1g emulsifying agent and polyoxyethylene sorbitan fatty acid ester-80 Hybrid Heating are heated to 50 DEG C as oil phase and obtain oil phase;
(3), the 1,3 butylene glycol of the Hibiscus Sabdariffa Linn extract of 0.02g embodiment 1 gained, 3.05g wetting agent and 1g glycerol, 2g and 0.05g hyaluronate sodium are joined in step (1) add in the deionized water after rheology control agent and be heated to 50 DEG C of mix homogeneously and obtain aqueous phase;
(4), the oil phase of step (2) gained is joined in the aqueous phase of step (3) gained, open homogenizer simultaneously, mixing speed is 10000-20000rpm/min, carry out emulsifying 3min, emulsifying terminates rear triethanolamine, sodium hydroxide or potassium hydroxide adjust ph are 6-7, continue to stir, control speed of agitator is 100-500rpm/min, during Temperature fall to 45 DEG C, add 0.3g antiseptic and 0.2g hydroxyphenyl methyl ester and 0.1g hydroxyphenyl propyl ester, continue mechanical agitation to stop to mix homogeneously and after naturally cooling to room temperature stirring, discharging, obtain a kind of skin protection gel containing Hibiscus Sabdariffa Linn extract.
embodiment 2
A kind of Hibiscus Sabdariffa Linn extract, prepare by the following method:
(1), add in ethyl acetate solvent by dry for Hibiscus Sabdariffa Linn, the mass ratio controlling Hibiscus Sabdariffa Linn and ethyl acetate solvent calculates, i.e. Hibiscus Sabdariffa Linn: ethyl acetate solvent is obtain mixed liquor after 1:10 mixes;
The mixed liquor control temperature of gained is 25 DEG C, and power is 150W, and frequency is after carrying out supersound extraction 20min under the ultrasound condition of 40kHz, with 0.45 μm of filtering with microporous membrane;
(2) it is carry out rotary evaporation in vacuo under the condition of 0.094 ~ 0.096MPa that the filtrate obtained after, step (1) being filtered controls vacuum, obtain Hibiscus Sabdariffa Linn extract concentrated solution, be-55 DEG C of lyophilizations by the Hibiscus Sabdariffa Linn extract concentrated solution control temperature of gained, obtain Hibiscus Sabdariffa Linn extract.
Foregoing be only the present invention conceive under basic explanation, and according to any equivalent transformation that technical scheme of the present invention is done, all should protection scope of the present invention be belonged to.
Claims (6)
1. containing the protective skin cream of Hibiscus Sabdariffa Linn extract, it is characterized in that calculating by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.02%
Solid grease 5%
Liquid fat 8%
Emulsifying agent 3.5%
Antiseptic 0.3%
Antioxidant 0.05%
Surplus is deionized water;
Described Hibiscus Sabdariffa Linn extract, is prepared from by the following method:
(1), add in deionized water or ethyl acetate solvent by dry for Hibiscus Sabdariffa Linn, the mass ratio controlling Hibiscus Sabdariffa Linn and deionized water or ethyl acetate solvent calculates, i.e. Hibiscus Sabdariffa Linn: deionized water or ethyl acetate solvent are obtain mixed liquor after 1:4-20 mixes;
The mixed liquor control temperature of gained is 25 DEG C, and power is 150W, and frequency is after carrying out supersound extraction 15-30min under the ultrasound condition of 40kHz, with 0.45 μm of filtering with microporous membrane;
(2), by step (1) filtering the rear filtrate control vacuum obtained is carry out rotary evaporation in vacuo under the condition of 0.094-0.096MPa, and obtain Hibiscus Sabdariffa Linn extract concentrated solution, control temperature is-55 DEG C and carries out lyophilization, obtains Hibiscus Sabdariffa Linn extract;
Described solid grease is the mixture of cetostearyl alcohol and glyceryl monostearate composition, calculates in mass ratio, i.e. cetostearyl alcohol: glyceryl monostearate is 4:1;
Described liquid fat is the mixture of white oil, dimethicone and Jojoba oil composition, calculates in mass ratio, i.e. white oil: dimethicone: Jojoba oil is 1:2:1;
Described emulsifying agent is the mixture that polyoxyethylene (2) stearic alcohol ether and polyoxyethylene (21) stearic alcohol ether form, and calculates in mass ratio, i.e. polyoxyethylene (2) stearic alcohol ether: polyoxyethylene (21) stearic alcohol ether is 1.5:2;
Described antiseptic is the mixture of hydroxyphenyl methyl ester and hydroxyphenyl propyl ester composition, calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene.
2. containing the emulsion of Hibiscus Sabdariffa Linn extract, it is characterized in that calculating by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.02%
Solid grease 4%
Liquid fat 10%
Emulsifying agent 3.5%
Wetting agent 0.05%
Rheology control agent 0.2%
Antiseptic 0.3%
Antioxidant 0.05%
Surplus is deionized water;
Described Hibiscus Sabdariffa Linn extract, is prepared from by the following method:
(1), add in deionized water or ethyl acetate solvent by dry for Hibiscus Sabdariffa Linn, the mass ratio controlling Hibiscus Sabdariffa Linn and deionized water or ethyl acetate solvent calculates, i.e. Hibiscus Sabdariffa Linn: deionized water or ethyl acetate solvent are obtain mixed liquor after 1:4-20 mixes;
The mixed liquor control temperature of gained is 25 DEG C, and power is 150W, and frequency is after carrying out supersound extraction 15-30min under the ultrasound condition of 40kHz, with 0.45 μm of filtering with microporous membrane;
(2), by step (1) filtering the rear filtrate control vacuum obtained is carry out rotary evaporation in vacuo under the condition of 0.094-0.096MPa, and obtain Hibiscus Sabdariffa Linn extract concentrated solution, control temperature is-55 DEG C and carries out lyophilization, obtains Hibiscus Sabdariffa Linn extract;
Described solid grease is that cetostearyl alcohol and stearic acid calculate in mass ratio, i.e. cetostearyl alcohol: stearic acid is the mixture of 3:1 composition;
Described liquid fat is the mixture of isopropyl palmitate, dimethicone and Jojoba oil composition, calculates in mass ratio, i.e. isopropyl palmitate: dimethicone: Jojoba oil is 5:3:2;
Described emulsifying agent is the mixture that polyoxyethylene (2) stearic alcohol ether and polyoxyethylene (21) stearic alcohol ether form, and calculates in mass ratio, i.e. polyoxyethylene (2) stearic alcohol ether: polyoxyethylene (21) stearic alcohol ether is 1.5:2;
Described wetting agent is hyaluronate sodium;
Described rheology control agent is hydroxyethyl-cellulose;
Described antiseptic is the mixture of hydroxyphenyl methyl ester and hydroxyphenyl propyl ester composition, calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene.
3. the preparation method of a kind of emulsion containing Hibiscus Sabdariffa Linn extract as claimed in claim 2, is characterized in that specifically comprising the steps:
(1), the oil phase of solid grease, liquid grease, emulsifying agent, antioxidant composition is heated to 65-90 DEG C of stirring and dissolving as A phase;
(2), Hibiscus Sabdariffa Linn extract, rheology control agent, wetting agent to be dissolved in deionized water and to be heated to 65-90 DEG C of insulation as B phase;
(3), under control homogenizer rotating speed is 10000-20000rpm/min condition, the B phase control of step (2) gained being added speed is that 50-100ml/min is joined in the A phase of step (1) gained, and continues homogenizing until A phase and B phase mix homogeneously with homogenizer;
(4), after step (3) A phase and B phase mix homogeneously, Temperature fall to 75 ~ 80 DEG C, carry out mechanical defoaming;
Namely described mechanical defoaming controls speed of agitator is that 100-500rpm/min carries out froth breaking;
(5), step (4) froth breaking complete after Temperature fall to 45 DEG C time, add antiseptic, continue mechanical agitation and stop to mix homogeneously and after naturally cooling to room temperature stirring, discharging, obtains a kind of emulsion containing Hibiscus Sabdariffa Linn extract;
Namely described mechanical agitation controls speed of agitator is 100-500rpm/min.
4. the preparation method of a kind of protective skin cream containing Hibiscus Sabdariffa Linn extract as claimed in claim 1, is characterized in that specifically comprising the steps:
(1), the oil phase of solid grease, liquid grease, emulsifying agent, antioxidant composition is heated to 65-90 DEG C of stirring and dissolving as A phase;
(2), Hibiscus Sabdariffa Linn extract to be dissolved in deionized water and to be heated to 65-90 DEG C of insulation as B phase;
(3), under control homogenizer rotating speed is 10000-20000rpm/min condition, the B phase control of step (2) gained being added speed is that 50-100ml/min is joined in the A phase of step (1) gained, and continues homogenizing until A phase and B phase mix homogeneously with homogenizer;
(4), after step (3) A phase and B phase mix homogeneously, Temperature fall to 75 ~ 80 DEG C, carry out mechanical defoaming;
Namely described mechanical defoaming controls speed of agitator is that 100-500rpm/min carries out froth breaking;
(5), step (4) froth breaking complete after Temperature fall to 45 DEG C time, add antiseptic, continue mechanical agitation and stop to mix homogeneously and after naturally cooling to room temperature stirring, discharging, obtains a kind of protective skin cream containing Hibiscus Sabdariffa Linn extract;
Namely described mechanical agitation controls speed of agitator is 100-500rpm/min.
5. containing the disposable skin protection gel of Hibiscus Sabdariffa Linn extract, it is characterized in that calculating by mass percentage, the content of its raw material and composed as follows:
Hibiscus Sabdariffa Linn extract 0.02%
Liquid fat 3%
Emulsifying agent 1%
Wetting agent 3.05%
Rheology control agent 0.5%
Antiseptic 0.3%
Antioxidant 0.05%
Surplus is deionized water;
Described Hibiscus Sabdariffa Linn extract, is prepared from by the following method:
(1), add in deionized water or ethyl acetate solvent by dry for Hibiscus Sabdariffa Linn, the mass ratio controlling Hibiscus Sabdariffa Linn and deionized water or ethyl acetate solvent calculates, i.e. Hibiscus Sabdariffa Linn: deionized water or ethyl acetate solvent are obtain mixed liquor after 1:4-20 mixes;
The mixed liquor control temperature of gained is 25 DEG C, and power is 150W, and frequency is after carrying out supersound extraction 15-30min under the ultrasound condition of 40kHz, with 0.45 μm of filtering with microporous membrane;
(2), by step (1) filtering the rear filtrate control vacuum obtained is carry out rotary evaporation in vacuo under the condition of 0.094-0.096MPa, and obtain Hibiscus Sabdariffa Linn extract concentrated solution, control temperature is-55 DEG C and carries out lyophilization, obtains Hibiscus Sabdariffa Linn extract;
Described liquid fat is the mixture that dimethicone and Cyclomethicone form, and calculates in mass ratio, i.e. dimethicone: Cyclomethicone is 2:1;
Described emulsifying agent is polyoxyethylene sorbitan fatty acid ester-80;
Described wetting agent is the mixture that glycerol, 1,3 butylene glycol and hyaluronate sodium form, and calculates in mass ratio, i.e. glycerol: 1,3 butylene glycol: hyaluronate sodium is 1:2:0.05;
Described rheology control agent is card ripple;
Described antiseptic is the mixture that hydroxyphenyl methyl ester and hydroxyphenyl propyl ester form, and calculates in mass ratio, i.e. hydroxyphenyl methyl ester: hydroxyphenyl propyl ester is 2:1;
Described antioxidant is 2,6-di-tert-butyl hydroxy toluene.
6. the preparation method of a kind of disposable skin protection gel containing Hibiscus Sabdariffa Linn extract as claimed in claim 5, is characterized in that specifically comprising the steps:
(1), get a certain amount of deionized water in beaker, start agitator, slowly poured in beaker by rheology control agent, it is for subsequent use that rheology control agent adds complete continuation stirring 15-20min;
(2), liquid fat, antioxidant and emulsifying agent Hybrid Heating are heated to 50 DEG C as oil phase and obtain oil phase;
(3), Hibiscus Sabdariffa Linn extract, wetting agent are joined in the deionized water of step (1) and obtain aqueous phase as Aqueous dispersions homogeneous heating to 50 DEG C;
(4), the oil phase of step (2) gained is joined in the aqueous phase of step (3) gained, open homogenizer simultaneously, mixing speed is 10000-20000rpm/min, carry out emulsifying 3min, emulsifying terminates rear triethanolamine, sodium hydroxide or potassium hydroxide adjust ph be 6-7, continue to stir, control speed of agitator is 100-500rpm/min, during Temperature fall to 45 DEG C, add antiseptic, continue mechanical agitation to stop to mix homogeneously and after naturally cooling to room temperature stirring, discharging, obtains a kind of skin protection gel containing Hibiscus Sabdariffa Linn extract.
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