CN104688617A - A cosmetic composition with excellent controlling and maintaining ph of skin - Google Patents
A cosmetic composition with excellent controlling and maintaining ph of skin Download PDFInfo
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- CN104688617A CN104688617A CN201410662651.7A CN201410662651A CN104688617A CN 104688617 A CN104688617 A CN 104688617A CN 201410662651 A CN201410662651 A CN 201410662651A CN 104688617 A CN104688617 A CN 104688617A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention relates to a cosmetics composition. The cosmetics composition according to an embodiment of the present invention includes gluconolactone, lactobionic acid, arginine, and glycyrrhetinic acid as active components.
Description
Technical field
The present invention relates to cosmetic composition.More specifically, the present invention relates to and comprise gluconolactone (Gluconolactone), lactobionic acid (Lactobionic Acid), arginine (Arginine) and enoxolone (Glycyrrhetinic acid) as active ingredient, the cosmetic composition that skin pH regulator and maintenance, antiphlogistic effects are outstanding.
Background technology
The most important functions of skin is the function of the defensive barrier (defense barrier) do not invaded etc. by outer damage and antibacterial as protection health.Skin is from outside; be made up of epidermis (epidermis), corium (dermis) and subcutaneous layer of fat (subcutaneous fat) three layers; the outmost horny layer being positioned at epidermis roughly exists 15 layers to 30 layers according to human body, play as protection skin not by the function of the most important barrier of external environment condition damage.The keratinocyte (keratinocyte) generated at the basal layer (basal layer) of epidermis arrives horny layer, abundant lipid is discharged from lamellar body (lamellar body), afterwards along with core disappears, be left the horn cell (corneocyte) as protein group.Horny layer is made up of horn cell (fragment of brick, brick) and the intercellular lipid film (plaster, mortar) of filling between it, performs protection human body not by the powerful defense function that outside physics, chemistry, biology stimulate.
The skin surface of young, healthy people presents the faintly acid of pH 4.0 ~ pH about 5.5, and it is favourable that this weakly acidic pH maintains constancy to skin barrier.But the skin of old man raises a little due to pH, is neutral or alkalescence.In this weakly alkaline environment, the activity forming relevant enzyme to lipid film reduces, corneodesmosome (corneodesmosome) firmly in conjunction with horn cell decomposes, also increase as to the come off activity of pepsin (serin protease) of relevant enzyme of cutin, cause skin barrier function abnormal.In aging skin, to sodium hydrogen exchanging pump (the Sodium-hydrogen exchanger-1 maintaining cuticular acid pH performance decisive role, NHE-1) performance reduces, due to the minimizing of this NHE-1, aging skin cannot maintain acid pH, result is thought after skin barrier damage, reverts to normal speed and greatly reduces.
Skin surface pH also plays material impact to the skin barrier function of allergic dermatitis patient.The surface p H of the dermatitis pathological changes of allergic dermatitis patient increases than non lesion portion, the increase of this pH not only directly reduces β-glucocerebrosidase (β-glucocerebrosidase) and ASM (acid sphingomyelinase) as synthesizing very important enzyme to ceramide (ceramide), and the activity as the serine protease (serine protease) of proteolytic enzyme is increased, bring out the decomposition of β-glucocerebrosidase and ASM (acid sphingomyelinase).Know in addition, because pH increases, Protease-Activated Receptor-2 (protease-activated receptor-2, PAR-2) after being activated, the secretion of lamellar body (lamellar body) is suppressed, and the supply of lipid needed for skin barrier is smooth, has an impact to skin barrier.The activity of the serine protease (serine protease) increased decomposes corneodesmosome, and cuticular solidness is reduced, and this is also a reason of skin barrier function damage.The damage of skin barrier becomes the reason of dry skin, and dry skin brings out pruritus, if scratch skin because of pruritus (pruritus), then repeatedly occurs the skin barrier therefore vicious cycle of damage again.If antigen is increased by the permeability of the skin barrier of damage, then bring out the sensitization to antigen, the dermatitis state of an illness can worsen further.
The pH of skin surface is also very important to the defense function of skin infection.Acid horny layer fully performs the defense function to infected by microbes such as antibacterial, fungus, viruses, if but cuticular pH increases, then antibacterial peptide reduces, promote the group of the pathogen such as staphylococcus aureus (Staphlococcus aureus) and streptococcus pyogenes (Streptococcus pyogenes), skin infection may occur.
As mentioned above, the sour environment of skin surface is very important to skin barrier maintenance constancy.When the aging skin making to become alkalescence recovers original faintly acid, cuticular intercellular lipid increases, and cutin comes off minimizings, and skin barrier function recovers, and this enlightening significance studied is great.If skin barrier recovers, then to the infection of the prevention sensitization of antigen and pathogen, to prevent the dermatitis of allergic dermatitis patient from worsening also helpful.
Related to this, in No. 2009-0054777th, Korean Patent Laid, disclose and a kind ofly in the group by lactic acid or its salt, 2-pyrrolidone-5-carboxylic acid or its salt and Amino acid profile, select skin pH regulator compositions of more than two kinds to form.
On the other hand, multiple hydroxy acid (PHA) is the organic carboxyl acid being combined with two or hydroxyl (hydroxyl group) more than it on the chain of aliphatic compound (aliphatic) or aromatic compound.Comprise hydroxyl compared to described 'alpha '-hydroxy acids (AHA) at alpha position, multiple positions that described PHA is comprising alpha position comprise hydroxyl.In PHA, hydroxyl is in neutral, and carboxyl shows acidity.
Described gluconolactone and lactobionic acid are as the kind in acid multiple hydroxy acid (PHA), because molecular weight is large, thus compared with original 'alpha '-hydroxy acids (α-hydroxy acid:AHA) composition, skin irritation is little, skin can be stored in for a long time, skin surface is maintained the weak acid environment as health status, and skin barrier function recovers, and can help younger, the healthy skin tape of maintenance.
Arginine (Arginine) has known the essential amino acids being present in organism, arterial relaxation is made in human body, make the flowing of blood smooth and easy, make the coronary heart disease of such as angina pectoris (angina), circulation-the relevant disease of such as intermittent claudication (the leg circulation that intermittent-claudication-is insufficient) and hypertension etc. improves, play antioxidation, immunoloregulation function, wound healing, heart disease prevention and cystitis treatments effect, promote that growth hormone release action and muscle are preserved, multiple usefulness and the effects such as body fat minimizing effect.
In addition, enoxolone (Glycyrrhetinic acid), as the composition being present in Radix Glycyrrhizae root, is the composition of the sweet taste sending Radix Glycyrrhizae, the effect of invigorating blood circulation.Radix Glycyrrhizae is the perennial herb belonging to pulse family, is distributed in the ground such as northeast China and Siberia, Mongolia, NORTH CHINA.Leaf is featheriness, the flower of 7-8 month purplish blue color with spike bloom for.Root and the lower portion of the stem are used as the therapeutic agent of sweeting agent and gastric ulcer, duodenal ulcer.Curved fruits is arciform, has thorn-like hair outward.Radix Glycyrrhizae is called as natural steroid, has the function of restraint of tyrosinase, has and hinders the effect of B16 cell, and the extensive use as the natural biocide of Detoxication and antiinflammatory, Radix Glycyrrhizae is conducive to acne, eczema, has cell regeneration, antiinflammatory, sedation.
Described enoxolone has anti-inflammatory (anti-inflammatory) effect.The first, β-glycyrrhetinicacid (enoxolone) is the potent inhibitor of 11 beta hydroxysteroid dehydrogenases, and anti-inflammatory (anti-inflammatory) glucocorticoid (glucocorticoids) is put aside.
The second, suppress the classical path (classical complement pathway) of complement active.Therefore, together use with hydrocortisone (hydrocortisone) and β-glycyrrhetinic acid (enoxolone), helpful to the treatment of inflammatory lung conditions.In addition, enoxolone (Glycyrrhetinic acid) is structurally similar with Cortisol (cortisol), has the effect suppressing the anti-inflammatory caused by cortisol.
In addition, orange blossom (orange blossom) is the flower that Fructus Citri sinensis (formal name used at school: citrus aurantium dulcis) is set, and originates in southern Europe, north African particularly Morocco, Algeria, Tunisia.From about 10th century, Arabic is used as therapeutic agent orange-tree, mainly the juice of fruit is used as medicine.In France, Louis 14 generation extracts aqua aurantii florum in Royal Palace from spend, and makes an addition in white sugar or white sugar water and is used as tranquilizer.In the U.S., aqua aurantii florum for making scone (scone) and fruit juice jelly (marshmallow).This orange blossom makes hemodilution, makes cell regeneration, and linalool enriches.
Summary of the invention
The problem that invention will solve
The object of the present invention is to provide a kind of cosmetic composition, when being applied in skin, skin pH is adjusted to for a long time the excellent of faintly acid (pH 4.0 ~ 5.5).
Another object of the present invention is to provide a kind of cosmetic composition, prevent skin irritation, harmless.
Another object of the present invention is to provide a kind of cosmetic composition, to alleviation and the anti-inflammatory excellent of the inflammation damaged because of irritated and skin barrier and cause.
Solve the scheme of problem
A kind of viewpoint of the present invention relates to cosmetic composition.In a concrete example, described cosmetic composition can comprise gluconolactone (gluconolactone), lactobionic acid (lactobionicacid), arginine (Arginine) and enoxolone (Glycyrrhetinic acid) as active ingredient.
In a concrete example, it is characterized in that, the weight ratio of the described gluconolactone, lactobionic acid, arginine and the enoxolone that comprise is that the weight ratio of 1:0.1 ~ 5:0.1 ~ 5:0.1 ~ 2 comprises
In a concrete example, it is characterized in that, described gluconolactone, lactobionic acid, arginine and enoxolone contain 0.01 % by weight to 40 % by weight relative to all weight package of described cosmetic composition.
In a concrete example, it is characterized in that, described cosmetic composition also comprises orange blossom extract.
In a concrete example, it is characterized in that, described orange blossom extract carries out hot water extraction or organic solvent extraction to orange blossom.
In a concrete example, it is characterized in that, when described cosmetic composition is applied in skin, pH is remained 20 little of 48 hours by the scope with 4.0 to 5.5.
In a concrete example, it is characterized in that, described cosmetic composition has the dosage form of group selected free solution, suspension, emulsion, paste, colloid, cream, lotion, powder, soap, form containing interfacial agent cleansing cream, oil, powder foundation, emulsion foundation, wax foundation and spraying.
In a concrete example, it is characterized in that, described cosmetic composition is oil-in-water (Oil-in-Water, O/W), Water-In-Oil (Water-in-Oil, W/O), water-in-silicone (Water-in-Silicone, W/S), Water-In-Oil bag oil (Oil-in-Water-in-Oil, O/W/O) or W/O/W (Water-in-Oilin-Water, W/O/W) dosage form.
Invention effect
Cosmetic composition of the present invention is harmless, to alleviation and the anti-inflammatory excellent of the inflammation damaged because of irritated and skin barrier and cause, simultaneously, when being applied in skin, can skin irritation be prevented, and for a long time skin pH regulator and the excellent being maintained solutions of weak acidity (pH 4.5 ~ 5.5).
Accompanying drawing explanation
Fig. 1 is the skin embodiment of the present invention 1 being applied in experimenter, and the skin of measurement changes along with the pH of the process of time.
Fig. 2 is skin comparative example 1 of the present invention being applied in experimenter, and the skin of measurement changes along with the pH of the process of time.
Fig. 3 is the skin (face) embodiment of the present invention 2 being applied in experimenter, and the skin of measurement changes along with the pH of the process of time.
Fig. 4 is the skin (arm) embodiment of the present invention 1 being applied in experimenter, and the skin of measurement changes along with the pH of the process of time.
Fig. 5 is the skin (leg) embodiment of the present invention 1 being applied in experimenter, and the skin of measurement changes along with the pH of the process of time.
Detailed description of the invention
In explanation is of the present invention, when judge to think to related known technology or formation illustrate unnecessarily may obscure main idea of the present invention time, description is omitted.
And the term that term described later defines as considering function in the present invention, it because of the intention of user, fortune user or can pass through example etc. and different, and therefore, its definition should be made based on of the present invention description content in the whole text to illustrate.
A kind of viewpoint of the present invention relates to cosmetic composition.In a concrete example, described cosmetic composition can comprise gluconolactone (gluconolactone), lactobionic acid (lactobionic acid), arginine (Arginine) and enoxolone (Glycyrrhetinic acid) as active ingredient.When comprising described composition, stability is outstanding, harmless, without skin irritation when smearing, and effectively can promote the pH regulator effect of antiphlogistic effects and skin.
Described gluconolactone as being used as the synthetic compounds of food additives, with soft tart flavour.The situation of carrying out at low temperatures reacting is few, generates bubble equably, as the raw material used in food, is also used as the purposes reducing pH.Described gluconolactone is effective to the photoaging state of an illness and sensitive skin, increases moisture moisturizing power, and providing skin to defend the regulating effect of membrane interaction, is manage effective raw material to wrinkle position, skin contraction, pore.
In a concrete example, described gluconolactone can relative to all weight package of described cosmetic composition containing 1 ~ 20 % by weight.In described scope, the effect without skin irritation ground regulation of skin pH can be outstanding.
Described lactobionic acid is from the derivative PHA of lactose (Milk Sugar), and the function that real towing hydrone also combines is strong, is the potential antioxidant of water supply ability brilliance.This composition makes fine wrinkles and wrinkle reduce, and closes skin histology and tightens, catabiosis is reduced, suppress the function of the destructive enzyme (MMP) reducing the function maintaining skin histology and intensity, thus protection skin is not by sun damage.
In a concrete example, described lactobionic acid can relative to all weight package of described cosmetic composition containing 1 ~ 20 % by weight.In described scope, the effect without skin irritation ground regulation of skin pH can be outstanding.
In the present invention, maintaining the object of the effect of skin pH for improving further without skin irritation, described arginine can be comprised.Described arginine is one of essential amino acids forming human body, and biological degradability is outstanding more than chemical raw material, and hydrophilic is strong, and the character that contain moisture is large, maintains moisture and the gloss of skin, activates skin, can regulate rough skin.In addition, activate glucose metabolism enzyme, activate the metabolism of Skin Cell, the regeneration effect of damaged skin can be outstanding.
In a concrete example, described arginine can comprise 0.1 ~ 5 % by weight relative to all weight of described cosmetic composition.In described scope, the effect without skin irritation ground regulation of skin pH can be outstanding.
Described enoxolone (Glycyrrhetinic acid or β-glycyrrhetinicacid) provide anti-inflammatory effect in the present invention without skin irritation, there is provided anti-inflammatory effect and natural steroid effect to skin etc. that is irritated and skin lipid damage, helping skin to alleviate stimulates and improves skin.
In a concrete example, enoxolone can relative to all weight package of described cosmetic composition containing 0.1 ~ 5 % by weight.In described scope, the skin pH regulator effect of cosmetic composition of the present invention, amelioration of inflammation and antiphlogistic effects can be outstanding.
In addition, in the present invention, described gluconolactone, lactobionic acid, arginine and enoxolone can comprise by the weight ratio of 1:0.1 ~ 5:0.1 ~ 5:0.1 ~ 2.Preferably, can comprise by the weight ratio of 1:0.5 ~ 3:0.1 ~ 3:0.1 ~ 1.More preferably, can comprise by the weight ratio of 1:0.5 ~ 1.2:0.3 ~ 1:0.1 ~ 0.5.
When the composition of described weight ratio is applied to of the present invention, the effect that is multiplied between the useful composition comprised in described composition is outstanding, when described cosmetic composition is applied in skin, harmless, without skin irritation, and effectively can promote the pH regulator effect of antiphlogistic effects and skin further.
In a concrete example, the content of described gluconolactone can be greater than the packet content of described arginine or enoxolone.
In another concrete example, the content of described lactobionic acid can be greater than the packet content of described arginine or enoxolone.
In another concrete example, described arginic content can be greater than the packet content of described enoxolone.
Apply the packet content of gluconolactone as above, lactobionic acid, arginine and enoxolone, when cosmetic composition is applied in skin, the effect that is multiplied of described composition is outstanding, harmless, without skin irritation, and effectively can promote the pH regulator effect of amelioration of inflammation, antiphlogistic effects and skin further.
In the present invention, described gluconolactone, lactobionic acid, arginine and enoxolone can comprise 0.01 % by weight to 40 % by weight relative to all weight of described cosmetic composition.Preferably, 0.1 % by weight to 30 % by weight can be comprised.More preferably, 0.5 % by weight to 25 % by weight can be comprised.Comprise in scope described, when being applied in skin, harmless, without skin irritation, and effectively can promote antiphlogistic effects and skin pH regulator effect further.
In addition, when cosmetic composition of the present invention is applied in skin, can be little of 48 hours periods 20, make pH be maintained at the scope of 4.0 to 5.5.Preferably, can be little of 48 hours periods 20, make pH be maintained at the scope of 4.5 to 5.5.
In another concrete example, described cosmetic composition can also comprise orange blossom extract.When comprising described orange blossom extract, outstanding with the effect that is multiplied of described composition, antiphlogistic effects, skin pH regulator and maintenance effect can be more outstanding.
Described orange blossom extract can utilize hot water or organic solvent to extract orange blossom.In a concrete example, described hot water extraction can comprise water 100 ~ 1000 weight portion relative to described orange blossom 100 weight portion and extract.In a concrete example, the mixture comprising described orange blossom and water can be heated at 30 DEG C ~ 100 DEG C 1 ~ 10 hours and extract.Preferably, 3 ~ 8 hours can be heated at 60 DEG C ~ 90 DEG C to extract.Under the described conditions, easily can extract while not damaging the active ingredient comprised in described orange blossom.
After described hot water extraction, can use stir extract, the common extracting method such as reflux cooling gets, merceration extraction, ultrasonic extraction or supercritical extraction, preferably, after reflux cooling extracts, the extracting solution received by described hot water extraction is filtered, concentrating under reduced pressure or drying, described orange blossom extract can be obtained.
In a concrete example, described organic solvent extraction can add water 10 ~ 500 weight portion in orange blossom 100 weight portion and organic solvent 10 ~ 500 weight portion extracts.Preferably, water 30 ~ 350 weight portion can be added in orange blossom 100 weight portion and organic solvent 50 ~ 300 weight portion extracts.The mixture comprising described orange blossom and water can be heated at 30 DEG C ~ 100 DEG C 1 ~ 10 hours to extract.Preferably, 3 ~ 8 hours can be heated at 60 DEG C ~ 90 DEG C to extract.Under the described conditions, easily can extract while not damaging in described orange blossom the useful composition comprised.
As the organic solvent used in described organic extraction, the alcohol (alcohol) etc. of acetone, ethyl acetate, ether, benzene, chloroform, hexane and carbon number 1 ~ 10 can be used.They separately or can mix two or more and use.When using organic solvent as above, easily can extract while not damaging in described orange blossom the useful composition comprised.
In addition, as the alcohol of the use in described organic solvent, such as, the low-grade monobasic alcohols such as methanol, ethanol, butanols, amylalcohol, hexanol can be used, the intermediate dihydroxylic alcohols of 1,2-pentanediol, 1,5-PD, hexanediol, heptandiol, ethohexadiol, decanediol etc., the rudimentary trihydroxylic alcohols etc. such as propylene glycol, 1,3 butylene glycol, glycerol.They separately or can mix two or more and use.
In a concrete example, orange blossom extract can relative to all weight package of described cosmetic composition containing 0.1 ~ 5 % by weight.In described scope, the regulating effect of the skin pH of cosmetic composition of the present invention can be outstanding.
In another concrete example, described gluconolactone, lactobionic acid, arginine, enoxolone and orange blossom extract can comprise by the weight ratio of 1:0.1 ~ 5:0.1 ~ 5:0.1 ~ 2:0.1 ~ 2.Preferably, can comprise by the weight ratio of 1:0.5 ~ 3:0.1 ~ 3:0.1 ~ 1:0.1 ~ 1.More preferably, can comprise by the weight ratio of 1:0.5 ~ 1.2:0.3 ~ 1:0.1 ~ 0.5:0.1 ~ 0.5.
When the composition of described weight ratio is applied to of the present invention, the effect that is multiplied between the useful composition comprised in described composition is outstanding, when described cosmetic composition is applied in skin, harmless, without skin irritation, and effectively can promote the pH regulator effect of antiphlogistic effects and skin further.
In a concrete example, the content of described gluconolactone can be greater than the packet content of described arginine, enoxolone or orange blossom extract.
In another concrete example, the content of described lactobionic acid can be greater than the packet content of described arginine, enoxolone or orange blossom extract.
In another concrete example, described arginic content can be greater than the packet content of described enoxolone or orange blossom extract.
When the cosmetic composition comprising ratio applying gluconolactone as above, lactobionic acid, arginine, enoxolone and orange blossom extract is applied in skin, the effect that is multiplied of described composition is outstanding, harmless, without skin irritation, and effectively can promote the pH regulator effect of antiphlogistic effects and skin further.
Any dosage form manufacture that cosmetic composition of the present invention can manufacture usually with the sector.In a concrete example, described cosmetic composition can have the dosage form of group selected free solution, suspension, emulsion, paste, colloid, cream, lotion, powder, soap, form containing interfacial agent cleansing cream, oil, powder foundation, emulsion foundation, wax foundation and spraying.
In a concrete example, cosmetic composition of the present invention can with oil-in-water (Oil-in-Water, O/W), Water-In-Oil (Water-in-Oil, W/O), water-in-silicone (Water-in-Silicone, W/S), Water-In-Oil bag oil (Oil-in-Water-in-Oil, or the manufacture of W/O/W (Water-in-Oil-in-Water, W/O/W) dosage form O/W/O).
When dosage form of the present invention is paste, cream or colloid, as vehicle component, animality oil, plant oil, wax, paraffin, starch, tragacanth, cellulose derivative, Polyethylene Glycol, siloxanes, bentonite, tripoli, Talcum or zinc oxide etc. can be utilized.
Dosage form of the present invention be powder or spraying time, as vehicle component, lactose, Talcum, tripoli, aluminium hydroxide, calcium silicates or Silon can be utilized, when especially spraying, the propellant comprising such as Chlorofluorocarbons (CFCs), propane/butane or dimethyl ether can be added.
Dosage form of the present invention be solution or emulsion time, as vehicle component, utilize solvent, solubilizing agent or emulsifying agent, such as there are water, ethanol, isopropyl alcohol, diethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3 butylene glycol oil, fatty acid glyceride, Polyethylene Glycol or sorbitan carboxylic esters.
When dosage form of the present invention is suspension, as vehicle component, the diluent of the liquid state of such as water, ethanol or propylene glycol can be utilized, the such as suspending agent of ethoxylation i-octadecanol, polyoxyethylene sorbitan ester and polyoxyethylene sorbitol acid anhydride ester, microcrystalline Cellulose, aluminium chlorhydroxide, bentonite, agar or tragacanth etc.
Dosage form of the present invention is for during containing interface-activating agent cleansing cream; as vehicle component, aliphatic alcohol sulfate, fatty alcohol ether sulphate, sulfosuccinic acid monoesters, isethionate, imidazolidine derivatives, methyl tauride, sarcosinate, fatty acid amide, ether sulfate, fatty acid amide betanin, fatty alcohol, fatty glyceride, fatty acid diethanolamine, plant oil, lanolin derivative or ethoxylated glycerol fatty acid ester etc. can be utilized.
Preferably, cosmetic composition of the present invention can also comprise polysorbate60, sorbitan sesquialter isostearate, stearic acid, hexadecanol, zamene, glycerol, butanediol, arginine, carbomer, tocopherol acetas, 1,2-hexanediol, Purified Water etc.
Below, by the preferred embodiments of the present invention, illustrate in greater detail formation of the present invention and effect.But, following examples are for helping understanding of the present invention, and scope of the present invention is not limited to following examples.Wherein, the content do not recorded is that person of ordinary skill in the field can analogize fully technically, and thus the description thereof will be omitted.
embodiment and comparative example
Utilize the composition and content recorded in following table 1, according to usual way, manufacture the cosmetic composition of embodiment 1 ~ 3 and comparative example 1 ~ 5 with the dosage form of cream form.
[table 1]
test example 1. skin pH measure of the change
Impact on the pH of aging skin when using product of the present invention to measure, the face of 5 50 ~ 70 years old women and arm are divided into eight regions respectively, smear the cosmetic composition (cream) of embodiment 1 ~ 3 and comparative example 1 ~ 5 respectively, after 12 hours, utilize Skin-pH-meter PH900 to measure skin pH and change.Its result is as shown in table 2 below.
[table 2]
As shown in Table 2 above, evaluation is thought, when using embodiment 1 ~ 3, compared with the situation of comparative example 1 ~ 5, reducing skin pH, being maintained at the excellent of faintly acid (4.5 ~ 5.5).
test example 2. skin pH day part changes and after 24 hours, pH maintains ability measurement
After applying the cosmetics of described embodiment 1 and comparative example 1, measure skin pH and change and maintenance ability.
With 5 50 years old ~ 70 years old women for object, separate at face, right side is coated with the cosmetics of exhibition embodiment 1, left side is coated with the cosmetics of exhibition comparative example 1, skin (face) pH state after utilizing Skin-pH-meter PH900, measure before smearing respectively, smearing 1 minute, after 1 hour, after 6 hours, after 12 hours, after 24 hours.Be the results are shown in lower Fig. 1 and Fig. 2.
Fig. 1 is the right side face embodiment of the present invention 1 being applied in experimenter 1 ~ 5, measures the pH change of the skin after the elapsed time.In addition, Fig. 2 is left side face comparative example 1 of the present invention being applied in experimenter 1 ~ 5, measures the pH change of the skin after the elapsed time.
Known in described Fig. 1 and Fig. 2, when smearing cosmetic composition of the present invention, with application as the glycolic of 'alpha '-hydroxy acids (AHA) and the comparative example 1 of lactic acid cosmetic composition compared with, in long-time (more than 24 hours) period skin pH is maintained at the excellent of faintly acid (pH 4.5 ~ 5.5).
test example 3. face, arm/leg pH day part change and after 24 hours, pH maintains ability measurement
Skin pH change and maintenance ability when measuring the cosmetics using described embodiment 1 and embodiment 2.
With 10 50 years old ~ 70 years old women for object, embodiment 2 described in face painting exhibition respectively, embodiment 1 described in arm and leg painting exhibition, measures skin pH before smearing, after 1 minute, after 1 hour, after 2 hours, after 5 hours, after 6 hours, after 24 hours respectively.Utilize Skin-pH-meter PH900 to measure, be the results are shown in lower Fig. 3 to Fig. 5.
Described Fig. 3 is the skin (face) embodiment 2 of the present invention being applied in experimenter, measure the pH change of the skin after the elapsed time, described Fig. 4 is the skin (arm) embodiment 1 of the present invention being applied in experimenter, measure the pH change of the skin after the elapsed time, Fig. 5 is the skin (leg) embodiment 1 of the present invention being applied in experimenter, measures the pH change of the skin after the elapsed time.
Known in described Fig. 3 to Fig. 5, when the cosmetic composition of described embodiment 1 ~ 2 of the present invention is applied in skin, the pH of skin is maintained at the excellent of faintly acid (pH 4.5 ~ 5.5) during long-time (more than 24 hours).
test example 4. Skin Irritation Test
In order to the cosmetics investigation Skin Irritation Test manufactured respectively with the compositions of described embodiment 1 ~ 3 and comparative example 1 ~ 5, implement skin patch test.Person under inspection selects the test position of 50 ~ 70 years old without the people of dermatosis, implements experiment altogether to 10 people.After drying, get goods 0.1g using 70% ethanol as the upper arm parts at patch position, after 24 hours periods implemented patch, remove patch, in 1 hour, check dermoreaction, next day (from patch after 48 hours) checks again.Dermoreaction judges to judge according to following inspection benchmark.Skin patch result of the test is shown in table 3.
* dermoreaction checks benchmark
-: reactionless
±: weak positive reaction (erythema)
+: positive reaction (erythema)
++: strong positive reaction (erythema, edema)
+++: serious positive reaction (erythema, edema, blister)
[table 3]
As known in above-mentioned table 3, the cosmetic composition of embodiment 1 ~ 3 of the present invention compared with described comparative example 1 ~ 5, almost without skin irritation.
test example 5. estimation of stability
In order to measure the stability for separation and discoloration for the cosmetics of described embodiment 1 ~ 3 and comparative example 1 ~ 5, utilize be maintained at setly 45 DEG C with the temperature chamber of 25 DEG C, set refrigerator and the sunshine condition being maintained at 4 DEG C, embodiment and comparative example compositions are loaded on shuttle, after keeping 8 time-of-weeks, relatively, measure separation and discoloration, be the results are shown in following table 4.Now, the separation of goods and discoloration are categorized as following 6 grades and evaluate.
[table 4]
* be separated and variable color metewand:
0: unchanged
1: be extremely slightly separated (variable color)
2: slight separation (variable color)
3: micro-serious separation (variable color)
4: serious separation (variable color)
5: be extremely seriously separated (variable color)
Known as shown in Table 4 above, the cosmetic composition of described embodiment 1 ~ 3 than the variable color of described comparative example 1 ~ 5 and segregation phenomenon few.
the evaluation of test example 6. skin improvement effects
Have rated and use the wound healing (antiinflammatory) during the cosmetics of described embodiment 1 ~ 3 and comparative example 1 ~ 5 to improve effect, skin sedation effect and overall preference degree.
Specifically, to accept object 40 people of laser surgery or peeling operation for object, after allowing every 5 people use cosmetics 2 time-of-week (2 times on the 1st (morning, evening)) of embodiment 1 ~ 3 and comparative example 1 ~ 5 respectively, with 10 points of method of scales (1: very bad, 10: very well) evaluate, the meaningful property that then utilized Duncan's multiplerange test to appraise and decide.Its result obtains result as shown in table 5 below.
[table 5]
As shown in Table 5 above, comprise the cosmetics (embodiment 1 ~ 3) of composition of the present invention compared with comparative example 1 ~ 3, it is higher that entirety demonstrates wound healing (antiinflammatory), skin sedation and overall preference degree simultaneously.
By described test example, confirm cosmetics of the present invention and for a long time skin pH is maintained at weakly acidic excellent, prevent skin irritation and skin sedation excellent, dosage form stability is outstanding, and wound healing (antiinflammatory) improves and entirety uses preference degree high.
Claims (8)
1. a cosmetic composition, it comprises gluconolactone (gluconolactone), lactobionic acid (lactobionic acid), arginine (Arginine) and enoxolone (Glycyrrhetinic acid) as active ingredient.
2. cosmetic composition according to claim 1, is characterized in that,
The weight ratio of the described gluconolactone, lactobionic acid, arginine and the enoxolone that comprise is 1:0.1 ~ 5:0.1 ~ 5:0.1 ~ 2.
3. cosmetic composition according to claim 1, is characterized in that,
Described gluconolactone, lactobionic acid, arginine and enoxolone contain 0.01 % by weight to 40 % by weight relative to all weight package of described cosmetic composition.
4. cosmetic composition according to claim 1, is characterized in that,
Described cosmetic composition also comprises orange blossom extract.
5. cosmetic composition according to claim 4, is characterized in that,
Described orange blossom extract carries out hot water extraction or organic solvent extraction to orange blossom.
6. cosmetic composition according to claim 1, is characterized in that,
When described cosmetic composition is applied in skin, pH is remained 20 little of 48 hours by the scope with 4.0 to 5.5.
7. cosmetic composition according to claim 1, is characterized in that,
Described cosmetic composition has the dosage form of group selected free solution, suspension, emulsion, paste, colloid, cream, lotion, powder, soap, form containing interfacial agent cleansing cream, oil, powder foundation, emulsion foundation, wax foundation and spraying.
8. cosmetic composition according to claim 1, is characterized in that,
Described cosmetic composition is oil-in-water (Oil-in-Water, O/W), Water-In-Oil (Water-in-Oil, W/O), water-in-silicone (Water-in-Silicone, W/S), Water-In-Oil bag oil (Oil-in-Water-in-Oil, or W/O/W (Water-in-Oilin-Water, W/O/W) dosage form O/W/O).
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| KR1020130150272A KR101422830B1 (en) | 2013-12-04 | 2013-12-04 | A COSMETIC COMPOSITION WITH EXCELLENT CONTROLLING AND MAINTAINING pH OF SKIN |
| KR10-2013-0150272 | 2013-12-04 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| CN114557915A (en) * | 2022-03-23 | 2022-05-31 | 伊美莱(广州)医疗技术有限公司 | Toning lotion and preparation method thereof |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
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| WO2019103666A1 (en) * | 2017-11-22 | 2019-05-31 | Essity Hygiene And Health Aktiebolag | Intimate skin conditioner veil comprising skin well-being agent |
| KR20200022887A (en) | 2018-08-24 | 2020-03-04 | 안웅진 | System for providing smart beauty service |
| KR102472033B1 (en) * | 2020-12-14 | 2022-11-29 | 주식회사 씨엠에스랩 | Cosmetic composition containing a mixture of rosmarinic acid and lemon balm leaf extract as an active ingredient |
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| JPH11193207A (en) * | 1997-12-26 | 1999-07-21 | Shiseido Co Ltd | Preparation for external use for skin |
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| KR20110070130A (en) * | 2009-12-18 | 2011-06-24 | 박영호 | The cosmetic composition for moisturizing skin |
| KR20130090169A (en) * | 2012-02-03 | 2013-08-13 | 주식회사 씨앤피차앤박화장품 | Composition for cosmetics |
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| CN1298292A (en) * | 1998-02-26 | 2001-06-06 | 荷兰联合利华有限公司 | Anti-irritants in cosmetic compositions |
| KR20110070130A (en) * | 2009-12-18 | 2011-06-24 | 박영호 | The cosmetic composition for moisturizing skin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11911498B2 (en) | 2020-06-01 | 2024-02-27 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN114557915A (en) * | 2022-03-23 | 2022-05-31 | 伊美莱(广州)医疗技术有限公司 | Toning lotion and preparation method thereof |
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| KR101422830B1 (en) | 2014-07-24 |
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