CN107362100A - A kind of papaw extract and preparation method thereof and the application in cosmetics - Google Patents

A kind of papaw extract and preparation method thereof and the application in cosmetics Download PDF

Info

Publication number
CN107362100A
CN107362100A CN201710762749.3A CN201710762749A CN107362100A CN 107362100 A CN107362100 A CN 107362100A CN 201710762749 A CN201710762749 A CN 201710762749A CN 107362100 A CN107362100 A CN 107362100A
Authority
CN
China
Prior art keywords
papaw
extract
oil
mass ratio
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710762749.3A
Other languages
Chinese (zh)
Inventor
章苏宁
侯筱婷
刘伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Technology
Original Assignee
Shanghai Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute of Technology filed Critical Shanghai Institute of Technology
Priority to CN201710762749.3A priority Critical patent/CN107362100A/en
Publication of CN107362100A publication Critical patent/CN107362100A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a kind of papaw extract, is then 1 according to mass ratio by papaw powder and ethanol or methanol solvate with powder is ground into after papaw fruit is dried：After 10 30 ratio is mixed, ultrasonic wave extraction is used at 60 ~ 80 DEG C, after liquid filtering with microporous membrane, collect filtrate, vacuum is controlled to obtain papaw extract concentrated solution to carry out rotary evaporation in vacuo under conditions of 0.094 0.096MPa, concentrate is freeze-dried, obtains papaw extract.Application of the described papaw extract as anti-allergic agent, the especially application in skin applies some make up, the mass ratio that papaw extract and skin apply some make up are 0.0002~10：100, papaw extract is added to during skin applies some make up, and there is the characteristics of preparation technology simple possible, the skin of final gained applies some make up natural safety, antianaphylactic while also have the characteristics of anti-aging effects etc..

Description

A kind of papaw extract and preparation method thereof and the application in cosmetics
Technical field
The invention belongs to field of household chemical, is related to a kind of cosmetics, specifically a kind of papaw extract and its Preparation method is applicable the application during skin care applies some make up with it in sensitive skin.
Background technology
Papaw is also known as chicken feet pawl, sweet tea midnight etc., is a kind of widely distributed Rhamnaceae deciduous tree, its fruit, which is rich in, to be had The multiple efficacies compositions such as glucose, polysaccharide, dammarane type triterpenoid saponin and calcium citrate malate, it is commonly applied to boil fructose, maltosemalt sugar cream, system drink Material, ferment wine brewing.Carpopodium it is sweet it is flat play the role of promoting digestion and enriching blood, rheumatism can be controlled, have relieve the effect of alcohol, diuresis, decompression, hypoglycemic, removing toxic substances etc. Effect.
The achievement in research of Modern Medical Field shows：Polysaccharide has the function that scavenging hydroxyl in papaw, in vitro In the removing experiment for carrying out hydroxy radical, papaw refined polysaccharide is preferable to the clearance rate of hydroxy radical.
Have not yet to see its related research report being applied to as antiallergy skin conditioner during skin applies some make up.
The content of the invention
For above-mentioned technical problem of the prior art, the invention provides a kind of papaw extract and preparation method thereof With its application in cosmetics, the application in this described a kind of papaw extract and preparation method thereof and its cosmetics will Solves the oxidation resistant ineffective technical problem of cosmetics antiallergy of the prior art.
The invention provides a kind of papaw extract, with powder is ground into after papaw fruit is dried, then by ten thousand Longevity fruit powder end is 1 according to mass ratio with ethanol or methanol solvate：After 10-30 ratio is mixed, with super at 60~80 DEG C Sound wave extracts 15-30min, by liquid with after 0.45 μm of filtering with microporous membrane, collects filtrate, it is 0.094- to control vacuum Rotary evaporation in vacuo is carried out under conditions of 0.096MPa and obtains papaw extract concentrated solution, concentrate is freeze-dried, obtains institute State papaw extract.
Present invention also offers a kind of face cream containing above-mentioned papaw extract, calculate by mass percentage, its The content and composition of raw material are as follows：
Papaw extract 0.02%-10%
Mineral grease 1-5%
Synthetic Oil 1-4%
Vegetable fat 1-5%
Animal fat 0-2%
Emulsifying agent 2-6%
NMF 2-10%
Preservative 0.05-0.2%
Antioxidant 0.01-0.1%
Surplus is deionized water；
Described mineral grease is the mixture that stearic acid and white oil form, and the mass ratio of described stearic acid and white oil is 4：1；
Described Synthetic Oil is the mixing of isobutyl palmitate, glycerin monostearate and dimethyl siloxane composition Thing, the mass ratio of described isobutyl palmitate, glycerin monostearate and dimethyl siloxane is 6：1：2；Described is natural Grease is the mixture that Sweet Almond Oil and olive oil form, and the mass ratio of the good olive oil of described Sweet Almond Oil is 1：2；
Described emulsifying agent is the stearic alcohol ether of polyoxyethylene (2), the stearic alcohol ether of polyoxyethylene (21), match Bick 305 emulsify The mixture of agent composition, the stearic alcohol ether of described polyoxyethylene (2), polyoxyethylene (21) stearic alcohol ether and match Bick 305 emulsify The mass ratio of agent is 2：3:3；
Described NMF is the mixture that glycerine and butanediol form, the mass ratio of described glycerine and butanediol be for 1:3；
Described preservative is the mixture that methyl hydroxybenzoate and propylben form, described methyl hydroxybenzoate and Buddhist nun The mass ratio for mooring golden propyl ester is 2：1；
Described antioxidant is 2,6- di-tert-butyl hydroxy toluenes.
Present invention also offers a kind of preparation method of above-mentioned face cream containing papaw extract, including following step Suddenly：
1) each reaction raw materials are weighed according to mass ratio；
2) oil phase 1 of mineral grease, Synthetic Oil, match Bick 305 emulsifying agent composition is heated to 65-90 DEG C of stirring and dissolving As A1 phases；
3) vegetable fat, the stearic alcohol ether of polyoxyethylene (2), the stearic alcohol ether of polyoxyethylene (21), antioxidant are formed Oil phase 2 is heated to 65-90 DEG C of stirring and dissolving as A2 phases；
4) papaw extract is dissolved in 5~30% deionized water and be heated to 50-70 DEG C insulation aqueous phase 1 as B1 phases；
5) NMF is dissolved in 5~30% deionized water, heating stirring is completely dispersed uniform aqueous phase to 65-90 DEG C 2 are used as B2 phases；
6) temperature is controlled at 70-85 DEG C, and the A1 phases obtained by step 2) and step 3) with A2 phases be mixed and stirred for It is even, total oil phase is made as A phases；
7) controlling temperature, mixer mixing speed is 500-700rpm/min, by step 5) and step 6) institute at 70-85 DEG C The B2 phases obtained with A phases be mixed and stirred for uniformly；
8) it is 500-700rpm/min to control mixer mixing speed, and the mixture obtained by step 7) is cooled into 50- 70 DEG C, then mixed with the B1 obtained by step 4)；
9) under the conditions of controlling homogenizer rotating speed to be 10000-20000rpm/min, by the mixture obtained by step 8) Thing is uniformly dispersed；
10) after step 9) is well mixed, when being naturally cooling to 40~48 DEG C, preservative is added, continues mechanical agitation extremely It is well mixed；It is 100-500rpm/min to control speed of agitator, and stops stirring after naturally cooling to room temperature, discharging, produces one Face cream of the kind containing papaw extract.
Present invention also offers a kind of emulsion containing above-mentioned papaw extract, calculate by mass percentage, it is former The content and composition of material are as follows：
Papaw extract 0.02%-10%
Mineral grease 1-5%
Synthetic Oil 1-4%
Vegetable fat 1-5%
Animal fat 0-2%
Emulsifying agent 2-6%
NMF 2-10%
Rheology control agent 0.05-1%
Preservative 0.05-0.2%
Antioxidant 0.01-0.1%
Surplus is deionized water；
Described mineral grease is the mixture that stearic acid and white oil form, and the mass ratio of described stearic acid and white oil is 3：1；
Described Synthetic Oil is the mixing of isobutyl palmitate, glycerin monostearate and dimethyl siloxane composition Thing, the mass ratio of described isobutyl palmitate, glycerin monostearate and dimethyl siloxane is 6：1：2；Described is natural The mass ratio of the mixture that grease forms for Sweet Almond Oil and olive oil, described Sweet Almond Oil and olive oil is 1：2；
Described emulsifying agent is the stearic alcohol ether of polyoxyethylene (2), the mixture of the stearic alcohol ether composition of polyoxyethylene (21), institute The stearic alcohol ether of polyoxyethylene (2), the mass ratio of polyoxyethylene (21) stearic alcohol ether stated are 2：3；Described NMF is glycerine With the mixture of 1,3-BDO composition, the mass ratio of described glycerine and butanediol is 2:3；
Described preservative is the matter of methyl hydroxybenzoate and propylben, described methyl hydroxybenzoate and propylben Amount is than being 2：1；
Described antioxidant is 2,6- di-tert-butyl hydroxy toluenes.
Present invention also offers a kind of preparation method of above-mentioned emulsion containing papaw extract, including following step Suddenly：
1) each raw material is weighed according to mass ratio；
2) oil phase of vegetable oil esters, mineral grease, Synthetic Oil, emulsifying agent, antioxidant composition is heated to 65-90 DEG C Stirring and dissolving is as A phases；
3) rheology control agent, NMF are dissolved in deionized water and are heated to 65-90 DEG C of insulation as B phases；
4) it is under the conditions of controlling homogenizer rotating speed to be 10000-20000rpm/min, the A obtained by step 2) is phased It is that 50-100ml/min is added it in the B phases obtained by step 3) that system, which adds speed, and continues homogeneous until A phases with homogenizer Mixed uniformly with B；
5) after step 4) A phases and B are mixed uniformly, 75~80 DEG C are naturally cooling to, carries out mechanical defoaming；Described machinery Defoaming controls speed of agitator to be defoamed for 200-500rpm/min；
6) when being naturally cooling to 45 DEG C after the completion of step 5) defoaming, preservative and papaw extract is added, continues machinery To well mixed and stop stirring after naturally cooling to room temperature, described churned mechanically speed of agitator is 200- for stirring 500rpm/min, discharging, produces a kind of emulsion containing papaw extract.
Present invention also offers a kind of toner containing above-mentioned papaw extract, calculate by mass percentage, its The content and composition of raw material are as follows：
Papaw extract 0.02%-10%
NMF 5-20%
Solubilizer 0.5-2%
Rheology control agent 0.05-0.5%
Preservative 0.05-0.2%
Essence 0.01-0.05%
Surplus is deionized water；
Described NMF is glycerine, propane diols, 1,3-BDO, the mixture of Sodium Hyaluronate composition, and described is sweet Oil, propane diols, the mass ratio of butanediol and hyaluronic acid are 5：5:5:0.03；
Described solubilizer is rilanit special；
Described rheology control agent is hydroxyethyl cellulose；
Described preservative is the mixture of hydroxyphenyl methyl esters and hydroxyphenyl propyl ester composition, described hydroxyphenyl methyl esters and hydroxyl The mass ratio of phenylpropyl acrylate is 2：1.
Present invention also offers a kind of preparation method of above-mentioned toner containing papaw extract, including following step Suddenly：
1) each raw material is weighed according to mass ratio；
2) deionized water is added in a reaction vessel, starts agitator, rheology control agent is slowly poured into beaker, Rheology control agent add finish continue stir 15-20min it is standby；
3) essence, solubilizer and preservative Hybrid Heating are heated to 45 DEG C as oil phase and obtain oil phase；
4) papaw extract, NMF are added in the deionized water of step 2) and are heated uniformly to as Aqueous dispersions 50 DEG C obtain aqueous phase；
5) aqueous phase obtained by step 4) is cooled to 45 DEG C, then the oil phase obtained by step 3) is added to obtained by step 4) In aqueous phase, while mixer is opened, it is 300-500rpm/min to control mixing speed, is disperseed, and mechanical agitation is equal to mixing It is even and naturally cool to and stop stirring after room temperature, discharging, produce a kind of toner containing papaw extract.
Present invention also offers application of the above-mentioned papaw extract as anti-allergic agent in skin applies some make up, Wan Shou The mass ratio that berry extract and skin apply some make up is 0.0002~10：100.
Find that papaw extract also has gentle skin effect and stronger antiallergy ability through present invention research, Available for gentle effective hypo-allergenic anti-oxidant skin conditioner is prepared, a series of skins prepared using the gentle antiallergy skin conditioner are used Cosmetics have that preparation technology simple possible, anti-hydroxy radical effect be good, natural safety, are adapted to sensitive skin, antianaphylactic same When have the characteristics of anti-aging effects, papaw extract of the invention is a kind of gentle antiallergy of ideal natural plants With anti-oxidant skin care ingredient.
The present invention compares with prior art, and its technological progress is significant.Papaw extract is added into skin to make up In product, have pure natural, safety, antiallergic effect good, there is certain antioxidant effect.And there is preparation technology simple possible The characteristics of, the skin of final gained applies some make up natural safety, antianaphylactic while also have the characteristics of anti-aging effects etc..
Brief description of the drawings
Fig. 1 is the antianaphylactic design sketch of papaw extract.
Embodiment
The present invention is expanded on further by way of example and in conjunction with the accompanying drawings, but is not intended to limit the present invention.
Embodiment 1
A kind of papaw extract, is prepared via a method which：
(1), papaw powder is added and gone in ethanol, controls the mass ratio of papaw and ethanol to calculate, i.e. papaw：Second Alcohol is 1：20 mixed after obtain mixed liquor；
It is 70 DEG C, power 150W that the mixed liquor of gained, which controls temperature, and ultrasound is carried out under the ultrasound condition that frequency is 40kHz After extracting 15-30min, with 0.45 μm of filtering with microporous membrane；
(2) filtrate obtained by after, step (1) is filtered controls vacuum to carry out vacuum rotation under conditions of 0.095MPa Turn evaporation, obtain papaw extract concentrated solution, control temperature dry for -55 DEG C of freezings the papaw extract concentrated solution of gained It is dry, obtain papaw extract.
The papaw extract of above-mentioned gained is resisted into sensitizing effect experiment respectively to investigate, it is comprised the following steps that：
(1) the papaw extract solution 5ml for being, 0.05g/ml with deionized water compound concentration is sample, in subject Left hand and right hand inner forearm same position select one piece of 3cm*3cm tested region respectively.
(2) tested region, is eluted into 90s with deionized water, at 20 DEG C, the interior of air humidity 50%, which is sat quietly 30 minutes, dries in the air It is dry.
(3) 50 μ L samples while in subject are smeared in the tested region of right finesse, 50 μ L are smeared in the tested region of left finesse Distilled water, smearing time are 30s.
(4), recipient site skin content of hemachrome blank value is tested using the detector for pigment of Mexameterv MX 18 EX0。
(5) subject sits quietly 15 minutes after, having been smeared in step (5), is then added dropwise to respectively in the tested region of two hands Quick dose of 50 μ L.
(6) subject sits quietly 5 minutes after, having smeared, and is then tested using the detector for pigment of Mexameterv MX 18 double Hand recipient site skin content of hemachrome EX1。
(7), skin content of hemachrome EX1It is completed rear subject to sit quietly 10min, then using Mexameterv MX 18 detector for pigment test both hands recipient site skin content of hemachrome EX2。
(8), skin content of hemachrome EX2It is completed rear subject to sit quietly 10min, then using Mexameterv MX 18 detector for pigment test both hands recipient site skin content of hemachrome EX3。
(9), skin content of hemachrome EX3It is completed rear subject to sit quietly 10min, then using Mexameterv MX 18 detector for pigment test both hands recipient site skin content of hemachrome EX4。
The data of acquisition do line chart, such as Fig. 1.It can be seen that blood red when blank control group and sample sets are not added dropwise sensitizing agent Plain blank value is close, and blank control skin ferroheme value after sensitizing agent is applied substantially rises, and it is anti-that the allergy such as redness occurs in skin Should, and apply the tested area skin ferroheme value changes very little of the papaw extract, skin without obvious allergic reaction, Illustrate that the papaw extract has the effect of antiallergy, hypo-allergenic, the feature skin care for being adapted to sensitive can be applied to To be made, safety is gentle to have both effectiveness skin care item simultaneously in product.
The papaw extract of above-mentioned gained is tested to scavenging hydroxyl respectively and investigated, it is comprised the following steps that：
(1) the papaw extract solution 5ml for being, 0.1mg/ml with absolute ethyl alcohol compound concentration is sample solution.
(2) 0.3ml crystal violets (0.4mmol/L), 1.2mlFeSO while in 10ml colorimetric cylinders A are added4Solution (1.0mmol/L) (blank control group), 0.3ml crystal violets (0.4mmol/L), 1.2mlFeSO are added in 10ml colorimetric cylinders B4It is molten Liquid (1.0mmol/L) and 1ml sample solutions (sample sets).
(3) sodium dihydrogen phosphate-citric acid solution (pH=4.0) constant volume, is used respectively.
(4) after, placing 10min, the absorbance A of sample sets and blank control group is surveyed at 580nm10And A00
(5), it is separately added into 0.6mlH in colorimetric cylinder A and colorimetric cylinder B2O2Solution (2.ommol/L), distinguish after shaking 15s The absorbance A of sample sets and blank control group is surveyed at 580nm1bAnd A0b。
(6), clearing amount △ A=(A of the papaw extract to hydroxy radical10-A1b)-(A00-A0b) characterize.
(7) 0.1ml, 0.2ml, 0.4ml, 0,6ml, 0.8ml, are separately added into same method test and contains 1% papaw Absorbance after extract solution.
(8), as can be seen from Table 1, understand that papaw extract has the function of scavenging hydroxyl by △ A ＞ 0, there is antioxygen Change skin-care effect.
The anti-hydroxy radical effect of table 1, papaw extract
Application Example 1
Using the papaw extract of the gained of embodiment 1 as antiallergy skin conditioner, the application in face cream is prepared, i.e., one Face cream of the kind containing papaw extract, is calculated, the content and composition of its raw material are as follows by mass percentage：
Described mineral grease is the mixture that stearic acid and white oil form, and is calculated in mass ratio, i.e. stearic acid：White oil is 4：1；
Described Synthetic Oil is the mixing of isobutyl palmitate, glycerin monostearate and dimethyl siloxane composition Thing, calculate in mass ratio, i.e. isobutyl palmitate：Glycerin monostearate is：Dimethyl siloxane 6：1：2；
Described natural oil is that the mixture that Sweet Almond Oil and olive oil form calculates in mass ratio, i.e. Sweet Almond Oil： Olive oil is 1：2；
Described emulsifying agent is the stearic alcohol ether of polyoxyethylene (2), the stearic alcohol ether of polyoxyethylene (21), match Bick 305 emulsify The mixture of agent composition, is calculated, i.e. polyoxyethylene (2) stearic alcohol ether in mass ratio：Polyoxyethylene (21) stearic alcohol ether：Match Bick 305 emulsifying agents are 2：3:3；
Described NMF is glycerine and butanediol, is calculated in mass ratio, i.e. glycerine：Butanediol is 1:3；
Described preservative is methyl hydroxybenzoate and propylben, is calculated in mass ratio, i.e. methyl hydroxybenzoate：Nipalgin Propyl ester is 2：1；
Described antioxidant is 2,6- di-tert-butyl hydroxy toluenes.
A kind of preparation method of above-mentioned face cream containing papaw extract, specifically comprises the following steps：
(1), it is 3.2g stearic acid and 0.8g white oil, 4.5g Synthetic Oil i.e. 3g palmitic acid by mineral grease 4g The glycerin monostearate of different monooctyl ester and 0.5g and 1g dimethyl siloxane, 1.5g match Bick 305 emulsifying agent form Oil phase 1 be heated to 65-90 DEG C of stirring and dissolving be incubated as A1 phases it is standby；
(2), by 2g vegetable fat be 0.65g Sweet Almond Oil and 1.35g olive oil, 1g polyoxyethylene (2) it is hard Lipidol ether, the 1.5g stearic alcohol ether of polyoxyethylene (21), 0.05g antioxidants are the oil of 2,6- di-tert-butyl hydroxy toluenes composition Phase 2 be heated to 65-90 DEG C of stirring and dissolving be incubated as A2 phases it is standby；
(3), 0.05g papaw extracts are dissolved in 5g deionized waters and be heated to 50-70 DEG C insulation aqueous phase 1 as B1 phases are standby；
(4), by 6g NMFs be 1.5g glycerine and 4.5g butanediols in 72.3g deionized waters, heating stirring to 65- 90 DEG C be completely dispersed uniform aqueous phase 2 be incubated as B2 phases it is standby；
(5), control temperature that the A1 phases obtained by step (1) and step (2) are mixed and stirred with A2 phases at 70-85 DEG C Mix uniformly, total oil phase is made as A phases；
(6), controlling temperature, mixer mixing speed is 500-700rpm/min, by step (4) and step at 70-85 DEG C (5) the B2 phases obtained by with A phases be mixed and stirred for uniformly；
(7) it is 500-700rpm/min, to control mixer mixing speed, and the mixture obtained by step (6) is cooled to 50-70 DEG C, then mixed with the B1 obtained by step (3)；
(8), will be mixed obtained by step (7), under the conditions of controlling homogenizer rotating speed to be 10000-20000rpm/min Compound homogeneous 3min, is uniformly dispersed；
(9), after step (8) is well mixed, when being naturally cooling to 45 DEG C, it is 0.066 nipalgin to add 0.1g preservatives Methyl esters and 0.034g propylbens, continue mechanical agitation to well mixed；And stop stirring after naturally cooling to room temperature, go out Material, produces a kind of face cream containing papaw extract.
Application Example 2
Using the papaw extract of the gained of embodiment 1 as antiallergy skin conditioner, the application in facial treatment milk is prepared, i.e., A kind of facial treatment milk containing papaw extract, is calculated by mass percentage, and the content and composition of its raw material are as follows：
Described mineral grease is the mixture that stearic acid and white oil form, and is calculated in mass ratio, i.e. stearic acid：White oil is 3：1；
Described Synthetic Oil is the mixing of isobutyl palmitate, glycerin monostearate and dimethyl siloxane composition Thing, calculate in mass ratio, i.e. isobutyl palmitate：Glycerin monostearate is：Dimethyl siloxane 6：1：2；
Described natural oil is that the mixture that Sweet Almond Oil and olive oil form calculates in mass ratio, i.e. Sweet Almond Oil： Olive oil is 1：2；
Described emulsifying agent is the stearic alcohol ether of polyoxyethylene (2), the mixture of the stearic alcohol ether composition of polyoxyethylene (21), is pressed Mass ratio calculates, i.e. polyoxyethylene (2) stearic alcohol ether：Polyoxyethylene (21) stearic alcohol ether is 2：3；
Described NMF is glycerine and butanediol, is calculated in mass ratio, i.e. glycerine：Butanediol is 2:3；
Described rheology control agent is hydroxyethyl cellulose；
Described preservative is methyl hydroxybenzoate and propylben, is calculated in mass ratio, i.e. methyl hydroxybenzoate：Nipalgin Propyl ester is 2：1；
Described antioxidant is 2,6- di-tert-butyl hydroxy toluenes.
A kind of preparation method of above-mentioned emulsion containing papaw extract, specifically comprises the following steps：
(1) it is, 0.8g Sweet Almond Oils and 1.6g olive oil, 4g mineral grease i.e. 3g stearic acid by 2.4g vegetable oil esters White oil, 3g Synthetic Oils with 1g are 2g isobutyl palmitate and 0.33g glycerin monostearate and 0.67g diformazan Radical siloxane, 3g emulsifying agents are that the 2g stearic alcohol ether of polyoxyethylene (2) and the 1g stearic alcohol ether of polyoxyethylene (21), 0.05g resist Oxidant is that the oil phase of 0.05g 2,6- di-tert-butyl hydroxy toluenes composition is heated to 65-90 DEG C of stirring and dissolving as A phases；
(2), it is 0.2g hydroxyethyl cellulose, 5g NMFs i.e. 2g glycerine and 3g fourth two by 0.2g rheology control agents Alcohol, which is dissolved in deionized water and is heated to 65-90 DEG C of insulation, is used as B phases；
(3), under the conditions of controlling homogenizer rotating speed to be 10000-20000rpm/min, by the A phases obtained by step (1) Control add speed be 50-100ml/min add it in the B phases obtained by step (2), and with homogenizer continue homogeneous until A phases and B are mixed uniformly；
(4) after, step (3) A phases and B are mixed uniformly, 75~80 DEG C are naturally cooling to, carries out mechanical defoaming；
Described mechanical defoaming controls speed of agitator to be defoamed for 200-500rpm/min；
(5) when, being naturally cooling to 45 DEG C after the completion of step (4) defoaming, preservative and papaw extract is added, continues machine Tool is stirred to well mixed and naturally cool to after room temperature and stop stirring, discharging, produces a kind of breast containing papaw extract Liquid.
Application Example 3
Using the papaw extract of the gained of embodiment 1 as antiallergy skin conditioner, the application in toner is prepared, i.e., one Toner of the kind containing papaw extract, is calculated, the content and composition of its raw material are as follows by mass percentage：
Described NMF is one kind or two in glycerine, 1,3 butylene glycol, hyaluronic acid, Sodium Hyaluronate and niacinamide The mixture of kind composition described above, is calculated, i.e. glycerine in mass ratio：Propane diols：Butanediol：Hyaluronic acid is 5：5:5:0.03；
The solubilizer is rilanit special；
Described rheology control agent is hydroxyethyl cellulose or card ripple；
Described preservative is the mixture of hydroxyphenyl methyl esters and hydroxyphenyl propyl ester composition, is calculated in mass ratio, i.e. oxybenzene Base methyl esters：Hydroxyphenyl propyl ester is 2：1；
Described essence is conventional perfume material mixture used for cosmetic；
A kind of preparation method of above-mentioned toner containing papaw extract, specifically comprises the following steps：
(1), take a certain amount of deionized water to start agitator in beaker, rheology control agent is slowly poured into beaker, flow Modified tone
Section agent add finish continue stir 15-20min it is standby；
(2) essence, solubilizer and preservative Hybrid Heating, are heated to 45 DEG C as oil phase and obtain oil phase；
(3), papaw extract, NMF are added in the deionized water of step (1) and uniformly added as Aqueous dispersions Hot to 50 DEG C obtain aqueous phase；
(4) aqueous phase obtained by step (3), is cooled to 45 DEG C, then the oil phase obtained by step (2) is added to step (3) In the aqueous phase of gained, while mixer is opened, it is 300-500rpm/min to control mixing speed, carries out scattered 10min, and machinery stirs Mix to well mixed and naturally cool to after room temperature and stop stirring, discharging, produce a kind of toner containing papaw extract.

Claims (8)

  1. A kind of 1. papaw extract, it is characterised in that：With powder is ground into after papaw fruit is dried, then by papaw Powder is 1 according to mass ratio with ethanol or methanol solvate：After 10-30 ratio is mixed, ultrasonic wave is used at 60~80 DEG C 15-30min is extracted, by liquid with after 0.45 μm of filtering with microporous membrane, collects filtrate, it is 0.094-0.096MPa to control vacuum Under conditions of carry out rotary evaporation in vacuo obtain papaw extract concentrated solution, concentrate is freeze-dried, obtains the papaw Extract.
  2. A kind of 2. face cream of the papaw extract containing described in claim 1, it is characterised in that calculate by mass percentage, The content and composition of its raw material are as follows：
    Papaw extract 0.02%-10%
    Mineral grease 1-5%
    Synthetic Oil 1-4%
    Vegetable fat 1-5%
    Animal fat 0-2%
    Emulsifying agent 2-6%
    NMF 2-10%
    Preservative 0.05-0.2%
    Antioxidant 0.01-0.1%
    Surplus is deionized water；
    The mass ratio of the mixture that described mineral grease forms for stearic acid and white oil, described stearic acid and white oil is 4：1；
    The mixture that described Synthetic Oil is isobutyl palmitate, glycerin monostearate and dimethyl siloxane form, institute The mass ratio of isobutyl palmitate, glycerin monostearate and the dimethyl siloxane stated is 6：1：2；
    The mixture that described natural oil forms for Sweet Almond Oil and olive oil, the quality of the good olive oil of described Sweet Almond Oil Than for 1：2；
    Described emulsifying agent is the stearic alcohol ether of polyoxyethylene (2), the stearic alcohol ether of polyoxyethylene (21), the match emulsifying agent group of Bick 305 Into mixture, described polyoxyethylene (2) stearic alcohol ether, polyoxyethylene (21) stearic alcohol ether and the match emulsifying agent of Bick 305 Mass ratio is 2：3:3；
    The mass ratio of the mixture that described NMF forms for glycerine and butanediol, described glycerine and butanediol is 1:3；
    The mixture that described preservative forms for methyl hydroxybenzoate and propylben, described methyl hydroxybenzoate and nipalgin The mass ratio of propyl ester is 2：1；
    Described antioxidant is 2,6- di-tert-butyl hydroxy toluenes.
  3. 3. the preparation method of a kind of face cream containing papaw extract described in claim 2, it is characterised in that including such as Lower step：
    1) each reaction raw materials are weighed according to mass ratio；
    2) using mineral grease, Synthetic Oil, match Bick 305 emulsifying agent composition oil phase 1 be heated to 65-90 DEG C of stirring and dissolving as A1 phases；
    3) oil phase 2 for forming vegetable fat, the stearic alcohol ether of polyoxyethylene (2), the stearic alcohol ether of polyoxyethylene (21), antioxidant 65-90 DEG C of stirring and dissolving is heated to as A2 phases；
    4) papaw extract is dissolved in 5~30% deionized water and is heated to the aqueous phase 1 of 50-70 DEG C of insulation as B1 Phase；
    5) NMF is dissolved in 5~30% deionized water, heating stirring is completely dispersed uniform aqueous phase 2 to 65-90 DEG C and made For B2 phases；
    6) temperature is controlled at 70-85 DEG C, the A1 phases obtained by step 2) and step 3) be mixed and stirred for uniformly with A2 phases, system Total oil phase is obtained as A phases；
    7) controlling temperature, mixer mixing speed is 500-700rpm/min at 70-85 DEG C, by obtained by step 5) and step 6) B2 phases with A phases be mixed and stirred for uniformly；
    8) it is 500-700rpm/min to control mixer mixing speed, and the mixture obtained by step 7) is cooled into 50-70 DEG C, Then mixed with the B1 obtained by step 4)；
    9) under the conditions of controlling homogenizer rotating speed to be 10000-20000rpm/min, by the mixture thing point obtained by step 8) Dissipate uniform；
    10) after step 9) is well mixed, when being naturally cooling to 40~48 DEG C, preservative is added, continues mechanical agitation to mixing Uniformly；It is 100-500rpm/min to control speed of agitator, and stops stirring after naturally cooling to room temperature, discharging, produces one kind and contains There is the face cream of papaw extract.
  4. A kind of 4. emulsion of the papaw extract containing described in claim 1, it is characterised in that calculate by mass percentage, its The content and composition of raw material are as follows：
    Papaw extract 0.02%-10%
    Mineral grease 1-5%
    Synthetic Oil 1-4%
    Vegetable fat 1-5%
    Animal fat 0-2%
    Emulsifying agent 2-6%
    NMF 2-10%
    Rheology control agent 0.05-1%
    Preservative 0.05-0.2%
    Antioxidant 0.01-0.1%
    Surplus is deionized water；
    The mass ratio of the mixture that described mineral grease forms for stearic acid and white oil, described stearic acid and white oil is 3：1；
    The mixture that described Synthetic Oil is isobutyl palmitate, glycerin monostearate and dimethyl siloxane form, institute The mass ratio of isobutyl palmitate, glycerin monostearate and the dimethyl siloxane stated is 6：1：2；
    Described natural oil is the quality of the mixture that Sweet Almond Oil and olive oil form, described Sweet Almond Oil and olive oil Than for 1：2；
    Described emulsifying agent is the stearic alcohol ether of polyoxyethylene (2), the mixture of the stearic alcohol ether composition of polyoxyethylene (21), described The stearic alcohol ether of polyoxyethylene (2), the mass ratio of polyoxyethylene (21) stearic alcohol ether are 2：3；Described NMF is glycerine and 1, The mass ratio of the mixture of 3- butanediols composition, described glycerine and butanediol is 2:3；
    Described preservative is the mass ratio of methyl hydroxybenzoate and propylben, described methyl hydroxybenzoate and propylben For 2：1；
    Described antioxidant is 2,6- di-tert-butyl hydroxy toluenes.
  5. 5. the preparation method of a kind of emulsion containing papaw extract described in claim 4, it is characterised in that including as follows Step：
    1) each raw material is weighed according to mass ratio；
    2) oil phase of vegetable oil esters, mineral grease, Synthetic Oil, emulsifying agent, antioxidant composition is heated to 65-90 DEG C of stirring Dissolving is used as A phases；
    3) rheology control agent, NMF are dissolved in deionized water and are heated to 65-90 DEG C of insulation as B phases；
    4) under the conditions of controlling homogenizer rotating speed to be 10000-20000rpm/min, the A phase controls obtained by step 2) are added Enter speed to add it in the B phases obtained by step 3) for 50-100ml/min, and continue homogeneous until A phases and B with homogenizer Mix uniformly；
    5) after step 4) A phases and B are mixed uniformly, 75~80 DEG C are naturally cooling to, carries out mechanical defoaming；Described mechanical defoaming Speed of agitator is controlled to be defoamed for 200-500rpm/min；
    6) when being naturally cooling to 45 DEG C after the completion of step 5) defoaming, preservative and papaw extract is added, continues mechanical agitation Stop stirring to being well mixed and naturally cooling to after room temperature, described churned mechanically speed of agitator is 200-500rpm/ Min, discharging, produces a kind of emulsion containing papaw extract.
  6. A kind of 6. toner of the papaw extract containing described in claim 1, it is characterised in that calculate by mass percentage, The content and composition of its raw material are as follows：
    Papaw extract 0.02%-10%
    NMF 5-20%
    Solubilizer 0.5-2%
    Rheology control agent 0.05-0.5%
    Preservative 0.05-0.2%
    Essence 0.01-0.05%
    Surplus is deionized water；
    Described NMF is glycerine, the mixture of propane diols, 1,3-BDO, Sodium Hyaluronate composition, described glycerine, third The mass ratio of glycol, butanediol and hyaluronic acid is 5：5:5:0.03；
    Described solubilizer is rilanit special；
    Described rheology control agent is hydroxyethyl cellulose；
    Described preservative is the mixture of hydroxyphenyl methyl esters and hydroxyphenyl propyl ester composition, described hydroxyphenyl methyl esters and hydroxyphenyl The mass ratio of propyl ester is 2：1.
  7. 7. the preparation method of a kind of toner containing papaw extract described in claim 6, it is characterised in that including such as Lower step：
    1) each raw material is weighed according to mass ratio；
    2) deionized water is added in a reaction vessel, starts agitator, rheology control agent is slowly poured into beaker, rheology Conditioning agent add finish continue stir 15-20min it is standby；
    3) essence, solubilizer and preservative Hybrid Heating are heated to 45 DEG C as oil phase and obtain oil phase；
    4) papaw extract, NMF are added in the deionized water of step 2) and are heated uniformly to 50 DEG C as Aqueous dispersions Obtain aqueous phase；
    5) aqueous phase obtained by step 4) is cooled to 45 DEG C, then the oil phase obtained by step 3) is added to the aqueous phase obtained by step 4) In, while open mixer, it is 300-500rpm/min to control mixing speed, is disperseed, mechanical agitation to it is well mixed simultaneously Stop stirring after naturally cooling to room temperature, discharging, produce a kind of toner containing papaw extract.
  8. 8. application of the papaw extract as anti-allergic agent in skin applies some make up described in claim 1, papaw extraction The mass ratio that thing and skin apply some make up is 0.0002~10：100.
CN201710762749.3A 2017-08-30 2017-08-30 A kind of papaw extract and preparation method thereof and the application in cosmetics Pending CN107362100A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710762749.3A CN107362100A (en) 2017-08-30 2017-08-30 A kind of papaw extract and preparation method thereof and the application in cosmetics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710762749.3A CN107362100A (en) 2017-08-30 2017-08-30 A kind of papaw extract and preparation method thereof and the application in cosmetics

Publications (1)

Publication Number Publication Date
CN107362100A true CN107362100A (en) 2017-11-21

Family

ID=60312175

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710762749.3A Pending CN107362100A (en) 2017-08-30 2017-08-30 A kind of papaw extract and preparation method thereof and the application in cosmetics

Country Status (1)

Country Link
CN (1) CN107362100A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394635A (en) * 2018-12-28 2019-03-01 上海应用技术大学 A kind of preparation method of Fructus Liquidambaris fruit extract and its application in cosmetics
CN112494386A (en) * 2020-12-15 2021-03-16 上海应用技术大学 Preparation method and application of blue butterfly extract with blue light resisting component

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336987A (en) * 2008-08-12 2009-01-07 西北农林科技大学 Preparation method of total flavone of Hovenia dulcisThunb
CN103599021A (en) * 2013-11-15 2014-02-26 上海应用技术学院 Roselle extract as well as preparation method thereof and application thereof in whitening skincare cosmetics

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336987A (en) * 2008-08-12 2009-01-07 西北农林科技大学 Preparation method of total flavone of Hovenia dulcisThunb
CN103599021A (en) * 2013-11-15 2014-02-26 上海应用技术学院 Roselle extract as well as preparation method thereof and application thereof in whitening skincare cosmetics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
落花未眠14: "拐枣总黄酮的提取与测定", 《百度文库，网址HTTPS://WENKU.BAIDU.COM/VIEW/542698BDDD3383C4BB4CD25D.HTML》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109394635A (en) * 2018-12-28 2019-03-01 上海应用技术大学 A kind of preparation method of Fructus Liquidambaris fruit extract and its application in cosmetics
CN112494386A (en) * 2020-12-15 2021-03-16 上海应用技术大学 Preparation method and application of blue butterfly extract with blue light resisting component

Similar Documents

Publication Publication Date Title
CN103705421B (en) A kind of milk moisturizing anti-aging cream and manufacture method thereof
CN107412073A (en) A kind of composition containing peach gum hydrolysate and its preparation method and application
CN101336874A (en) Water-solubility active extract in fruit skin, preparation method and use thereof
CN102614103B (en) Middle and old-aged nourishing and wrinkle-resisting cream and preparation method thereof
CN104814881B (en) A kind of moisturizing remediation composition and the epidermis Biomimetic membranes liquid crystal complex constructed by it
CN110314118A (en) Have effects that anti-aging, the composition repaired and its preparation method and application
CN109157447B (en) Application of cherokee rose fruit extract in whitening, moisturizing and anti-aging skin care product and preparation method thereof
CN109157469A (en) For improving the compound and preparation method thereof of eye part skin comprehensively
CN109330965B (en) A cosmetic composition containing plant extract
CN107281005A (en) A kind of preparation method of the nanometer emulsified liquid of anti-wrinkle composition and its PIT
CN109535269A (en) A kind of preparation process and its application of dendrobium nobile micromolecular polysaccharide extracting solution
WO2002005662A1 (en) Physiologically functional foods or cosmetics containing sphingoglycolipids and processes for their production
CN106692023A (en) Multifunctional bio-fiber traditional Chinese medicine mask and manufacturing method thereof
CN110585083A (en) Preparation method of okra-based extract and application of okra-based extract as cosmetic matrix
CN101461763A (en) Method for producing cosmetics containing notoginseng polysaccharide and use
CN107362100A (en) A kind of papaw extract and preparation method thereof and the application in cosmetics
CN109394633A (en) Purple common perilla seed and its application in moisturizing or anti-oxidation efficacy cosmetics
CN106236656B (en) A kind of compact eye cream of rosemary
CN107375087A (en) A kind of shower cream and preparation method thereof
CN110917105A (en) Allergy-relieving cosmetic composition and preparation method thereof
JP2022173364A (en) Skin external preparation
CN105919905A (en) Wild apricot eucommia ulmoides moisturizing and nourishing cream and preparation method thereof
CN108078836A (en) A kind of milky lotion and preparation method thereof
CN107468576A (en) A kind of composition containing burdock extract and its application in cosmetics
CN106821901A (en) A kind of creme with the wrinkle of skin effect of reduction circumference of eyes

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20171121

WD01 Invention patent application deemed withdrawn after publication