CN103582644B - 酞嗪酮-吡咯并嘧啶羧酰胺衍生物 - Google Patents

酞嗪酮-吡咯并嘧啶羧酰胺衍生物 Download PDF

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Publication number
CN103582644B
CN103582644B CN201280028413.XA CN201280028413A CN103582644B CN 103582644 B CN103582644 B CN 103582644B CN 201280028413 A CN201280028413 A CN 201280028413A CN 103582644 B CN103582644 B CN 103582644B
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CN
China
Prior art keywords
base
oxo
piperidin
pyrrolo
pyrimidine
Prior art date
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Expired - Fee Related
Application number
CN201280028413.XA
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English (en)
Chinese (zh)
Other versions
CN103582644A (zh
Inventor
T.施滕格尔
T.迈尔
A.曼
J.施塔德尔维泽
D.弗罗克齐
A.帕尔
E.贝内迪克图斯
M.黑斯曼
T.卡纳歇尔
R.胡松格
C.齐特
H.C.霍尔斯特
R-P.胡梅尔
M.菲尔特尔豪斯
H.特诺尔
T.东克恩
A.哈切尔曼
C.黑斯林格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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Takeda GmbH
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Application filed by Takeda GmbH filed Critical Takeda GmbH
Publication of CN103582644A publication Critical patent/CN103582644A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280028413.XA 2011-06-17 2012-06-12 酞嗪酮-吡咯并嘧啶羧酰胺衍生物 Expired - Fee Related CN103582644B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11170440.9 2011-06-17
EP11170440 2011-06-17
PCT/EP2012/061084 WO2012171900A1 (en) 2011-06-17 2012-06-12 Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives

Publications (2)

Publication Number Publication Date
CN103582644A CN103582644A (zh) 2014-02-12
CN103582644B true CN103582644B (zh) 2016-07-20

Family

ID=44764312

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280028413.XA Expired - Fee Related CN103582644B (zh) 2011-06-17 2012-06-12 酞嗪酮-吡咯并嘧啶羧酰胺衍生物

Country Status (22)

Country Link
US (2) US20140112945A1 (enExample)
EP (1) EP2721030B1 (enExample)
JP (1) JP5980318B2 (enExample)
KR (1) KR20140037195A (enExample)
CN (1) CN103582644B (enExample)
AR (1) AR086915A1 (enExample)
AU (1) AU2012269133A1 (enExample)
BR (1) BR112013031791A2 (enExample)
CA (1) CA2837248A1 (enExample)
CL (1) CL2013003556A1 (enExample)
CO (1) CO6852074A2 (enExample)
CR (1) CR20130656A (enExample)
DO (1) DOP2013000298A (enExample)
EA (1) EA023713B1 (enExample)
EC (1) ECSP13013076A (enExample)
ES (1) ES2564882T3 (enExample)
MA (1) MA35269B1 (enExample)
MX (1) MX2013014888A (enExample)
PE (1) PE20140648A1 (enExample)
PH (1) PH12013502546A1 (enExample)
TN (1) TN2013000439A1 (enExample)
WO (1) WO2012171900A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018510891A (ja) 2015-04-09 2018-04-19 ガルデルマ・ソシエテ・アノニム 抗菌性インジゴナチュラリス又はインジゴ産生植物抽出物及びその使用
TWI732754B (zh) 2015-04-09 2021-07-11 瑞士商高德美公司 中藥青黛萃取物及其製備方法
TW201642890A (zh) * 2015-04-09 2016-12-16 高德美公司 以青黛或產靛藍植物提取物治療異位性皮膚炎
MX389026B (es) 2015-04-09 2025-03-20 Galderma Sa Una composicion farmaceutica y el uso de la misma.
WO2022006470A1 (en) 2020-07-01 2022-01-06 Vanderbilt University Methods of treatment for a kidney disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1249749A (zh) * 1997-01-15 2000-04-05 比克·古尔顿·劳姆贝尔格化学公司 2,3－二氮杂萘酮
WO2004018451A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
WO2011023693A1 (en) * 2009-08-26 2011-03-03 Nycomed Gmbh Methylpyrrolopyrimidinecarboxamides

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GB8828477D0 (en) 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
EP0407028B2 (en) 1989-05-31 1999-07-07 FISONS plc Medicament inhalation device and formulation
GB8921222D0 (en) 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
IL97065A (en) 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
DE4003272A1 (de) 1990-02-03 1991-08-08 Boehringer Ingelheim Kg Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen
EP0636362B1 (en) 1990-03-23 1999-12-22 Minnesota Mining And Manufacturing Company The use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations
EP0553298B1 (en) 1990-10-18 1994-11-17 Minnesota Mining And Manufacturing Company Aerosol formulation comprising beclomethasone 17,21 dipropionate
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
IL104068A (en) 1991-12-12 1998-10-30 Glaxo Group Ltd Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant
GB9213874D0 (en) 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
GB9306703D0 (en) 1993-03-31 1993-05-26 Fisons Plc Inhalation device
IL111194A (en) 1993-10-08 1998-02-08 Fisons Plc Process for the production of medicament formulations
US6255303B1 (en) * 1998-03-14 2001-07-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone PDE III/IV inhibitors
CA2338680C (en) 1998-08-04 2008-10-14 Jago Research Ag Medicinal aerosol formulations
US6397838B1 (en) 1998-12-23 2002-06-04 Battelle Pulmonary Therapeutics, Inc. Pulmonary aerosol delivery device and method
JP4530548B2 (ja) 1999-04-23 2010-08-25 バテル・メモリアル・インスティテュート 効率がよい物質移動用電気流体力学式エーロゾル噴霧器およびエーロゾルを生成しかつ所望の位置に給送する方法
WO2000064590A1 (en) 1999-04-23 2000-11-02 Battelle Memorial Institute Directionally controlled ehd aerosol sprayer
NZ522882A (en) * 2000-06-05 2004-07-30 Altana Pharma Bv Pyridazinone compounds effective as beta-2-adrenoreceptor agonists as well as PDE4-inhibitors
ATE320242T1 (de) 2000-10-09 2006-04-15 3M Innovative Properties Co Medizinische aerosolzusammensetzung
EA200300836A1 (ru) * 2001-02-15 2004-02-26 Алтана Фарма Аг Производные фталазинон-пиперидина в качестве ингибиторов pde4
PL363312A1 (en) * 2001-04-25 2004-11-15 Altana Pharma Ag Novel phthalazinones
KR101131684B1 (ko) * 2002-08-10 2012-03-28 니코메드 게엠베하 Ｐｄｅ４ 억제제로서의 피롤리딘디온 치환된피페리딘-프탈라존
WO2004018449A1 (en) 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
WO2004062671A2 (en) * 2003-01-14 2004-07-29 Altana Pharma Ag Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
WO2005075457A1 (en) 2004-02-04 2005-08-18 Altana Pharma Ag Phthalazinone-derivatives as pde4 inhibitors
AU2005210042B2 (en) 2004-02-04 2011-04-21 Takeda Gmbh 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
AR070454A1 (es) * 2008-02-27 2010-04-07 Nycomed Gmbh Pirrolopirimidincarboxamidas y composiciones farmaceuticas que las comprenden

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1249749A (zh) * 1997-01-15 2000-04-05 比克·古尔顿·劳姆贝尔格化学公司 2,3－二氮杂萘酮
WO2004018451A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
WO2011023693A1 (en) * 2009-08-26 2011-03-03 Nycomed Gmbh Methylpyrrolopyrimidinecarboxamides

Also Published As

Publication number Publication date
CA2837248A1 (en) 2012-12-20
EP2721030B1 (en) 2015-12-16
MA35269B1 (fr) 2014-07-03
AU2012269133A1 (en) 2014-01-30
BR112013031791A2 (pt) 2017-01-31
JP5980318B2 (ja) 2016-08-31
TN2013000439A1 (en) 2015-03-30
EA023713B1 (ru) 2016-07-29
WO2012171900A1 (en) 2012-12-20
JP2014517021A (ja) 2014-07-17
PE20140648A1 (es) 2014-05-30
AR086915A1 (es) 2014-01-29
US20140112945A1 (en) 2014-04-24
EA201400001A1 (ru) 2014-05-30
EP2721030A1 (en) 2014-04-23
PH12013502546A1 (en) 2014-01-27
ECSP13013076A (es) 2014-01-31
DOP2013000298A (es) 2014-03-31
MX2013014888A (es) 2014-02-27
ES2564882T3 (es) 2016-03-29
US20160108049A1 (en) 2016-04-21
CO6852074A2 (es) 2014-01-30
CR20130656A (es) 2014-02-18
CL2013003556A1 (es) 2014-06-13
CN103582644A (zh) 2014-02-12
KR20140037195A (ko) 2014-03-26

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