CN103492348A - 旋光的二氢苯并呋喃衍生物的制备方法 - Google Patents

旋光的二氢苯并呋喃衍生物的制备方法 Download PDF

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CN103492348A
CN103492348A CN201280018878.7A CN201280018878A CN103492348A CN 103492348 A CN103492348 A CN 103492348A CN 201280018878 A CN201280018878 A CN 201280018878A CN 103492348 A CN103492348 A CN 103492348A
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compound
following formula
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山野光久
后藤充孝
梶原武志
前田广幸
小西隆博
瀬良美佐代
近藤裕一郎
山崎诚司
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Takeda Pharmaceutical Co Ltd
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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CN201280018878.7A 2011-02-17 2012-02-16 旋光的二氢苯并呋喃衍生物的制备方法 Pending CN103492348A (zh)

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JP2011-032610 2011-02-17
JP2011032610 2011-02-17
PCT/JP2012/054337 WO2012111849A1 (en) 2011-02-17 2012-02-16 Production method of optically active dihydrobenzofuran derivative

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Cited By (4)

* Cited by examiner, † Cited by third party
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CN104177320A (zh) * 2014-08-27 2014-12-03 广东东阳光药业有限公司 新型脲取代联苯类化合物及其组合物及用途
CN106977478A (zh) * 2017-04-21 2017-07-25 山东大学 一种2‑（6‑羟基‑2,3‑二氢苯并呋喃‑3‑基）乙酸甲酯的手性拆分方法
CN107543872A (zh) * 2016-06-29 2018-01-05 南京长澳医药科技有限公司 通过手性高效液相色谱法分离测定甲苯磺酸依度沙班水合物与其异构体杂质的方法
CN114539168A (zh) * 2020-11-27 2022-05-27 武汉大学 一种合成Piragliatin及其类似物的方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103145663B (zh) * 2013-03-01 2016-03-23 上海高准医药有限公司 (s)-2-(2,3-二氢苯并呋喃-3-基)乙酸衍生物，其制备方法及其在医药上的应用
CN104250239B (zh) * 2013-06-29 2016-09-07 山东轩竹医药科技有限公司 芳香多环羧酸衍生物
CN104370864B (zh) * 2013-08-14 2016-04-13 成都苑东生物制药股份有限公司 一种2-(6-羟基-2,3-二氢苯并呋喃-3-基)乙腈化合物和以该化合物制备tak-875药物的方法
JP6533778B2 (ja) * 2013-09-26 2019-06-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｇｐｒ４０アゴニストとしてのインダニルオキシジヒドロベンゾフラニル酢酸誘導体を調製するための方法および中間体
AU2014372114A1 (en) 2013-11-14 2016-06-09 Cadila Healthcare Limited Novel heterocyclic compounds
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
CA2980096C (en) * 2015-03-19 2019-12-17 Daiichi Sankyo Company, Limited Solid preparations of [(1r,5s,6s)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate stabilized by containing a specific antioxidant, and methodsfor preparing the same
CN107427483B (zh) 2015-03-19 2021-06-29 第一三共株式会社 含有着色剂的固体制剂
CN105418563B (zh) * 2015-12-28 2017-11-10 山东大学 Tak‑875类似物及其制备方法与应用
US10538490B2 (en) 2016-10-25 2020-01-21 Boehringer Ingelheim International Gmbh Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CN110177773B (zh) 2017-01-26 2023-08-25 勃林格殷格翰国际有限公司 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途
WO2019160882A1 (en) 2018-02-13 2019-08-22 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
WO2019204609A1 (en) 2018-04-19 2019-10-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
BR112020026746A2 (pt) 2018-07-13 2021-03-30 Gilead Sciences, Inc. Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição.
US12083226B2 (en) 2018-07-30 2024-09-10 Daiichi Sankyo Company, Limited Stabilizer-containing solid drug formulation
CN112955435B (zh) 2018-10-24 2024-09-06 吉利德科学公司 Pd-1/pd-l1抑制剂
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101616913A (zh) * 2006-06-27 2009-12-30 武田药品工业株式会社 稠环化合物

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010224A1 (en) 1995-09-13 1997-03-20 Takeda Chemical Industries, Ltd. Benzoxazepine compounds, their production and use as lipid lowering agents
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
US20030187023A1 (en) 2000-07-17 2003-10-02 Keiji Kubo Sulfone derivatives, process for their production and use thereof
PL376733A1 (pl) 2002-11-01 2006-01-09 Takeda Pharmaceutical Company Limited Środek do zapobiegania lub leczenia neuropatii
AU2003277576A1 (en) 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
WO2004048363A1 (ja) 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited イミダゾール誘導体、その製造法および用途
EP1630152A4 (en) 2003-05-30 2009-09-23 Takeda Pharmaceutical CONDENSED CYCLIC COMPOUND
EP1669352A4 (en) 2003-09-30 2008-12-17 Takeda Pharmaceutical THIAZOLINE DERIVATIVE AND ITS USE
EP1695961A4 (en) 2003-12-17 2007-10-24 Takeda Pharmaceutical UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE
AU2004309271A1 (en) 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
US7585880B2 (en) 2003-12-26 2009-09-08 Takeda Pharmaceutical Company Limited Phenylpropanoic acid derivatives
EP1726580A4 (en) 2004-03-15 2008-02-13 Takeda Pharmaceutical AMINOPHNYLPROPANO ACID DERIVATIVE
EP1731505B1 (en) 2004-03-30 2015-01-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
GB0428101D0 (en) * 2004-12-23 2005-01-26 Astrazeneca Ab Chemical Processes & Intermediates
EP2308839B1 (en) 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
JP5084503B2 (ja) 2005-07-29 2012-11-28 武田薬品工業株式会社 シクロプロパンカルボン酸化合物
JPWO2007013694A1 (ja) 2005-07-29 2009-02-12 武田薬品工業株式会社 フェノキシアルカン酸化合物
CA2617969A1 (en) 2005-08-10 2007-02-15 Takeda Pharmaceutical Company Limited Therapeutic agent for diabetes
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
JP5306818B2 (ja) 2006-10-18 2013-10-02 武田薬品工業株式会社 縮合複素環化合物
US8410087B2 (en) 2006-10-19 2013-04-02 Takeda Pharmaceutical Company Limited Indole compound
EP2128138A1 (en) 2007-01-29 2009-12-02 Takeda Pharmaceutical Company Limited Pyrazole compound
CA2677736A1 (en) 2007-02-09 2008-08-21 Takeda Pharmaceutical Company Limited Fused ring compounds as partial agonists of ppar-gamma
WO2008101197A1 (en) 2007-02-18 2008-08-21 University Of Florida Research Foundation, Inc. Catalysts containing n-heterocyclic carbenes for enantioselective synthesis
JPWO2008136428A1 (ja) 2007-04-27 2010-07-29 武田薬品工業株式会社 含窒素５員複素環化合物
WO2008156757A1 (en) 2007-06-19 2008-12-24 Takeda Pharmaceutical Company Limited Indazole compounds for activating glucokinase
US20120172351A1 (en) 2009-06-09 2012-07-05 Nobuyuki Negoro Novel fused cyclic compound and use thereof
JP5129209B2 (ja) 2009-08-03 2013-01-30 ゴールドフラッグ株式会社 ブラジャー及び該ブラジャー付き下着とこれをインナーとしたアウター

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101616913A (zh) * 2006-06-27 2009-12-30 武田药品工业株式会社 稠环化合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WENJUN TANG, XUMU ZHANG: "New Chiral Phosphorus Ligands for Enantioselective Hydrogenation", 《CHEMICAL REVIEWS》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104177320A (zh) * 2014-08-27 2014-12-03 广东东阳光药业有限公司 新型脲取代联苯类化合物及其组合物及用途
CN107543872A (zh) * 2016-06-29 2018-01-05 南京长澳医药科技有限公司 通过手性高效液相色谱法分离测定甲苯磺酸依度沙班水合物与其异构体杂质的方法
CN107543872B (zh) * 2016-06-29 2022-03-08 南京长澳医药科技有限公司 通过手性高效液相色谱法分离测定甲苯磺酸依度沙班水合物与其异构体杂质的方法
CN106977478A (zh) * 2017-04-21 2017-07-25 山东大学 一种2‑（6‑羟基‑2,3‑二氢苯并呋喃‑3‑基）乙酸甲酯的手性拆分方法
CN106977478B (zh) * 2017-04-21 2019-04-09 山东大学 一种2-(6-羟基-2,3-二氢苯并呋喃-3-基)乙酸甲酯的手性拆分方法
CN114539168A (zh) * 2020-11-27 2022-05-27 武汉大学 一种合成Piragliatin及其类似物的方法
CN114539168B (zh) * 2020-11-27 2023-11-17 武汉大学 一种合成Piragliatin及其类似物的方法

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