CN103432009B - A kind of whitening agent liposomal microcapsule composition and its preparation method and application - Google Patents
A kind of whitening agent liposomal microcapsule composition and its preparation method and application Download PDFInfo
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- CN103432009B CN103432009B CN201310414407.4A CN201310414407A CN103432009B CN 103432009 B CN103432009 B CN 103432009B CN 201310414407 A CN201310414407 A CN 201310414407A CN 103432009 B CN103432009 B CN 103432009B
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Abstract
The invention discloses a kind of whitening agent liposomal microcapsule composition and its preparation method and application.Whitening agent liposomal microcapsule composition of the present invention is made up of whitening agent 5-30%, polyhydric alcohol 2-50%, phosphatidase 1-30%, oils and fats 1-30%, emulsifying agent 1-10%, deionized water 1-30%.Whitening agent of the present invention is coated by lecithin, and lecithin is very similar to skin lipid structure, is easy to the deep layer that penetrates to the skin, thus overcomes the defect that whitening agent is difficult to be absorbed by the skin; Oxygen-barrier in whitening agent after coated by lecithin and air, thus overcome the defect of the easy oxidized variable color of these whitening agents; When using the whitening product containing whitening agent liposomal microcapsule composition of the present invention, whitening agent slow releasing, can keep long-time white-skinned face function.
Description
Technical field
The present invention relates to a kind of whitening agent liposomal microcapsule composition, be specifically related to a kind of whitening agent liposomal microcapsule composition and its preparation method and application.
Background technology
The color of human body skin depends mainly on melanic Content and distribution situation in skin.Melanin is produced by the melanocyte being present in stratum basale, the adjustment of nerve-endocrine factor and the impact of external environment condition in its metabolic receptor.As skin be subject to external ultraviolet radiation irradiate time, the tryrosinase in skin can be activated, accelerate melanic generation, occur the reaction of tanned and mottle.The effect of the whitening active ingredients in skin-lightening cosmetic is to stop melanic biosynthesis, or by human activin epidermis and hypodermal cell antiradical activities, promote the metabolic turnover of tegumentary chromatophore, reduce pigmentation degree and the excessive keratinization of epidermis, make Skin Cell high resilience and gloss.
Whitening composition mainly contains in the market: arbutin, vitamin C, kojic acid, ferulic acid etc.These whitening agents all have good whitening effect, but these whitening agents all exist easily, and by dioxygen oxidation in air, variable color and difficulty such as to be absorbed by the skin at the defect, as vitamin C is unfavorable for that skin absorbs, and very easily oxidation stain and lose whitening effect when heat, light.
Summary of the invention
The performances such as in order to solve existing whitening composition Problems existing, the object of the invention is to provide a kind of whitening agent liposomal microcapsule composition, and said composition has stimulates little, stable in properties, be easily absorbed by the skin, whitening effect is good.
Another object of the present invention is used in skin-lightening cosmetic by above-mentioned whitening agent liposomal microcapsule composition, makes that zest is little, stable in properties, respond well skin-lightening cosmetic.
For realizing the first object of the present invention, present invention employs following technical scheme: a kind of whitening agent liposomal microcapsule composition, is characterized in that the component comprising following percentage by weight:
Whitening agent 5-30%;
Polyhydric alcohol 2-50%;
Phosphatidase 1-30%;
Oils and fats 1-30%;
Emulsifying agent 1-10%;
Deionized water 1-40%.
Described whitening agent is one or both and above mixture in arbutin, vitamin C, kojic acid, ferulic acid, glabridin, phenethanol resorcinol, nicotiamide.
Described polyhydric alcohol is one or both and above mixture in glycerol, 1,2-PD, 1,3 butylene glycol.
Described phospholipid is one or both mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin.
Described oils and fats is one or both and above mixture in caprylic/capric triglyceride, C12-15 alcohol benzoate, tocopherol acetas, isopropyl palmitate, Oleum Camelliae, Fructus Maydis oil.
Described emulsifying agent is one or both and above mixture in cetyl polyethylene/polypropylene glycol-10/1 polydimethylsiloxane, methyl sesquistearate, glyceryl monostearate, iso stearic acid of glycerine ester, glyceryl oleate.
A manufacture method for whitening agent liposomal microcapsule composition, comprises the following steps:
(1) by whitening agent, polyhydric alcohol, water mixing, at 60-80 DEG C, stirring and dissolving is even, is aqueous phase.
(2) by oils and fats, phospholipid, emulsifying agent mixing, at 60-80 DEG C, stirring and dissolving is even, is oil phase.
(3) mixed with oil phase by aqueous phase, after stirring, by high pressure homogenizer process, high pressure homogenize pressure is 80-150MPa, and cycle-index is 1-10 time, namely obtains whitening agent liposomal microcapsule composition of the present invention.
For realizing the second object of the present invention, present invention employs following technical scheme: by the application of above-mentioned whitening agent liposomal microcapsule composition in preparation skin-lightening cosmetic, it is characterized in that in skin-lightening cosmetic containing above-mentioned whitening agent liposomal microcapsule composition, its consumption is 0.1-40%, and preferable amount is 5-20%.Except containing except above-mentioned whitening agent liposomal microcapsule composition, the usual composition that applicable skin-lightening cosmetic uses suitably can be added as required, as matrix components such as wetting agent, emollient, water, emulsifying agents.
The dosage form of skin-lightening cosmetic is not particularly limited, and can be solution, emulsion, cream frost shape, spray etc.
The invention has the beneficial effects as follows: whitening agent is coated by lecithin, lecithin is very similar to skin lipid structure, is easy to the deep layer that penetrates to the skin, thus overcomes the defect that whitening agent is difficult to be absorbed by the skin; Oxygen-barrier in whitening agent after coated by lecithin and air, thus overcome the defect of the easy oxidized variable color of these whitening agents; When using the whitening product containing whitening agent liposomal microcapsule composition of the present invention, whitening agent slow releasing, can keep long-time white-skinned face function.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
the preparation of embodiment 1 whitening agent liposomal microcapsule composition (I)
(1) by 5% vitamin C, 8% ferulic acid, 5% glabridin, 10%1,2-propylene glycol, 8%1,3-butanediols, 31% deionized water mixing, at 60-80 DEG C, stirring and dissolving is even, is aqueous phase.
(2) by 15% isopropyl palmitate, 10% caprylic/capric triglyceride, 6% soybean lecithin, 2% glyceryl monostearate mixing, at 60-80 DEG C, stirring and dissolving is even, is oil phase.
(3) mixed with oil phase by aqueous phase, after stirring, by high pressure homogenizer process, high pressure homogenize pressure is 90MPa, and cycle-index is 4 times, namely obtains whitening agent liposomal microcapsule composition (I) of the present invention.
the preparation of embodiment 2 whitening agent liposomal microcapsule composition (II)
(1) by 6% kojic acid, 6% arbutin, 4% nicotiamide, 15% glycerol, 6%1,3-butanediols, 30% deionized water mixing, at 60-80 DEG C, stirring and dissolving is even, is aqueous phase.
(2) by 6% tocopherol acetas, 12% caprylic/capric triglyceride, 8% Oleum Camelliae, 4% soybean lecithin, 3% methyl sesquistearate mixing, at 60-80 DEG C, stirring and dissolving is even, is oil phase.
(3) mixed with oil phase by aqueous phase, after stirring, by high pressure homogenizer process, high pressure homogenize pressure is 100MPa, and cycle-index is 3 times, namely obtains whitening agent liposomal microcapsule composition (II) of the present invention.
The preparation of embodiment 3 whitening and skin-protecting breast
Table 1 provides the whitening and skin-protecting breast formula containing whitening agent liposomal microcapsule composition, and the consumption of each material represents with mass fraction.
Table 1
The preparation method of whitening and skin-protecting breast: by the dimethyl siloxane in formula table, isopropyl palmitate, caprylic/capric glyceride, monoglyceride, glyceryl oleate citrate, methyl hydroxybenzoate, propylparaben mixing, be heated to 80 DEG C, fusing stirs, as oil phase; By the 1,3 butylene glycol in formula table, deionized water mixing, be heated to 85 DEG C, stirring and dissolving is even, as aqueous phase.Oil phase and aqueous phase are added in emulsifying pot, stir, add whitening agent liposomal microcapsule composition, emulsifying homogeneous, after 10 minutes, when stirring is cooled to 50 DEG C, adds essence, stirs, be cooled to 38 DEG C, be whitening and skin-protecting breast.
the preparation of the common whitening and skin-protecting breast of comparative example 1
Table 2 provides common whitening and skin-protecting breast formula, and the consumption of each material represents with mass fraction.
Table 2
The preparation method of whitening and skin-protecting breast: by the dimethyl siloxane in formula table, isopropyl palmitate, caprylic/capric glyceride, monoglyceride, glyceryl oleate citrate, methyl hydroxybenzoate, propylparaben mixing, be heated to 80 DEG C, fusing stirs, as oil phase; By the 1,3 butylene glycol in formula table, vitamin C, ferulic acid, glabridin, deionized water mixing, be heated to 85 DEG C, stirring and dissolving is even, as aqueous phase.Oil phase and aqueous phase are added in emulsifying pot, stir, emulsifying homogeneous, after 10 minutes, when stirring is cooled to 50 DEG C, adds essence, stirs, be cooled to 38 DEG C, be whitening and skin-protecting breast.
the evaluation of embodiment 4 heat-resistant stability
Common whitening and skin-protecting breast prepared by the breast of the whitening and skin-protecting containing whitening agent liposomal microcapsule composition and the comparative example 1 embodiment 3 prepared, is placed on respectively in transparent plastic bottle, is placed in 48 DEG C of calorstats, observe the outward appearance of primary production every 3 days.Found that: common whitening and skin-protecting breast prepared by comparative example 1 is 5 days time, and product color starts to become micro-yellow from white, and deepen gradually along with passage of time color; And whitening and skin-protecting breast Continuous Observation 20 days prepared by embodiment 3, the color and luster of product still keeps white, does not occur the phenomenon of color change.This illustrates, after liposomal, whitening agent microcapsule is better than not having the heat-resistant stability of coated whitening agent.
the evaluation of embodiment 5 light fastness stability
Common whitening and skin-protecting breast prepared by the breast of the whitening and skin-protecting containing whitening agent liposomal microcapsule composition and the comparative example 1 embodiment 3 prepared, is placed on respectively in transparent plastic bottle, is placed in solar exposure place, observe the outward appearance of primary production every 1 day.Found that: common whitening and skin-protecting breast prepared by comparative example 1 is 2 days time, and product color starts to become micro-yellow from white, and deepen gradually along with passage of time color; And during whitening and skin-protecting breast Continuous Observation 18 days prepared by embodiment 3, product color starts to become micro-yellow from white.This illustrates, after liposomal, whitening agent microcapsule is better than not having the light fastness stability of coated whitening agent.
Claims (3)
1. a whitening agent liposomal microcapsule composition, it is characterized in that being made up of the component of following percentage by weight: vitamin C 5%, ferulic acid 8%, glabridin 5%, 1,2-propylene glycol 10%, 1,3 butylene glycol 8%, deionized water 31%, isopropyl palmitate 15%, caprylic/capric triglyceride 10%, soybean lecithin 6%, glyceryl monostearate 2%; The preparation method of compositions is as follows: by vitamin C, ferulic acid, glabridin, 1,2-PD, 1,3 butylene glycol, deionized water mixing, at 60-80 DEG C, stirring and dissolving is even, is aqueous phase; By isopropyl palmitate, caprylic/capric triglyceride, soybean lecithin, glyceryl monostearate mixing, at 60-80 DEG C, stirring and dissolving is even, is oil phase; Mixed with oil phase by aqueous phase, after stirring, by high pressure homogenizer process, high pressure homogenize pressure is 90MPa, and cycle-index is 4 times, to obtain final product.
2. a whitening agent liposomal microcapsule composition, it is characterized in that being made up of the component of following percentage by weight: kojic acid 6%, arbutin 6%, nicotiamide 4%, glycerol 15%, 1,3 butylene glycol 6%, deionized water 30%, tocopherol acetas 6%, caprylic/capric triglyceride 12%, Oleum Camelliae 8%, soybean lecithin 4%, methyl sesquistearate 3%; The preparation method of compositions is as follows: by kojic acid, arbutin, nicotiamide, glycerol, 1,3 butylene glycol, deionized water mixing, at 60-80 DEG C, stirring and dissolving is even, is aqueous phase; By tocopherol acetas, caprylic/capric triglyceride, Oleum Camelliae, soybean lecithin, the mixing of methyl sesquistearate, at 60-80 DEG C, stirring and dissolving is even, is oil phase; Mixed with oil phase by aqueous phase, after stirring, by high pressure homogenizer process, high pressure homogenize pressure is 100MPa, and cycle-index is 3 times, to obtain final product.
3. the application of a kind of whitening agent liposomal microcapsule composition described in any one of claim 1-2 in preparation skin-lightening cosmetic, it is characterized in that its consumption is 0.1-40% by weight percentage containing the whitening agent liposomal microcapsule composition described in any one of claim 1-2 in skin-lightening cosmetic.
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