CN106389137B - A kind of linseed oil liposome and its preparation and application - Google Patents
A kind of linseed oil liposome and its preparation and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of linseed oil liposomes and the preparation method and application thereof, the linseed oil liposome is made of the raw material of following quality proportioning: 00 part of phosphatidase 1,10~50 parts of cholesterol, 10~50 parts of surfactant, 5~20 parts of linseed oil, 0.05~0.5 part of antioxidant, 0.2~5 part of cosmetic active ingredient；Alpha-linolenic acid content is high in resulting linseed oil liposome, and property is stablized, while the ability of alpha-linolenic acid and the active constituent skin permeation under liposome effect is stronger, and skin effect is more preferable, and the duration is longer.The product technology is mature, simple process, is suitble to industrialized production.Content >=0.10% of alpha-linolenic acid in the linseed oil liposome, partial size are 10~100nm.
Description
(1) technical field
The invention belongs to cosmetic technical fields, and in particular to a kind of linseed oil liposome and preparation method thereof.
(2) background technique
With rapid economic development, people's living standard improves living environment quality decline simultaneously, and rhythm of life accelerates work
Make pressure aggravation, people surface layer protector tube-skin is by increasingly severe damage, as skin blemish is imperfect, pigment is de-
Fall deposition, scar proliferation, dry skin water shortage and aging aggravation etc..Therefore, people more pay attention to improving looks, to cosmetics
Requirement be also no longer limited only to cover, and require its have protection, repair skin and beauty and other effects.
Linseed oil is rich in unsaturated fatty acid, and wherein alpha-linolenic acid content is up to 50% or more.Alpha-linolenic acid is to skin
With excellent affinity and penetration, easily infiltration skin surface to deep layer is repaired with lipid nutrient needed for supplementing skin
With enhancing Skin Cell natural barrier function, the normal configuration and function of Skin Cell film and interstitial are maintained and enhanced；Simultaneously also
Ventilative water-retaining film can be formed in skin surface, weaken the moisture loss of deep skin, skin is made to keep wet, flexible.Cause
This, linseed oil is applied to make skin smooth, soft and moist, delicate and high resilience in skin protection cosmetics；Applied to hair careization
The hydration moisture-keeping function that its cells of superficial layer can be enhanced in cosmetic by essential fatty acid in supplement scalp and hair, improves withered
Yellow, dry and astringent hair quality makes hair healthy, smooth and glossy.In addition, linseed oil is α-Asia as a kind of rare ω -3 that is rich in
Some skin problems are such as had dry skin coarse, chap, wrinkle, itch, allergy, eczema, acne by the crude vegetal of numb acid
Repairing and treating have obvious effect, especially high-quality cold pressed flax seed oil for treatment skin allergy, eczema, chap,
A variety of scytitis such as infant anthma, skin burn all have significantly improvement and therapeutic effect.
Linseed oil used for cosmetic is mainly made by cold pressing, is also needed after precipitating filtering by depickling, is deodorized and removes
The technical treatments such as bacterium, oil colours is shallower, is in yellow liquid, has light nut faint scent.But due to unsaturated lipid in linseed oil
Fat acid is extremely unstable, is easy to be influenced and oxidation deterioration by environmental conditions such as photo-thermal, seriously affects its function affect.It will be micro-
The protection that capsule technique is applied to linseed oil can not only effectively prevent unsaturated fat acid oxidase, improve its stability simultaneously
Expand its application range, but also bad smell can be shielded, change that properties of product, effective component is released in control cosmetics
It puts, keeps its effect more preferable.
Liposome is development of the microcapsules to depth, typically refers to the duplicature spherical vesicle being made of phosphatide, can wrap
Bury hydrophily, lipophilicity or amphiphilic species.Liposome main wall material phosphatide is one of constituent of biomembrane, bio-compatible
Good, the no immunosuppressive action of property, highly-safe small toxicity.The partial size of nano liposomes is in nano-scale range, penetrates physiology
Tissue barrier is very capable.Liposome for skin can be penetrated in cosmetics, will control active constituent slowly release by
Absorption of human body can enduringly play the role of local maintenance, promote the distribution of active constituent in the tissue, provide its biological utilisation
Degree reduces or without using chemical transdermal enhancer.
(3) summary of the invention
The object of the present invention is to provide a kind of linseed oil liposomes and preparation method thereof, are mainly used in preparation makeup
Product.The present invention is the required unsaturated fatty acid to be adequately protected in linseed oil using liposome technology.The technology not only makes α-
Linolenic acid and other active components are easier to penetrate skin under the action of liposome, while the two also can produce synergistic effect, protect
It protects and improves skin and use more time saving convenience so that the cosmetics function of adding the liposome is more comprehensive, it is constantly full
The demand that sufficient people improve looks.
The technical solution adopted by the present invention is that:
The present invention provides a kind of linseed oil liposome, the linseed oil liposome by following quality proportioning raw material system
At: 00 part of phosphatidase 1,10~50 parts of cholesterol, 10~50 parts of surfactant, 5~20 parts of linseed oil, antioxidant 0.05~
0.5 part, 0.2~5 part of cosmetic active ingredient；The surfactant is polysorbas20, Tween 80, cholate, polyethylene glycol
400, mixing one or more of in polyethylene glycol laurate, glycerin monostearate and bi-tristearin, it is preferably poly-
One of ethylene glycol laurate, polyethylene glycol 400 and glycerin monostearate；The antioxidant is vitamin E, dimension life
One or more of mixing in plain C and superoxide dismutase, preferred vitamin E and vitamin C are with 0.5~2:1's of mass ratio
Mixing；The cosmetic active ingredient is collagen, Co-Q10, hyaluronic acid, resveratrol, ceramide and glycyrrhizin
The mixing of middle one or more, preferably one of collagen, glycyrrhizin, hyaluronic acid and resveratrol.
Further, the linseed oil liposome is made of the raw material of following quality proportioning: 00 part of phosphatidase 1, cholesterol 15
~40 parts, 12~40 parts of surfactant, 8~18 parts of linseed oil, 0.1~0.4 part of antioxidant, cosmetic active ingredient
0.5~4.0 part.
Further, the linseed oil liposome is made of the raw material of following quality proportioning: 00 part of phosphatidase 1, cholesterol
20~30 parts, 15~30 parts of surfactant, 10~15 parts of linseed oil, 0.20~0.30 part of antioxidant, cosmetic active
1.0~3.0 parts of ingredient.
Further, the most preferably described linseed oil liposome is made of the raw material of following quality proportioning: 00 part of phosphatidase 1,
25 parts of cholesterol, 20 parts of polyethylene glycol laurate, 12 parts of linseed oil, 0.25 part of antioxidant, 2.0 parts of collagen；Institute
Stating antioxidant is vitamin E and vitamin C with the mixing of mass ratio 1.5:1.
The present invention also provides a kind of preparation method of linseed oil liposome, the methods are as follows:
(1) formula ratio is pressed, by phosphatide, cholesterol, surfactant, dehydrated alcohol is added, 40~50 DEG C of mixing are simultaneously abundant
Stirring obtains solution a to dissolving；The dehydrated alcohol volumetric usage is calculated as 10mL/g with Phospholipids amount；
(2) formula ratio is pressed, by linseed oil, antioxidant, cosmetic active ingredient, is thoroughly mixed uniformly, obtains
Solution b；
(3) step (2) solution b is added in the solution a that step (1) obtains, stirs evenly, obtains solution c；
(4) solution c is molten by 55~60 DEG C of the temperature of speed instillation of 1~2 drop per second, the phosphoric acid buffer of pH 6.5~7.0
In liquid, stirring forms suspension；The phosphate buffer and dehydrated alcohol volume ratio are 2~5:1；
(5) by suspension, rotary evaporation in vacuo removes ethyl alcohol at 40~60 DEG C, obtains solution d；
(6) solution d is subjected under 100~160MPa pressure homogenization, is taken out when lotion is transparent or semitransparent, from
It is so cooled to room temperature to get linseed oil liposome is arrived.
The invention further relates to the linseed oil liposomes to apply in preparing cosmetics.
Linseed oil of the present invention is the seed flax seed of flax family (Linaceae) plant flax, squeezes through cold pressing or hot pressing is squeezed and extracted
Refined oily liquids.
Solution a of the present invention, solution b, solution c, solution d refer both to the solution of different step acquisition, and letter does not have in itself
Meaning.
Compared with prior art, beneficial effect of the present invention is mainly reflected in:
The present invention provides a kind of linseed oil liposome and the preparation method and application thereof, resulting linseed oil liposome
Middle alpha-linolenic acid content is high, and property is stablized, while the ability of alpha-linolenic acid and the active constituent skin permeation under liposome effect
Stronger, skin effect is more preferable, and the duration is longer.Relative to alpha-linolenic acid being directly added into for cosmetics obtained, α-Asia
Numb acid is oxidizable, and process is neutralized to go bad using preceding product is oxidizable, and alpha-linolenic acid is played in skin permeation in use process
Partial oxidation may be generated because of ingress of air before effect, the cosmetics for adding the liposome are then not in similar ask
Topic, while the liposome is transparency liquid, can be added in the cosmetics of any liquid and semi-solid, breach α-flax
The limitation of acid or linseed oil, it is more convenient to use.The product technology is mature, simple process, is suitble to industrialized production.Institute
Content >=0.10% of alpha-linolenic acid in linseed oil liposome is stated, partial size is 10~100nm.
(4) specific embodiment
The present invention is described further combined with specific embodiments below, but protection scope of the present invention is not limited in
This:
Linseed oil used in the embodiment of the present invention is the seed flax seed of flax family (Linaceae) plant flax, squeezes through cold pressing or hot pressing is squeezed
Oily liquids made of Hydrolysis kinetics.
Polyethylene glycol laurate is purchased from Jiangsu Hai'an Petrochemical Plant.
Polyethylene glycol 400 is purchased from Jiangsu Hai'an Petrochemical Plant.
Glycerin monostearate is purchased from Jiangsu Hai'an Petrochemical Plant.
Collagen is purchased from Jiangsu Fu Shengde bioengineering Co., Ltd.
Glycyrrhizin, molecular formula C15H12O4, it is purchased from Shanghai Ren Bang Biotechnology Co., Ltd.
Hyaluronic acid, molecular formula C28H44N2O23, it is purchased from Guangzhou Sheng Xin Chemical Industry Science Co., Ltd.
Resveratrol, molecular formula C14H12O3, Shaanxi Sen Fu natural product Co., Ltd.
Embodiment 1
1, raw material proportioning: phosphatidase 1 00g, cholesterol 30g, polyethylene glycol laurate 15g, linseed oil 10g, vitamin E
0.10g, vitamin C 0.10g, collagen 3.0g.
2, the preparation of linseed oil liposome:
(1) formula ratio is pressed, by phosphatide, cholesterol, polyethylene glycol laurate, is added 1000mL dehydrated alcohol, 40~50
DEG C mix and be stirred well to dissolution, obtain solution a；
(2) formula ratio is pressed, by linseed oil, vitamin E, vitamin C, collagen, is thoroughly mixed uniformly, obtains
Solution b；
(3) above-mentioned solution b is added in the solution a that step (1) obtains, is stirred evenly, obtain solution c；
(4) solution c is instilled 58 DEG C of temperature, pH 7.0 by the speed of 1 drop per second, the phosphate buffer solution of volume 2500mL
In, stirring forms suspension；
(5) by suspension, rotary evaporation in vacuo removes ethyl alcohol at 40~60 DEG C, obtains solution d；
(6) above-mentioned solution d is handled under 100~160MPa pressure, is taken out when lotion is transparent or semitransparent, it is naturally cold
But to room temperature to get arrive linseed oil liposome 143.1g.
Using alpha-linolenic acid content in high resolution gas chromatography method (method is with embodiment 5) measurement linseed oil liposome, adopt
Partial size is measured with particle size analyzer, it is 3.82% that alpha-linolenic acid content in linseed oil liposome, which is made, by above-mentioned formula, partial size
For 89nm.
Embodiment 2
1, raw material proportioning: phosphatidase 1 00g, cholesterol 25g, polyethylene glycol laurate 20g, linseed oil 12g, vitamin E
0.15g, vitamin C 0.10g, resveratrol 2.0g.
2, the preparation of linseed oil liposome:
(1) formula ratio is pressed, by phosphatide, cholesterol, polyethylene glycol laurate, is added 1000mL dehydrated alcohol, 40~50
DEG C mix and be stirred well to dissolution, obtain solution a；
(2) formula ratio is pressed, by linseed oil, vitamin E, vitamin C, resveratrol, is thoroughly mixed uniformly, obtains
Solution b；
(3) above-mentioned solution b is added in the solution a that step (1) obtains, is stirred evenly, obtain solution c；
(4) solution c is instilled into temperature 60 C, pH 6.8, the phosphate buffer solution of volume 3000mL by the speed of 1 drop per second
In, stirring forms suspension；
(5) by suspension, rotary evaporation in vacuo removes ethyl alcohol at 40~60 DEG C, obtains solution d；
(6) above-mentioned solution d is handled under 100~160MPa pressure, is taken out when lotion is transparent or semitransparent, it is naturally cold
But to room temperature to get arrive linseed oil liposome 149.6g.
Using alpha-linolenic acid content in high resolution gas chromatography method (method is with embodiment 5) measurement linseed oil liposome, adopt
Partial size is measured with particle size analyzer, it is 4.62% that alpha-linolenic acid content in linseed oil liposome, which is made, by above-mentioned formula, partial size
For 78nm.
Embodiment 3
1, raw material proportioning: phosphatidase 1 00g, cholesterol 35g, 23g polyethylene glycol 400, linseed oil 15g, vitamin E
0.20g, vitamin C 0.20g, glycyrrhizin 3.0g.
2, the preparation of linseed oil liposome:
(1) formula ratio is pressed, by phosphatide, cholesterol, polyethylene glycol 400,1000mL dehydrated alcohol, 40~50 DEG C of mixing are added
And it is stirred well to dissolution, obtain solution a；
(2) formula ratio is pressed, by linseed oil, vitamin E, vitamin C, glycyrrhizin, is thoroughly mixed uniformly, obtains molten
Liquid b；
(3) above-mentioned solution b is added in the solution a that step (1) obtains, is stirred evenly, obtain solution c；
(4) solution c is instilled 55 DEG C of temperature, pH 6.6 by the speed of 1 drop per second, the phosphate buffer solution of volume 4000mL
In, stirring forms suspension；
(5) by suspension, rotary evaporation in vacuo removes ethyl alcohol at 40~60 DEG C, obtains solution d；
(6) above-mentioned solution d is handled under 100~160MPa pressure, is taken out when lotion is transparent or semitransparent, it is naturally cold
But to room temperature to get arrive linseed oil liposome 156.8g.
Using alpha-linolenic acid content in high resolution gas chromatography method (method is with embodiment 5) measurement linseed oil liposome, adopt
Partial size is measured with particle size analyzer, it is 5.86% that alpha-linolenic acid content in linseed oil liposome, which is made, by above-mentioned formula, partial size
For 95nm.
Embodiment 4
1, raw material proportioning: phosphatidase 1 00g, cholesterol 30g, glycerin monostearate 19g, linseed oil 13g, vitamin E
0.15g, vitamin C 0.20g, hyaluronic acid 2.5g.
2, the preparation of linseed oil liposome:
(1) formula ratio is pressed, by phosphatide, cholesterol, glycerin monostearate, is added 1000mL dehydrated alcohol, 40~50 DEG C
Dissolution is mixed and be stirred well to, solution a is obtained；
(2) formula ratio is pressed, by linseed oil, vitamin E, vitamin C, hyaluronic acid, is thoroughly mixed uniformly, obtains
Solution b；
(3) above-mentioned solution b is added in the solution a that step (1) obtains, is stirred evenly, obtain solution c；
(4) solution c is instilled 58 DEG C of temperature, pH 6.8 by the speed of 1 drop per second, the phosphate buffer solution of volume 3500mL
In, stirring forms suspension；
(5) by suspension, rotary evaporation in vacuo removes ethyl alcohol at 40~60 DEG C, obtains solution d；
(6) above-mentioned solution d is handled under 100~160MPa pressure, is taken out when lotion is transparent or semitransparent, it is naturally cold
But to room temperature to get arrive linseed oil liposome 151.8g.
Using alpha-linolenic acid content in high resolution gas chromatography method (method is with embodiment 5) measurement linseed oil liposome, adopt
Partial size is measured with particle size analyzer, it is 5.02% that alpha-linolenic acid content in linseed oil liposome, which is made, by above-mentioned formula, partial size
For 82nm.
Embodiment 5
Alpha-linolenic acid content is measured using high resolution gas chromatography method in linseed oil liposome of the present invention, method:
0.25 μ m 0.32mm × 30m of Wonda Cap WAX capillary column, carrier gas are high pure nitrogen, flow velocity 1.0mLmin-1, point
Stream is than 5:1, and 190 DEG C of column temperature, injector temperature is 250 DEG C, and fid detector temperature is 250 DEG C, air 450mLmin-1, hydrogen
45mL·min-1；Partial size is measured using particle size analyzer.Since alpha-linolenic acid is easily affected by environment, the stabilization of liposome
Property will seriously affect the functional effect of cosmetics finished product.It is research pair with 2 formulation product of embodiment to investigate liposome stability
As sealing packaging measures the packet of liposome alpha-linolenic acid content and product during room temperature using high resolution gas chromatography method
Rate is buried, i.e. embedding rate=(oil content-surface oil content)/oil content × 100%, measurement result is as shown in table 1.It is tied by detection
Fruit can be seen that liposome, and less than 4%, embedding rate change rate is less than alpha-linolenic acid change rate in storing 12 months shelf-lifves
5%, the stability of the formula liposome is preferable.
1 linseed oil liposome of table alpha-linolenic acid content and embedding rate variation during storage
Claims (8)
1. a kind of linseed oil liposome, it is characterised in that the linseed oil liposome by following quality proportioning raw material system
At: 00 part of phosphatidase 1,10~50 parts of cholesterol, 10~50 parts of surfactant, 5~20 parts of linseed oil, antioxidant 0.05~
0.5 part, 0.2~5 part of cosmetic active ingredient；The surfactant is polysorbas20, Tween 80, cholate, polyethylene glycol
400, mixing one or more of in polyethylene glycol laurate, glycerin monostearate and bi-tristearin；It is described anti-
Oxidant is mixing one or more of in vitamin E, vitamin C and superoxide dismutase；The cosmetic active ingredient
For mixing one or more of in collagen, Co-Q10, hyaluronic acid, resveratrol, ceramide and glycyrrhizin；
The linseed oil liposome the preparation method comprises the following steps:
(1) formula ratio is pressed, by phosphatide, cholesterol, surfactant, dehydrated alcohol is added, 40~50 DEG C mix and are sufficiently stirred
To dissolution, solution a is obtained；The dehydrated alcohol volumetric usage is calculated as 10mL/g with Phospholipids amount；
(2) formula ratio is pressed, by linseed oil, antioxidant, cosmetic active ingredient, is thoroughly mixed uniformly, obtains solution
b；
(3) step (2) solution b is added in the solution a that step (1) obtains, stirs evenly, obtains solution c；
(4) by solution c by it is per second 1~2 drop speed instill 55~60 DEG C of temperature, pH6.5~7.0 phosphate buffer solution in,
Stirring forms suspension；The phosphate buffer and dehydrated alcohol volume ratio are 2~5:1；
(5) by suspension, rotary evaporation in vacuo removes ethyl alcohol at 40~60 DEG C, obtains solution d；
(6) solution d is subjected under 100~160MPa pressure homogenization, is taken out when lotion is transparent or semitransparent, it is naturally cold
But to room temperature to get arrive linseed oil liposome.
2. linseed oil liposome as described in claim 1, it is characterised in that the surfactant is polyethylene glycol lauric acid
One of ester, polyethylene glycol 400 and glycerin monostearate.
3. linseed oil liposome as described in claim 1, it is characterised in that the antioxidant is vitamin E and vitamin C
With the mixing of 0.5~2:1 of mass ratio.
4. linseed oil liposome as described in claim 1, it is characterised in that the cosmetic active ingredient is collagen, sweet
One of careless element, hyaluronic acid and resveratrol.
5. linseed oil liposome as described in claim 1, it is characterised in that the linseed oil liposome is matched by following quality
The raw material of ratio is made: 00 part of phosphatidase 1,15~40 parts of cholesterol, and 12~40 parts of surfactant, 8~18 parts of linseed oil, antioxygen
0.1~0.4 part of agent, 0.5~4.0 part of cosmetic active ingredient.
6. linseed oil liposome as described in claim 1, it is characterised in that the linseed oil liposome is matched by following quality
The raw material of ratio is made: 00 part of phosphatidase 1,20~30 parts of cholesterol, 15~30 parts of surfactant, 10~15 parts of linseed oil, resisting
0.20~0.30 part of oxidant, 1.0~3.0 parts of cosmetic active ingredient.
7. linseed oil liposome as described in claim 1, it is characterised in that the linseed oil liposome is matched by following quality
The raw material of ratio is made: 00 part of phosphatidase 1,25 parts of cholesterol, and 20 parts of polyethylene glycol laurate, 12 parts of linseed oil, antioxidant
0.25 part, 2.0 parts of collagen；The antioxidant is vitamin E and vitamin C with the mixing of mass ratio 1.5:1.
8. linseed oil liposome described in a kind of claim 1 is preparing the application in cosmetics.
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| CN113116824B (en) * | 2021-04-08 | 2023-04-14 | 陕西科技大学 | Nano liposome and preparation method and application thereof |
| CN113057912B (en) * | 2021-04-12 | 2022-06-21 | 杭州易蓬科技有限公司 | Antioxidant and anti-inflammatory composition containing vegetable oil and preparation method thereof |
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| CN101530390A (en) * | 2008-03-14 | 2009-09-16 | 西安中基高技术产业发展有限公司 | Preparation of Alpha-linolenic acid nanoliposome preparation and prescription |
| CN101780232A (en) * | 2010-03-23 | 2010-07-21 | 南昌大学 | Coix seed oil proliposome and preparation method thereof |
| CN104800119B (en) * | 2015-04-21 | 2017-12-26 | 长江大学 | A kind of Lavender liposome and preparation method thereof |
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