CN104000832B - A kind of preparation method of three-dimensional emulsio olei jecoris piscis - Google Patents
A kind of preparation method of three-dimensional emulsio olei jecoris piscis Download PDFInfo
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- CN104000832B CN104000832B CN201410257556.9A CN201410257556A CN104000832B CN 104000832 B CN104000832 B CN 104000832B CN 201410257556 A CN201410257556 A CN 201410257556A CN 104000832 B CN104000832 B CN 104000832B
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Abstract
The invention belongs to technical field of medicine preparation, relate to a kind of method mentioned from the aqueous phase of Emulsion in emulsion layer by vitamin C and be used for preparing three-dimensional emulsio olei jecoris piscis；Including the preparation of soybean phospholipid solution, the preparation of phospholipid microcapsule and three processing steps of emulsifying: being joined by soybean phospholipid in dehydrated alcohol, stirring, to being completely dissolved, obtains soybean phospholipid solution；Again vitamin C is put into and boiling-bed drying sprays into soybean phospholipid solution, dried vitamin C soybean phospholipid microcapsule；Then cod-liver oil, vitamin A and vitamin D mix and blend are dissolved in soybean oil, sequentially add vitamin C soybean phospholipid microcapsule and purified water and stir, then traditional method of indicating the pronunciation of a Chinese character emulsifying, prepare three-dimensional emulsio olei jecoris piscis finished product；Its preparation technology route is ripe, and product is nutritious, and mouthfeel taste is good, and processing cost is low, safe and reliable.
Description
Technical field:
The invention belongs to technical field of medicine preparation, relate to a kind of vitamin C being mentioned from the aqueous phase of Emulsion emulsion layer
In and for preparing the Technology of three-dimensional emulsio olei jecoris piscis, the preparation side of a kind of novel three-dimensional emulsio olei jecoris piscis
Method.
Background technology:
It is the necessary thing that growth in humans grows that three-dimensional cod-liver oil emulsion is mainly composed of vitamin A and D, C, vitamin A and D
Matter, especially constant, skeleton and the life of tooth to fetus, the growth of infant, the integrity of epithelial tissue, vision, blood calcium and phosphorus
Long growths etc. play an important role, and vitamin C participates in internal antibody, collagen is formed and tissue repairing, and sugar, fat, protein
Metabolism, keep blood vessel complete, three-dimensional cod-liver oil emulsion for prevention and treatment because of vitamin A and D, C lack caused by various
Disease, such as nyctalopia, xerophthalmia, keratomalacia, rickets, osteomalacia etc.；Traditional three-dimensional cod-liver oil emulsion is
The Emulsion of a kind of oil-in-water emulsifiers i.e. o/w type, its main component contains fat-soluble A, D and water soluble vitamins
C, vitamin C is dissolved in the aqueous phase of Emulsion, and it is the most unstable in water, easily degrades, and solves vitamin C in aqueous
Unstable problem the most mostly uses following two kinds of methods: one is the production method with reference to vitamin C injection, whole production process
To carry out under oxygen-free environment, and to add the adjuvant such as chelating agen, antioxidant, because three-dimensional cod-liver oil emulsion is Orally taken emulsion, and be many
Dose package, so its processing preparation process is difficulty with omnidistance anaerobic, uses this strict control technique also simply to alleviate
Ascorbic degraded, can not thoroughly solve degradation problem；Two is vitamin C to be made clathrate, liposome etc. apply solid
Body preparation, semi-solid preparation aspect, this kind of clathrate is not suitable for being applied to Emulsion.
Summary of the invention:
It is an object of the invention to the shortcoming overcoming prior art to exist, seeking design provides one by vitamin C from breast
The aqueous phase of agent mention in emulsion layer and prepare three-dimensional emulsio olei jecoris piscis process, first by vitamin C, soybean phospholipid nothing
Water-ethanol is prepared as vitamin C soybean phospholipid microcapsule, and isolation vitamin C contacts with water, steady in Emulsion of raising vitamin C
Qualitative, and use vitamin C soybean phospholipid microcapsule as emulsifying agent, oil phase and aqueous phase are prepared as the process of Emulsion.
To achieve these goals, the preparation method of the three-dimensional emulsio olei jecoris piscis that the present invention relates to includes soybean phospholipid solution
Preparation, the preparation of phospholipid microcapsule and three processing steps of emulsifying:
(1) soybean phospholipid solution preparation: soybean phospholipid is joined in dehydrated alcohol, stir 10～15 minutes to the most molten
Solve, obtain soybean phospholipid solution；
(2) prepared by phospholipid microcapsule: after vitamin C is crossed 100 mesh sieves, places in boiling-bed drying, under fluidized state
Spraying into soybean phospholipid solution, control temperature is 45～55 DEG C and is dried 20～30 minutes, obtains vitamin C soybean phospholipid microcapsule；
(3) emulsifying: cod-liver oil, vitamin A and vitamin D mix and blend are dissolved in soybean oil, sequentially adds dimension raw
Element C soybean phospholipid microcapsule and purified water stirring, then traditional method of indicating the pronunciation of a Chinese character emulsifying 30 minutes, obtain three-dimensional emulsio olei jecoris piscis finished product.
The ascorbic coating material that the present invention relates to is soybean phospholipid, and soybean phospholipid is the phospholipid extracted from Semen sojae atricolor
Mixture, is one of the lipid component of needed by human body, and soybean phospholipid also has and reduces blood fat and effect of cholesterol, and to heart and brain blood
Pipe disease has prevention effects, is also widely used in the industries such as food and medicine, is safe food additive and pharmaceutic adjuvant, Semen sojae atricolor
What phospholipid can not only be used for vitamin C microcapsule prepares material, again can be as the emulsifying agent of three-dimensional cod-liver oil.
The composition of the three-dimensional emulsio olei jecoris piscis that the present invention relates to includes oil phase, aqueous phase and emulsifying agent, and oil phase is matter in Emulsion
Amount percentage ratio is 55～90%, and wherein, it is soybean oil 55～85% that each composition in oil phase accounts for the mass percent of Emulsion, fish liver
Oil 0.5～10%, vitamin A 0.001～0.01%, vitamin D 0.00001～0.0001%；Aqueous phase is purified water, at Emulsion
In mass percent be 10～45%；Emulsifying agent is vitamin C soybean phospholipid microcapsule, and the mass percent in Emulsion is
0.1～3%.
The component of preparing of the vitamin C soybean phospholipid microcapsule that the present invention relates to is: vitamin C and Encapsulating materials soybean phospholipid
Mass ratio be 1:2.5～6, the mass ratio of soybean phospholipid and solvent dehydrated alcohol is 1～10:100；Dehydrated alcohol was for preparing
The solvent used in journey, in vitamin with soybean phospholipid microcapsule preparation process, dehydrated alcohol is by evaporation type Ex-all.
Compared with prior art, its preparation technology route is ripe, and product is nutritious, and mouthfeel taste is good for the present invention, processing
Low cost, safe and reliable.
Detailed description of the invention:
Below by embodiment, the invention will be further described.
Embodiment 1: the preparation of a kind of applicable three-dimensional emulsio olei jecoris piscis of being grown up.
The three-dimensional emulsio olei jecoris piscis 1000g of the present embodiment preparation, its each ingredient components content is, oil phase: cod-liver oil 10g, dimension
Raw element A0.062g, vitamin D 0.163mg, soybean oil 652g；Emulsifying agent: vitamin C 1.54g；Soybean phospholipid 5.235g；Yu Zhe
Purified water for aqueous phase；Need dehydrated alcohol 79g.
The preparation process of the present embodiment is:
(1) soybean phospholipid of commercially available prod is joined in 79g dehydrated alcohol stirring and dissolving uniformly after, be configured to Semen sojae atricolor phosphorus
Lipoprotein solution；
(2) insert in the boiling-bed drying of routine after the vitamin C of commercially available prod being crossed 100 mesh sieves, under fluidized state
Spraying in drying bed by soybean phospholipid solution prepared by step (1) again, temperature control makes vitamin C drying under the conditions of 45～55 DEG C,
It is prepared as vitamin C soybean phospholipid microcapsule；
(3) first the cod-liver oil of commercially available prod, vitamin A and vitamin D are stirred the most successively and be dissolved in soybean oil, then divide
It is not sequentially added into vitamin C soybean phospholipid microcapsule and purified water, carries out traditional method of indicating the pronunciation of a Chinese character emulsifying after stirring and i.e. obtain three-dimensional fish in 30 minutes
Liver oil emulsion products.
Embodiment 2: the preparation of the three-dimensional emulsio olei jecoris piscis that a kind of child is suitable for.
The present embodiment makes three-dimensional emulsio olei jecoris piscis 1000g, and its each constituent content is, oil phase: cod-liver oil 10g, vitamin
A0.03g, vitamin D 0.338mg, soybean oil 652g；Emulsifying agent: vitamin C 1.54g, soybean phospholipid 5.235g；The rest is water
The purified water of phase；Need dehydrated alcohol 79g.
The preparation process of the present embodiment is:
(1) first soybean phospholipid is joined in dehydrated alcohol, after stirring and dissolving, be configured to soybean phospholipid solution；
(2) vitamin C is crossed 100 mesh sieves, insert in boiling-bed drying, spray into soybean phospholipid when boiling molten
Liquid, is dried at 45～55 DEG C, is prepared as vitamin C soybean phospholipid microcapsule；
(3) cod-liver oil, vitamin A, vitamin D are dissolved in soybean oil the most successively, then are separately added into vitamin C successively
Soybean phospholipid microcapsule and purified water, carry out traditional method of indicating the pronunciation of a Chinese character emulsifying and within 30 minutes, i.e. obtain three-dimensional emulsio olei jecoris piscis product after stirring.
The three-dimensional cod-liver oil emulsion of the outturn sample of the present embodiment and traditional handicraft contrasts the investigation experiment that keeps sample for a long time and grinds
Study carefully, and samplings in 0,3,6,9,12,18,24 months after placement, and its ascorbic content is measured, it stays for a long time
Sample is investigated result of the test and be see table:
As seen from the above table, product of the present invention is after keeping sample for a long time and investigating 24 months, and indices is all normal after testing, and dimension is raw
Element C understands palliating degradation degree through assay and is less than far away conventional three-dimensional cod-liver oil emulsion, prepared by the new technology that the present invention uses
Ascorbic stability in three-dimensional emulsio olei jecoris piscis is substantially better than traditional handicraft.
Claims (2)
1. the preparation method of a three-dimensional emulsio olei jecoris piscis, it is characterised in that include the preparation of soybean phospholipid solution, phospholipid microcapsule system
Standby and three processing steps of emulsifying:
(1) soybean phospholipid solution preparation: soybean phospholipid is joined in dehydrated alcohol, stir 10～15 minutes to being completely dissolved,
Obtain soybean phospholipid solution；
(2) prepared by phospholipid microcapsule: after vitamin C is crossed 100 mesh sieves, places in boiling-bed drying, sprays under fluidized state
Soybean phospholipid solution, control temperature is 45～55 DEG C and is dried 20～30 minutes, obtains vitamin C soybean phospholipid microcapsule；
(3) emulsifying: cod-liver oil, vitamin A and vitamin D mix and blend are dissolved in soybean oil, sequentially add vitamin C big
Fabaceous lecithin microcapsule and purified water also stir, and then traditional method of indicating the pronunciation of a Chinese character emulsifying 30 minutes obtain three-dimensional emulsio olei jecoris piscis finished product；Its composition
Including oil phase, aqueous phase and emulsifying agent, oil phase, aqueous phase and emulsifying agent mass percent in Emulsion be respectively 55～90%, 10～
45% and 0.1～3%, total amount is 100%, and wherein, aqueous phase is purified water, and emulsifying agent is vitamin C soybean phospholipid microcapsule, oil phase
In each composition to account for the mass percent of Emulsion be soybean oil 55～85%, cod-liver oil 0.5～10%, vitamin A 0.001～
0.01%, vitamin D 0.00001～0.0001%.
The preparation method of three-dimensional emulsio olei jecoris piscis the most according to claim 1, it is characterised in that ascorbic coating material
For soybean phospholipid；The component of vitamin C soybean phospholipid microcapsule is: vitamin C is 1 with the mass ratio of Encapsulating materials soybean phospholipid:
2.5～6, soybean phospholipid is 1～10:100 with the mass ratio of solvent dehydrated alcohol；Dehydrated alcohol is the molten of use in preparation process
Agent, in vitamin with soybean phospholipid microcapsule preparation process, dehydrated alcohol is by evaporation type Ex-all.
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| CN107802648A (en) * | 2017-12-14 | 2018-03-16 | 浙江海洋大学 | A kind of concocting method of the natural cod-liver oil of anti-curing osteoporosis |
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Address after: No.2 Shuangjing Road, Liuting Industrial Park, Chengyang District, Qingdao City, Shandong Province Patentee after: Qingdao Shuangwhale Pharmaceutical Co.,Ltd. Address before: No.2 Shuangjing Road, Liuting Industrial Park, Chengyang District, Qingdao City, Shandong Province Patentee before: QINGDAO DOUBLE WHALE PHARMACEUTICAL Co.,Ltd. |