CN106692199A - Preparation method of cod-liver oil - Google Patents
Preparation method of cod-liver oil Download PDFInfo
- Publication number
- CN106692199A CN106692199A CN201510783736.5A CN201510783736A CN106692199A CN 106692199 A CN106692199 A CN 106692199A CN 201510783736 A CN201510783736 A CN 201510783736A CN 106692199 A CN106692199 A CN 106692199A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- cod
- soybean lecithin
- capsule
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Abstract
The invention relates to a preparation method of cod-liver oil. In accordance with composition and formulation, the percentage by mass of an oil phase in an emulsion is 55-90%, wherein the percentages by mass of various ingredients in the oil phase in the emulsion are as follows: 55-85% of soybean oil, 0.5-10% of cod-liver oil, 0.001-0.01% of vitamin A and 0.00001-0.0001% of vitamin D; the percentage by mass of an aqueous phase in the emulsion is 10-45%; the percentage by mass of an emulsifying agent in the emulsion is 0.1-3%, wherein a vitamin C soybean phospholipid micro-capsule in the emulsifying agent consists of the following ingredients: vitamin C and a capsule-forming material, namely soybean phospholipid, at the mass ratio of 1: (2.5-6), and soybean phospholipid and a solvent, namely absolute ethyl alcohol, at the mass ratio of 1: (10-100); and the preparation method comprises three processing steps: preparing a soybean phospholipid solution, preparing the phospholipid micro-capsule and conducting emulsifying. The preparation method is mature in preparation process route, and the finished product (the cod-liver oil) is rich in nutrition, good in taste, low in processing cost, safe and reliable and environment-friendly to eat.
Description
Technical field：
The invention belongs to pharmaceutical technology field, it is related to a kind of preparation method of cod-liver oil.
Background technology：
Three-dimensional cod-liver oil emulsion main component is vitamin A and D, C, and vitamin A and D are
The necessary material of growth in humans's development, especially to fetus, the development of infant, epithelial tissue
Growing etc. for the constant of integrality, eyesight, blood calcium and phosphorus, bone and tooth plays an important role,
Vitamin C participates in internal antibody, collagen and is formed and tissue repairing, and sugar, fat, egg
The metabolism of white matter, keeps blood vessel complete, and three-dimensional cod-liver oil emulsion is used to prevent and treat because of vitamin
A and D, C lack caused various diseases, such as yctalopia, ophthalmoxerosis, keratomalacia
Disease, rickets, osteomalacia etc.；Traditional three-dimensional cod-liver oil emulsion is a kind of oil-in-water type
Emulsifying agent is the emulsion of o/w types, and its main component contains fat-soluble A, D and water
Soluble vitamin C, vitamin C is dissolved in the water phase of emulsion, and it is very unstable in water,
Easily degrade, and solve the problems, such as that vitamin C is unstable in aqueous and mostly use now
Two kinds of methods below：One is the production method with reference to vitamin C injection, and whole production process will
Carried out under oxygen-free environment, and add the auxiliary materials such as chelating agent, antioxidant, because of three-dimensional cod-liver oil emulsion
It is Orally taken emulsion, and is multiple-unit container, so its processing preparation process whole process nothing difficult to realize
Oxygen, also simply ascorbic degraded is alleviated using this strict control technique, can not
Thoroughly solve degradation problem；Two is that vitamin C is made into inclusion compound, liposome etc. to apply
Solid pharmaceutical preparation, semisolid preparation aspect, this kind of inclusion compound are not suitable for being applied to emulsion.
The content of the invention：
It is an object of the invention to the shortcoming for overcoming prior art to exist, seek design and provide a kind of
Vitamin C is mentioned in emulsion layer from the water phase of emulsion and three-dimensional emulsio olei jecoris piscis are prepared
Process, is first prepared into vitamin C soybean by vitamin C, soybean lecithin absolute ethyl alcohol
Phosphatide micro-capsule, so as to completely cut off contact of the vitamin C with water, raising vitamin C is in emulsion
Stability, vitamin C soybean lecithin micro-capsule is played emulsification, and by oil phase and water
Mutually it is prepared into the process of emulsion.
To achieve these goals, the compositing formula of cod-liver oil of the present invention is：Oil phase exists
Mass percent is in emulsion：55~90%, wherein, each composition in oil phase is accounted in emulsion
Mass percent is：Soybean oil 55~85%, cod-liver oil 0.5~10%, vitamin A 0.001~
0.01%, vitamin D 0.00001~0.0001%；Mass percent of the water in emulsion be：
10~45%；Mass percent of the emulsifying agent in emulsion be：0.1~3%, wherein, emulsification
Vitamin C soybean lecithin micro-capsule into being grouped into agent：Vitamin C is big with Encapsulating materials
The mass ratio of Fabaceous Lecithin is 1：2.5~6, soybean lecithin is with the mass ratio of solvent absolute ethyl alcohol
1~10:100.
The preparation method of cod-liver oil of the present invention includes that the preparation of soybean lecithin solution, phosphatide are micro-
Capsule is prepared and three processing steps of emulsification：
(1) soybean lecithin solution is prepared：Soybean lecithin is added in absolute ethyl alcohol, is stirred
To being completely dissolved, soybean lecithin solution is obtained final product within 10~15 minutes；
(2) prepared by phosphatide micro-capsule：After vitamin C is crossed into 100 mesh sieves, boiling is placed into dry
In dry bed, soybean lecithin solution is sprayed under fluidized state, control temperature to be done for 45~55 DEG C
Dry 20~30 minutes, obtain final product vitamin C soybean lecithin micro-capsule；
(3) emulsify：Cod-liver oil, vitamin A, vitamin D stirring are dissolved in soybean oil,
Sequentially add vitamin C soybean lecithin micro-capsule and purified water and stir, traditional method of indicating the pronunciation of a Chinese character emulsification
30 minutes, obtain final product cod-liver oil finished product.
Compared with prior art, its preparation technology route is ripe for the present invention, and product is nutritious,
Mouthfeel taste is good, and processing cost is low, safe and reliable, eats environment-friendly.
Specific embodiment：
Below by embodiment, the invention will be further described.
Embodiment 1：A kind of preparation of applicable cod-liver oil of being grown up.
The present embodiment prepares dimension emulsio olei jecoris piscis 1000g, and its each ingredient components content is：Fish
Liver oil 10g；Vitamin A 0.062g；Vitamin D 0.163mg；Vitamin C 1.54g；
Soybean lecithin 5.235g；Absolute ethyl alcohol：79g；Soybean oil 600g；Purified water 304g.
The preparation process of the present embodiment is：
(1) by the soybean lecithin of commercially available prod be added to stirring and dissolving in absolute ethyl alcohol it is uniform after,
It is configured to soybean lecithin solution；
(2) vitamin C of commercially available prod is crossed and conventional boiling-bed drying is inserted after 100 mesh sieves
In, during the soybean lecithin solution for again preparing step (1) under fluidized state sprays into drying bed,
Temperature control makes vitamin C drying under the conditions of 45~55 DEG C, is prepared into vitamin C soybean lecithin micro-
Capsule；
(3) first the cod-liver oil of commercially available prod, vitamin A and vitamin D are stirred successively respectively
It is dissolved in soybean oil, then is sequentially added into vitamin C soybean lecithin micro-capsule and purified water, stirs
Traditional method of indicating the pronunciation of a Chinese character emulsification is carried out after mixing uniformly and obtains final product cod-liver oil product within 30 minutes.
Embodiment 2：A kind of preparation of the three-dimensional emulsio olei jecoris piscis that children are applicable.
The present embodiment is made three-dimensional emulsio olei jecoris piscis 1000g, and its each component content is：Fish liver
Oily 10g；Vitamin A 0.03g；Vitamin D 0.338mg；Vitamin C 1.54g；Soybean phosphorus
Fat 5g；Absolute ethyl alcohol 79g；Soybean oil 600g；The rest is purified water 304g.
The preparation method of the present embodiment is：
(1) first soybean lecithin is added in absolute ethyl alcohol, after stirring and dissolving, is configured to big
Fabaceous Lecithin solution；
(2) vitamin C is crossed into 100 mesh sieves, is inserted in boiling-bed drying, in the state of boiling
Lower penetrating soybean lecithin solution, dries at 45~55 DEG C, is prepared into vitamin C soybean lecithin
Micro-capsule；
(3) cod-liver oil, vitamin A, vitamin D are dissolved in soybean oil successively respectively, then
Vitamin C soybean lecithin micro-capsule and purified water are separately added into successively, and the traditional method of indicating the pronunciation of a Chinese character is carried out after stirring
Emulsification obtains final product three-dimensional emulsio olei jecoris piscis product for 30 minutes.
The outturn sample of the present embodiment carries out long-term with the three-dimensional cod-liver oil emulsion contrast of traditional handicraft
Keep sample investigation experimental study, and samplings in 0,3,6,9,12,18,24 months after placement
Ascorbic content is measured, its investigation result of the test that keeps sample for a long time see the table below：
As seen from the above table, after product of the present invention is through the long-term investigation that keeps sample, indices are equal after testing
Normally, vitamin C understands that palliating degradation degree is much less than traditional cod-liver oil through assay.
Claims (2)
1. a kind of preparation method of cod-liver oil, it is characterised in that compositing formula is：Oil phase is in breast
Mass percent is in agent：55~90%, wherein, the matter that each composition in oil phase is accounted in emulsion
Measuring percentage is：Soybean oil 55~85%, cod-liver oil 0.5~10%, vitamin A 0.001~
0.01%, vitamin D 0.00001~0.0001%；Mass percent of the water in emulsion be：
10~45%；Mass percent of the emulsifying agent in emulsion be：0.1~3%, wherein, emulsification
Vitamin C soybean lecithin micro-capsule into being grouped into agent：Vitamin C is big with Encapsulating materials
The mass ratio of Fabaceous Lecithin is 1：2.5~6, soybean lecithin is with the mass ratio of solvent absolute ethyl alcohol
1~10:100.
2. the preparation method of cod-liver oil according to claim 1, its preparation method includes
Soybean lecithin solution is prepared, prepared by phosphatide micro-capsule and three processing steps of emulsification：
(1) soybean lecithin solution is prepared：Soybean lecithin is added in absolute ethyl alcohol, is stirred
To being completely dissolved, soybean lecithin solution is obtained final product within 10~15 minutes；
(2) prepared by phosphatide micro-capsule：After vitamin C is crossed into 100 mesh sieves, boiling is placed into dry
In dry bed, soybean lecithin solution is sprayed under fluidized state, control temperature to be done for 45~55 DEG C
Dry 20~30 minutes, obtain final product vitamin C soybean lecithin micro-capsule；
(3) emulsify：Cod-liver oil, vitamin A, vitamin D stirring are dissolved in soybean oil,
Sequentially add vitamin C soybean lecithin micro-capsule and purified water and stir, traditional method of indicating the pronunciation of a Chinese character emulsification
30 minutes, obtain final product cod-liver oil finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510783736.5A CN106692199A (en) | 2015-11-16 | 2015-11-16 | Preparation method of cod-liver oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510783736.5A CN106692199A (en) | 2015-11-16 | 2015-11-16 | Preparation method of cod-liver oil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106692199A true CN106692199A (en) | 2017-05-24 |
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ID=58931961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510783736.5A Pending CN106692199A (en) | 2015-11-16 | 2015-11-16 | Preparation method of cod-liver oil |
Country Status (1)
| Country | Link |
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| CN (1) | CN106692199A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107802648A (en) * | 2017-12-14 | 2018-03-16 | 浙江海洋大学 | A kind of concocting method of the natural cod-liver oil of anti-curing osteoporosis |
| CN108283649A (en) * | 2017-06-16 | 2018-07-17 | 湖南中和制药有限公司 | Three-dimensional cod-liver oil emulsion and its preparation process |
-
2015
- 2015-11-16 CN CN201510783736.5A patent/CN106692199A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108283649A (en) * | 2017-06-16 | 2018-07-17 | 湖南中和制药有限公司 | Three-dimensional cod-liver oil emulsion and its preparation process |
| CN107802648A (en) * | 2017-12-14 | 2018-03-16 | 浙江海洋大学 | A kind of concocting method of the natural cod-liver oil of anti-curing osteoporosis |
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Legal Events
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170524 |