CN103393579B - Preparation method for whitening and repairing lipid nanoparticle emulsion - Google Patents
Preparation method for whitening and repairing lipid nanoparticle emulsion Download PDFInfo
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Abstract
The invention relates to a preparation method for a whitening and repairing lipid nanoparticle emulsion. The preparation method comprises the following steps: A, weighing a lipid material and heating the lipid material to a temperature of 75 to 85 DEG C so as to obtain a liquid oil phase; B, weighing an Ormosia henryi bark extract, an Indian currant extract and a dragon's blood extract in proportion so as to obtain whitening and repairing active matters; C, uniformly mixing the whitening and repairing active matters with the lipid material, then heating to a temperature of 75 to 85 DEG C and carrying out uniform stirring so as to obtain a liquid oil phase; D, weighing a mixture of hydrogenated lecithin and sucrose fatty acid ester so as to form a mixed emulsifier; E, weighing and mixing the mixed emulsifier and distilled water and heating to a temperature of 75 to 85 DEG C so as to obtain a liquid water phase; and F, uniformly mixing the liquid oil phase and the liquid water phase with stirring so as to obtain mixed liquor, carrying out cyclic homogenization 10 to 15 times at a pressure of 70 to 150 MPa and a temperature of 75 to 90 DEG C and cooling to room temperature so as to obtain the whitening and repairing lipid nanoparticle emulsion. The invention has the advantage that the three active matters consisting of the Ormosia henryi bark extract, the Indian currant extract and the dragon's blood extract can be loaded at the same time.
Description
Technical field
The present invention relates to lipid nanoparticle preparing technical field, particularly the preparation method of lipid nanoparticle emulsion is repaired in a kind of whitening.
Background technology
Lignum pterocarpi indici (PTEROCARPUS MARSUPIUM) bark extract (Chinese INCI title: Lignum pterocarpi indici bark extract) be commonly used to treat cardiovascular diseases and diabetes in India's Ayurveda medical system in ancient times.Now clear and definite, the pterostilbene of Lignum pterocarpi indici bark extract (Pterostilbene) is its crucial active component.The manufacturer of the Lignum pterocarpi indici bark extract using in the present invention is U.S. SABINSA company, white or off-white color lenticular powder, and commodity are called PTEROWHITE, the pterostilbene that contains 90% purity.Pterostilbene can reach white-skinned face function by the approach of PPAR α induction nucleus formation, can suppress the effect of the lipid peroxidation of cell membrane simultaneously, can also be by suppressing COX-2 performance anti-inflammatory efficacy.Lignum pterocarpi indici bark extract adds its white-skinned face function of main manifestations in cosmetic formulations to.
Indian currant (Emblica Officinalis) extract (Chinese INCI title: Indian currant extract), being derived from east Ayurveda medicinal herbs, growing in the quiet and beautiful overall situation of India's high mountain, is one of important component during India medicinal herbs are learned.The manufacturer of the Indian currant extract that the present invention uses is U.S. SABINSA company, ecru powder, and main active is the tannin of 10% β-glucogallic acid and total 50%.Indian currant extract not only has remarkable antioxidant properties, can also stimulate natural Antioxidant Enzyme Systems in body, adds its anti-oxidation efficacy of main manifestations in cosmetic formulations to.
Sanguis draconis extract (Chinese INCI title: Peru's croton resin extract), have another name called Sanguis Draxonis, it is Herba indigoferae Pseudotinctoriae important in Chinese medicine, Ming Dynasty Ni Zhumo bun < < book on Chinese herbal medicine converges in speech > > to be recorded, and Sanguis Draxonis is controlled all incised wounds and the toxic swelling not granulation promoting meat that festers.Modern science demonstration, its main active is thaspine (Taspine) and procyanidin (PAC).The sanguis draconis extract that the present invention uses, manufacturer is NATUREX company, commodity are called Dragon ' s Blood.Wherein procyanidin PAC content reaches 50%, makes it have strong anti-oxidation characteristic, and thaspine content is 2%, can strengthen mitochondria enzyme activity, promotes skin repair.Sanguis draconis extract, by promoting Fibronectin synthetic, is repaired corium epidermis adhesion, fills corium bottom in addition by a large amount of generation collagen protein I and III, impels cell tissue to repair skin, adds its maintenance effect of main manifestations in cosmetic formulations to.
Lignum pterocarpi indici bark extract and the less stable of sanguis draconis extract in cosmetic formulations, easily oxidized and cause content to reduce very soon; The problem that Indian currant extract exists be run into bivalent metal ion will variable color.Color will be by the colourless dark yellow that becomes in oxidized process for Lignum pterocarpi indici bark extract, sanguis draconis extract will become dark brown by golden yellow, Indian currant extract runs into bivalent metal ion and can gray, these variations directly cause active matter content to decline, active matter change color can cause final finished appearance degradation, has affected and has promoted the use of.
Summary of the invention
The technical problem to be solved in the present invention is that the preparation method of the lipid nanoparticle emulsion with whitening repair of a kind of Lignum pterocarpi indici of load simultaneously bark extract, Indian currant extract, sanguis draconis extract is provided.
For solving the problems of the technologies described above, the present invention by the following technical solutions: the preparation method of lipid nanoparticle emulsion is repaired in a kind of whitening, it is characterized in that adopting following steps:
A: weigh matrix material, be heated to 75-85 ℃, obtain liquid oil phase; Described matrix material is glyceryl stearate or glyceryl stearate and the mixture of one or more in oils and fats what follows, and described oils and fats is narrow wing Suo Luo Shuan (SHOREA STENOPTERA) seed fat, sal tree (SHOREA ROBUSTA) seed fat, Garcinia indica (GARCINIA INDICA) seed fat, illipe (BASSIA LATIFOLIA) fruit fat;
B: take Lignum pterocarpi indici bark extract, Indian currant extract, sanguis draconis extract for the 2.6-ratio of 8: 1.4-5: 1 in mass ratio, above-mentioned three kinds of materials are mixed, obtain composite whitening repairing activity thing;
C: 0.188-takes composite whitening repairing activity thing and matrix material at 0.333: 1 in mass ratio, mix homogeneously post-heating to 75-85 ℃, are stirred to and dissolve mix homogeneously completely, obtain liquid oil phase;
D: 0.5-2:1 takes the mixture of hydrolecithin and sucrose fatty acid ester in mass ratio, forms blended emulsifier;
E: for the ratio of 0.1-0.25:1 takes step D gained blended emulsifier and distilled water, be heated to 75-85 ℃ in mass ratio, mix homogeneously obtains liquid water;
F: described liquid oil phase and liquid water mixing and stirring are obtained to mixed liquor, by mixed liquor under 70-150MPa pressure, 75-90 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 10-15 time, in high pressure homogenizer outlet, use chiller, guarantee that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 ℃, obtains nanoemulsions after homogenizing completes; Gained nanoemulsions is cooled to room temperature, adds appropriate antiseptic, obtain whitening and repair lipid nanoparticle emulsion.
Matrix material of the present invention must comprise glyceryl stearate, can certainly adopt the mixture of glyceryl stearate and narrow wing Suo Luo Shuan (SHOREA STENOPTERA) seed fat, sal tree (SHOREA ROBUSTA) seed fat, Garcinia indica (GARCINIA INDICA) seed fat, illipe (BASSIA LATIFOLIA) fruit fat.The preparation method of described whitening remediation composition capable lipid nanoparticle emulsion, by selecting suitable matrix material, the Lignum pterocarpi indici of load simultaneously bark extract, Indian currant extract, three kinds of active component of sanguis draconis extract, can effectively guarantee that three kinds of active component are covered by lipid nanoparticle simultaneously, improved its cooperative effect, also the stability of active matter, transdermal characteristic and slow-releasing by the structure of lipid nanoparticle, have been improved.The present invention, by suitable pressure, temperature and homogenization cycles are set, can be controlled at the particle diameter of whitening remediation composition capable lipid nanoparticle within the scope of 100-150nm, be conducive to skin and absorb, and product stability is good.
For forming stable lipid nanoparticle emulsion; the emulsifying agent that the present invention adopts is the mixture of hydrolecithin and sucrose fatty acid ester; hydrolecithin is as the SOYA SPL 75H of Korea S NEUROPID company, PHOSPHOLIPON 90 H of German LIPOID company etc.; Sucrose fatty acid ester is as the SURFHOPE SE COSME C1815 of MIT, SURFHOPE SE COSME C1616 etc.
The whitening remediation composition capable lipid nanoparticle emulsion of preparing by the inventive method rotating speed be in per minute 10000 centrifuges that turn centrifugal 30 minutes not stratified; Under 45 degree environment, preserve not stratified, invariant color in three months; Normal temperature storage 3 years is not stratified, excellent in stability.
By the human experimentation in 28 days of 30 example, prove, the cosmetics of lipid nanoparticle emulsion are repaired in the whitening that is added with 10% embodiment tetra-preparations, in this example, actual Lignum pterocarpi indici bark extract 0.325%, Indian currant extract 0.175%, the sanguis draconis extract 0.125% of containing in these cosmetics, its gross activity thing content is 0.45%, but the effect of its whitening reparation is better than only adding 0.45% Lignum pterocarpi indici bark extract, the cosmetics that are also better than only adding 0.45% Indian currant extract or only add 0.45% sanguis draconis extract.Meanwhile, be also better than process lipid nanoparticle processing, and directly add the same basic components cosmetics of Lignum pterocarpi indici bark extract 0.325%, Indian currant extract 0.175%, sanguis draconis extract 0.125%.In the experiment of this example, skin whiteness is used the U.S. CHECK II of DATACOLOR company color difference meter to measure, and creasy surface is by German PRIMOS skin rapid three dimensional imaging system measurement, and whole skin smoothness is measured by the VISIA CR of U.S. CANFIELD company.
The situation of change of using cosmetics detection of skin whiteness variation after 28 days, wrinkle depth variation and the whole skin smoothness of adding functional component, experimental data is as follows:
| Sample title | The relative recruitment of whiteness (%) | The relative reduction of wrinkle depth (%) | The whole relative recruitment of smoothness (%) |
| A | 22 | 10 | 13 |
| B | 18 | 14 | 15 |
| C | 11 | 21 | 25 |
| D | 31 | 16 | 18 |
| E | 40 | 35 | 37 |
Note: A adds the sample of 0.45% Lignum pterocarpi indici bark extract, B adds the sample of 0.45% Indian currant extract, C adds the sample of 0.45% sanguis draconis extract, D directly adds the sample of 0.325% Lignum pterocarpi indici bark extraction, 0.175% Indian currant extract, 0.125% sanguis draconis extract, and E adds the liposome nano granule (active matter total amount is equivalent to 0.45%) containing Lignum pterocarpi indici bark extraction 0.325%, Indian currant extract 0.175%, sanguis draconis extract 0.125%.
Under 45 ℃ of environment, to place three months, lipid nanoparticle emulsion is repaired in the whitening of the embodiment of the present invention 1 to embodiment 5, and appearance color all still presents oldlace, with the standard sample comparison that is kept at 5 ℃ of cryostates, without obvious outward appearance and color change.With Ma Erwen particle diameter tester, measure, its whitening is repaired lipid nanoparticle emulsion mean diameter also without significant change.
The whitening remediation composition capable lipid nanoparticle emulsion of preparing by the inventive method, its gross activity thing mass ratio in lipid nanoparticle emulsion can reach 2.25-7.75%, under room temperature, viscosity is less than 1000cps, can coldly join and join in cosmetic formulations, in whitening, repair in effect cosmetics easy to use.
Pass through liquid chromatogram measuring, the cosmetics of lipid nanoparticle emulsion (Lignum pterocarpi indici bark extraction 0.325%, Indian currant extract 0.175%, sanguis draconis extract 0.125%) are repaired in the whitening that is added with 10% embodiment of the present invention four preparations, gross activity thing content is 4.5%, under room temperature, place three months, above-mentioned three kinds of active matter content storage rates are respectively 95.1%, 92.8%, 99.2%.Active matter is not processed through the inventive method, and directly add that Lignum pterocarpi indici bark extracts 0.325%, the same basic components cosmetics of Indian currant extract 0.175%, sanguis draconis extract 0.125%, above-mentioned three kinds of active matter content storage rates are respectively 73.3%, 62.5%, 82.2%.Whitening remediation composition capable lipid nanoparticle emulsion prepared by visible the inventive method is highly stable.
The particle diameter that lipid nanoparticle is repaired in whitening prepared by the present invention can be controlled at 100-150nm, and not only particle diameter is little, and lipid conformation pro-skin, result of use is obvious, and low viscosity, and water dispersible is good, easy to use, can effectively extend half-life of active substance, increase the effect series products shelf-life.It is simple and convenient that this method also has preparation process, constant product quality, and large-scale industrial is produced convenient grade for beneficial effect.
The present invention is composite by above-mentioned Lignum pterocarpi indici bark extract, Indian currant extract, sanguis draconis extract, Lignum pterocarpi indici bark extract is brought into play its whitening effect, Indian currant extract performance anti-oxidation efficacy, sanguis draconis extract is repaired skin, three kinds of collaborative collocation of functional component, action effect compare independent use any one of them, under same equal size, effect is better.By Lignum pterocarpi indici bark extract, Indian currant extract, the composite lipid nanoparticle emulsion that is prepared into of sanguis draconis extract; the protection that utilizes lipid nanoparticle to have; slow release and can improve transdermal characteristic, adds in cosmetic formulations, can make its cooperative effect, stability all be improved.Overcome in use poor stability of Lignum pterocarpi indici bark extract, Indian currant extract, sanguis draconis extract, easily oxidized technological deficiency.
In sum, the inventive method has the following advantages: lipid nanoparticle emulsion is repaired in the whitening that can prepare the Lignum pterocarpi indici of load simultaneously bark extract, Indian currant extract, three kinds of active matters of sanguis draconis extract, there is whitening reparation effect remarkable, active matter is stable be not easy oxidized, emulsion-stabilizing invariant color, facilitates the cold advantage joining in cosmetic formulations of joining.
The specific embodiment
embodiment mono-:
A preparation method for lipid nanoparticle emulsion is repaired in whitening, adopts following steps:
A. be 2:1:1:1:1 in mass ratio, take 11.666g glyceryl stearate, the narrow wing Suo of 5.833g Luo Shuan seed fat, 5.833g sal tree seed fat, 5.833g Garcinia indica seed fat, 5.833g illipe fruit fat, mixture is in beaker, and 75 ℃ of heating in water bath, obtain liquid oil phase; This mixture fusing point is 48 ℃;
B. in the ratio of 2.67:1.67:1, take 4.0g Lignum pterocarpi indici bark extract, 2.5g Indian currant extract, 1.5g sanguis draconis extract, joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stirs 5 minutes, be uniformly mixed, remain on 75 ℃;
C. be that the ratio of 0.15: 1 takes 21.0g emulsifying agent (hydrolecithin (trade name SOYA SPL 75H) 10.5g wherein in mass ratio, sucrose fatty acid ester (trade name SURFHOPE SE COSME C1815) 10.5g) and 136.0g distilled water, put into beaker, be heated to 75 ℃, stir and obtain liquid water;
D. above-mentioned oil phase and water are mixed, stir, pour high pressure homogenizer emulsifying into, controlled pressure is at 70MPa, circulation homogenizing 8 times; Use chiller, controlling homogenizer outlet temperature is 90 ℃;
E: the high-temperature nano emulsion obtaining is quickly cooled to room temperature, add appropriate DMDM Hydantoin antiseptic, stir, can obtain the reparation of the whitening containing Lignum pterocarpi indici bark extract, Indian currant extract, the sanguis draconis extract lipid nanoparticle emulsion that mean diameter is about 150nm, whitening repairing activity thing total content is 4.0%.
embodiment bis-:
A preparation method for lipid nanoparticle emulsion is repaired in whitening, adopts following steps:
A. be 1.5:0.5:1 in mass ratio, take 12g glyceryl stearate, the narrow wing Suo of 4g Luo Shuan seed fat and 8g illipe fruit fat and be mixed in beaker, 85 ℃ of heating in water bath, obtain liquid oil phase; This mixture fusing point is 56 ℃;
B. in the ratio of 6: 2: 1, take 3.0g Lignum pterocarpi indici bark extract, 1.0g Indian currant extract, 0.5g sanguis draconis extract, joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stirs 5 minutes, be uniformly mixed, remain on 85 ℃;
C. be that the ratio of 0.2: 1 takes 28.5g emulsifying agent (hydrolecithin (trade name is PHOSPHOLIPON 90 H) 9.5g wherein in mass ratio, sucrose fatty acid ester (trade name is SURFHOPE SE COSME C1616) 19g) and 143.0g distilled water, put into beaker, be heated to 85 ℃, stir and obtain liquid water;
D. above-mentioned oil phase and water are mixed, stir, pour high pressure homogenizer emulsifying into, controlled pressure is at 150MPa, circulation homogenizing 10 times; Use chiller, controlling homogenizer outlet temperature is 95 ℃;
E. the high-temperature nano emulsion obtaining is quickly cooled to room temperature, adding appropriate antiseptic stirs, can obtain the reparation of the whitening containing Lignum pterocarpi indici bark extract, Indian currant extract, the sanguis draconis extract lipid nanoparticle emulsion that mean diameter is about 100nm, whitening repairing activity thing total content is 2.25%.
embodiment tri-:
A preparation method for lipid nanoparticle emulsion is repaired in whitening, adopts following steps:
A. be 4:2:1:1 in mass ratio, take 20g glyceryl stearate, 10g sal tree seed fat, 5g Garcinia indica seed fat, 5g illipe fruit fat is mixed in beaker, 85 ℃ of heating in water bath, obtain liquid oil phase; This mixture fusing point is 63 ℃;
B. be the ratio of 5.3: 4: 1 in mass ratio, take 8.0g Lignum pterocarpi indici bark extract, 6.0g Indian currant extract, 1.5g sanguis draconis extract, joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 80 ℃;
C. be that the ratio of 0.25: 1 takes 28.9g emulsifying agent (hydrolecithin (commodity are called PHOSPHOLIPON 90 H) 7.22g wherein in mass ratio, hydrolecithin (trade name SOYA SPL 75H) 7.22g, sucrose fatty acid ester (trade name SURFHOPE SE COSME C1815) 7.23g, sucrose fatty acid ester (trade name SURFHOPE SE COSME C1616) 7.23g) and 115.6g distilled water, put into beaker, be heated to 80 ℃, stir and obtain liquid water;
D. above-mentioned oil phase and water are mixed, stir, pour high pressure homogenizer emulsifying into, controlled pressure is at 100MPa, circulation homogenizing 12 times; Use chiller, controlling homogenizer outlet temperature is 85 ℃;
E. the high-temperature nano emulsion obtaining is quickly cooled to room temperature, add appropriate antiseptic, can obtain the reparation of the whitening containing Lignum pterocarpi indici bark extract, Indian currant extract, the sanguis draconis extract lipid nanoparticle emulsion that mean diameter is about 110nm, whitening repairing activity thing content is 7.75%.
embodiment tetra-:
A preparation method for lipid nanoparticle emulsion is repaired in whitening, adopts following steps:
A. be 1.5:1 in mass ratio, take 36g glyceryl stearate and 24g Garcinia indica seed fat is mixed in beaker, 85 ℃ of heating in water bath, obtain liquid oil phase; This mixture fusing point is 80 ℃;
B. be the ratio of 2.6: 1.4: 1 in mass ratio, take 6.5g Lignum pterocarpi indici bark extract, 3.5g Indian currant extract, 2.5g sanguis draconis extract, joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 78 ℃;
C. be the ratio of 0.1: 1 in mass ratio, take 11.5g emulsifying agent (hydrolecithin (trade name SOYA SPL 75H) 2.65g wherein, sucrose fatty acid ester (trade name SURFHOPE SE COSME C1616) 8.85g) and 116.0g distilled water, put into beaker, be heated to 78 ℃, stir and obtain liquid water;
D. above-mentioned oil phase and water are mixed, stir, pour high pressure homogenizer emulsifying into, controlled pressure is at 120MPa, circulation homogenizing 15 times; Use chiller, controlling homogenizer outlet temperature is 82 ℃;
E. the high-temperature nano emulsion obtaining is quickly cooled to room temperature, add appropriate antiseptic, can obtain the reparation of the whitening containing Lignum pterocarpi indici bark extract, Indian currant extract, the sanguis draconis extract lipid nanoparticle emulsion that mean diameter is about 110nm, whitening repairing activity thing content is 4.5%.
embodiment five:
A preparation method for lipid nanoparticle emulsion is repaired in whitening, adopts following steps:
A. be 4:3:2:1:1 in mass ratio, take glyceryl stearate 12.72g, narrow wing Suo Luo Shuan seed fat 9.54g, sal tree seed fat 6.32g, Garcinia indica seed fat 3.18g, illipe fruit fat 3.18g mixture is in beaker, 85 ℃ of heating in water bath, obtain liquid oil phase; This mixture fusing point is 49 ℃;
B. in the ratio of 8: 5: 1, take 4.0g Lignum pterocarpi indici bark extract, 2.5g Indian currant extract, 0.5g sanguis draconis extract, joined in above-mentioned liquid oil phase, control agitator speed is 500rpm, stir 5 minutes, be uniformly mixed, remain on 82 ℃;
C. be that the ratio of 0.18: 1 takes 24.1g emulsifying agent (hydrolecithin (commodity are called PHOSPHOLIPON 90 H) 16.1g wherein in mass ratio, sucrose fatty acid ester (trade name SURFHOPE SE COSME C1616) 8.0g) and 133.9g distilled water, put into beaker, be heated to 82 ℃, stir and obtain liquid water;
D. above-mentioned oil phase and water are mixed, stir, pour high pressure homogenizer emulsifying into, controlled pressure 135MPa, circulation homogenizing 15 times; Use chiller, controlling homogenizer outlet temperature is 90 ℃;
E. the high-temperature nano emulsion obtaining is quickly cooled to room temperature, add two (methylol) imidazolidinyl antiseptic of 0.3%, can obtain the reparation of the whitening containing Lignum pterocarpi indici bark extract, Indian currant extract, the sanguis draconis extract lipid nanoparticle emulsion that mean diameter is about 100nm, whitening repairing activity thing content is 3.5%.
Claims (1)
1. a preparation method for lipid nanoparticle emulsion is repaired in whitening, it is characterized in that adopting following steps:
A: weigh matrix material, be heated to 75-85 ℃, obtain liquid oil phase; Described matrix material is glyceryl stearate or glyceryl stearate and the mixture of one or more in oils and fats what follows, and described oils and fats is narrow wing Suo Luo Shuan seed fat, sal tree seed fat, Garcinia indica seed fat, illipe fruit fat;
B: take Lignum pterocarpi indici bark extract, Indian currant extract, sanguis draconis extract for the 2.6-ratio of 8: 1.4-5: 1 in mass ratio, above-mentioned three kinds of materials are mixed, obtain composite whitening repairing activity thing;
C: 0.188-takes composite whitening repairing activity thing and liquid oil phase at 0.333: 1 in mass ratio, mix homogeneously post-heating to 75-85 ℃ are stirred to and dissolve mix homogeneously completely, obtain liquid oil phase;
D: 0.5-2:1 takes the mixture of hydrolecithin and sucrose fatty acid ester in mass ratio, forms blended emulsifier;
E: for the ratio of 0.1-0.25:1 takes step D gained blended emulsifier and distilled water, be heated to 75-85 ℃ in mass ratio, mix homogeneously obtains liquid water;
F: described liquid oil phase and liquid water mixing and stirring are obtained to mixed liquor, by mixed liquor under 70-150MPa pressure, 75-90 ℃ of temperature conditions, by high pressure homogenizer circulation homogenizing 10-15 time, in high pressure homogenizer outlet, use chiller, guarantee that high pressure homogenizer outlet section mixeding liquid temperature is no more than 90 ℃, obtains nanoemulsions after homogenizing completes; Gained nanoemulsions is cooled to room temperature, adds appropriate antiseptic, obtain whitening and repair lipid nanoparticle emulsion.
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| CN103690380B (en) * | 2013-12-12 | 2015-04-22 | 珀莱雅化妆品股份有限公司 | Method for preparing whitening nanoparticle emulsion with solid phase core |
| CN104970987B (en) * | 2014-04-11 | 2018-01-19 | 珀莱雅化妆品股份有限公司 | The preparation method of the liposome of skin is damaged after a kind of reparation allergy |
| CN104306269B (en) * | 2014-11-04 | 2017-02-01 | 珀莱雅化妆品股份有限公司 | Preparation method of cyclodextrin inclusion compound liposome with whitening effect |
| CN104523442B (en) * | 2014-12-15 | 2018-03-06 | 苏州纳康生物科技有限公司 | Symwhite-337 lipid nano particle and its production and use |
| CN107080708B (en) * | 2017-03-30 | 2020-04-03 | 广州善草纪化妆品有限公司 | Mild multi-effect face cleaning composition |
| CN106943315A (en) * | 2017-05-17 | 2017-07-14 | 秀瑞斯（天津）科技有限公司 | Exquisite waist conditioning formulations, preparation method and application method |
| CN108354864B (en) * | 2018-03-30 | 2020-07-28 | 浙江工业大学 | Preparation method of emulsion with whitening and moisturizing effects |
| CN108635264A (en) * | 2018-06-17 | 2018-10-12 | 佛山文森特知识产权服务有限公司 | Shu Min skin care compositions and its application |
| CN111821209B (en) * | 2020-08-20 | 2023-04-28 | 中国科学院华南植物园 | Compound natural whitening anti-wrinkle composition and application |
| CN113208942B (en) * | 2021-05-07 | 2022-01-07 | 宝萃生物科技有限公司 | Pterostilbene nanoemulsion as well as preparation method and application thereof |
| CN115337235B (en) * | 2022-07-25 | 2023-06-13 | 上海林清轩生物科技有限公司 | Multiple whitening pathway composition containing safflower camellia extract |
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| JP2003081749A (en) * | 2001-09-13 | 2003-03-19 | Nonogawa Shoji Kk | Skin care preparation |
| ES2342931T3 (en) * | 2002-01-18 | 2010-07-19 | Merck Patent Gmbh | COMPOSITION FOR SKIN CLEARING. |
| US20080050334A1 (en) * | 2006-08-24 | 2008-02-28 | L'oreal | Cosmetic composition comprising an extract of emblica officinalis, a hydroxy acid, and an N-substituted aminosulfonic acid, and methods of using same |
| US20100240767A1 (en) * | 2009-03-23 | 2010-09-23 | Muhammed Majeed | Melanogenesis inhibitiuon by 3,5-dimethoxy-4'-hydroxystilbenes and cosmeceutical compositions thereof |
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