CN103429592A - 作为mps-1和tkk抑制剂用于治疗过度增殖性病症的6-取代的咪唑并吡嗪 - Google Patents

作为mps-1和tkk抑制剂用于治疗过度增殖性病症的6-取代的咪唑并吡嗪 Download PDF

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Publication number
CN103429592A
CN103429592A CN2011800678029A CN201180067802A CN103429592A CN 103429592 A CN103429592 A CN 103429592A CN 2011800678029 A CN2011800678029 A CN 2011800678029A CN 201180067802 A CN201180067802 A CN 201180067802A CN 103429592 A CN103429592 A CN 103429592A
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CN
China
Prior art keywords
alkyl
amino
imidazo
cyclopropyl
pyrazin
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Pending
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CN2011800678029A
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English (en)
Chinese (zh)
Inventor
M·科皮茨
U·克拉尔
R·若泰拉特
D·科泽蒙德
R·博尔曼
B·巴德尔
P·利瑙
G·西迈斯特
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Bayer Pharma AG
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Bayer Pharma AG
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Publication of CN103429592A publication Critical patent/CN103429592A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2011800678029A 2010-12-17 2011-12-13 作为mps-1和tkk抑制剂用于治疗过度增殖性病症的6-取代的咪唑并吡嗪 Pending CN103429592A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP10195635 2010-12-17
EP10195699.3 2010-12-17
EP10195699 2010-12-17
EP10195635.7 2010-12-17
EP11170158 2011-06-16
EP11170158.7 2011-06-16
EP11170163.7 2011-06-16
EP11170163 2011-06-16
PCT/EP2011/072591 WO2012080236A1 (en) 2010-12-17 2011-12-13 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders

Publications (1)

Publication Number Publication Date
CN103429592A true CN103429592A (zh) 2013-12-04

Family

ID=45218758

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800678029A Pending CN103429592A (zh) 2010-12-17 2011-12-13 作为mps-1和tkk抑制剂用于治疗过度增殖性病症的6-取代的咪唑并吡嗪

Country Status (6)

Country Link
US (1) US20140135319A1 (enExample)
EP (1) EP2651945A1 (enExample)
JP (1) JP2013545779A (enExample)
CN (1) CN103429592A (enExample)
CA (1) CA2821819A1 (enExample)
WO (1) WO2012080236A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100852A (ja) * 1984-09-28 1985-06-04 Hitachi Ltd 情報伝送方法
TWI541243B (zh) 2010-09-10 2016-07-11 拜耳知識產權公司 經取代咪唑并嗒
GB201212513D0 (en) * 2012-07-13 2012-08-29 Ucb Pharma Sa Therapeutic agents
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
WO2014020041A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
JP6377068B2 (ja) 2012-11-16 2018-08-22 ユニバーシティ・ヘルス・ネットワーク ピラゾロピリミジン化合物
SG11201600373YA (en) * 2013-07-31 2016-02-26 Gilead Sciences Inc Syk inhibitors
JP6095857B2 (ja) * 2013-11-15 2017-03-15 ユニバーシティ・ヘルス・ネットワーク ピラゾロピリミジン化合物
PT3105218T (pt) 2014-02-13 2019-12-05 Incyte Corp Ciclopropilaminas como inibidores de lsd1
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
DK3105226T3 (da) 2014-02-13 2019-10-14 Incyte Corp Cyclopropylaminer som lsd1-inhibitorer
EP3105219B9 (en) 2014-02-13 2018-10-03 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
EP3626720A1 (en) 2015-04-03 2020-03-25 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
CA2981844A1 (en) 2015-04-17 2016-10-20 Netherlands Translational Research Center B.V. Prognostic biomarkers for ttk inhibitor chemotherapy
KR102710120B1 (ko) 2015-08-12 2024-09-27 인사이트 홀딩스 코포레이션 Lsd1 저해제의 염
PE20190377A1 (es) 2016-04-22 2019-03-08 Incyte Corp Formulaciones de un inhibidor de lsd 1
CA3057159A1 (en) * 2017-04-12 2018-10-18 Magenta Therapeutics Inc. Aryl hydrocarbon receptor antagonists and uses thereof
CN111542597A (zh) * 2017-10-31 2020-08-14 美真达治疗公司 用于扩增造血干细胞和祖细胞的组合物和方法
JP7235047B2 (ja) 2018-05-08 2023-03-08 日本新薬株式会社 アザベンゾイミダゾール化合物及び医薬
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
US20210379033A1 (en) * 2018-10-17 2021-12-09 Magenta Therapeutics Inc. Methods of treating cancer with aryl hydrocarbon receptor antagonists

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040220189A1 (en) * 2003-02-20 2004-11-04 Sugen, Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors
US20050009832A1 (en) * 2003-02-20 2005-01-13 Sugen, Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
CN1694706A (zh) * 2002-09-23 2005-11-09 先灵公司 用作依赖细胞周期蛋白的激酶抑制剂的新的咪唑并吡嗪
CN1694886A (zh) * 2002-09-23 2005-11-09 先灵公司 作为周期素依赖性激酶抑制剂的咪唑并吡嗪
WO2007056468A1 (en) * 2005-11-10 2007-05-18 Schering Corporation Methods for inhibiting protein kinases
CN101300233A (zh) * 2005-09-09 2008-11-05 先灵公司 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂
CN101331135A (zh) * 2005-11-10 2008-12-24 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的新型咪唑并吡嗪
CN101370811A (zh) * 2005-11-10 2009-02-18 先灵公司 作为蛋白激酶抑制剂的咪唑并吡嗪化合物
WO2009024585A2 (en) * 2007-08-21 2009-02-26 Biofocus Dpi Limited Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis
WO2010124826A1 (en) * 2009-04-29 2010-11-04 Bayer Schering Pharma Aktiengesellschaft Substituted imidazoquinoxalines
WO2011013729A1 (ja) * 2009-07-30 2011-02-03 オンコセラピー・サイエンス株式会社 Ｔｔｋ阻害作用を有する縮合イミダゾール誘導体
CN102971321A (zh) * 2010-03-18 2013-03-13 拜耳知识产权有限责任公司 咪唑并吡嗪
CN103038235A (zh) * 2010-06-01 2013-04-10 拜耳知识产权有限责任公司 取代的咪唑并吡嗪

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
AR061229A1 (es) 2006-06-06 2008-08-13 Schering Corp Imidazopirazinas como inhibidores de la proteina quinasa
US8268809B2 (en) * 2006-09-05 2012-09-18 Emory University Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
WO2008057512A2 (en) 2006-11-08 2008-05-15 Schering Corporation Imidazopyrazines as protein kinase inhibitors
WO2009024824A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab 2-anilinopurin-8-ones as inhibitors of ttk/mps1 for the treatment of proliferative disorders
CN102596932A (zh) 2009-09-04 2012-07-18 拜耳医药股份有限公司 作为酪氨酸苏氨酸激酶抑制剂的取代氨基喹喔啉
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343295A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
WO2012080234A1 (en) * 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft Substituted 6-imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
US9212184B2 (en) * 2010-12-17 2015-12-15 Bayer Intellectual Property Gmbh 6-thio-substituted imidazo[1,2-a]pyrazines as Mps-1 inhibitors
WO2012080230A1 (en) * 2010-12-17 2012-06-21 Bayer Pharma Aktiengesellschaft 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1694706A (zh) * 2002-09-23 2005-11-09 先灵公司 用作依赖细胞周期蛋白的激酶抑制剂的新的咪唑并吡嗪
CN1694886A (zh) * 2002-09-23 2005-11-09 先灵公司 作为周期素依赖性激酶抑制剂的咪唑并吡嗪
US20050009832A1 (en) * 2003-02-20 2005-01-13 Sugen, Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US20040220189A1 (en) * 2003-02-20 2004-11-04 Sugen, Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhbitors
CN101300233A (zh) * 2005-09-09 2008-11-05 先灵公司 氮杂稠合的细胞周期蛋白依赖性激酶抑制剂
CN101331135A (zh) * 2005-11-10 2008-12-24 先灵公司 作为细胞周期蛋白依赖激酶抑制剂的新型咪唑并吡嗪
WO2007056468A1 (en) * 2005-11-10 2007-05-18 Schering Corporation Methods for inhibiting protein kinases
CN101370811A (zh) * 2005-11-10 2009-02-18 先灵公司 作为蛋白激酶抑制剂的咪唑并吡嗪化合物
WO2009024585A2 (en) * 2007-08-21 2009-02-26 Biofocus Dpi Limited Imidazo [1,2-a] pyrazine compounds for treatment of viral infections such as hepatitis
WO2010124826A1 (en) * 2009-04-29 2010-11-04 Bayer Schering Pharma Aktiengesellschaft Substituted imidazoquinoxalines
WO2011013729A1 (ja) * 2009-07-30 2011-02-03 オンコセラピー・サイエンス株式会社 Ｔｔｋ阻害作用を有する縮合イミダゾール誘導体
CN102971321A (zh) * 2010-03-18 2013-03-13 拜耳知识产权有限责任公司 咪唑并吡嗪
CN103038235A (zh) * 2010-06-01 2013-04-10 拜耳知识产权有限责任公司 取代的咪唑并吡嗪

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Publication number Publication date
CA2821819A1 (en) 2012-06-21
EP2651945A1 (en) 2013-10-23
US20140135319A1 (en) 2014-05-15
WO2012080236A1 (en) 2012-06-21
JP2013545779A (ja) 2013-12-26

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Application publication date: 20131204