CN103396409B - 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 - Google Patents

作为akt蛋白激酶抑制剂的嘧啶基环戊烷 Download PDF

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CN103396409B
CN103396409B CN201310128477.3A CN201310128477A CN103396409B CN 103396409 B CN103396409 B CN 103396409B CN 201310128477 A CN201310128477 A CN 201310128477A CN 103396409 B CN103396409 B CN 103396409B
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compound
alkyl
formula
fluoro
phenyl
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CN103396409A (zh
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约瑟夫.本克希克
詹姆斯.F.布莱克
詹姆斯.M.格雷厄姆
马丁.F.亨特曼
尼古拉斯.C.卡兰
伊恩.S.米切尔
斯蒂芬.T.施拉克特
基思.L.斯潘瑟
校登明
徐睿
迈克.韦尔克
梁军
布赖恩.S.萨芬娜
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Genentech Inc
Array Biopharma Inc
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Array Biopharma Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Cardiology (AREA)
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CN201310128477.3A 2007-07-05 2008-07-03 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 Active CN103396409B (zh)

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US94813807P 2007-07-05 2007-07-05
US60/948,138 2007-07-05
US2008808P 2008-01-09 2008-01-09
US61/020,088 2008-01-09

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CN103396409B true CN103396409B (zh) 2015-03-11

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CN2008801058695A Active CN101801955B (zh) 2007-07-05 2008-07-03 作为akt蛋白激酶抑制剂的嘧啶基环戊烷

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US (1) US8618097B2 (https=)
EP (1) EP2170863B1 (https=)
JP (2) JP5628028B2 (https=)
KR (2) KR101650956B1 (https=)
CN (2) CN103396409B (https=)
AR (1) AR067413A1 (https=)
AU (1) AU2008272830B8 (https=)
BR (1) BRPI0813999A2 (https=)
CA (1) CA2692502C (https=)
CO (1) CO6251283A2 (https=)
CR (1) CR11229A (https=)
EC (1) ECSP109937A (https=)
ES (1) ES2551352T3 (https=)
MA (1) MA31679B1 (https=)
NZ (1) NZ582692A (https=)
RU (1) RU2486181C2 (https=)
SG (1) SG185274A1 (https=)
TW (1) TWI450720B (https=)
WO (1) WO2009006567A2 (https=)

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CN102015708B (zh) * 2008-01-09 2014-03-26 阵列生物制药公司 作为akt蛋白激酶抑制剂的嘧啶基环戊烷
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KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
KR102728619B1 (ko) 2017-12-27 2024-11-08 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 판토테네이트 키나제의 소분자 조절제
CA3092677A1 (en) * 2018-03-06 2019-09-12 Icahn School Of Medicine At Mount Sinai Serine threonine kinase (akt) degradation / disruption compounds and methods of use
KR20210006356A (ko) * 2018-04-04 2021-01-18 아비나스 오퍼레이션스, 인코포레이티드 단백질분해 조절제 및 연관된 사용 방법
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US12103924B2 (en) 2020-06-01 2024-10-01 Icahn School Of Medicine At Mount Sinai Mitogen-activated protein kinase kinase (MEK) degradation compounds and methods of use
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