CN103360439B - 制备肝素五糖的新中间体及其制备方法 - Google Patents

制备肝素五糖的新中间体及其制备方法 Download PDF

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Publication number
CN103360439B
CN103360439B CN201210102415.0A CN201210102415A CN103360439B CN 103360439 B CN103360439 B CN 103360439B CN 201210102415 A CN201210102415 A CN 201210102415A CN 103360439 B CN103360439 B CN 103360439B
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China
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compound
formula
alkyl group
benzyl
group
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Expired - Fee Related
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CN201210102415.0A
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English (en)
Chinese (zh)
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CN103360439A (zh
Inventor
丁毅力
郭阳辉
白骅
吴迎秋
白灵卫
杨仕保
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Zhejiang Hisun Pharmaceutical Co Ltd
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Zhejiang Hisun Pharmaceutical Co Ltd
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Priority to CN201210102415.0A priority Critical patent/CN103360439B/zh
Priority to US14/389,806 priority patent/US9624315B2/en
Priority to JP2015503738A priority patent/JP2015514098A/ja
Priority to PCT/CN2013/073601 priority patent/WO2013149576A1/zh
Priority to EP13772346.6A priority patent/EP2837635B1/en
Priority to IN9026DEN2014 priority patent/IN2014DN09026A/en
Publication of CN103360439A publication Critical patent/CN103360439A/zh
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Publication of CN103360439B publication Critical patent/CN103360439B/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201210102415.0A 2012-04-02 2012-04-02 制备肝素五糖的新中间体及其制备方法 Expired - Fee Related CN103360439B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201210102415.0A CN103360439B (zh) 2012-04-02 2012-04-02 制备肝素五糖的新中间体及其制备方法
US14/389,806 US9624315B2 (en) 2012-04-02 2013-04-02 Preparation of new intermediate of heparin pentasaccharide and preparation method thereof
JP2015503738A JP2015514098A (ja) 2012-04-02 2013-04-02 ヘパリン五糖の新規中間体の調製およびその調製方法
PCT/CN2013/073601 WO2013149576A1 (zh) 2012-04-02 2013-04-02 制备肝素五糖的新中间体及其制备方法
EP13772346.6A EP2837635B1 (en) 2012-04-02 2013-04-02 New intermediates for the preparation of heparin pentasaccharide and preparation methods thereof
IN9026DEN2014 IN2014DN09026A (https=) 2012-04-02 2013-04-02

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201210102415.0A CN103360439B (zh) 2012-04-02 2012-04-02 制备肝素五糖的新中间体及其制备方法

Publications (2)

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CN103360439A CN103360439A (zh) 2013-10-23
CN103360439B true CN103360439B (zh) 2017-12-15

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CN201210102415.0A Expired - Fee Related CN103360439B (zh) 2012-04-02 2012-04-02 制备肝素五糖的新中间体及其制备方法

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Country Link
US (1) US9624315B2 (https=)
EP (1) EP2837635B1 (https=)
JP (1) JP2015514098A (https=)
CN (1) CN103360439B (https=)
IN (1) IN2014DN09026A (https=)
WO (1) WO2013149576A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102718808A (zh) * 2012-06-04 2012-10-10 浙江星月药物科技股份有限公司 一类多糖衍生物及其中间体的制备方法
CN103570774B (zh) * 2012-08-07 2017-08-25 博瑞生物医药（苏州）股份有限公司 一种戊糖化合物的纯化方法
CN103992364B (zh) * 2014-03-25 2016-08-10 南京天翔医药科技有限公司 一种磺达肝癸钠的分离提取方法
CN103965269B (zh) * 2014-04-16 2018-05-04 杭州华东医药集团新药研究院有限公司 低水分高纯度的磺达肝癸钠及其制备方法
CN104098618A (zh) * 2014-07-25 2014-10-15 河北常山生化药业股份有限公司 磺达肝癸钠中间体及其中间体和磺达肝癸钠的制备方法
CN105037452B (zh) * 2015-06-19 2018-10-09 天津红日药业股份有限公司 一种快速制备高纯度磺达肝癸钠的精制方法
EP3398971A4 (en) * 2015-12-30 2019-09-25 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. SULFATED HEPARINOLIGOSACCHARIDE AND MANUFACTURING METHOD AND APPLICATION THEREOF
CN108148101B (zh) * 2016-12-03 2021-12-24 烟台东诚药业集团股份有限公司 一种制备磺达肝癸钠的新工艺方法
CN115057896A (zh) * 2022-07-28 2022-09-16 苏州柯默拓医药科技有限公司 一种磺达肝癸钠的合成方法
CN117567665A (zh) * 2023-11-10 2024-02-20 山东大学 一种肝素六糖及其制备方法与应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
CN1558911A (zh) * 2001-09-07 2004-12-29 合成肝素五糖
US20110003980A1 (en) * 2009-03-10 2011-01-06 The University Of Tokyo Oligo-Aminosaccharide compound
WO2011014793A2 (en) * 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
US20110306757A1 (en) * 2008-10-08 2011-12-15 Laboratorios Farmaceuticos Rovi, S.A. Process for the synthesis of unprotected pentasaccharides from a protected pentasaccharide precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
AU2009299118B2 (en) * 2008-10-03 2015-12-17 Glycan Biosciences Llc Anionic conjugates of glycosylated bacterial metabolite
CN102718808A (zh) * 2012-06-04 2012-10-10 浙江星月药物科技股份有限公司 一类多糖衍生物及其中间体的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
CN1558911A (zh) * 2001-09-07 2004-12-29 合成肝素五糖
US20110306757A1 (en) * 2008-10-08 2011-12-15 Laboratorios Farmaceuticos Rovi, S.A. Process for the synthesis of unprotected pentasaccharides from a protected pentasaccharide precursor
US20110003980A1 (en) * 2009-03-10 2011-01-06 The University Of Tokyo Oligo-Aminosaccharide compound
WO2011014793A2 (en) * 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis of a tetrasaccharide substrate of heparanase;Jianfang Chen，等;《Carbohydrate Research》;20080618;第343卷;Fig1、Scheme4 *

Also Published As

Publication number Publication date
US20150299340A1 (en) 2015-10-22
EP2837635A4 (en) 2015-05-27
WO2013149576A1 (zh) 2013-10-10
EP2837635B1 (en) 2017-10-18
JP2015514098A (ja) 2015-05-18
US9624315B2 (en) 2017-04-18
EP2837635A1 (en) 2015-02-18
IN2014DN09026A (https=) 2015-05-22
CN103360439A (zh) 2013-10-23

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Termination date: 20190402