CN103351221B - The production method of Chinese medicinal materials - Google Patents
The production method of Chinese medicinal materials Download PDFInfo
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- CN103351221B CN103351221B CN201310252497.1A CN201310252497A CN103351221B CN 103351221 B CN103351221 B CN 103351221B CN 201310252497 A CN201310252497 A CN 201310252497A CN 103351221 B CN103351221 B CN 103351221B
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- Prior art keywords
- hydrochlorate
- potassium
- grams
- glucose
- nutrient substance
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 25
- 239000000463 material Substances 0.000 title claims abstract description 15
- 239000002777 nucleoside Substances 0.000 claims abstract description 66
- 125000003835 nucleoside group Chemical group 0.000 claims abstract description 65
- 239000000126 substance Substances 0.000 claims abstract description 49
- 235000015097 nutrients Nutrition 0.000 claims abstract description 48
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 45
- 239000008103 glucose Substances 0.000 claims abstract description 45
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 29
- 239000002773 nucleotide Substances 0.000 claims abstract description 27
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 12
- 239000001103 potassium chloride Substances 0.000 claims abstract description 12
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 12
- 159000000000 sodium salts Chemical class 0.000 claims abstract description 11
- 239000003337 fertilizer Substances 0.000 claims abstract description 8
- 229910052700 potassium Inorganic materials 0.000 claims description 52
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 51
- 239000011591 potassium Substances 0.000 claims description 51
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 claims description 30
- 229950006790 adenosine phosphate Drugs 0.000 claims description 30
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 28
- 239000002253 acid Substances 0.000 claims description 27
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 10
- 241000218636 Thuja Species 0.000 claims description 6
- WUBAOANSQGKRHF-XVFCMESISA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-methyloxolan-2-yl]pyrimidine-2,4-dione Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C=C1 WUBAOANSQGKRHF-XVFCMESISA-N 0.000 claims description 4
- UGUILUGCFSCUKR-GJMOJQLCSA-N 1-[(2r,4s,5r)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(C)=C1 UGUILUGCFSCUKR-GJMOJQLCSA-N 0.000 claims description 4
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 4
- XGYIMTFOTBMPFP-KQYNXXCUSA-N 5'-deoxyadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 XGYIMTFOTBMPFP-KQYNXXCUSA-N 0.000 claims description 4
- WDRISBUVHBMJEF-MROZADKFSA-N 5-deoxy-D-ribose Chemical compound C[C@@H](O)[C@@H](O)[C@@H](O)C=O WDRISBUVHBMJEF-MROZADKFSA-N 0.000 claims description 4
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims description 4
- PNPLHKHBANFGMS-WFIJOQBCSA-N [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [Na].[Na].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 PNPLHKHBANFGMS-WFIJOQBCSA-N 0.000 claims description 4
- KURVIXMFFSNONZ-WFIJOQBCSA-L disodium;[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(=O)NC(=O)C=C1 KURVIXMFFSNONZ-WFIJOQBCSA-L 0.000 claims description 4
- 229940061671 uridine 5-mo-phos disod Drugs 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 16
- 235000008216 herbs Nutrition 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 description 31
- 108020004707 nucleic acids Proteins 0.000 description 31
- 150000007523 nucleic acids Chemical class 0.000 description 29
- 239000007921 spray Substances 0.000 description 20
- 239000000203 mixture Substances 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 17
- 150000001413 amino acids Chemical class 0.000 description 16
- 239000012752 auxiliary agent Substances 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 14
- 238000000855 fermentation Methods 0.000 description 11
- 230000004151 fermentation Effects 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 7
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 7
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 230000012010 growth Effects 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- -1 nucleic acid small molecules Chemical class 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 229910052698 phosphorus Inorganic materials 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000000967 suction filtration Methods 0.000 description 5
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- 229920000742 Cotton Polymers 0.000 description 4
- 240000007594 Oryza sativa Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 4
- 239000003513 alkali Substances 0.000 description 4
- 238000002425 crystallisation Methods 0.000 description 4
- 230000008025 crystallization Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 230000008635 plant growth Effects 0.000 description 4
- 229960000329 ribavirin Drugs 0.000 description 4
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 239000006227 byproduct Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 229910052748 manganese Inorganic materials 0.000 description 3
- 239000011572 manganese Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 description 2
- 244000061176 Nicotiana tabacum Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- NCMVOABPESMRCP-SHYZEUOFSA-N 2'-deoxycytosine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 NCMVOABPESMRCP-SHYZEUOFSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 description 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 101710104378 Putative malate oxidoreductase [NAD] Proteins 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- WIXIBOVGGNRVQH-WFIJOQBCSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)N=C(N)C=C1 WIXIBOVGGNRVQH-WFIJOQBCSA-N 0.000 description 1
- VHUKPXJCIYLZCH-WFIJOQBCSA-N [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)NC(=O)C=C1 Chemical compound [K].[K].[C@@H]1([C@H](O)[C@H](O)[C@@H](COP(=O)(O)O)O1)N1C(=O)NC(=O)C=C1 VHUKPXJCIYLZCH-WFIJOQBCSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 150000007516 brønsted-lowry acids Chemical class 0.000 description 1
- 150000007528 brønsted-lowry bases Chemical class 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 239000000039 congener Substances 0.000 description 1
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- 230000018109 developmental process Effects 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000008558 metabolic pathway by substance Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000003895 organic fertilizer Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 229940072033 potash Drugs 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
- 235000015320 potassium carbonate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 239000010802 sludge Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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- 210000001541 thymus gland Anatomy 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses the production method of <b> Chinese medicinal materials, belong to Producing medicinal herbs field, </b> at Chinese medicinal materials growing period, applying fertilizer and nutrient substance; Described nutrient substance is: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2.5 grams, glucose 7.5 grams, and nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, the nutrient substance obtained with glucose; Or: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 5 grams, glucose 5 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, the nutrient substance obtained with glucose; Nucleosides hydrochlorate refers to: the sodium salt of four kinds of 5 ˊ-mixed nucleotides or sylvite; Deoxynucleoside hydrochlorate refers to: the sodium salt of five kinds of 5 ˊ-deoxidation mixed nucleotides or sylvite; Described growing period uses time of nutrient substance and concentration is: initial bloom stage and full-bloom stage each once, concentration 100-260ppm.The present invention: cost is low, method is easy, increases production, increases income, synergy, improves quality effective.
Description
The application is application number 201010514217.6, the applying date: on October 21st, 2010, and denomination of invention is the divisional application of " nutrient substance of a kind of Promoting plant growth and preparation method thereof ".
Technical field
The present invention relates to the production method of a kind of plant, particularly a kind of production method of Chinese medicinal materials.
Background technology
Greatly develop plant husbandry, forestry, promote that crop yield increases income, make our country green, it is the problem that various countries scientist pays close attention to research, the growth of plant be unable to do without and supplements the nutrients, present plant husbandry, mainly by executing N,P,K fertilizers and organic fertilizer to promote crop growth, use too much fertilizer very large on the impact of the quality and flavor of farm crop, be unfavorable for green agriculture development and
Food safety and environmental protection.Therefore, people have studied and nucleic acid related growth element, nutrient substance, fertilizer.In theory: nucleic acid is the basic substance forming life, is the basis of substance metabolism and energy metabolism, the character of nucleic acid and the difference of quantity can cause raw
The diversity of species and growth conditions.For congener life entity, the quantity of nucleic acid and the difference of existence form are certainly
Determine that the power of this life entity is prosperous to decline.Therefore, nucleic acid substances is for the output increased in farm crop and even the production of whole vegitabilia
Improve with product quality and have irreplaceable effect; The nucleic acid small molecules such as nucleosides, Nucleotide, pyrimidine and purine are particularly several
Nucleosides hydrochlorate and deoxynucleoside hydrochlorate and cooperation thereof, not only can the growth of effectively regulating plant, again can as battalion
The source of supporting is absorbed rapidly by plant, strengthens plant root vigor, improves plant anti-adversity ability, thus improve crop output, improve product quality.Nucleic acid small molecules has enhancing improving activity of root system to plant, improves root to the absorption of phosphorus, potash fertilizer; Improve the activity of farm crop malic enzyme and succsinic acid enzyme, promote the assimilative capacity of plant, strengthen photosynthetic intensity, to plant-growth have adjustment and trophism (Wang Xi etc. the research [J] of the application and function mechanism of nucleic acid degradation product in Rice Production. raw
Thing chemistry and Acta Biophysica Sinica, 1975,7 (1): 31-39).Chinese patent literature (publication number: 101186534) public
1., lixiviate nuclease opened a kind of preparation method containing nucleic acid degradation product foliage fertilizer, concrete step is:, 2., dissolves ribose
Nucleic acid (alkali lye hydrotropy), 3., the hydrolysis of nucleic acid, must contain the multiple nucleic acids small molecules such as nucleosides, Nucleotide, purine, pyrimidine and a small amount of reducing sugar and few large, middle and trace element, the method take Yeast Nucleic Acid as raw material, with enzymatic hydrolysis, there is production cost high, degraded is not thorough, and few containing deoxynucleotide composition, mixed system nucleotide salt yield is low, various nucleosides hydrochlorate and the mutual mixing ratio imbalance of deoxynucleotide salt face are very large on result of use impact.Chinese patent literature (publication number: 101050143) disclose a kind of nutrient substance promoting crop growth, it is made up of ribavirin and glucose, production and the guanosine of ribavirin are in close relations, and this patent exists ribavirin high cost, the unconspicuous problem of practical effect.
Summary of the invention
The object of this invention is to provide the production method of a kind of plant, particularly a kind of production method of Chinese medicinal materials.
Its production cost is low, and technique is simple, is easy to large-scale production and popularization; Rationally, nontoxic, harmless, noresidue, without any adverse side effect for various nucleosides hydrochlorate and the mutual mixing ratio of deoxynucleotide salt face; Increase production, increase income, synergy, strengthen resistance, improve quality effective.
The present invention is achieved in that
The production method of Chinese medicinal materials, at Chinese medicinal materials growing period, applying fertilizer and nutrient substance;
Described nutrient substance is: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2.5 grams, glucose 7.5 grams, nucleosides hydrochlorate and deoxidation core
Thuja acid salt is pulverized, and mixes, the nutrient substance obtained with glucose;
Or: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 5 grams, glucose 5 grams, nucleosides hydrochlorate and deoxynucleotide
Salt is pulverized, and mixes, the nutrient substance obtained with glucose.
Described nucleosides hydrochlorate refers to: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or potassium, 5 '-cytidylic acid disodium or potassium, 5 '-uridine monophosphate disodium or potassium, the sodium salt of four kinds of 5 '-mixed nucleotides or sylvite;
Deoxynucleoside hydrochlorate refers to: 5 '-Desoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid (AMP) disodium or potassium, 5 '-Deoxyribose cytidine acid disodium or potassium, 5 '-deoxyuridine acid disodium or potassium, 5 '-deoxythymidine acid disodium or potassium, the sodium salt of five kinds of 5 '-deoxidation mixed nucleotides or sylvite;
Described growing period uses time of nutrient substance and concentration is: initial bloom stage and full-bloom stage each once, concentration 100-260ppm.
The production method of Chinese medicinal materials, in described nucleosides hydrochlorate and deoxynucleoside hydrochlorate, weight percent is: nucleosides hydrochlorate 85%, deoxynucleoside hydrochlorate 15%.
Composition containing nucleosides hydrochlorate and deoxynucleoside hydrochlorate of the present invention refers to also known as nutrient substance: it is primarily of nucleosides
Hydrochlorate and deoxynucleoside hydrochlorate, auxiliary agent composition, its weight percent is: nucleosides hydrochlorate and deoxynucleoside hydrochlorate 10-80%, auxiliary agent 20-90%, and described auxiliary agent refers to: sugar is or/and amino acid.
Nutrient substance, in nucleosides hydrochlorate and deoxynucleoside hydrochlorate, weight percent is: nucleosides hydrochlorate 85-99%, deoxidation core
Thuja acid salt 1-15%. nutrient substance, in nucleosides hydrochlorate and deoxynucleoside hydrochlorate, weight percent is: nucleosides hydrochlorate 88-96%, deoxynucleoside hydrochlorate 4-12%.
Nutrient substance, nucleosides hydrochlorate and deoxynucleoside hydrochlorate and auxiliary agent, weight percent is: nucleosides hydrochlorate and deoxynucleoside hydrochlorate 10-30%, auxiliary agent 70-90%.
Nutrient substance, auxiliary agent is sugar or amino acid.
Nutrient substance, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are sodium salt or sylvite.
The preparation method of nutrient substance provided by the present invention, concrete steps are as follows: take nucleic acid as raw material, mainly from fermentation
Mycelium after factory's fermentation adopts the nucleic acid of dry method or wet production to be raw material:
1., the hydrolysis of nucleic acid is the ratio mixed nucleus bronsted lowry acids and bases bronsted lowry liquid of 1:20-30 according to nucleic acid, buck weight ratio, and alkali lye is
5.5-7N, under 30-45 DEG C of condition, stirs 10-14 hours, obtains nucleosides hydrochlorate and deoxynucleoside acid salt solution, filters, and filtrate adjusts pH8-8.5, concentrating under reduced pressure;
2., decolouring, dry concentrated solution is added activated carbon decolorizing, suction filtration it, filtrate reduced in volume is to moisture 10-25%;
3., crystallization with clear water dissolve dry after nucleosides hydrochlorate and deoxynucleoside hydrochlorate, its solution adds alcohol and separates out, and crystallization is taken out
Be filtered dry dry, obtain white core thuja acid salt and deoxynucleoside hydrochlorate and water soluble mixt.
4., by nucleosides hydrochlorate and deoxynucleoside hydrochlorate and water soluble mixt pulverize, cross 200 mesh sieves and mix with auxiliary agent again
Evenly.
In nucleic acid hydrolysis process described in this preparation method, alkali lye used is sodium hydroxide or potassium hydroxide solution.
In the present invention, nucleosides hydrochlorate mainly refers to: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or
Potassium, 5 '-cytidylic acid disodium or potassium, the sodium salt of 5 '-uridine monophosphate disodium or potassium four kinds of 5 '-mixed nucleotides or sylvite; Deoxynucleoside hydrochlorate refers to: 5 '-Desoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid (AMP) disodium or potassium, 5 '-Deoxyribose cytidine acid disodium or potassium, 5 '-deoxyuridine acid disodium,, the sodium salt of 5 '-deoxythymidine acid disodium or potassium five kinds of 5 '-deoxidation mixed nucleotides or sylvite.The source of nucleosides hydrochlorate and deoxynucleoside hydrochlorate is take nucleic acid as raw material, mainly the nucleic acid of dry method or wet production is adopted to be raw material from the mycelium after fermentation plant fermentation, this kind of nucleic acid is a small amount of thymus nucleic acid (DNA) of main mixing with Yeast Nucleic Acid (RNA), makes with alkali lye hydrolysis; Auxiliary agent is mainly derived from two aspects: 1, the nucleic acid of dry method or wet production is also containing impurity such as sugar, protein, various metals or nonmetallic ions, has amino acid, sugared part and nitrogen, phosphorus, potassium, iron, calcium, magnesium, zinc, copper, manganese etc. after hydrolysis; 2, exogenously to add: sugar (reducing sugar, non-reducing sugar: as glucose, sucrose also have fructose etc.), amino acid, large, middle and trace element etc.
The Promoting plant growth nutrient substance formed primarily of nucleosides hydrochlorate and deoxynucleoside hydrochlorate, auxiliary agent that the present invention adopts
And be take nucleic acid as raw material, mainly from fermentation plant (Gourmet Powder Factory, brew-house, antibiotics plant, yeast factory, Amino Acid Factory, paper mill, active sludge after sewage disposal, petroleum fermentation etc.) byproduct (tankage) mycelium after fermentation adopts the nucleic acid of dry method or wet production to be the preparation method of raw material hydrolysis, (product of ribavirin is added with currently available products and method, directly with the product of Yeast Nucleic Acid hydrolysis, enzyme solution) compare and have the following advantages: 1, its production cost of Yeast Nucleic Acid is produced low from the mycelium after fermentation plant fermentation, be easy to large-scale production and popularization, 2, the nucleic acid that mycelium is produced contains useful impurity, in addition Base hydrolysis method, technique is simple, mixed system nucleotide salt yield is high, and rationally, amino acid, sugared part and other organic-inorganic auxiliary agent content are higher for various nucleosides hydrochlorate and the mutual mixing ratio of deoxynucleotide salt face, therefore, increasing both production and income synergy, strengthens resistance, improves quality effective, 3, nontoxic, harmless, noresidue, without any adverse side effect, 4, be widely used in grain, cotton, oil, cigarette, tea, really, dish, Chinese medicinal materials, flowers, plant and the mushroom product such as forest.
Embodiment
Embodiment 1: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 1 gram, glucose 6 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 2: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 1 gram, sucrose 2 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 3: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2 grams, glucose 8 grams, nucleosides hydrochlorate is with de-
Oxygen nucleosides hydrochlorate is pulverized, and mixes, obtain nutrient substance with glucose.
Embodiment 4: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 1.5 grams, glucose 8.5 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 5: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 1 gram, glucose 9 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 6: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2.5 grams, glucose 7.5 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 7: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 4 grams, 6 grams, fructose, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 8: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 5 grams, glucose 5 grams, nucleosides hydrochlorate and deoxynucleoside hydrochlorate are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 9: get Nucleotide potassium and 1 gram, deoxynucleotide potassium, glucose 9 grams, Nucleotide potassium and deoxynucleotide potassium are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 10: get Nucleotide potassium and 1.5 grams, deoxynucleotide potassium, glucose 8.5 grams, Nucleotide potassium and deoxidation
Nucleotide potassium is pulverized, and mixes, obtain nutrient substance with glucose.
Embodiment 11: get Nucleotide potassium and 2 grams, deoxynucleotide potassium, glucose 8 grams, Nucleotide potassium and deoxynucleoside
Acid potassium is pulverized, and mixes, obtain nutrient substance with glucose.
Embodiment 12: get Nucleotide potassium and 2.5 grams, deoxynucleotide potassium, glucose 7.5 grams, Nucleotide potassium and deoxidation
Nucleotide potassium is pulverized, and mixes, obtain nutrient substance with glucose.
Embodiment 13: get Nucleotide potassium and 3 grams, deoxynucleotide potassium, glucose 7 grams, Nucleotide potassium and deoxynucleoside
Acid potassium is pulverized, and mixes, obtain nutrient substance with glucose.
Embodiment 14: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 1.5 grams, glucose 4.5 grams, 4 grams, amino acid, nucleosides hydrochlorate and deoxynucleoside hydrochlorate and amino acid are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 15: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2 grams, glucose 4 grams, 4 grams, amino acid, nucleosides hydrochlorate and deoxynucleoside hydrochlorate and amino acid are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 16: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 3 grams, glucose 4 grams, 3 grams, amino acid, nucleosides hydrochlorate and deoxynucleoside hydrochlorate and amino acid are pulverized, and mix, obtain nutrient substance with glucose.
Embodiment 17: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2 grams, 8 grams, amino acid, nucleosides hydrochlorate and deoxynucleoside
Hydrochlorate and amino acid are pulverized, and mix, obtain nutrient substance.
Embodiment 18: by the crude product Yeast Nucleic Acid obtained from the mycelium of fermentation plant's byproduct by dry method or wet method
(RNA) 100 grams, be dissolved in the sodium hydroxide solution of 3 liters of 6.3N, under 37 DEG C of conditions, stir 12 hours, obtain and mainly refer to contain: 5 '-adenylic acid (AMP) disodium, 5 '-bird adenylic acid (AMP) disodium, 5 '-cytidylic acid disodium, the sodium salt of 5 '-uridine monophosphate disodium, four kinds of 5 '-mixed nucleotides (also has deoxynucleoside hydrochlorate: 5 '-Desoxyadenosine acid disodium, 5 '-deoxidation bird adenylic acid (AMP) disodium, 5 '-Deoxyribose cytidine acid disodium, 5 '-deoxyuridine acid disodium, , the sodium salt of 5 '-deoxythymidine acid disodium, five kinds of 5 '-deoxidation mixed nucleotides and amino acid, sugar part and nitrogen, phosphorus, potassium, iron, calcium, magnesium, zinc, copper, manganese etc.) solution, filter, filtrate is neutralized to pH8-8.5, be evaporated to appropriate, concentrated solution is added activated carbon decolorizing, suction filtration it, filtrate reduced in volume is to moisture 15%, nearly dry new-nucleo and Sodium Deoxyribomuleotide is dissolved by proper amount of clear water, its solution adds alcohol and separates out, crystallization suction filtration is dry, about obtain 85-90 grams, white core thuja acid salt and deoxynucleoside hydrochlorate and a certain amount ofly to help and agent water soluble mixt, gains are pulverized, crosses 200 mesh sieves, mix with auxiliary agent (when again adding auxiliary agent).
Embodiment 19: by 100 grams, the crude product Yeast Nucleic Acid (RNA) obtained from the mycelium of fermentation plant's byproduct by dry method or wet method, be dissolved in the potassium hydroxide solution of 2.5 liters of 6N, under 40 DEG C of conditions, stir 10 hours, obtain and mainly refer to contain: 5 '-adenylic acid (AMP) dipotassium, 5 '-bird adenylic acid (AMP) dipotassium, 5 '-cytidylic acid dipotassium, the sylvite of 5 '-uridylic acid dipotassium, four kinds of 5 '-mixed nucleotides (also has deoxynucleoside hydrochlorate: 5 '-deoxyadenylic acid dipotassium, 5 '-deoxidation bird adenylic acid (AMP) dipotassium, 5 '-deoxycytidylic acid(dCMP) dipotassium, 5 '-deoxyuridylic acid dipotassium, , the sylvite of 5 '-deoxythymidylic acid dipotassium, five kinds of 5 '-deoxidation mixed nucleotides and amino acid, sugar part and nitrogen, phosphorus, potassium, iron, calcium, magnesium, zinc, copper, manganese etc.) solution, filter, filtrate is neutralized to pH8-8.5, be evaporated to appropriate, concentrated solution is added activated carbon decolorizing, suction filtration it, filtrate reduced in volume to 20%, dissolve near dry Nucleotide potassium and deoxynucleotide potassium by proper amount of clear water, its solution adds alcohol and separates out, and crystallization suction filtration is dry, about 88-93 grams of white core thuja acid sylvite and deoxynucleoside acid potassium salt and a certain amount of auxiliary agent and water soluble mixt.Gains are pulverized, crosses 200 mesh sieves, mix with auxiliary agent (when again adding auxiliary agent).
Embodiment 20: paddy rice: spray twice, first time is watered 30 liters with 20 grams of nutrient substances (containing glucose 80-85%'s), about concentration 100ppm for initial bloom stage (heading about 10%), evenly sprays on one mu of paddy rice.Second time is full-bloom stage, after first time sprays, within 5-6 days, be watered 30 liters with 20 grams of nutrient substances, evenly sprays and gets final product on one mu of paddy rice (mu volume increase 70-100 kilograms, volume increase about 15%).
Embodiment 21: cotton: spray twice, first time also can initial bloom stage in the flower bud phase, is watered 30 with 30 grams of nutrient substances
Rise, evenly spray on one mu of cotton.Second time full-bloom stage is watered 36 liters with 30 grams and evenly sprays on one mu of cotton
(mu volume increase more than 7%).
Embodiment 22: rape: spray twice, first time is initial bloom stage, is watered 20 liters sprays on one mu of rape with 20 grams of nutrient substances.Second time is full-bloom stage, is watered 30 liters, sprays on one mu of rape with 20 grams, volume increase 15-20 kilogram.
Embodiment 23: tobacco: spray twice, each use 30 grams, is often watered 30 kilograms, about concentration 200ppm, spray on one mu of tobacco leaf, spray and carry out 20-26 day in time in May, (the south north time is slightly different), first time sprays, 3-6 day in June carry out second time to spray, about concentration 150ppm, Quality advance grade, volume increase about 20%.
Embodiment 24: tealeaves: at growth germination period, spray first time, after often plucking, spray once, about concentration 180ppm.
Embodiment 25: capsicum: each once at initial bloom stage and full-bloom stage, concentration 200-300ppm, mu volume increase 40% ~
80%。
Embodiment 26: strawberry: spray in the fruitlet phase, be watered 18 liters with 10 grams and spray, spraying 3 ~ 4 times after harvesting can increase production 38% in batches.
Embodiment 27: Chinese medicinal materials: the Chinese medicinal materials of different sites, using method differs, generally initial bloom stage and full-bloom stage each
Once, concentration 100-260ppm.
Embodiment 28: mushroom: spray once in every 3 days from fruiting, concentration 100-150ppm, volume increase 50-80%, shortens collecting time 1/3rd.
Claims (2)
1. the production method of Chinese medicinal materials, is characterized in that: at Chinese medicinal materials growing period, applying fertilizer and nutrient substance;
Described nutrient substance is: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 2.5 grams, glucose 7.5 grams, nucleosides hydrochlorate and deoxidation core
Thuja acid salt is pulverized, and mixes, the nutrient substance obtained with glucose;
Or: get nucleosides hydrochlorate and deoxynucleoside hydrochlorate 5 grams, glucose 5 grams, nucleosides hydrochlorate and deoxynucleotide
Salt is pulverized, and mixes, the nutrient substance obtained with glucose;
Described nucleosides hydrochlorate refers to: 5 '-adenylic acid (AMP) disodium or potassium, 5 '-bird adenylic acid (AMP) disodium or potassium, 5 '-cytidylic acid disodium or potassium, 5 '-uridine monophosphate disodium or potassium, the sodium salt of four kinds of 5 '-mixed nucleotides or sylvite;
Deoxynucleoside hydrochlorate refers to: 5 '-Desoxyadenosine acid disodium or potassium, 5 '-deoxidation bird adenylic acid (AMP) disodium or potassium, 5 '-Deoxyribose cytidine acid disodium or potassium, 5 '-deoxyuridine acid disodium or potassium, 5 '-deoxythymidine acid disodium or potassium, the sodium salt of five kinds of 5 '-deoxidation mixed nucleotides or sylvite;
Described growing period uses time of nutrient substance and concentration is: initial bloom stage and full-bloom stage each once, concentration 100-260ppm.
2. the production method of Chinese medicinal materials according to claim 1, is characterized in that: in described nucleosides hydrochlorate and deoxynucleoside hydrochlorate, weight percent is: nucleosides hydrochlorate 85%, deoxynucleoside hydrochlorate 15%.
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| CN102145999A (en) * | 2010-11-24 | 2011-08-10 | 高旌 | Auxin |
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| CN102146005B (en) * | 2010-11-25 | 2014-12-10 | 高旌 | Application method of auxin |
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