CN103327975A - 用于治疗多形性成胶质母细胞瘤的含有马西替坦的组合物 - Google Patents

用于治疗多形性成胶质母细胞瘤的含有马西替坦的组合物 Download PDF

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Publication number
CN103327975A
CN103327975A CN2012800059659A CN201280005965A CN103327975A CN 103327975 A CN103327975 A CN 103327975A CN 2012800059659 A CN2012800059659 A CN 2012800059659A CN 201280005965 A CN201280005965 A CN 201280005965A CN 103327975 A CN103327975 A CN 103327975A
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pharmaceutically acceptable
therapeutic agent
acceptable salt
cytotoxin
treatment
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Pending
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CN2012800059659A
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English (en)
Chinese (zh)
Inventor
乌尔斯·瑞格纳斯
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45787254&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN103327975(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of CN103327975A publication Critical patent/CN103327975A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2012800059659A 2011-02-04 2012-02-03 用于治疗多形性成胶质母细胞瘤的含有马西替坦的组合物 Pending CN103327975A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2011/050494 2011-02-04
IB2011050494 2011-02-04
PCT/IB2012/050513 WO2012104822A1 (en) 2011-02-04 2012-02-03 Combinations comprising macitentan for the treatment of glioblastoma multiforme

Publications (1)

Publication Number Publication Date
CN103327975A true CN103327975A (zh) 2013-09-25

Family

ID=45787254

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012800059659A Pending CN103327975A (zh) 2011-02-04 2012-02-03 用于治疗多形性成胶质母细胞瘤的含有马西替坦的组合物

Country Status (21)

Country Link
US (1) US20130310407A1 (enExample)
EP (2) EP2670405B1 (enExample)
JP (2) JP5642892B2 (enExample)
KR (1) KR101563069B1 (enExample)
CN (1) CN103327975A (enExample)
AR (1) AR085132A1 (enExample)
AU (1) AU2012213036A1 (enExample)
BR (1) BR112013019680A2 (enExample)
CA (1) CA2823994A1 (enExample)
CL (1) CL2013002193A1 (enExample)
CO (1) CO6761366A2 (enExample)
EA (1) EA201391131A1 (enExample)
IL (1) IL227747A0 (enExample)
MA (1) MA34952B1 (enExample)
MX (1) MX2013008798A (enExample)
PH (1) PH12013501461A1 (enExample)
SG (1) SG192600A1 (enExample)
TN (1) TN2013000333A1 (enExample)
TW (1) TW201309298A (enExample)
WO (1) WO2012104822A1 (enExample)
ZA (1) ZA201306613B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007031933A2 (en) 2005-09-12 2007-03-22 Actelion Pharmaceuticals Ltd Stable pharmaceutical composition comprising a pyrimidine-sulfamide
ES2543280T3 (es) 2009-08-10 2015-08-17 Board Of Regents, The University Of Texas System Tratamiento de metástasis cerebrales con inhibidores de los receptores de endotelina en combinación con un agente quimioterapéutico citotóxico
CN103397308A (zh) * 2013-08-01 2013-11-20 光垒光电科技(上海)有限公司 用于mocvd设备的喷淋头
TWI559928B (en) * 2014-08-20 2016-12-01 Academia Sinica Methods for enhancing permeability to blood-brain barrier and uses thereof
KR101701619B1 (ko) 2015-06-26 2017-02-01 건양대학교산학협력단 뇌교종 세포 치료를 위한 테모졸로마이드와 비타민 d가 포함된 조성물
KR102574253B1 (ko) 2020-12-15 2023-09-07 주식회사 시선테라퓨틱스 펩티드 핵산 복합체를 유효성분으로 함유하는 교모세포종 예방 또는 치료용 조성물
CN115317604B (zh) * 2022-08-11 2023-09-22 南京脑科医院 一种靶向胶质瘤的共载放疗增敏阳离子纳米制剂及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053557A1 (en) * 2000-12-18 2002-07-11 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
WO2009104149A1 (en) * 2008-02-20 2009-08-27 Actelion Pharmaceuticals Ltd Combination comprising paclitaxel for treating ovarian cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007031933A2 (en) 2005-09-12 2007-03-22 Actelion Pharmaceuticals Ltd Stable pharmaceutical composition comprising a pyrimidine-sulfamide
WO2008111092A1 (en) * 2007-03-09 2008-09-18 Fresenius Kabi Oncology Limited Crystalline temozolomide monohydrate and process for preparation thereof
ES2543280T3 (es) * 2009-08-10 2015-08-17 Board Of Regents, The University Of Texas System Tratamiento de metástasis cerebrales con inhibidores de los receptores de endotelina en combinación con un agente quimioterapéutico citotóxico

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002053557A1 (en) * 2000-12-18 2002-07-11 Actelion Pharmaceuticals Ltd Novel sulfamides and their use as endothelin receptor antagonists
WO2009104149A1 (en) * 2008-02-20 2009-08-27 Actelion Pharmaceuticals Ltd Combination comprising paclitaxel for treating ovarian cancer

Also Published As

Publication number Publication date
CL2013002193A1 (es) 2014-05-09
MA34952B1 (fr) 2014-03-01
EP2965757A1 (en) 2016-01-13
TW201309298A (zh) 2013-03-01
WO2012104822A1 (en) 2012-08-09
AU2012213036A1 (en) 2013-09-19
EP2670405B1 (en) 2015-09-02
JP2015057409A (ja) 2015-03-26
JP2014504636A (ja) 2014-02-24
BR112013019680A2 (pt) 2016-10-11
MX2013008798A (es) 2013-10-17
KR101563069B1 (ko) 2015-10-23
CA2823994A1 (en) 2012-08-09
JP5642892B2 (ja) 2014-12-17
KR20130118981A (ko) 2013-10-30
IL227747A0 (en) 2013-09-30
ZA201306613B (en) 2015-04-29
US20130310407A1 (en) 2013-11-21
EP2670405A1 (en) 2013-12-11
CO6761366A2 (es) 2013-09-30
EA201391131A1 (ru) 2013-12-30
AR085132A1 (es) 2013-09-11
PH12013501461A1 (en) 2019-03-22
SG192600A1 (en) 2013-09-30
TN2013000333A1 (en) 2015-01-20
NZ615005A (en) 2015-10-30

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