CN103298780A - 异羟肟酸衍生物及其在治疗细菌感染中的用途 - Google Patents

异羟肟酸衍生物及其在治疗细菌感染中的用途 Download PDF

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Publication number
CN103298780A
CN103298780A CN2011800639128A CN201180063912A CN103298780A CN 103298780 A CN103298780 A CN 103298780A CN 2011800639128 A CN2011800639128 A CN 2011800639128A CN 201180063912 A CN201180063912 A CN 201180063912A CN 103298780 A CN103298780 A CN 103298780A
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China
Prior art keywords
methyl
diynyl
benzamide
hydroxymethyl
trans
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Pending
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CN2011800639128A
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English (en)
Chinese (zh)
Inventor
拉麦施·卡萨
马丁·舍灵汉姆·里恩塞尔
詹姆士·布拉德利·阿根
卢青（简）
王丹
蒂姆·丘奇
海因兹·E·摩泽尔
菲利普·A·帕顿
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Achaogen Inc
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Achaogen Inc
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Publication of CN103298780A publication Critical patent/CN103298780A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2011800639128A 2010-11-10 2011-11-04 异羟肟酸衍生物及其在治疗细菌感染中的用途 Pending CN103298780A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41231110P 2010-11-10 2010-11-10
US61/412,311 2010-11-10
PCT/US2011/059280 WO2012154204A1 (en) 2010-11-10 2011-11-04 Hydroxamic acid derivatives and their use in the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
CN103298780A true CN103298780A (zh) 2013-09-11

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CN2011800639128A Pending CN103298780A (zh) 2010-11-10 2011-11-04 异羟肟酸衍生物及其在治疗细菌感染中的用途

Country Status (14)

Country Link
EP (1) EP2638006A1 (enExample)
JP (1) JP2014501716A (enExample)
KR (1) KR20140023869A (enExample)
CN (1) CN103298780A (enExample)
AR (1) AR083760A1 (enExample)
AU (1) AU2011367819A1 (enExample)
BR (1) BR112013011693A2 (enExample)
CA (1) CA2817211A1 (enExample)
EA (1) EA201390626A1 (enExample)
IL (1) IL226270A0 (enExample)
MX (1) MX2013005200A (enExample)
SG (1) SG190243A1 (enExample)
TW (1) TW201249786A (enExample)
WO (1) WO2012154204A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113957098A (zh) * 2021-09-13 2022-01-21 湖南工业大学 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用
CN116730870A (zh) * 2023-08-08 2023-09-12 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008154642A2 (en) 2007-06-12 2008-12-18 Achaogen, Inc. Antibacterial agents
WO2013170030A1 (en) * 2012-05-09 2013-11-14 Achaogen, Inc. Antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
JP2017515906A (ja) 2014-05-16 2017-06-15 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ 抗菌性キナゾロン−４（３ｈ）−オン誘導体
KR20170086079A (ko) 2014-11-19 2017-07-25 액테리온 파마슈티칼 리미티드 항균성 벤조티아졸 유도체
EA032138B1 (ru) 2014-12-16 2019-04-30 Новартис Аг СОЕДИНЕНИЯ ИЗОКСАЗОЛГИДРОКСАМИНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ ИНГИБИТОРОВ LpxC
EP3448375B1 (en) 2016-04-25 2023-09-27 Duke University Benzoylglycine derivatives and methods of making and using same
CA3026356A1 (en) 2016-06-14 2017-12-21 Novartis Ag Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
CA3090833A1 (en) * 2018-02-10 2019-08-15 Kbp Biosciences Co., Ltd. Compound acting as antibiotics
CN110563611B (zh) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062601A2 (en) * 2003-01-08 2004-07-29 Chiron Corporation Antibacterial agents
CN101209974A (zh) * 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途
US20100190766A1 (en) * 2007-06-12 2010-07-29 Achaogen, Inc. Antibacterial agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
US6541276B2 (en) 1996-10-28 2003-04-01 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
WO2000061134A1 (en) 1999-04-09 2000-10-19 British Biotech Pharmaceuticals Limited Antimicrobial agents
DE102006032709A1 (de) 2006-07-14 2008-01-17 BSH Bosch und Siemens Hausgeräte GmbH Luftschallgedämmte Lebensmittelmühle
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
PH12012502087A1 (en) * 2010-04-20 2015-04-15 Taisho Pharmaceutical Co Ltd Novel hydroxamic acid derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062601A2 (en) * 2003-01-08 2004-07-29 Chiron Corporation Antibacterial agents
CN101209974A (zh) * 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途
US20100190766A1 (en) * 2007-06-12 2010-07-29 Achaogen, Inc. Antibacterial agents

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113957098A (zh) * 2021-09-13 2022-01-21 湖南工业大学 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用
CN116730870A (zh) * 2023-08-08 2023-09-12 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法
CN116730870B (zh) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法
WO2025031048A1 (zh) * 2023-08-08 2025-02-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Also Published As

Publication number Publication date
WO2012154204A1 (en) 2012-11-15
EA201390626A1 (ru) 2013-12-30
EP2638006A1 (en) 2013-09-18
AU2011367819A1 (en) 2013-05-02
AR083760A1 (es) 2013-03-20
JP2014501716A (ja) 2014-01-23
MX2013005200A (es) 2013-06-28
KR20140023869A (ko) 2014-02-27
CA2817211A1 (en) 2012-11-15
IL226270A0 (en) 2013-07-31
TW201249786A (en) 2012-12-16
SG190243A1 (en) 2013-06-28
BR112013011693A2 (pt) 2016-08-09

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