JP2014501716A - ヒドロキサム酸誘導体および細菌感染の処置におけるその使用 - Google Patents

ヒドロキサム酸誘導体および細菌感染の処置におけるその使用 Download PDF

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JP2014501716A
JP2014501716A JP2013538794A JP2013538794A JP2014501716A JP 2014501716 A JP2014501716 A JP 2014501716A JP 2013538794 A JP2013538794 A JP 2013538794A JP 2013538794 A JP2013538794 A JP 2013538794A JP 2014501716 A JP2014501716 A JP 2014501716A
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Prior art keywords
methyl
hydroxymethyl
diynyl
buta
hydroxyamino
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JP2013538794A
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Japanese (ja)
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JP2014501716A5 (enExample
Inventor
ラメシュ カサー，
マーティン シェリングハム リンゼル，
ジェイムズ ブラッドリー アジェン，
キン （ジェーン） リュウ，
ダン ワン，
ティム チャーチ，
ヘインツ イー． モーザー，
フィリップ エー． パテン，
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アカオジェン インコーポレイテッド
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Publication of JP2014501716A publication Critical patent/JP2014501716A/ja
Publication of JP2014501716A5 publication Critical patent/JP2014501716A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2013538794A 2010-11-10 2011-11-04 ヒドロキサム酸誘導体および細菌感染の処置におけるその使用 Pending JP2014501716A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41231110P 2010-11-10 2010-11-10
US61/412,311 2010-11-10
PCT/US2011/059280 WO2012154204A1 (en) 2010-11-10 2011-11-04 Hydroxamic acid derivatives and their use in the treatment of bacterial infections

Publications (2)

Publication Number Publication Date
JP2014501716A true JP2014501716A (ja) 2014-01-23
JP2014501716A5 JP2014501716A5 (enExample) 2014-12-18

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JP2013538794A Pending JP2014501716A (ja) 2010-11-10 2011-11-04 ヒドロキサム酸誘導体および細菌感染の処置におけるその使用

Country Status (14)

Country Link
EP (1) EP2638006A1 (enExample)
JP (1) JP2014501716A (enExample)
KR (1) KR20140023869A (enExample)
CN (1) CN103298780A (enExample)
AR (1) AR083760A1 (enExample)
AU (1) AU2011367819A1 (enExample)
BR (1) BR112013011693A2 (enExample)
CA (1) CA2817211A1 (enExample)
EA (1) EA201390626A1 (enExample)
IL (1) IL226270A0 (enExample)
MX (1) MX2013005200A (enExample)
SG (1) SG190243A1 (enExample)
TW (1) TW201249786A (enExample)
WO (1) WO2012154204A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021513543A (ja) * 2018-02-10 2021-05-27 山東亨利醫藥科技有限責任公司 抗菌剤化合物

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2691987C (en) 2007-06-12 2016-08-16 Achaogen, Inc. Antibacterial agents
EP2847162A1 (en) * 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
KR20160098503A (ko) 2013-12-19 2016-08-18 액테리온 파마슈티칼 리미티드 항균성 1h-인다졸 및 1h-인돌 유도체
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
WO2015173329A1 (en) 2014-05-16 2015-11-19 Actelion Pharmaceuticals Ltd Antibacterial quinazoline-4(3h)-one derivatives
BR112017010474A2 (pt) 2014-11-19 2017-12-26 Actelion Pharmaceuticals Ltd derivados antibacterianos de benzotiazol
HUE047225T2 (hu) 2014-12-16 2020-04-28 Novartis Ag LpxC inhibitor izoxazol hidroxámsav-vegyületek
AU2017257755B2 (en) 2016-04-25 2021-05-06 Duke University Benzoylglycine derivatives and methods of making and using same
SMT202000524T1 (it) 2016-06-14 2020-11-10 Novartis Ag Forma cristallina di (r)-4-(5-(ciclopropiletinil)isossazol-3-il)-n-idrossi-2-metil-2-(metilsolfonil)butanammide come agente antibatterico
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
CN110563611B (zh) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
CN113957098A (zh) * 2021-09-13 2022-01-21 湖南工业大学 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用
CN116730870B (zh) 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519772A (ja) * 2003-01-08 2006-08-31 カイロン コーポレイション 抗菌剤
JP2010530372A (ja) * 2007-06-12 2010-09-09 アカオゲン，インコーポレーテッド 抗菌剤
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
WO2011132712A1 (ja) * 2010-04-20 2011-10-27 大正製薬株式会社 新規なヒドロキサム酸誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
US6716878B1 (en) 1999-04-09 2004-04-06 Vernalis (Oxford) Limited Antimicrobial agents
DE102006032709A1 (de) 2006-07-14 2008-01-17 BSH Bosch und Siemens Hausgeräte GmbH Luftschallgedämmte Lebensmittelmühle
CN101209974A (zh) * 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006519772A (ja) * 2003-01-08 2006-08-31 カイロン コーポレイション 抗菌剤
JP2010530372A (ja) * 2007-06-12 2010-09-09 アカオゲン，インコーポレーテッド 抗菌剤
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
WO2011132712A1 (ja) * 2010-04-20 2011-10-27 大正製薬株式会社 新規なヒドロキサム酸誘導体

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021513543A (ja) * 2018-02-10 2021-05-27 山東亨利醫藥科技有限責任公司 抗菌剤化合物
JP7412004B2 (ja) 2018-02-10 2024-01-12 山東亨利醫藥科技有限責任公司 抗菌剤化合物

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Publication number Publication date
IL226270A0 (en) 2013-07-31
CN103298780A (zh) 2013-09-11
EA201390626A1 (ru) 2013-12-30
KR20140023869A (ko) 2014-02-27
MX2013005200A (es) 2013-06-28
EP2638006A1 (en) 2013-09-18
BR112013011693A2 (pt) 2016-08-09
WO2012154204A1 (en) 2012-11-15
SG190243A1 (en) 2013-06-28
AU2011367819A1 (en) 2013-05-02
AR083760A1 (es) 2013-03-20
CA2817211A1 (en) 2012-11-15
TW201249786A (en) 2012-12-16

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