CN103298482B - 用于免疫耐受性诱导和免疫诊断的fviii肽 - Google Patents

用于免疫耐受性诱导和免疫诊断的fviii肽 Download PDF

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Publication number
CN103298482B
CN103298482B CN201180063117.9A CN201180063117A CN103298482B CN 103298482 B CN103298482 B CN 103298482B CN 201180063117 A CN201180063117 A CN 201180063117A CN 103298482 B CN103298482 B CN 103298482B
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CN
China
Prior art keywords
fviii
peptide
amino acid
seq
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180063117.9A
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English (en)
Chinese (zh)
Other versions
CN103298482A (zh
Inventor
卡塔琳娜·诺拉·施泰尼茨
保拉·玛利亚·威廉明娜范黑尔登
比吉特·玛利亚·赖佩特
汉斯-彼得·施瓦茨
哈特穆特·埃利希
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Priority to CN201510431485.4A priority Critical patent/CN104926947A/zh
Publication of CN103298482A publication Critical patent/CN103298482A/zh
Application granted granted Critical
Publication of CN103298482B publication Critical patent/CN103298482B/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
CN201180063117.9A 2010-10-27 2011-10-27 用于免疫耐受性诱导和免疫诊断的fviii肽 Active CN103298482B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510431485.4A CN104926947A (zh) 2010-10-27 2011-10-27 用于免疫耐受性诱导和免疫诊断的fviii肽

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40740210P 2010-10-27 2010-10-27
US61/407,402 2010-10-27
US201161467894P 2011-03-25 2011-03-25
US61/467,894 2011-03-25
US201161502476P 2011-06-29 2011-06-29
US61/502,476 2011-06-29
PCT/US2011/058165 WO2012058480A1 (en) 2010-10-27 2011-10-27 Fviii peptides for immune tolerance induction and immunodiagnostics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510431485.4A Division CN104926947A (zh) 2010-10-27 2011-10-27 用于免疫耐受性诱导和免疫诊断的fviii肽

Publications (2)

Publication Number Publication Date
CN103298482A CN103298482A (zh) 2013-09-11
CN103298482B true CN103298482B (zh) 2015-08-19

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201180063117.9A Active CN103298482B (zh) 2010-10-27 2011-10-27 用于免疫耐受性诱导和免疫诊断的fviii肽
CN201510431485.4A Pending CN104926947A (zh) 2010-10-27 2011-10-27 用于免疫耐受性诱导和免疫诊断的fviii肽

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Country Status (20)

Country Link
US (3) US8969524B2 (enExample)
EP (2) EP3260132B1 (enExample)
JP (2) JP6122780B2 (enExample)
KR (2) KR102040867B1 (enExample)
CN (2) CN103298482B (enExample)
AR (1) AR083586A1 (enExample)
AU (2) AU2011319747C1 (enExample)
BR (1) BR112013010362A2 (enExample)
CA (1) CA2815239C (enExample)
DK (1) DK2632479T3 (enExample)
EA (1) EA034494B1 (enExample)
ES (2) ES2912455T3 (enExample)
HK (1) HK1215442A1 (enExample)
MX (1) MX347805B (enExample)
NZ (2) NZ609474A (enExample)
PL (2) PL3260132T3 (enExample)
PT (1) PT2632479T (enExample)
SG (2) SG189914A1 (enExample)
TW (3) TW201730205A (enExample)
WO (1) WO2012058480A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063031A2 (en) 2004-12-06 2006-06-15 Haplomics Allelic variants of human factor viii
PL2917232T3 (pl) * 2012-11-12 2017-09-29 Apitope International Nv Pochodzące od czynnika VIII peptydy do zastosowania w leczeniu hemofilii A
US10272163B2 (en) 2012-12-07 2019-04-30 The Regents Of The University Of California Factor VIII mutation repair and tolerance induction
EP2968499A4 (en) * 2013-03-15 2016-11-30 Haplomics Inc COMPOSITIONS AND METHODS FOR THE IMMUNO-TOLERANCE INDUCTION FOR FACTOR VIII SPATIAL THERAPIES IN PERSONS WITH HEMOPHILIA A
WO2015192101A1 (en) * 2014-06-12 2015-12-17 University Of Hawaii Uses of humanized cobra venom factor for reducing or preventing immunogenicity
CA2973529A1 (en) * 2015-01-26 2016-08-04 Cellectis Cll1-specific multi-chain chimeric antigen receptor
SG11201808475XA (en) 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
WO2009071886A1 (en) * 2007-12-04 2009-06-11 Apitope Technology (Bristol) Limited Fviii peptides and their use in tolerising haemophiliacs
WO2009095646A3 (en) * 2008-01-28 2010-03-11 Circassia Limited Peptides from factor viii

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485314B2 (en) * 2002-05-06 2009-02-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Induction of antigen specific immunologic tolerance
WO2005114221A2 (en) * 2004-05-21 2005-12-01 The Institute For Systems Biology Compositions and methods for quantification of serum glycoproteins
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
ES2474573T3 (es) 2006-01-04 2014-07-09 Baxter International Inc Medio de cultivo celular sin oligop�ptidos
US7673687B2 (en) 2007-12-05 2010-03-09 Halliburton Energy Services, Inc. Cement compositions comprising crystalline organic materials and methods of using same
DE202007017320U1 (de) 2007-12-07 2008-02-28 Dittmann, Ludwig Vorrichtung zur Raumbeduftung
US20110081362A1 (en) 2008-01-31 2011-04-07 The Brigham And Women's Hospital, Inc. Treatment of cancer
US20100168018A1 (en) 2008-11-07 2010-07-01 Baxter International Inc. Factor viii formulations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087161A1 (en) * 2002-04-18 2003-10-23 Merck Patent Gmbh Modified factor viii
WO2009071886A1 (en) * 2007-12-04 2009-06-11 Apitope Technology (Bristol) Limited Fviii peptides and their use in tolerising haemophiliacs
WO2009095646A3 (en) * 2008-01-28 2010-03-11 Circassia Limited Peptides from factor viii

Also Published As

Publication number Publication date
SG189914A1 (en) 2013-06-28
DK2632479T3 (en) 2017-08-07
EA034494B1 (ru) 2020-02-13
US20120135019A1 (en) 2012-05-31
EP2632479B1 (en) 2017-06-14
JP2014505014A (ja) 2014-02-27
AU2016202155A1 (en) 2016-04-28
KR102222864B1 (ko) 2021-03-04
TW201231065A (en) 2012-08-01
TW201730205A (zh) 2017-09-01
ES2639039T3 (es) 2017-10-25
KR102040867B1 (ko) 2019-11-07
PL2632479T3 (pl) 2017-09-29
CN103298482A (zh) 2013-09-11
AR083586A1 (es) 2013-03-06
AU2011319747B2 (en) 2016-01-07
US20170267743A1 (en) 2017-09-21
CA2815239C (en) 2019-02-26
AU2011319747A1 (en) 2013-05-02
WO2012058480A1 (en) 2012-05-03
CA2815239A1 (en) 2012-05-03
EP2632479A1 (en) 2013-09-04
US9512198B2 (en) 2016-12-06
TWI580430B (zh) 2017-05-01
MX2013004753A (es) 2013-09-13
EP3260132A1 (en) 2017-12-27
BR112013010362A2 (pt) 2016-08-02
NZ609474A (en) 2015-06-26
CN104926947A (zh) 2015-09-23
EP3260132B1 (en) 2022-02-09
SG10201600656WA (en) 2016-02-26
PT2632479T (pt) 2017-07-24
US20150203567A1 (en) 2015-07-23
HK1215442A1 (zh) 2016-08-26
MX347805B (es) 2017-05-15
KR20130128404A (ko) 2013-11-26
JP6122780B2 (ja) 2017-04-26
TW201708251A (zh) 2017-03-01
JP2017095463A (ja) 2017-06-01
NZ703514A (en) 2017-02-24
US8969524B2 (en) 2015-03-03
AU2016202155B2 (en) 2018-02-01
PL3260132T3 (pl) 2022-08-08
AU2011319747C1 (en) 2016-07-14
KR20190126189A (ko) 2019-11-08
EA201390617A1 (ru) 2013-10-30
ES2912455T3 (es) 2022-05-26

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C06 Publication
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TR01 Transfer of patent right

Effective date of registration: 20160811

Address after: Aupu, Switzerland

Patentee after: Hundred deep limited liability company

Patentee after: Hundred deep company

Address before: Illinois State

Patentee before: Baxter International Inc.

Patentee before: Bakst Helth Co., Ltd.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210630

Address after: Osaka

Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd.

Address before: Aupu, Switzerland

Patentee before: BAXALTA GmbH

Patentee before: Baishen Co.