CN103288759A - 达克米替尼的制备方法 - Google Patents
达克米替尼的制备方法 Download PDFInfo
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- CN103288759A CN103288759A CN2013101808834A CN201310180883A CN103288759A CN 103288759 A CN103288759 A CN 103288759A CN 2013101808834 A CN2013101808834 A CN 2013101808834A CN 201310180883 A CN201310180883 A CN 201310180883A CN 103288759 A CN103288759 A CN 103288759A
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- FGGRNQBLWZFUSW-UHFFFAOYSA-N CN(C=Nc(c1c2)cc(OC)c2[N+]([O-])=O)C1=O Chemical compound CN(C=Nc(c1c2)cc(OC)c2[N+]([O-])=O)C1=O FGGRNQBLWZFUSW-UHFFFAOYSA-N 0.000 description 1
- RKVHLPALBATZEA-UHFFFAOYSA-N CN(C=Nc1cc(F)ccc11)C1=O Chemical compound CN(C=Nc1cc(F)ccc11)C1=O RKVHLPALBATZEA-UHFFFAOYSA-N 0.000 description 1
- PPGWFCHOWMFNRI-UHFFFAOYSA-N COc(cc1N=CN2)ccc1C2=O Chemical compound COc(cc1N=CN2)ccc1C2=O PPGWFCHOWMFNRI-UHFFFAOYSA-N 0.000 description 1
- QRZFUQFQXCRJRR-UHFFFAOYSA-N COc1cc2ncnc(Nc(cc3Cl)ccc3F)c2cc1N Chemical compound COc1cc2ncnc(Nc(cc3Cl)ccc3F)c2cc1N QRZFUQFQXCRJRR-UHFFFAOYSA-N 0.000 description 1
- LVXJQMNHJWSHET-AATRIKPKSA-N COc1cc2ncnc(Nc(cc3Cl)ccc3F)c2cc1NC(/C=C/CN1CCCCC1)=O Chemical compound COc1cc2ncnc(Nc(cc3Cl)ccc3F)c2cc1NC(/C=C/CN1CCCCC1)=O LVXJQMNHJWSHET-AATRIKPKSA-N 0.000 description 1
- VKEKKVCWODTGAP-UHFFFAOYSA-N COc1cc2ncnc(Nc(cc3Cl)ccc3F)c2cc1[N+]([O-])=O Chemical compound COc1cc2ncnc(Nc(cc3Cl)ccc3F)c2cc1[N+]([O-])=O VKEKKVCWODTGAP-UHFFFAOYSA-N 0.000 description 1
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CN201310180883.4A CN103288759B (zh) | 2013-05-16 | 2013-05-16 | 达克米替尼的制备方法 |
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CN201310180883.4A CN103288759B (zh) | 2013-05-16 | 2013-05-16 | 达克米替尼的制备方法 |
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CN103288759A true CN103288759A (zh) | 2013-09-11 |
CN103288759B CN103288759B (zh) | 2015-05-20 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021238835A1 (zh) * | 2020-05-25 | 2021-12-02 | 苏州晶云药物科技股份有限公司 | (2e)-n-[4-[(3-氯-4-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]-4-(1-哌啶基)-2-丁烯酰胺的晶型及其制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1724521A (zh) * | 2005-07-14 | 2006-01-25 | 沈阳中海生物技术开发有限公司 | 新的喹唑啉类衍生物、含有其的药物组合物以及它们的用途 |
WO2006090163A1 (en) * | 2005-02-26 | 2006-08-31 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
CN1858040A (zh) * | 2005-05-08 | 2006-11-08 | 中国科学院上海药物研究所 | 5,8-二取代喹唑啉及其制备方法和用途 |
CN1972688A (zh) * | 2004-05-06 | 2007-05-30 | 沃尼尔·朗伯有限责任公司 | 4-苯胺基-喹唑啉-6-基-酰胺类化合物 |
CN101357905A (zh) * | 2007-08-01 | 2009-02-04 | 上海艾力斯医药科技有限公司 | 4-[3-氯-4-(3-氟-苄氧基)-苯胺基]-6-取代胺基-喹唑啉衍生物的制备方法 |
CN102942529A (zh) * | 2012-11-09 | 2013-02-27 | 贵州大学 | 4-(4-取代哌嗪)-5,6,7-三烷氧基喹唑啉类化合物及其制备方法和应用 |
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2013
- 2013-05-16 CN CN201310180883.4A patent/CN103288759B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1972688A (zh) * | 2004-05-06 | 2007-05-30 | 沃尼尔·朗伯有限责任公司 | 4-苯胺基-喹唑啉-6-基-酰胺类化合物 |
WO2006090163A1 (en) * | 2005-02-26 | 2006-08-31 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
CN1858040A (zh) * | 2005-05-08 | 2006-11-08 | 中国科学院上海药物研究所 | 5,8-二取代喹唑啉及其制备方法和用途 |
CN1724521A (zh) * | 2005-07-14 | 2006-01-25 | 沈阳中海生物技术开发有限公司 | 新的喹唑啉类衍生物、含有其的药物组合物以及它们的用途 |
CN101357905A (zh) * | 2007-08-01 | 2009-02-04 | 上海艾力斯医药科技有限公司 | 4-[3-氯-4-(3-氟-苄氧基)-苯胺基]-6-取代胺基-喹唑啉衍生物的制备方法 |
CN102942529A (zh) * | 2012-11-09 | 2013-02-27 | 贵州大学 | 4-(4-取代哌嗪)-5,6,7-三烷氧基喹唑啉类化合物及其制备方法和应用 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021238835A1 (zh) * | 2020-05-25 | 2021-12-02 | 苏州晶云药物科技股份有限公司 | (2e)-n-[4-[(3-氯-4-氟苯基)氨基]-7-甲氧基-6-喹唑啉基]-4-(1-哌啶基)-2-丁烯酰胺的晶型及其制备方法 |
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CN103288759B (zh) | 2015-05-20 |
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Effective date of registration: 20200511 Address after: 210000 Qinhuai Avenue 288, Yongyang Street, Lishui District, Nanjing City, Jiangsu Province Patentee after: Nanjing xunyin Seismic Technology Co., Ltd Address before: 215000 Jiangsu Province, Suzhou City Industrial Park Commercial Plaza Building 1 room 1305 Lianfeng Co-patentee before: Xu Xuenong Patentee before: SUZHOU MIRACPHARMA TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20200927 Address after: 244000 Huayuan Road, Tongling, Anhui, No. 192 on the first floor Patentee after: Tongling Shangdong hi tech Innovation Co., Ltd Address before: 210000 Qinhuai Avenue 288, Yongyang Street, Lishui District, Nanjing City, Jiangsu Province Patentee before: Nanjing xunyin Seismic Technology Co.,Ltd. |
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