CN103254278B - 奶酪蛋白的酶水解产物中鉴定的生物活性肽及其生产方法 - Google Patents

奶酪蛋白的酶水解产物中鉴定的生物活性肽及其生产方法 Download PDF

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Publication number
CN103254278B
CN103254278B CN201310023562.3A CN201310023562A CN103254278B CN 103254278 B CN103254278 B CN 103254278B CN 201310023562 A CN201310023562 A CN 201310023562A CN 103254278 B CN103254278 B CN 103254278B
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peptides
seq
casein
activity
bioactive
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Chinese (zh)
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CN103254278A (zh
Inventor
I.雷西奥桑彻茨
A.奎罗斯德尔博斯奎
B.赫南德茨勒德斯马
J.A.戈梅茨鲁茨
M.米古尔卡斯特罗
M.L.阿米戈加里多
I.洛佩茨埃克斯波西托
M.M.拉莫斯冈扎勒茨
A.阿莱克桑德里德阿蒂纳诺
M.康特雷拉斯戈梅茨
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Consejo Superior de Investigaciones Científicas
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4732—Casein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
    • A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201310023562.3A 2005-06-08 2006-06-08 奶酪蛋白的酶水解产物中鉴定的生物活性肽及其生产方法 Expired - Fee Related CN103254278B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200501373A ES2319475B1 (es) 2005-06-08 2005-06-08 Peptidos bioactivos identificados en hidrolizados enzimaticos de caseinas lacteas y procedimiento de obtencion.
ESP200501373 2005-06-08
CN200680029333.0A CN101305017B (zh) 2005-06-08 2006-06-08 奶酪蛋白的酶水解产物中鉴定的生物活性肽及其生产方法

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CN103254278A CN103254278A (zh) 2013-08-21
CN103254278B true CN103254278B (zh) 2015-07-22

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CN200680029333.0A Expired - Fee Related CN101305017B (zh) 2005-06-08 2006-06-08 奶酪蛋白的酶水解产物中鉴定的生物活性肽及其生产方法

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Country Status (12)

Country Link
US (1) US8354502B2 (enExample)
EP (2) EP2495250A3 (enExample)
JP (1) JP2008545774A (enExample)
KR (1) KR101343904B1 (enExample)
CN (2) CN103254278B (enExample)
AU (1) AU2006256720A1 (enExample)
BR (1) BRPI0611729A2 (enExample)
CA (1) CA2611416C (enExample)
ES (1) ES2319475B1 (enExample)
MX (1) MX2007015528A (enExample)
NO (1) NO20080103L (enExample)
WO (1) WO2006131586A1 (enExample)

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DE10331202A1 (de) 2003-07-10 2005-03-31 S.K. Enterprise Gmbh Verwendung von Molkenpermeat zur Behandlung des Metabolischen Syndroms
ZA200807389B (en) * 2006-03-24 2010-03-31 Unilever Plc Healthy food product
DE102006036285A1 (de) * 2006-08-03 2008-02-07 "S.U.K." Beteiligungs Gmbh Fraktionen aus Molkepermeat und deren Verwendung zur Prävention und Therapie des Typ-2 Diabetes und des Metabolischen Syndroms
EP2253324A1 (en) * 2009-04-30 2010-11-24 Consejo Superior De Investigaciones Cientificas Use of a casein-derived peptide and compositions thereof as antihypertensive
EP2540308A1 (en) * 2010-02-24 2013-01-02 Morinaga Milk Industry Co., Ltd. Therapeutic agent for eating disorders
CN103232526B (zh) * 2012-12-12 2015-06-24 上海交通大学 一种生物活性多肽lplp及其制备和应用
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9345741B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9345727B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component and uses thereof
CN103616454B (zh) * 2013-12-06 2015-06-03 贝因美婴童食品股份有限公司 一种定量检测人β-酪蛋白含量的方法以及试剂盒
CN104073539B (zh) * 2014-06-17 2017-03-29 黑龙江省乳品工业技术开发中心 一种牛乳β‑酪蛋白多元活性肽的制备方法及其应用
JP2017048124A (ja) * 2015-08-31 2017-03-09 森永乳業株式会社 アミノペプチダーゼａ阻害剤
EP3170507B1 (en) 2015-11-20 2022-12-21 Consejo Superior de Investigaciones Científicas (CSIC) Antihypertensive peptides from olive oil
CN107337710A (zh) * 2017-07-26 2017-11-10 盐城卫生职业技术学院 一种抗高血压活性肽The‑The‑Pro及应用和药物组合物
CN107814838A (zh) * 2017-12-07 2018-03-20 浙江辉肽生命健康科技有限公司 一种生物活性多肽ypqrdmpiqaf及其制备方法和应用
CN107880106B (zh) * 2017-12-11 2020-06-16 浙江辉肽生命健康科技有限公司 一种生物活性多肽vpitptlnre及其制备方法和应用
KR102073824B1 (ko) * 2018-04-11 2020-02-05 강원대학교산학협력단 간 보호용 건강기능식품 및 이의 제조 방법
CN111574585B (zh) * 2019-01-30 2021-10-01 浙江省医学科学院 一种鳕鱼皮寡肽及其分离纯化方法和应用
CN110498833B (zh) * 2019-08-30 2021-01-15 华南理工大学 一种具有ace抑制作用的三肽及其应用
US11326176B2 (en) 2019-11-22 2022-05-10 Mozza Foods, Inc. Recombinant micelle and method of in vivo assembly
US12359212B2 (en) 2019-11-22 2025-07-15 Mozza Foods, Inc. Recombinant micelle and method of in vivo assembly
CN111777665B (zh) * 2020-07-24 2022-07-05 北京林业大学 一种核桃粕抗氧化肽faw及其制备方法与应用
CN115505025A (zh) * 2022-11-10 2022-12-23 东北农业大学 一种基于老年人静态消化模型的乳清蛋白源抗氧化肽的筛选
CN116444608B (zh) * 2022-11-30 2024-06-25 内蒙古伊利实业集团股份有限公司 乳源活性肽dpsffake及其制备方法与应用
CN116444619B (zh) * 2022-11-30 2024-07-16 内蒙古伊利实业集团股份有限公司 乳源活性肽ypfpgpihnslp及其制备方法与应用
CN116444609B (zh) * 2022-11-30 2024-06-04 内蒙古伊利实业集团股份有限公司 乳源活性肽lppplpsrwpl及其制备方法与应用
CN118005726A (zh) * 2024-01-31 2024-05-10 上海交通大学 一种来源于驼奶的生物活性肽wpeylkt及其制备方法和应用
CN119170106B (zh) * 2024-11-20 2025-02-11 中国农业大学 一种马乳乳清蛋白源抗氧化肽筛选和制备方法及其应用
CN122036877A (zh) * 2024-11-22 2026-05-15 贵阳学院 一种乳源广谱抗菌肽w-4及其应用
CN120535604B (zh) * 2025-06-04 2026-07-24 华南理工大学 一种健骨乳蛋白提取物及其制备方法和应用
CN121471310A (zh) * 2026-01-07 2026-02-06 深圳保时健生物工程有限公司 一种促骨骼生长牛奶蛋白肽及其制备方法与应用
CN122060051B (zh) * 2026-04-21 2026-07-31 宁波大学 一种基于微生物发酵-酶解联用制备的多功能乳铁蛋白肽及其应用

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US20100048464A1 (en) 2010-02-25
WO2006131586B1 (es) 2007-02-01
WO2006131586A1 (es) 2006-12-14
BRPI0611729A2 (pt) 2010-10-05
MX2007015528A (es) 2008-02-25
ES2319475B1 (es) 2010-02-16
EP1905779A1 (en) 2008-04-02
KR20080045108A (ko) 2008-05-22
ES2319475A1 (es) 2009-05-07
CA2611416A1 (en) 2006-12-14
US8354502B2 (en) 2013-01-15
EP2495250A2 (en) 2012-09-05
KR101343904B1 (ko) 2013-12-23
CA2611416C (en) 2015-10-06
EP1905779A4 (en) 2010-09-01
CN101305017B (zh) 2014-08-06
AU2006256720A1 (en) 2006-12-14
EP2495250A3 (en) 2013-07-10
NO20080103L (no) 2008-03-04
JP2008545774A (ja) 2008-12-18
CN101305017A (zh) 2008-11-12
CN103254278A (zh) 2013-08-21

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