CN103230574A - Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof - Google Patents
Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medical composition for treating porcine epizootic diarrhea. The composition comprises the following components in parts by weight as follows; 80+/-5 parts of honeysuckle, 150+/-10 parts of Agastache rugosus, 80+/-5 parts of Codonopsis pilosula, 80+/-5 parts of Rhizoma Atractylodis Macrocephalae, 10+/-5 parts of Mangnolia officinalis, 100+/-5 parts of Pinellia ternate, 80+/-5 parts of Poria cocos, 50+/-5 parts of Poria cocos and 80+/-5 parts of liquorice. The traditional Chinese medical composition disclosed by the invention has the advantages of high integral curative effect, difficulty in generation of tolerance, low residue, small toxic and side effects and the like, has the remarkable inhibiting effect to growth and propagation of many virus pathogenies, even has the pharmacological effect of killing pathogenies, and has very important economic and social meanings for promoting healthy development of pig industry.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly, relate to a kind of Chinese medicine composition and application thereof for the treatment of porcine epizootic diarrhea.
Background technology
Porcine epizootic diarrhea (PED) is that (porcine epidemic diarrhea virus PEDV) causes a kind of acute infectious intestinal disease of pig by Porcine epidemic diarrhea virus.Mainly cause porcine epizootic diarrhea.But various ages, each product boar be infection morbidity all, and the sickness rate of suckling pig, feeder pig, growing and fattening pigs can reach 100%, and the sow sickness rate is 15%～90%.Its characteristics of incidence is: age in days is little, severe symptoms, and age in days is big, mild symptoms.The suckling pig dehydration of being everlasting behind diarrhoea 3～4 d in 1 age in week is dead, and case fatality rate reaches 80%.Wean pig, growing and fattening pigs symptom is lighter, sustainable 4～7 d that suffer from diarrhoea, and vomiting and anorexia only take place in adult pig.
The porcine epizootic diarrhea symptom is to cause diarrhea of pigs, vomiting, dehydration, symptom such as become thin.Its main pathology variation characteristic is intestinal mucosa hyperemia, edema, and intestinal mucosa comes off etc.Diarrhoea sees piglet usually, also sees sow, and it has been that piglet growth is obstructed and the high major reason of mortality rate.At present, PED worldwide is widely current, and has brought serious economy loss to pig industry.When particularly the autumn and winter changed according to the season, the piglet sickness rate was up to 90%, and mortality rate is up to 95%, had 70% pig farm influenced by this disease approximately.Bring heavy losses in these years for China's pig industry.The zone of being everlasting is popular, the heterogeneous susceptible of patient, and infectiousness is strong, and the mortality rate height often causes large quantities of piglet death.Very the person causes being annihilated, and is very harmful to pig industry, is badly in need of seeking suitable antiviral antibacterials and comes the specific aim treatment, becomes a noticeable worldwide problem.At present the transmissible gastroenteritis of swine doctor trained in Western medicine is not still had desirable Therapeutic Method, do not have specific drug yet.The method of taking just is mitigation symptoms, reduces death, shortens the course of disease, reduces loss.Be generation and the popular normal employing vaccination therapy of preventing this disease, but vaccine effect is not good enough, controlling above-mentioned disease fully by vaccine has great difficulty.Use hyper-immune serum, yolk antibody treatment primary disease, although curative effect is better, cost is too high.Abuse chemical medicine, antibiotic and monomer medicine without restraint, both produced the super many drug-induced disease such as quick of polynary drug resistance and receptor, cause animal products to pollute again, jeopardize human food's safe and sanitary.Chinese medicine derives from animal, plant and mineral, contains multiple biological effective components, and wherein most of Chinese medicines are to be raw material with the natural plants, aboundresources, obtain easily, respond well, cheap, toxic and side effects is small, almost noresidue, no Drug resistance, free from environmental pollution.Therefore, select for use Chinese medicine preparation to substitute chemical medicine, antibiotic seems particularly important.
Chinese veterinarian thinks that porcine epizootic diarrhea belongs to Chinese veterinarian " cold cholera " category, and Chinese veterinarian's cholera is hurried with onset, suddenly outbreak, vomiting and dirarrhea, stomachache or bitterly disease not.Due to illness become and arise from no time, spend freely formal confused, so the name cholera.The scope of Chinese veterinarian's cholera is wider, comprises the diseases such as cholera, pasracholera, acute gastroenteritis and bacterial food poisoning of doctor trained in Western medicine.
Primary disease is multiple is born in autumn and winter season, and suffering from poultry has situations such as the greedy cool and rotten food of turning sour of feed again mostly, so think mainly due to experiencing due to the cold-damp foul gas and unhygienic diet.Because the foul tired spleen of cold-damp, taste are injured, lifting mistake department, and abnormal ascent-descent between clear YANG and turbid YIN, mechanism of qi is disorderly contrary, does so vomit and diarrhoea to hand over.Said as " danxi's experiential therapy cholera " piece of writing: " interior long-pending to some extent, sense to some extent causes into vomiting and diarrhoea outward ".Because of its vomiting and diarrhoea, so the body fluid excessive loss at short notice, wan and sallow looking can occur, and orbit sink, and muscle arteries and veins contraction is anxious, critical syndrome such as extreme cold of the limbs.
Chinese veterinarian thinks that the generation of primary disease mainly is that (1) feeds unclean: it is unclean to feed, and mistake is advanced the rotten rotten food of turning sour, or cold and cool feedstuff, can impairing the spleen and stomach, and pure and impure mixing mutually forms.(2) experience seasonal pathogen: in the season of autumn and winter, the damp transpiration if it is inappropriate to take good care of oneself, is experienced the foul pestilential pathogen of cold-damp, or sleeps in the open because coveting cold, cold-damp invasion, the exopathogen oxious gas is strongly fragrantly held back middle Jiao, all can make taste injured, dysfunction of the spleen in transportation and transformation, disorder of QI movement, lifting mistake department, abnormal ascent-descent between clear YANG and turbid YIN, disorderly in the intestines and stomach, vomiting and dirarrhea forms.
Primary disease mainly is to experience the foul gas of cold-damp, cold-damp disturbing the spleen, and deficiency of spleen-QI and stomach-QI, hypoactivity of YANG in middle-JIAO, yang deficiency is then given birth to endogenous cold, stagnate and cause mechanism of qi, lifting is disorderly contrary, and the spleen master transports fortuneization and sending up the lucid YANG, stomach receiving food and drink and the turbid descending the moon, void has coldly in the present, and lifting dereliction of duty is so suffer from abdominal pain loss of appetite for vomiting and diarrhea.Sick deeply few cloudy to the cold-evil, the gas of negative and positive is mutually along connecing, thus outward then extremity faint contraryly, E Han Curled crouches, Mental fatigue somnolence.In then vomit not the desire drink, the stomachache diarrhea.Control and should removing dampness ward off dirty, warming spleen and stomach for dispelling cold, dysentery is controlled in spleen invigorating.
Modern veterinary's pharmacological research and clinical prolonged application facts have proved that Chinese medicine has whole curative effect height, be difficult for producing drug resistance, residual low, advantages such as toxic and side effects is little, its growth and breeding to many virus causing diseases has significant inhibitory effect, even reaches the pharmacological effect of killing cause of disease.Therefore, we are according to the cause of disease of pig virus diarrhoea, pathogenesis, clinical pathology and drug mechanism carry out Chinese medicine compound control transmissible gastroenteritis of swine, develop evident in efficacy, reliable in quality, it is convenient to use, cheap compound Chinese medicinal preparation, and in Swine Production, apply, have very important economy and social meaning for the sound development that promotes pig industry.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defective, a kind of Chinese medicine composition and application thereof for the treatment of porcine epizootic diarrhea is provided, this Chinese medicine composition has whole curative effect height, be difficult for to produce drug resistance, residual low, advantage such as toxic and side effects is little, its growth and breeding to many virus causing diseases has significant inhibitory effect, even can reach the pharmacological effect of killing cause of disease, have very important economy and social meaning for the sound development that promotes pig industry.
In order to solve the problems of the technologies described above, the invention provides following technical scheme:
A kind of Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 ± 5 parts, Herba Pogostemonis: 150 ± 10 parts, Radix Codonopsis: 80 ± 5 parts, the Rhizoma Atractylodis Macrocephalae: 80 ± 5 parts, Cortex Magnoliae Officinalis: 100 ± 5 parts, the Rhizoma Pinelliae: 100 ± 5 parts, Poria: 80 ± 5 parts, Rhizoma Zingiberis Recens: 50 ± 5 parts, Radix Glycyrrhizae: 80 ± 5 parts.
Preferably, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 parts, Herba Pogostemonis: 150 parts, Radix Codonopsis: 80 parts, the Rhizoma Atractylodis Macrocephalae: 80 parts, Cortex Magnoliae Officinalis: 100 parts, the Rhizoma Pinelliae: 100 parts, Poria: 80 parts, Rhizoma Zingiberis Recens: 50 parts, Radix Glycyrrhizae: 80 parts.
The application of the Chinese medicine composition for the treatment of porcine epizootic diarrhea of the present invention in preparation treatment porcine epizootic diarrhea medicine.
Using method: medicine can be pulverized when specifically using, sieve, behind the mixing directly for the poultry feeding, but also the poultry feeding is given in its active ingredient of reuse water extraction.
Use amount: the pig as every kg body weight gives 3-5 the medicine of gram.
The present invention has following beneficial effect:
Medicine of the present invention is with the hot warm cold expelling of Herba Pogostemonis, removing dampness by means of aromatics, regulate the flow of vital energy and in, stomach function regulating is pleased spleen, wards off the evil preventing or arresting vomiting, the double the exterior and the interior of controlling is monarch.The Flos Lonicerae detoxifcation is warded off dirty; Cortex Magnoliae Officinalis circulation of qi promoting removing dampness, the chest stuffiness relieving relieving distension; The sun of Rhizoma Zingiberis Recens warm the middle warmer and go out interior cold helps Herba Pogostemonis to stretch to send out a yang-energy, and can stopping nausea and vomiting by lowering the adverse flow of QI, makes gastric qi and suitable; Radix Codonopsis QI invigorating invigorating YANG, the spleen invigorating the lucid yang sending up cooperates Rhizoma Zingiberis, coordinates the QI of the spleen and stomach lifting; Be ministerial drug altogether.Rhizoma Pinelliae dampness sending down the abnormal ascending QI, the stomach function regulating preventing or arresting vomiting; Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying helps the Radix Codonopsis QI invigorating; Poria spleen invigorating fortune is wet, is adjuvant drug altogether.Radix Glycyrrhizae QI invigorating and middle emergency, and can separate the poison of Radix Aconiti Lateralis Preparata, can relax Radix Aconiti Lateralis Preparata, the hot strong property of Rhizoma Zingiberis again for making and all medicines.Healthy energy is unobstructed, and is then evil contrary from removing.
The present invention has that removing dampness by means of aromatics, detoxifcation row are turbid, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors function.Prescription is fully with reference to Chinese veterinarian's eight guiding principles for diagnosis, defensive-qi-nutrient-blood, determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs theory, giving consideration to both the exterior and interior, QI and blood is ruled together, special with YAOJING, compatibility is careful and precise, has embodied " prevention of diseae " again, the prevention thought of " preventing exacerbation after being taken ill ", embodied medication as using military forces, the road of using military forces is essence, and the road of medication is pure prescription characteristic.
The specific embodiment
Product embodiments:
Embodiment 1
The Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 85 parts, Herba Pogostemonis: 160 parts, Radix Codonopsis: 85 parts, the Rhizoma Atractylodis Macrocephalae: 85 parts, Cortex Magnoliae Officinalis: 105 parts, the Rhizoma Pinelliae: 105 parts, Poria: 85 parts, Rhizoma Zingiberis Recens: 55 parts, Radix Glycyrrhizae: 85 parts.
Embodiment 2
The Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 75 parts, Herba Pogostemonis: 140 parts, Radix Codonopsis: 75 parts, the Rhizoma Atractylodis Macrocephalae: 75 parts, Cortex Magnoliae Officinalis: 95 parts, the Rhizoma Pinelliae: 95 parts, Poria: 75 parts, Rhizoma Zingiberis Recens: 45 parts, Radix Glycyrrhizae: 75 parts.
Embodiment 3
The Chinese medicine composition for the treatment of porcine epizootic diarrhea, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 parts, Herba Pogostemonis: 150 parts, Radix Codonopsis: 80 parts, the Rhizoma Atractylodis Macrocephalae: 80 parts, Cortex Magnoliae Officinalis: 100 parts, the Rhizoma Pinelliae: 100 parts, Poria: 80 parts, Rhizoma Zingiberis Recens: 50 parts, Radix Glycyrrhizae: 80 parts.
Application Example
Be to use Flos Lonicerae 8kg in the present embodiment, Herba Pogostemonis 15 kg, Radix Codonopsis 8 kg, the Rhizoma Atractylodis Macrocephalae 8 kg, Cortex Magnoliae Officinalis 10 kg, the Rhizoma Pinelliae 10 kg, Poria 8 kg, Rhizoma Zingiberis Recens 5 kg, Radix Glycyrrhizae 8 kg.Accurately take by weighing each medicine according to the above ratio, drying is pulverized, and crosses 60 mesh sieves, mixing, and packing is standby.
Prophylactic tria
In epidemic situation the pig farm takes place, 100 health pig that do not fall ill is divided into 2 groups at random, 50 every group, the 1st group is the chemoprophylaxis group; The 2nd group is matched group; The 1st group every pig feedstuff every day adds hello this product 15g(piglets and reduces by half), connect and fed 7 days; The 2nd group is not added; Two groups of other measures of pig are all by the pig farm immune programme for children of normally sterilizing.
The result shows: the sickness rate of chemoprophylaxis group porcine epizootic diarrhea is 15.0%, and the matched group sickness rate is 82.0%, and spirit, the appetite of medicine group morbidity pig all is better than matched group, and illness symptom is also light than matched group.The prevention group give after the morbidity with treatment after, cure rate is 73.0%; And matched group is 39.0%.
Therapeutic test
The present invention adopts the random double blind test method to carry out the porcine epizootic diarrhea therapeutic test of various dose treatment natural occurrence, and selects the positive medicine matched group of florfenicol for use.Observe the present invention to the porcine epizootic diarrhea therapeutical effect, to inquire into its Application feasibility in Production of Livestock and Poultry.
Therapeutic test to the porcine epizootic diarrhea of natural occurrence: the sick pig that natural occurrence is made a definite diagnosis porcine epizootic diarrhea through clinical diagnosis and laboratory diagnosis is divided into 5 groups, 30 every group at random.The 1-3 group is treatment group (basic, normal, high dosage); The 4th group is florfenicol powder positive drug matched group; The 5th group of positive matched group (infecting not administration).Isolated rearing respectively, situations such as the symptom of the sick pig of itemized record, healing, death.
Medication, administration time: 1 group of medicine: every pig this product 15g(piglets of feeding every day reduces by half), connect and fed 5 days; 2 groups of medicines: every pig this product 30g(piglets of feeding every day reduces by half), connect and fed 5 days; 3 groups of medicines: every pig this product 45g(piglets of feeding every day reduces by half), connect and fed 5 days.The positive drug matched group: every pig this product (10%) florfenicol powder 20mg/ kg body weight (in florfenicol) of feeding every day connects and fed 5 days; Positive controls: not administration.
Experimental result: behind the treatment group medicine feed 24h, the spirit of the sick pig of medicine group is better than positive controls, adds up death toll behind 36 h, and the medicine group is obviously lacked than the positive controls death toll by sick pig; Observe behind 48 h, improvement in various degree appears in each group of medicine, and positive controls still has dead generation the successively.Behind 3 d, spirit, the appetite of the sick pig of medicine group take a favorable turn (increase from sucking amount, feeding capacity and find out), and feces is normal
Statistical result shows that height, middle dosage treatment group cure rate are 65.0%, and mortality rate, total effective rate are 26.5%, 78.5% respectively; Positive controls (not administration) mortality rate (in 10 ages in days) is 92.0%, high, middle dosage treatment group mortality rate (in 10 ages in days) is 43.0%, and treatment is organized the disease pig than the sick pig of matched group, show as sx, the course of disease shortens, and experimental results show that the high, medium and low dosage of the present invention has therapeutical effect to Porcine Epidemic Diarrhea, the energy relief of symptoms, reduce mortality rate, and high, middle dosage reduces mortality rate, improving the effect that aspect such as cure rate all is better than florfenicol.High, middle dosage the present invention can reach the effect of curing the disease, improve survival rate, and both zero differences on 0.05 level, so dosage, so not only economic curative effect but also remarkable in can adopting during clinical use.
From result of the test, the present invention has removing dampness by means of aromatics, the functions such as row is turbid, recuperating depleted YANG and rescuing the patient from collapse, dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, replenishing QI to invigorate the spleen, strengthening vital QI to eliminate pathogenic factors of detoxifying.Do not find that in the clinical trial process this medicine has untoward reaction.High, medium and low dosage has better therapeutic effect to Porcine Epidemic Diarrhea.The therapeutic effect of low dose group is lower than height, middle dosage group, middle and high dosage group there are no significant aspect mortality rate, cure rate and total effective rate difference.Should be according to weight and the treatment cost of the state of an illness, the suggestion clinical practice is with middle dosage (pig 30～50g; Every day, be used in conjunction 3～5 days; Or mixed feeding, every 1kg feedstuff 20～40g) is used in conjunction 3～5 days for well.
For clear and definite toxic and side effects of the present invention, in the hope of its safety is made accurately, objective appraisal, for the clinical trial medication provides scientific basis, guarantee clinical drug safety, carried out toxicity test of the present invention.
By mice being carried out LD50 of the present invention and mtd test shows, after design dosage oral administration, it is normal respectively to organize mice behavior sign in 7 days, poisoning symptom and death all do not occur.So can't measure LD50, and have to be maximum dose level with maximum dosage-feeding 70g/kg.After slaughtering in the 8th day, each organizes the mice internal organs does not all have pathological changes, and pathological characters is not found in the liver,kidney,spleen histological examination yet.Hemogram and serum GPT are active to detect result and normal mouse there was no significant difference.
Use Chinese herb compound the present invention to produce toxicity and the order of severity in order to grasp because of continuous, and the development after the drug withdrawal and recovery situation, reference provided for drafting data for clinical drug use dosage.Carried out subacute toxicity test of the present invention mice, in experimental period, except high dose group is ingested because drug dose causes the palatability difference to influence greatly, all the other respectively organize the mice diet, behavior, and feces is all normal, physically well develop, do not have any poisoning symptom, weightening finish and nutrition except high dose group and matched group significant difference, all the other there are no significant differences.The hemogram of each group and serum GPT are all in normal range.Histological examination, liver,kidney,spleen etc. all do not have obvious poisoning pathological changes.By the 3-10 of the clinical application amount 30d that doubly feeds, do not see toxic and side effects yet, the clinical medicine dose that said preparation is described is very safe.
Medicine of the present invention is according to the listing terms of packing, in temperature: 40 ℃ ± 2 ℃, relative humidity: accelerate experiment 3 months under 75% ± 5% condition, quality does not have significant change.In temperature: 25 ℃ ± 2 ℃ relative humiditys: long term test is 24 months under 60% ± 10% condition, and quality does not have significant change.
Above-mentioned result of the test shows that medicine of the present invention storage quality under rated condition is stable.
It should be noted that at last: the above only is the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment the present invention is had been described in detail, for a person skilled in the art, it still can be made amendment to the technical scheme that aforementioned each embodiment puts down in writing, and perhaps part technical characterictic wherein is equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. a Chinese medicine composition for the treatment of porcine epizootic diarrhea is characterized in that, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 ± 5 parts, Herba Pogostemonis: 150 ± 10 parts, Radix Codonopsis: 80 ± 5 parts, the Rhizoma Atractylodis Macrocephalae: 80 ± 5 parts, Cortex Magnoliae Officinalis: 100 ± 5 parts, the Rhizoma Pinelliae: 100 ± 5 parts, Poria: 80 ± 5 parts, Rhizoma Zingiberis Recens: 50 ± 5 parts, Radix Glycyrrhizae: 80 ± 5 parts.
2. the Chinese medicine composition for the treatment of porcine epizootic diarrhea according to claim 1 is characterized in that, it is grouped into by the one-tenth of following weight portion:
Flos Lonicerae: 80 parts, Herba Pogostemonis: 150 parts, Radix Codonopsis: 80 parts, the Rhizoma Atractylodis Macrocephalae: 80 parts, Cortex Magnoliae Officinalis: 100 parts, the Rhizoma Pinelliae: 100 parts, Poria: 80 parts, Rhizoma Zingiberis Recens: 50 parts, Radix Glycyrrhizae: 80 parts.
3. the application of the Chinese medicine composition of the described treatment porcine epizootic diarrhea of claim 1 in preparation treatment porcine epizootic diarrhea medicine.
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| CN106692624A (en) * | 2016-11-26 | 2017-05-24 | 安徽裕龙种植农民专业合作社 | Method for preventing epidemic diarrhea of pork pig |
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