CN104645274A - Traditional Chinese medicine composition for treating cow acute gastroenteritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cow acute gastroenteritis and preparation method thereof Download PDFInfo
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- CN104645274A CN104645274A CN201310593923.8A CN201310593923A CN104645274A CN 104645274 A CN104645274 A CN 104645274A CN 201310593923 A CN201310593923 A CN 201310593923A CN 104645274 A CN104645274 A CN 104645274A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cow acute gastroenteritis and a preparation method thereof. The traditional Chinese medicine composition comprises the following ingredients, by weight, 10-30 parts of white peony root, 10-20 parts of radix scutellariae, 5-20 parts of fructus aurantii, 1-10 parts of fortune eupatorium herb, 1-10 parts of magnolia cortex, 5-20 parts of pinellia tuber, 1-10 parts of ginger and 1-5 parts of licorice root. The traditional Chinese medicine composition has antimicrobial, anti-inflammation, heat-clearing and antidiarrheal effects, has little toxic and side effect, is not easy to generate drug resistance, has no drug residue, is convenient to use, is low-cost, meets requirements of safe veterinary drug and animal-derived food safety guarantee, and is an ideal traditional Chinese medicine composition for treating cow acute gastroenteritis.
Description
Technical field
The invention belongs to field of veterinary, especially a kind ofly treat Chinese medicine composition of dairy cow acute gastroenteritis and preparation method thereof.
Background technology
Dairy cow acute gastroenteritis due to feeding and management improper, eaten mouldy, rotten and freezing feedstuff, eaten poisonous plants, one of pesticide or the milch cow common disease caused by other poisonous substances by mistake.Its clinical main manifestations is disease just poor appetite, and drink is for increasing, and body temperature increases, diarrhoea, and loose and watery stool is medicated porridge sample or water sample, the mucous membrane tissue being mixed with blood in feces He coming off; Later stage defecation incontinence, myasthenia of limbs, muscular tremor, lethargy or spasm.Ill rear milch cow is declined to a great extent in peak period milk yield of giving milk, and loses weight, and causes huge economic loss to dairy.Clinical treatment common antibiotics etc. is treated, and makes Resistant strain increasing, and medicine has the residual health also directly threatening the mankind in human body.Animal body easily absorbs Chinese medicine preparation, and toxic and side effects is little, and noresidue, without Drug resistance, pollution-free, therefore it has natural advantage in the treatment of dairy cow acute gastroenteritis.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of dairy cow acute gastroenteritis, this Chinese medicine composition, have effect of antibacterial, antiinflammatory, heat clearing away, antidiarrheal, have no side effect, not easily produce drug resistance, bioavailability is high.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of dairy cow acute gastroenteritis.
The present invention is achieved by the following technical solutions:
Treat a Chinese medicine composition for dairy cow acute gastroenteritis, component and the ratio of weight and number thereof of its Chinese medicine composition are respectively:
Treat a preparation method for the Chinese medicine composition of dairy cow acute gastroenteritis, the step of its preparation method is as follows:
(1) take the Radix Paeoniae Alba, Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae respectively according to weight proportion, be ground into powder, and respectively all by 80 mesh sieves;
(2) Radix Paeoniae Alba after sieving in step (1), Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae are put in blending tank, abundant mix homogeneously, the Chinese medicine composition finished product of the dairy cow acute gastroenteritis that namely obtains medical treatment.
Advantage of the present invention and beneficial effect are:
The Radix Paeoniae Alba contained in the Chinese medicine composition of 1, this treatment dairy cow acute gastroenteritis, Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, the Chinese medicinal ingredients such as Rhizoma Zingiberis Recens and Radix Glycyrrhizae, it has good preventive and therapeutic effect to the gastroenteritis that antibacterial and mycete etc. cause, antibacterial action successful.
2, the Chinese medicine composition broad-spectrum high efficacy of this treatment dairy cow acute gastroenteritis, steady quality, easily absorbs, and does not affect by temperature and acid-base value, can reach blood peak concentration of drug in the short period with extremely low concentration.
3, the present invention has effect of antibacterial, antiinflammatory, heat clearing away, antidiarrheal, and toxic and side effects is little, has no drug resistance, drug residue free, easy to use, cost is lower, meeting safe veterinary drug, ensure the requirement of animal-derived food safety, is a kind of Chinese medicine composition of ideal treatment dairy cow acute gastroenteritis.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
The Radix Paeoniae Alba involved in the present invention, Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae all commercially can be bought and obtain.
Embodiment 1
Treat a Chinese medicine composition for dairy cow acute gastroenteritis, component and the weight thereof of its Chinese medicine composition are respectively: Radix Paeoniae Alba 10g; Radix Scutellariae 10g; Fructus Aurantii 5g; Herba Eupatorii 1g; Cortex Magnoliae Officinalis 1g; Rhizoma Pinelliae 5g; Rhizoma Zingiberis Recens 1g; Radix Glycyrrhizae 1g.
Treat a preparation method for the Chinese medicine composition of dairy cow acute gastroenteritis, the step of preparation method is as follows:
(1) take the Radix Paeoniae Alba, Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae respectively according to weight proportion, be ground into powder, and respectively all by 80 mesh sieves;
(2) Radix Paeoniae Alba after sieving in step (1), Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae are put in blending tank, abundant mix homogeneously, the Chinese medicine composition finished product of the dairy cow acute gastroenteritis that namely obtains medical treatment.
Embodiment 2
Treat a Chinese medicine composition for dairy cow acute gastroenteritis, component and the weight thereof of its Chinese medicine composition are respectively: Radix Paeoniae Alba 30g; Radix Scutellariae 20g; Fructus Aurantii 20g; Herba Eupatorii 10g; Cortex Magnoliae Officinalis 10g; Rhizoma Pinelliae 20g; Rhizoma Zingiberis Recens 10g; Radix Glycyrrhizae 5g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treat a Chinese medicine composition for dairy cow acute gastroenteritis, component and the weight thereof of its Chinese medicine composition are respectively: Radix Paeoniae Alba 20g; Radix Scutellariae 15g; Fructus Aurantii 17g; Herba Eupatorii 5g; Cortex Magnoliae Officinalis 5g; Rhizoma Pinelliae 17g; Rhizoma Zingiberis Recens 5g; Radix Glycyrrhizae 3g.
The step of its preparation method is with embodiment 1.
Clinical practice
In order to verify the clinical therapeutic efficacy of the present invention to dairy cow acute gastroenteritis, we have carried out the therapeutic test of dairy cow acute gastroenteritis in milk cattle cultivating base, Wuqing District, Tianjin.In test, often organizing Chinese medicine composition is divided into basic, normal, high three dosage to carry out grouping administration to animal, carry out comparitive study with the routine medication of cattle farm acute gastroenteritis, thus evaluate Chinese medicine composition of the present invention at dairy cow acute gastroenteritis therapeutic effect and optimum amount.
1, materials and methods
1.1 experimental animal
Select acute gastroenteritis morbidity milch cow 20, often organize 4.Milch cow is raised according to normal feeding and management program.
1.2 trial drug
The present invention is prepared by our company.
Sulphaguanidine tablet: 0.5g × 1000 slice/bag, Linyi, Shandong Jin Cui veterinary drug company limited, product batch number * * * * * *
1.3 test method
The case of dairy cow acute gastroenteritis is made a definite diagnosis primarily of incidence and clinical symptoms, then sick cattle random packet is treated by experimenter.
The diagnostic criteria of 1.4 dairy cow acute gastroenteritiss
Clinical symptoms:
Sick cattle initial stage poor appetite, drink is for increasing, and body temperature increases, conjunctiva flushing, xanthochromia, xerostomia, frowziness, and ruminate and reduce or stop, asoscope is dry; Diarrhoea, loose and watery stool is medicated porridge sample or water sample, stench, the mucous membrane tissue being mixed with vigorous liquid, blood in feces and coming off, and what have is mixed with pus; Have stomachache in various degree and muscular tremor, swollen abdomen is rolled up, and intestinal sound weakens, and occurs suffering from diarrhoea and being mixed with blood, and intestinal sound equipment is bright, slightly suffers from abdominal pain.Later stage intestinal sound disappears, slack anus, defecation incontinence, and stomach wall is crispaturaed, myasthenia of limbs, muscular tremor, and spirit is highly depressed, enophthalmos, and conjunctiva be bluish violet, tongue shrinkage, thready and weak pulse and fast, per minutely reaches 80-100 time, lethargy or spasm, then rapid death.Inflammation is confined to the duodenal gastroenteritis of harmonization of the stomach, and ill domestic animal oral cavity is slitted greasy or dry, and abnormal smells from the patient is smelly, and yellow fur is thick; Discharge feces slow, amount is few, argol is little, color is dark, the mucus of surface coverage volume; Often there is slight colic symptoms.
1.5 experimental animal groupings and process
Each case is included into trial drug group of the present invention at random respectively, its dosage difference be divided into following four groups and sulphaguanidine tablet matched group as follows:
Testing 1 group is matched group, does not process;
Testing 2 groups is low dose group of the present invention, 1/2 times amount administration of clinical recommended dose (per kilogram of body weight 0.5g), spice, successive administration 5 days;
Testing 3 groups is dosage group in the present invention, clinical recommended dose (per kilogram of body weight 1g) administration, spice, successive administration 5 days;
Testing 4 groups is high dose group of the present invention, 2 times amount administrations of clinical recommended dose (per kilogram of body weight 2g), spice, successive administration 5 days;
Testing 5 groups is sulphaguanidine tablet group, uses to specifications: spice, by per kilogram of body weight 0.2g administration, and successive administration 5 days.
1.6 therapeutic effect decision methods
Clinical symptom disappearance, cuts open inspection without obvious pathological change.
Cure: clinical symptom disappearance, defecation recovers normal.
Effective: clinical symptom relief, feces water sample alleviates.
Invalid: each clinical symptoms in criterion does not alleviate or aggravates.
1.7 statistical analysis
Through X2 inspection, test 2 groups of cure rates and total effective rate significantly lower than other each group (P < 0.05) other each group differences not significantly (P > 0.05).
2 result of the tests
To the milch cow suffering from acute gastroenteritis, give this Chinese medicine composition of various dose respectively, after spice, by comparing with matched group, the clinical symptoms of sick cattle obviously alleviates, and level of giving milk is recovered.Low dose group therapeutic effect is not obvious, and therapeutic effect and the milk yield recovery level of middle dosage group all reach desirable requirement; Sulphaguanidine tablet treatment of control group effect is ideal, but milk yield recovers level obviously not as the present invention.The results are shown in Table 1.
Table 1 observation of curative effect
3 interpretations of result
Analyze from clinical symptoms, treatment of giving milk, each and every one aspect of cure rate three, the therapeutic effect of middle dosage group and high dose group is apparently higher than other treatment group, wherein best with the prevention effect of middle dosage group.Sulphaguanidine tablet matched group has certain therapeutic effect, but after treatment, milk production of cow is affected, and economic loss is larger.
4 conclusions
The present invention is by the administration of per kilogram of body weight 1g spice, dairy cow acute gastroenteritis was treated in continuous 5 days, to due to feeding and management improper, eaten mouldy, rotten and freezing feedstuff, eaten poisonous plants, pesticide or the dairy cow acute gastroenteritis Be very effective caused by other poisonous substances by mistake.
Claims (2)
1. treat a Chinese medicine composition for dairy cow acute gastroenteritis, it is characterized in that: the component of this Chinese medicine composition and ratio of weight and number thereof are:
2. a preparation method for the Chinese medicine composition for the treatment of dairy cow acute gastroenteritis as claimed in claim 1, is characterized in that: the step of this preparation method is as follows:
(1) take the Radix Paeoniae Alba, Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae respectively according to weight proportion, be ground into powder, and respectively all by 80 mesh sieves;
(2) Radix Paeoniae Alba after sieving in step (1), Radix Scutellariae, Fructus Aurantii, Herba Eupatorii, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Rhizoma Zingiberis Recens and Radix Glycyrrhizae are put in blending tank, abundant mix homogeneously, the Chinese medicine composition finished product of the dairy cow acute gastroenteritis that namely obtains medical treatment.
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| CN201310593923.8A CN104645274A (en) | 2013-11-21 | 2013-11-21 | Traditional Chinese medicine composition for treating cow acute gastroenteritis and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105435191A (en) * | 2015-12-31 | 2016-03-30 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for preventing and treating acute diarrhea after delivery of dairy cow and preparation process of traditional Chinese medicine composition |
| CN106539970A (en) * | 2015-09-22 | 2017-03-29 | 刘吴阳 | It is a kind of to cure calf coccidiosiss property enteritis prescription |
| CN107638556A (en) * | 2017-11-06 | 2018-01-30 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of rabbit gastroenteritis and preparation method thereof |
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| CN1348801A (en) * | 2001-10-26 | 2002-05-15 | 陈新 | Veterinary medicine for preventing and treating animal's gastrointestinal tract diseases |
| CN102755623A (en) * | 2012-07-27 | 2012-10-31 | 廖天源 | Medicine for treating acute gastroenteritis and preparation method thereof |
| CN103202987A (en) * | 2013-04-13 | 2013-07-17 | 上海浦东高星生物技术研究所 | Acute gastroenteritis pills |
| CN103230574A (en) * | 2013-04-25 | 2013-08-07 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof |
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2013
- 2013-11-21 CN CN201310593923.8A patent/CN104645274A/en active Pending
Patent Citations (4)
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| CN1348801A (en) * | 2001-10-26 | 2002-05-15 | 陈新 | Veterinary medicine for preventing and treating animal's gastrointestinal tract diseases |
| CN102755623A (en) * | 2012-07-27 | 2012-10-31 | 廖天源 | Medicine for treating acute gastroenteritis and preparation method thereof |
| CN103202987A (en) * | 2013-04-13 | 2013-07-17 | 上海浦东高星生物技术研究所 | Acute gastroenteritis pills |
| CN103230574A (en) * | 2013-04-25 | 2013-08-07 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medical composition for treating porcine epizootic diarrhea and application thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106539970A (en) * | 2015-09-22 | 2017-03-29 | 刘吴阳 | It is a kind of to cure calf coccidiosiss property enteritis prescription |
| CN105435191A (en) * | 2015-12-31 | 2016-03-30 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for preventing and treating acute diarrhea after delivery of dairy cow and preparation process of traditional Chinese medicine composition |
| CN105435191B (en) * | 2015-12-31 | 2019-02-19 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition and its preparation process for preventing and treating milk cow postpartum acute diarrhea |
| CN107638556A (en) * | 2017-11-06 | 2018-01-30 | 天津瑞贝特科技发展有限公司 | Treat Chinese medicine composition of rabbit gastroenteritis and preparation method thereof |
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Application publication date: 20150527 |