CN103179989A - 用于递送编码免疫原的rna的小脂质体 - Google Patents

用于递送编码免疫原的rna的小脂质体 Download PDF

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CN103179989A
CN103179989A CN2011800511618A CN201180051161A CN103179989A CN 103179989 A CN103179989 A CN 103179989A CN 2011800511618 A CN2011800511618 A CN 2011800511618A CN 201180051161 A CN201180051161 A CN 201180051161A CN 103179989 A CN103179989 A CN 103179989A
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rna
liposome
liposomes
virus
immunogen
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A·吉尔
A·维尔玛
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Novartis Vaccines and Diagnostics Inc
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Novartis Vaccines and Diagnostics Inc
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Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of CN103179989A publication Critical patent/CN103179989A/zh
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
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    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • C12N2770/36011—Togaviridae
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CN2011800511618A 2010-08-31 2011-08-31 用于递送编码免疫原的rna的小脂质体 Pending CN103179989A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37883110P 2010-08-31 2010-08-31
US61/378,831 2010-08-31
PCT/US2011/049873 WO2012030901A1 (en) 2010-08-31 2011-08-31 Small liposomes for delivery of immunogen-encoding rna

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CN103179989A true CN103179989A (zh) 2013-06-26

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US (1) US9254265B2 (https=)
EP (6) EP4008357B1 (https=)
JP (2) JP2013538569A (https=)
CN (1) CN103179989A (https=)
AU (8) AU2011296062A1 (https=)
BR (1) BR112013004879A2 (https=)
CA (1) CA2809678A1 (https=)
DK (4) DK4043040T3 (https=)
ES (4) ES2941244T3 (https=)
FI (3) FI4008357T3 (https=)
HR (4) HRP20230501T1 (https=)
HU (4) HUE061463T2 (https=)
LT (4) LT4066819T (https=)
MX (1) MX341989B (https=)
PL (4) PL4066819T3 (https=)
PT (4) PT4043040T (https=)
RS (4) RS63890B1 (https=)
RU (1) RU2671482C2 (https=)
SI (4) SI4043040T1 (https=)
SM (4) SMT202300096T1 (https=)
WO (1) WO2012030901A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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CN106659803A (zh) * 2014-04-23 2017-05-10 摩登纳特斯有限公司 核酸疫苗
CN110430894A (zh) * 2017-02-01 2019-11-08 莫得纳特斯公司 编码活化致癌基因突变肽的免疫调节治疗性mrna组合物
CN113230394A (zh) * 2021-04-30 2021-08-10 广州源博医药科技有限公司 一种用于牛病毒性腹泻的rna疫苗及其构建方法
CN116194139A (zh) * 2020-05-20 2023-05-30 旗舰创业创新第六有限责任公司 免疫原性组合物及其用途

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