CN103156798A - Cosmetic composition for anti-oxidation or skin whitening containing extract of medicinal herbs mixture - Google Patents
Cosmetic composition for anti-oxidation or skin whitening containing extract of medicinal herbs mixture Download PDFInfo
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- CN103156798A CN103156798A CN2012105564143A CN201210556414A CN103156798A CN 103156798 A CN103156798 A CN 103156798A CN 2012105564143 A CN2012105564143 A CN 2012105564143A CN 201210556414 A CN201210556414 A CN 201210556414A CN 103156798 A CN103156798 A CN 103156798A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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Abstract
The invention provides a cosmetic composition for anti-oxidation, which is capable of removing radical generated by various physical, chemical and environmental factors, or a cosmetic composition capable of preventing melanin deposition and having good skin whitening effect. The cosmetic composition contains extract of medicinal herbs mixture, and can prevent oxidation caused by reactive oxygen in skin and have good anti-oxidation effect, and can prevent melanin deposition and have good skin whitening effect. The cosmetic composition comprises effective contents like as arum, sichuan lovage rhizome, and almond extract.
Description
Technical field
The antioxidation that the present invention relates to eliminate the free radical that the active oxygen due to generations such as various physics, chemistry and environmental factorss the causes compositions that applies some make up maybe can stop melanin deposition and the cosmetic composition of skin-whitening effect brilliance, particularly, relate to and contain the medical material mixed extract and can suppress the oxidation that in skin, active oxygen causes and antioxidant effect is remarkable, hinder the dermal melanin precipitation and the cosmetic composition of whitening effect excellence.
Background technology
Known active oxygen due to the generations such as various physics, chemistry and environmental factors such as enzyme system, reductive metabolism, chemical drugs, public hazards material and photochemical reaction in body plays destruction non-selective, non reversibility to cellularity composition lipid, protein, sugar and DNA etc., thereby causes the various diseases such as cell senescence or cancer.In addition, the various body endoperoxides such as lipid peroxide that the result of the lipid peroxidation that these active oxygens cause generates also produce Oxidative demage and cause various dysfunctions cell, thereby become the cause of disease of various diseases.Therefore, the antioxidants such as free radical scavenger (free radical scavengers) or peroxide formation inhibitor are expected to inhibitor or the therapeutic agent of the aging and various diseases that causes as these oxides.
In addition, many factors participate in to determine the human body skin-color, wherein makes the factors such as whether the inside and outside pigments of human body such as the thickness of activeness, vascularity, skin of melanocyte (melanocyte) and carotenoid, bilirubin contain particularly important.
Wherein, especially most important factor is called melanic black pigment for what the various enzyme effects such as tryrosinase in the melanocyte in human body generated.The environmental factorss such as the physiologic factor related with inherited genetic factors, hormone secretion, pressure etc. and ultraviolet radiation exert an influence to this melanin.
The melanin that generates in the melanocyte of body skin is the phenols polymer substance with complex form of black pigment and protein; the skin organ below corium is protected in blocking-up from the ultraviolet that shines upon, also effectively taking on simultaneously to catch the free radical that generates in the skin body etc. and the effect of protection skin internal protein and gene.
So, the melanin that produces due to the inside and outside stress stimulation of skin is even be after stress disappearing until the stable material that can not disappear before discharging to the outside by skin keratin.But the excessive generation of melanin is can bring out nevus, freckle, point to wait pigementation disease and brought bad esthetic result.
In addition, because the increase of leisure population is liked out of doors movable people and increased, the demand of the melanin deposition that ultraviolet blocking-up is caused also increases.
For catering to people's this demand, be with ascorbic acid, kojic acid, arbutin, hydroquinone, glutathion or their derivant in the past or have tryrosinase and hinder active material and cosmetics or pharmaceuticals and be used in conjunction with, but, due to the problems such as their whitening effect, the safety issue to skin, the dosage form that occurs when cosmetics coordinate and stability, the restriction of being used.
Herba Asari is the herbaceos perennial of Aristolochiaceae, the rhizome more piece, and two blades that the end of stem grows stretch to both sides.Herba Asari is the medical material with the root drying of Herba Asari, and the title of Herba Asari is title superfine due to root and that get with acid.Be called in " official reads township's name " and wash the heart, or also referred to as thin, few hot, Herba Ceratophylli Demeersi.Leaf is heart-shaped, wide 5-10cm, edge-smoothing.Flower grows 1 at the leaf among for reddish violet when leaf sprouts.Fruit is berry, and end is with the perianth sliver, and there is the seed of 20 left and right the inside.Root gathered in 5-7 month, and shady and cool place is dry.The property of medicine is gentle, acrid in the mouth.Effect is constantly discharged for being used for flu nasal obstruction, rhinorrhea, throat secretions, perspire when not perspiring, with pathogen to external discharge.And the urgent flu that is used for is had a high fever, and headache is serious and the symptom such as can't stand.Discharge a large amount of expectorant that chronic bronchitis or bronchiectasis cause, cough and to play antitussive effect when serious.In addition, making powder during stomatitis just smears and can be cured at once.But forbid during the headache that the deficiency of vital energy, hyperhidrosis or anemia cause, can not with the Rhizoma et radix veratri (Radix Rhizoma Veratri) compatibility.Also spread among the people containing in toothache place and can be eased pain and as analgesics.The prescription of representative has asarum decoction.
Rhizoma Chuanxiong is to belong to umbelliferous herbaceos perennial.The township is called rhizome of chuanxiong Qiong, and formal name used at school is Cnidiumofficinale MAKINO.Chinese Flora also generally has plantation in Korea S, and height is 30-60 ㎝, and stem is upright, the top branch.The leaf alternate, 2 times winglike compound leaves, the petiole of root leave is long, and stem leaf upwards diminishes gradually, and leaf base becomes sheath stem is wrapped up, and lobule is avette or lanceolar, has to incise shape sawtooth and sharp sawtooth.Flower was opened in August, formed large umbel at an end and stem end.Tender leaf is edible as wild herbs, and rhizome is dry as medical material.Contain a large amount of volatile oils and the perfume (or spice) of distinguishing the flavor of.Main constituent has cnidiumm lactone (cnidilide), neocindilide (neocnidilide), Rhizoma Chuanxiong lactone (ligustilide) etc.Confirm to have sedation effect to the central nervous system by animal pharmacological experiment, also confirm to have hypotensive activity weak but that continue.Can increase the contractility in uterus in the test of smooth muscle, and also have bactericidal action and demonstrate the effect of the growth that suppresses escherichia coli, dysentery bacillus, green pus bacterium, dermatophytes.This medicine property of medicine is gentle, sour in the mouth, makes blood circulation vigorous after entering in body, and eliminate pain has analgesic effect.Therefore multiplex in headache.The menstruation that also can be used for gynecological has some setbacks, dysmenorrhea, puerperal abdonimal pain and the symptom such as dizzy.In addition, also make the functional activation of liver, can play the blood effect of transferring when being used for anemia.The effect that also has the pain to the depressed cardia of myocardial contraction also to take a favorable turn.Waist and shank skeleton be weak, when people that muscle spasm often occurs takes, above-mentioned symptom can improve.Avoid and the Rhizoma Coptidis compatibility, clothes are hindered vigour for a long time.Be put into pre-favorable moth-proof in wardrobe among the people.Representational prescription has vault to return soup, multiplex in the woman antenatal and puerperal.Rhizoma Chuanxiong is one of medical material that often uses in South Korea.
Semen Armeniacae Amarum be in domestic Rosaceae Prunus mandshurica var.glabra, Prunusmandshurica, the dry seed of Prunus sibirica.Effect with relieving cough and expelling phlegm is used as the medical material for the treatment of cough, asthma, bronchitis, acute hepatitis etc. among the people.The main component of Semen Armeniacae Amarum is citric acid, malic acid, amygdalin, olein etc., especially is rich in addition calcium and phosphorus, also contains saccharic, calcium, sodium, cellulosic, vitamin A, B, C etc.Provide moisturizing and nutrition to coarse and dry skin, also have the effect of removing microgroove, freckle and whitening and exfoliation.Recorded in Compendium of Materia Medica and reached the Therapeutic Method that kind more than 200 is utilized Semen Armeniacae Amarum, as seen more than its purposes and drug effect, therefore also have the another name of " Fructus Pruni in pharmacy ", the facial film of Semen Armeniacae Amarum pulverizing manufacturing is used for the treatment of skin pigment precipitation, furuncle, the pustules etc. such as black naevus, freckle.
Summary of the invention
Goal of the invention
The present inventor screens various natural goodses in order to address the above problem and seek more excellent antioxidation and whitening raw material, the medical material mixed extract that found that Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum composition is compared simple extract, the antioxidant whitening effect is significantly excellent, thereby has completed the present invention.
Therefore, the object of the present invention is to provide and contain Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract as the cosmetic composition of effective ingredient.Another object of the present invention is to provide and contain Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract as the antioxidation of the effective ingredient compositions that applies some make up.Another order of the present invention is to provide and contains Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract and have the cosmetic composition that free radical is eliminated function as effective ingredient.Another purpose of the present invention is to provide and contains the cosmetic composition that Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract have the skin-whitening effect as effective ingredient.
Technical scheme
In order to achieve the above object, the invention provides and contain Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract as the cosmetic composition of effective ingredient.
The below describes the present invention in detail.
Herba Asari extract of the present invention, Rhizoma Chuanxiong extract and Semen Armeniacae Amarum extract can obtain by this area usual way, and its method is not particularly limited.Instantiation is, adds ethanol in Herba Asari, Rhizoma Chuanxiong or Semen Armeniacae Amarum with drying, after effective component extracting, carries out sedimentation after reflux, extract,, and is concentrated by the filtrate decompression that filtration and centrifugalize separate, thereby obtains the extract of Herba Asari, Rhizoma Chuanxiong or Semen Armeniacae Amarum.
Herba Asari of the present invention, Rhizoma Chuanxiong and Semen Armeniacae Amarum mixed extract with respect to the gross weight of compositions, contain the 0.001-20 % by weight; Preferably, contain the 0.005-10 % by weight.Less than 0.001 % by weight, the effect that can't obtain expecting; Surpass 20 % by weight, might cause the degeneration of the fouling cosmetics of etc.ing, the viscosity adjustment of cosmetics polarity becomes difficulty, easily generation phase transfer and can't develop State of cosmetics when the emulsion dosage form is made, and production economy also reduces.
The mixing ratio of the Herba Asari extract that contains in cosmetic composition of the present invention, Rhizoma Chuanxiong extract and Semen Armeniacae Amarum extract is the 1:1-3:1-3 weight ratio.Surpass this mixing ratio and can't expect the cooperative effect of composition.
Cosmetic composition provided by the invention contains the mixed extract of Herba Asari extract as above, Rhizoma Chuanxiong extract and Semen Armeniacae Amarum extract, thereby can show the effect of the skin oxidation reaction that ultraviolet blocking-up, other outside harmful components are brought out and hinder the calm and whitening effect that obtains of dermal melanin.
Cosmetic composition of the present invention can be used for the whitening of skin antioxidant and applies some make up, its dosage form is not particularly limited, and can be for example frost before emulsion, frost, astringent, elite, facial film, gel, powder, lipstick, adornment, foundation cream, skin care liquid or the dosage form of skin-adherent type cosmetics or the dosage form of percutaneous dosing.
Beneficial effect
Confirmed in the present invention that the cosmetic composition that contains careful extract, Rhizoma Chuanxiong extract and Semen Armeniacae Amarum extract has the antioxidant effect of DPPH generation inhibition and improves ultraviolet (ultraviolet rays; UV) the Pigmented effect that causes and the whitening effect that brings.Thereby Herba Asari of the present invention, Rhizoma Chuanxiong and Semen Armeniacae Amarum mixed extract can be effective to antioxidation, whitening apply some make up compositions or pharmaceutical compositions.
The specific embodiment
Reach by the following examples experimental example and illustrate the present invention, but protection scope of the present invention and can't help that their limit.
Comparative example 1: the manufacturing of Herba Asari extract
Add 70% ethanol 2L in dry Herba Asari 300g, reflux, extract, 3 times was 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains extract 24g by concentrating under reduced pressure.
Comparative example 2: the manufacturing of Rhizoma Chuanxiong extract
Add 70% ethanol 2L in dry Rhizoma Chuanxiong 300g, reflux, extract, 3 times was 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains extract 33g by concentrating under reduced pressure.
Comparative example 3: the manufacturing of Semen Armeniacae Amarum extract
Add 70% ethanol 2L in dry Semen Armeniacae Amarum 300g, reflux, extract, 3 times was 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains extract 35g by concentrating under reduced pressure.
Embodiment 1: the mixed extract manufacturing of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum
After the Semen Armeniacae Amarum extract 20g of the Rhizoma Chuanxiong extract 20g of the Herba Asari extract 20g of comparative example 1, comparative example 2 and comparative example 3 is mixed, add 70% ethanol water 400ml to dissolve fully, then 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains the mixed extract 46g of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum by concentrating under reduced pressure.
Embodiment 2: the mixed extract manufacturing of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum
After the Semen Armeniacae Amarum extract 12g of the Rhizoma Chuanxiong extract 36g of the Herba Asari extract 12g of comparative example 1, comparative example 2 and comparative example 3 is mixed, add 70% ethanol water 450ml to dissolve fully, then 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains the mixed extract 49g of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum by concentrating under reduced pressure.
Embodiment 3: the mixed extract manufacturing of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum
After the Semen Armeniacae Amarum extract 36g of the Rhizoma Chuanxiong extract 12g of the Herba Asari extract 12g of comparative example 1, comparative example 2 and comparative example 3 is mixed, add 70% ethanol water 450ml to dissolve fully, then 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains the mixed extract 48g of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum by concentrating under reduced pressure.
Embodiment 4: the mixed extract manufacturing of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum
After the Semen Armeniacae Amarum extract 25.5g of the Rhizoma Chuanxiong extract 25.5g of the Herba Asari extract 8.5g of comparative example 1, comparative example 2 and comparative example 3 is mixed, add 70% ethanol water 450ml to dissolve fully, then 15 ℃ of lower sedimentations 1 day.Then, filter with filter cloth and with centrifugalize, residue is separated with filtrate, the filtrate of separation obtains the mixed extract 48g of Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum by concentrating under reduced pressure.
Experimental example 1: antioxidant effect test (DPPH test)
Used by by organic free radical DPPH(1 1-diphenyl-2-nitro hydrazyl (1,1-diphenyl-2-picryl hydrazyl)) reduction (antioxidant is oxidation) and the absorbance that occurs change to estimate antioxidation can method.The oxidation of DPPH is inhibited mensuration due to following example, and absorbance is compared the degree that matched group reduces, and the concentration that demonstrates the absorbance of minimizing 50% with the absorbance with respect to matched group is estimated as effective antioxidation concentration.
100 μ M(are in ethanol) DPPH solution 190 μ l and described comparative example, embodiment 1-4 extract and comparison test portion and each 10 μ l manufacturing reactant liquor of contrast test portion, after 30 minutes, measure absorbance in reaction under 37 ℃ under 540nm.The contrast test portion uses watermiscible vitamin E (Trolox) in widely used synthetized oxidation preventive agent.
The DPPH analysis result of each material is shown in following table 1.
Table 1
DPPH analysis result (suppressing %) (IC50: the concentration of the test portion when absorbance reduces 50% owing to adding test portion)
By confirming in table 1, the mixed extract of the Herba Asari of embodiment of the present invention 1-4, Rhizoma Chuanxiong and Semen Armeniacae Amarum is compared the single extract of comparative example, demonstrate better activity, demonstrate with antioxidant well known in the art in the similar oxidation resistance of watermiscible vitamin E.
Experimental example 2: the mensuration of utilizing the chromatophorous melanin generation inhibition of mouse
For the melanin of confirming described comparative example and embodiment extract and contrast test portion generates inhibition, utilize the pigment cell of mouse to measure.
At first, Mus pigment cell (Mel-Ab the cell) (Dooley of C57BL/6 mice will be derived from, T.P.et al, Skin pharmacol, 7, pp 188-200) access contains in the DMEM culture medium of 10% hyclone, 100nM 12-O-TPA (12-O-tetradecanoylphorbol-13-acetate), 1nM cholera toxin (cholera toxin), at 37 ℃, 5%CO
2Condition under cultivate.With the Mel-Ab cell cultivated with 0.25% insulin-EDTA separation, at the 24-orifice plate with 10
5The concentration cultured cell of cells/well (cells/well), second day begin add as substances and cultivate with the hydroquinone of 10ppm, described comparative example, embodiment extract and contrast test portion for three days on end.At this moment, described hydroquinone uses as positive controls.Then remove culture fluid, with after PBS washing, with 1N dissolution of sodium hydroxide cell, measure absorbance under 400nm, then calculate melanin generating suppression according to following mathematical expression 1, with its result in (method of Dooley) shown in table 2.
Mathematical expression 1
The absorbance of the absorbance/matched group of melanin generating suppression (%)=100-(substances * 100)
Table 2
Substances | Melanin generating suppression (%) |
Comparative example 1 (10ppm) | 12.5 |
Comparative example 2 (10ppm) | 24.8 |
Comparative example 3 (10ppm) | 23.1 |
Embodiment 1 (10ppm) | 49.5 |
Embodiment 2 (10ppm) | 51.4 |
Embodiment 3 (10ppm) | 50.5 |
Embodiment 4 (10ppm) | 52.0 |
Hydroquinone (matched group) | 50.8 |
Matched group | 0 |
As above shown in table 2, the single extract that Herba Asari, Rhizoma Chuanxiong and the Semen Armeniacae Amarum mixed extract that confirmation embodiment of the present invention 1-4 obtains compared comparative example demonstrates better melanin generating suppression, especially, mixed extract demonstrates the melanin generating suppression with the similar degree of hydroquinone.
Claims (6)
1. a cosmetic composition, is characterized in that, described cosmetic composition contains Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract as effective ingredient.
2. cosmetic composition according to claim 1, wherein, take the gross weight of described cosmetic composition as benchmark, the content of described Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract is the 0.001-20 % by weight.
3. cosmetic composition according to claim 1 and 2, wherein, the weight ratio of described Herba Asari, Rhizoma Chuanxiong and Semen Armeniacae Amarum extract is 1:1-3:1-3.
4. cosmetic composition according to claim 1 and 2, wherein, described cosmetic composition is the antioxidation compositions.
5. cosmetic composition according to claim 1 and 2, wherein, described cosmetic composition has the free radical scavenging function.
6. cosmetic composition according to claim 1 and 2, wherein, described cosmetic composition is the skin-whitening compositions.
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KR1020110137197A KR101904800B1 (en) | 2011-12-19 | 2011-12-19 | Cosmetic composition for anti-oxidation or skin whintening containing extract of medicinal herbs mixture |
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CN105708771A (en) * | 2016-04-25 | 2016-06-29 | 温州博远工业设计有限公司 | Formula and preparation technology of skin-whitening and beautifying effective composition |
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CN105708771A (en) * | 2016-04-25 | 2016-06-29 | 温州博远工业设计有限公司 | Formula and preparation technology of skin-whitening and beautifying effective composition |
CN114522125A (en) * | 2022-03-07 | 2022-05-24 | 广州睿森生物科技有限公司 | Anti-aging composition and application thereof in cosmetics |
Also Published As
Publication number | Publication date |
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JP2013126980A (en) | 2013-06-27 |
KR20130070062A (en) | 2013-06-27 |
KR101904800B1 (en) | 2018-10-10 |
JP6154606B2 (en) | 2017-06-28 |
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