CN114522125A - Anti-aging composition and application thereof in cosmetics - Google Patents

Anti-aging composition and application thereof in cosmetics Download PDF

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Publication number
CN114522125A
CN114522125A CN202210223617.4A CN202210223617A CN114522125A CN 114522125 A CN114522125 A CN 114522125A CN 202210223617 A CN202210223617 A CN 202210223617A CN 114522125 A CN114522125 A CN 114522125A
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extract
parts
aging composition
portions
weight
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CN114522125B (en
Inventor
姚玲娣
谢水林
聂舟
叶少玲
潘晓燕
王晓慧
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Guangzhou Rui Sen Biotechnology Co ltd
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Guangzhou Rui Sen Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses an anti-aging composition and application thereof in cosmetics, and relates to the field of cosmetics. The anti-aging composition comprises the following components in parts by weight: golden chamomile extract: 0.1 to 5.5 portions; rice germ extract: 0.01 to 0.5 portion; ligusticum chuanxiong Hort extract: 0.01 to 3 portions; snow lotus herb extract: 0.01 to 2 portions; the deionized water is made up to 100 parts. This application is through a plurality of plant extract component interactions, forms the complementary system of many units, has abundant biological activity, and the component is appropriate, can restrain breeding of fungi and reduce melanocyte's proliferation activity, and whole promotion is whitened, anti-wrinkle, the skin softening function, has better prevention and repairing effect to dealing with the skin of elder generation, and along with the increase of length of time of using, the anti-ageing effect is better, is fit for sensitive muscle crowd simultaneously and uses.

Description

Anti-aging composition and application thereof in cosmetics
Technical Field
The invention relates to the field of cosmetics, in particular to an anti-aging composition and application thereof in cosmetics.
Background
With the increase of age, the metabolism ability of the body is also slowed down, the skin gradually loses elasticity, pores are enlarged, the skin of a human body gradually enters a natural aging state from 20 to 25 years old, the aging speed is different according to different genetic genes and living habits of each person, the aging time is different, the appearance of the early age is not obvious, and the skin can be seen only after about 30 years old. The aged skin with sensitive skin not only loses elasticity, has fine wrinkles, is declined in metabolic capability, reduces the moisture content of the horny layer, but also is accompanied by phenomena of easy stimulation, pruritus, stabbing pain, burning, tightness and the like when the skin is dry.
In response to the condition of resisting the aging of sensitive muscles, the method needs to start in the direction of 'mild prevention' and 'effective maintenance', and combines plant natural skin care factors to repair and maintain the health of the skin before the skin goes into aging. Most products in the market are mainly focused on lifting, tightening and nursing or moisturizing of aged skin, and some anti-aging products exist, but the anti-aging effect is single and low in degree of significance, the anti-aging effect of sensitive muscles is low, the skin care ingredients are various, the irritation is strong, the effect rate of the ingredients can be reflected to be low, the products in the market are deficient in the aspect of preventing the aged sensitive muscles, the satisfaction degree of user experience is low, and the effect after use is not obvious.
Disclosure of Invention
The invention provides an anti-aging composition and application thereof in cosmetics, which promote whitening and anti-wrinkle functions of products so as to improve the anti-aging effect.
In order to solve the technical problems, the invention provides an anti-aging composition, which comprises the following components in parts by weight: golden yellow chamomile extract: 0.1 to 5.5 portions; rice germ extract: 0.01 to 0.5 portion; extract of Ligusticum wallichii: 0.01 to 3 portions; snow lotus herb extract: 0.01 to 2 portions; the deionized water is made up to 100 parts.
By adopting the scheme, various plant extract components have rich biological activity, wherein the chamomile extract contains cyclic ethers, flavonoids, total volatile oil and the like, and has different inhibiting effects on fungal breeding; the cholesterol and ceramide in rice germ have effect in promoting generation, are important components of sebum, and can improve skin softness, and have synergistic effect after adding herba Saussureae Involueratae extract, and have remarkable effects in softening skin, removing wrinkle and resisting aging, ferulic acid in rhizoma Ligustici Chuanxiong extract can inhibit or reduce melanocyte proliferation activity, and ligustrazine has hydrogen peroxide (H)2O2) The ability to remove DPPH free radicals (DPPH) and lipid peroxidation, and can achieve good whitening effect; this application is through a plurality of component interactions, forms the complementary system of many units, and the component is appropriate, and the whole promotion is whitened, anti-wrinkle function, has better prevention and repair to the skin of just old.
Preferably, the anti-aging composition comprises the following components in parts by weight: golden yellow chamomile extract: 2.5-4.5 parts; rice germ extract: 0.1 to 0.25 portion; extract of Ligusticum wallichii: 1-1.9 parts; snow lotus herb extract: 0.8 to 1.3 portions; the deionized water is made up to 100 parts.
Preferably, the anti-aging composition further comprises 5 to 15 parts by weight of a humectant selected from one or more of rice bran oil, squalane, beta-glucan, mannose, maltitol and coconut (coco NUCIFERA) oil.
Preferably, the humectant comprises beta-glucan, rice bran oil and maltitol.
By adopting the scheme, when the beta-glucan, the rice bran oil and the maltitol are compounded to be used as the humectant, the humectant has a synergistic interaction effect with other plant extract components in the components, can promote the plant extract components to exert whitening and anti-wrinkle effects, combines a moisturizing function, and integrally improves the anti-aging effect.
Preferably, the anti-aging composition further comprises 0.1-1 part by weight of an antibacterial preservative, wherein the antibacterial preservative is one or more of butanediol, phenoxyethanol and glyceryl caprylate.
Preferably, the antibacterial preservative is glyceryl caprylate.
Preferably, the anti-aging composition further comprises 0.1 to 6 parts by weight of a thickener.
Preferably, the thickening agent is one or more of carbomer, cetyl betaine and BOSWELLIA SERRATA (BOSWELLIA SERRATA) gum.
In order to solve the above technical problems, it is a second object of the present invention to provide a cosmetic use of an anti-aging composition.
Preferably, the cosmetic comprises one of essence, smoothing toner, ampoule, beauty lotion, mask and cream.
Compared with the prior art, the embodiment of the invention has the following beneficial effects:
the application is through a plurality of component interactions of golden yellow chamomile extract, rice germ extract, ligusticum chuanxiong hort extract and snow lotus extract, and the component is appropriate, inhibits breeding of fungi and reduces melanocyte's proliferation activity, wholly promotes to whiten, anti-wrinkle, skin-softening function, has better prevention and repair effect to dealing with the skin of just old age, and along with the increase of length of time of use, anti-just old age effect is better, is fit for sensitive muscle crowd simultaneously and uses.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The application provides an anti-aging composition, which is applied to the field of cosmetics and comprises the following components in parts by weight: extract of golden yellow chamomile (Chrysanthellum INDICUM): 0.1 to 5.5 portions; rice (ORYZA SATIVA) germ extract: 0.01 to 0.5 portion; rhizoma Chuanxiong (Ligusticum CHUANXIONG) extract: 0.01 to 3 portions; SAUSSUREA INVOLUCRATA (SAUSSUREA INVOLUCRATA) extract: 0.01 to 2 portions; and deionized water to make up to 100 parts.
In a further preferred embodiment, the anti-premature composition comprises the following components in parts by weight: extract of golden yellow chamomile (Chrysanthellum INDICUM): 2.5-4.5 parts; rice (ORYZA SATIVA) germ extract: 0.1 to 0.25 portion; rhizoma Chuanxiong (Ligusticum CHUANXIONG) extract: 1-1.9 parts; SAUSSUREA INVOLUCRATA (SAUSSUREA INVOLUCRATA) extract: 0.8 to 1.3 portions; and deionized water to make up to 100 parts.
In a further preferred embodiment, the anti-aging composition further comprises 5 parts to 15 parts of a humectant.
In a further preferred embodiment, the humectant may be at least one of rice bran oil, squalane, beta-glucan, mannose, maltitol and coconut (coco NUCIFERA) oil.
In a further preferred embodiment, the anti-aging composition further comprises 0.1 parts to 1 part of an antimicrobial preservative.
In a further preferred embodiment, the antimicrobial preservative may be at least one of butylene glycol, phenoxyethanol, and glyceryl caprylate.
In a further preferred embodiment, the anti-aging composition further comprises 0.1 parts to 6 parts of a thickener.
In a further preferred embodiment, the thickening agent may be at least one of carbomer, cetyl betaine, and BOSWELLIA SERRATA (BOSWELLIA SERRATA) gum.
The following description is given in conjunction with specific examples and comparative examples in table 1 to demonstrate the practical effects of the scheme of the present application.
TABLE 1-EXAMPLES 1-8 AND COMPARATIVE EXAMPLES 1-6 the compositions in the anti-premature compositions in percent by mass
Figure BDA0003534711270000041
Figure BDA0003534711270000051
Performance test
1. Chick embryo test (irritation test):
selecting chicken embryos: 75 fresh, clean and intact chick embryos with the mass of 50g-60g are selected and divided into 14 groups, and each group comprises 5 chick embryos. (when the chick embryos are incubated to 9 days of age, the chick embryos should be checked in eggs to discard unfertilized, inactive or defective chick embryos, and not used when the chick embryos are severely misshapen, broken or thinly shelled.
And (3) testing environment: the room temperature is 20-25 ℃, the relative humidity is 45-70%, the incubation temperature is 37.5 +/-0.5 ℃, the relative humidity is 55-70%, the frequency of a turntable is 3-6 times/h, and the chick embryos at 9 days do not need to rotate when being incubated.
And (3) operation specification: performing egg-lighting inspection on 9-day-old chick embryos, and marking the positions of air chambers on the surfaces of the eggshells; removing marked egg shell parts (placing 1 silicone rubber ring on the chorioallantoic membrane of each egg embryo) by using dental zigzag forceps to expose white egg membrane, sucking and dripping a test object by using a suction pipe to moisten the egg membrane, observing the condition of the blood vessel system of the egg embryo by using an amplifying mirror lamp after 5min, wherein the blood vessel congestion, the blood vessel bleeding and the blood coagulation blood vessel are the stimulation reaction conditions, and calculating the IS value according to a stimulation evaluation method in a cosmetic eye stimulation corrosive chick embryo chorioallantoic membrane test SN/T2329-2009.
And (4) test conclusion: according to the conditions of observing the chick embryo blood vessel system and the IS value, the IS mean value tested in the embodiment 1-8 IS less than or equal to 1, and the condition IS not stimulated; in comparative examples 1-6, the IS mean value of the test IS not more than 1, which IS a non-irritant condition, and the product of the application can be applied to sensitive skin.
2. And (3) testing the whitening effect:
the test environmental conditions are as follows: under a stable indoor environment, the indoor temperature is 24-27 ℃, and the relative humidity is 40-50%.
The test method comprises the following steps: selecting volunteers with age of 25-40 years, skin color L values close and belonging to sensitive muscles, carrying out use test on each test object corresponding to 5 volunteers, measuring initial ITA values of each group of volunteers by adopting a multifunctional skin tester (model: MPA580) produced by Courage Khazaka Germany, respectively using the test objects of examples 1-8 and comparative examples 1-6, lasting for 4 weeks for 2 times every day, testing the ITA values of each group of volunteers (taking an average value), and evaluating the whitening effect of the test objects, wherein the higher the ITA value is the better the whitening effect, and the test results are shown in the following table 1.
TABLE 1 ITA value test results for examples 1-8 and comparative examples 1-6
Figure BDA0003534711270000061
Figure BDA0003534711270000071
3. And (3) anti-wrinkle test:
test objects: selecting 56 volunteers of 25-40 ages, dividing into 14 groups, wherein each group comprises 4 persons, and the volunteers have habit of using skin care products at ordinary times, cleaning the tested parts with warm water and standard facial cleanser (laboratory formula), waiting for 30min in a room according with the specification, and collecting and observing basic data of cheek parts and canthus parts, wherein the tested index is wrinkle volume.
And (3) testing conditions are as follows: testing the environmental temperature: 20 ℃ to 22 ℃, relative humidity: 40% -60% (detection equipment: Visia skin detector).
The test method comprises the following steps: after the test of each index is completed, the test materials of the examples and the comparative examples are randomly distributed to 4 volunteers in each example, and the volunteers use the test materials according to the product instruction and respectively use the test materials in the morning and the evening every day for 4 weeks. The return visit test is carried out at the same time point after the product is used for two weeks and four weeks, and each test flow is consistent with the basic data acquisition. (note: rate of change ═ (after use-before use)/before use), the test results are shown in table 2.
TABLE 2-wrinkle resistance test results of examples 1-8 and comparative examples 1-6
Figure BDA0003534711270000072
Figure BDA0003534711270000081
As shown in tables 1 and 2, the skin whitening effect and the anti-wrinkle effect of the test substances of examples 1 to 8 were higher than those of comparative examples 1 to 6, which was more significant in change of the ITA value and the anti-wrinkle test after use and more excellent in the final amount. The whitening effect and the anti-wrinkle effect of the test substance in example 4 are optimal, and specifically, the ITA value and the anti-wrinkle test change rate at 4 weeks are not only the maximum in incremental change, but also the optimal values.
The tested substances of the comparative examples 1-2 have inconsistent contents of the components and poor interaction effect of the components, so that the synergistic effect among the components is not obvious; the test articles of comparative examples 3 to 6 exhibited significantly reduced whitening and anti-wrinkle effects due to insufficient or lack of synergy of some of the components. Therefore, when only the golden chamomile, the rice germ, the ligusticum wallichii and the snow lotus extract are compounded according to a certain proportion, the synergistic effect is achieved, and the optimal anti-wrinkle and whitening effects are achieved.
The above-mentioned embodiments are provided to further explain the objects, technical solutions and advantages of the present invention in detail, and it should be understood that the above-mentioned embodiments are only examples of the present invention and are not intended to limit the scope of the present invention. It should be understood that any modifications, equivalents, improvements and the like, which come within the spirit and principle of the invention, may occur to those skilled in the art and are intended to be included within the scope of the invention.

Claims (10)

1. The anti-premature composition is characterized by comprising the following components in parts by weight: golden yellow chamomile extract: 0.1 to 5.5 portions; rice germ extract: 0.01 to 0.5 portion; extract of Ligusticum wallichii: 0.01 to 3 portions; snow lotus herb extract: 0.01 to 2 portions; the deionized water is made up to 100 parts.
2. The anti-aging composition of claim 1, wherein the anti-aging composition comprises the following components in parts by weight: golden yellow chamomile extract: 2.5-4.5 parts; rice germ extract: 0.1 to 0.25 portion; extract of Ligusticum wallichii: 1-1.9 parts; snow lotus herb extract: 0.8 to 1.3 portions; the deionized water is made up to 100 parts.
3. The anti-aging composition of claim 1, further comprising 5 to 15 parts by weight of a humectant selected from one or more of rice bran oil, squalane, beta glucan, mannose, maltitol and coconut (COCOS NUCIFERA) oil.
4. An anti-aging composition according to claim 3, wherein the humectant comprises β -glucan, rice bran oil and maltitol.
5. The anti-aging composition of claim 1, further comprising 0.1 to 1 part by weight of an antimicrobial preservative selected from one or more of butylene glycol, phenoxyethanol, and glyceryl caprylate.
6. The anti-aging composition of claim 1, wherein the antimicrobial preservative is caprylate.
7. The anti-aging composition of claim 1, further comprising 0.1 to 6 parts by weight of a thickening agent.
8. An anti-aging composition according to claim 7, wherein the thickening agent is one or more of carbomer, cetyl betaine and BOSWELLIA SERRATA (BOSWELLIA SERRATA) gum.
9. Use of an anti-aging composition according to any of claims 1 to 8 in cosmetics.
10. The use of an anti-aging composition according to claim 9 in a cosmetic, wherein the cosmetic comprises one of a serum, a toner, an ampoule, a beauty lotion, a mask, and a cream.
CN202210223617.4A 2022-03-07 2022-03-07 Anti-aging composition and application thereof in cosmetics Active CN114522125B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002201122A (en) * 2000-10-24 2002-07-16 Maruzen Pharmaceut Co Ltd Skin whitening cosmetic preparation
CN103156798A (en) * 2011-12-19 2013-06-19 株式会社爱茉莉太平洋 Cosmetic composition for anti-oxidation or skin whitening containing extract of medicinal herbs mixture
CN104473836A (en) * 2014-11-20 2015-04-01 柳江县联华纸制品厂 Cleansing wet tissue
JP2015155394A (en) * 2014-02-21 2015-08-27 佐藤製薬株式会社 photoaging inhibitor
US20150245991A1 (en) * 2014-02-28 2015-09-03 HDDC Holdings, LLC Anti-aging dermal composition comprising herbal extracts
CN106852839A (en) * 2016-12-04 2017-06-16 长沙协浩吉生物工程有限公司 A kind of compound method of moisturizing essence
CN109288710A (en) * 2018-11-16 2019-02-01 广东圣蜜生物科技有限公司 A kind of external skin-care composition and preparation method thereof that solid is anti-ageing
CN110507584A (en) * 2019-09-29 2019-11-29 北京红蓝猫生物科技有限公司 A kind of lanatechead saussurea herb with flower anti-Fatigue Composition and skin care item and preparation method thereof
CN111700836A (en) * 2020-07-24 2020-09-25 嘉文丽(福建)化妆品有限公司 Composition capable of improving skin color and whitening skin and skin care product containing composition
CN114028284A (en) * 2021-10-29 2022-02-11 广州零添加主义生物技术有限公司 Skin care composition with functions of resisting allergy, relieving and repairing sensitive skin and preparation method thereof

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002201122A (en) * 2000-10-24 2002-07-16 Maruzen Pharmaceut Co Ltd Skin whitening cosmetic preparation
CN103156798A (en) * 2011-12-19 2013-06-19 株式会社爱茉莉太平洋 Cosmetic composition for anti-oxidation or skin whitening containing extract of medicinal herbs mixture
JP2015155394A (en) * 2014-02-21 2015-08-27 佐藤製薬株式会社 photoaging inhibitor
US20150245991A1 (en) * 2014-02-28 2015-09-03 HDDC Holdings, LLC Anti-aging dermal composition comprising herbal extracts
CN104473836A (en) * 2014-11-20 2015-04-01 柳江县联华纸制品厂 Cleansing wet tissue
CN106852839A (en) * 2016-12-04 2017-06-16 长沙协浩吉生物工程有限公司 A kind of compound method of moisturizing essence
CN109288710A (en) * 2018-11-16 2019-02-01 广东圣蜜生物科技有限公司 A kind of external skin-care composition and preparation method thereof that solid is anti-ageing
CN110507584A (en) * 2019-09-29 2019-11-29 北京红蓝猫生物科技有限公司 A kind of lanatechead saussurea herb with flower anti-Fatigue Composition and skin care item and preparation method thereof
CN111700836A (en) * 2020-07-24 2020-09-25 嘉文丽(福建)化妆品有限公司 Composition capable of improving skin color and whitening skin and skin care product containing composition
CN114028284A (en) * 2021-10-29 2022-02-11 广州零添加主义生物技术有限公司 Skin care composition with functions of resisting allergy, relieving and repairing sensitive skin and preparation method thereof

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