CN103053585A - Synergistic insecticidal composition containing dinotefuran and clothianidin, and application thereof - Google Patents

Synergistic insecticidal composition containing dinotefuran and clothianidin, and application thereof Download PDF

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Publication number
CN103053585A
CN103053585A CN2011103208830A CN201110320883A CN103053585A CN 103053585 A CN103053585 A CN 103053585A CN 2011103208830 A CN2011103208830 A CN 2011103208830A CN 201110320883 A CN201110320883 A CN 201110320883A CN 103053585 A CN103053585 A CN 103053585A
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China
Prior art keywords
clothianidin
mti
synergistic insecticidal
synergistic
insecticidal compositions
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CN2011103208830A
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Chinese (zh)
Inventor
杨寿海
刘德友
葛九敢
陈志忠
贠琰
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Nanjing Huazhou Pharmaceutical Co Ltd
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Nanjing Huazhou Pharmaceutical Co Ltd
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Priority to CN2011103208830A priority Critical patent/CN103053585A/en
Publication of CN103053585A publication Critical patent/CN103053585A/en
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Abstract

The invention discloses a synergistic insecticidal composition containing dinotefuran and clothianidin, and an application thereof. The synergistic insecticidal composition employs dinotefuran and clothianidin as main effective components, wherein a weight ratio of dinotefuran to clothianidin is 1-80 : 1-70. The insecticidal composition can produce a relatively high synergistic interaction effect, overcomes or delays pest resistance, has fast insecticidal speed and long efficacy duration and reduces pesticide cost. The insecticidal composition can be used for preventing hemiptera pests and lepidoptera pests, is particularly suitable for preventing plant hopper, aleyrodid, leafhopper and aphid, and has an effect obviously higher than that of a single dosage.

Description

A kind of Synergistic insecticidal compositions and application thereof that contains MTI-446 and clothianidin
Technical field
The invention belongs to pesticide field, be specifically related to a kind of Synergistic insecticidal compositions and application thereof take MTI-446 and clothianidin as main active ingredient.
Background technology
MTI-446 (dinotefuran) is the third generation nicotinic insecticide of Mitsui chemical company exploitation.The chemical constitution of itself and existing nicotinic insecticide is far from each other, and chloro-pyridine base, chloro thiazolyl before its tetrahydrofuran base has replaced do not contain the halogen family element.Simultaneously, also different with nicotine at aspect of performance.So people are referred to as " furans nicotine " at present.MTI-446 chemical name: 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine.
A new generation's anabasine insecticide MTI-446 Main Function makes the insect paralysis dead in insect neurotransmission system.This medicament insecticidal spectrum is wide, has remarkable interior sorptivety and thoroughly acts on, and namely shown very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, and crop without poisoning, be can be used for numerous crops such as paddy rice, fruit tree, vegetables.To rice grub brown planthopper, white-backed planthopper, small brown rice planthopper, rice leafhopper, rice spider rafter stinkbug, star stinkbug, green rice bug resemble, red must fleahopper, the negative mixed worm of rice, rice cylinder water snout moth's larva be efficient.Effective to striped rice borer, oryza chinensis class.Efficient to vegetables, fruit insect Phytophthira, aleyrodid class, a red-spotted lizard class, unaspis shield kuwana, the green stinkbug of Zhu, peach fruit borer, tangerine lyonetid, the thin moth of tea, striped flea-beetle, the beans fly of diving.The cured a red-spotted lizard in diagonal angle, diamond-back moth, two secret notes are chrysomelid, tea golden thistle horse, onion thrips, golden thistle horse, oranges and tangerines golden thistle horse, soybean pod gall-midge, tomato Liriomyza are effective.MTI-446 has very wide insecticidal spectrum, and fool proof again to crop, people and animals and environment, is equipped with the using method of various uses again, this agricultural chemicals large-tonnage agricultural chemicals that is expected to become international.
Clothianidin (Clothianidin) belongs to anabasine insecticide, and sterling is white crystalline powder, 176.8 ℃ of fusing points, chemical name (E)-1-(2-chloro-1,3-thiazoles-5-ylmethyl)-3-methyl-2-nitroguanidine.
Clothianidin be a kind of active high, have interior absorption, tag and the broad spectrum pesticide of stomach poison function.The mechanism of action is in conjunction with the nAChR that is positioned at neural post-synapse.Be applicable to foliar spray, soil treatment effect.Show to have greater activity and better control efficiency through indoor toxicity test to trialeurodes vaporariorum with to the field control effectiveness test of tomato Bemisia tabaci.Show preferably quick-acting, the lasting period is about 7 days.Be mainly used in paddy rice, vegetables, fruit tree and other crop, control Semiptera, coleoptera, diptera and some lepidoptera pest.
Rice fulgorid and aphid are under the condition of present long-term prescription, resistance increases gradually, the agricultural chemicals single dose descends gradually to the effect of control of insect, study discovery through the inventor, the synergistic complex of agricultural chemicals is expanding prevention spectrum and the effective measures that improve preventive effect, not yet finds up to now the Pesticidal combination of relevant MTI-446 and clothianidin.
Summary of the invention
The purpose of this invention is to provide a kind of Synergistic insecticidal compositions that contains MTI-446 and clothianidin.
Another object of the present invention provides said composition and prevents and treats application on the insecticidal materials of resistance Semiptera, coleopteran pest in preparation.
For achieving the above object, MTI-446 and clothianidin that the present invention will grow the lasting period are composite, obtain new and effective multifunctional insecticide composition.This insecticidal materials has good preventive effect to Semiptera and the coleopteran pest that plant hopper, aleyrodid, leafhopper and aphid etc. produce resistance easily; And suppress insect to the pesticide resistance generation of unitary agent (MTI-446 or clothianidin are arbitrary).
The objective of the invention is to be achieved through the following technical solutions:
A kind of Synergistic insecticidal compositions that contains MTI-446 and clothianidin is characterized in that it take MTI-446 and clothianidin as main active ingredient, and wherein, the weight ratio of MTI-446 and clothianidin is 1~80: 1~70.The weight ratio of MTI-446 and clothianidin preferred 1~50 in this Synergistic insecticidal compositions: 1~60, more preferably 1~20: 1~20.
In the present composition, the two percentage by weight that accounts for composition of MTI-446 and clothianidin is 1~80%.Be preferably 5~50%, most preferably 5~40%.The effective ingredient of above-mentioned Insecticidal combinations is present in the composition with the synergy effective dose." % " of the present invention is mass percent.
Above-mentioned Insecticidal combinations is take MTI-446 and clothianidin as main active ingredient (active component), and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals.Be preferably missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion and water dispersion granule.
Described auxiliary agent can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, polyoxyethylene polyoxy third rare block compound (such as farming breast 33 #), the one or more combinations in the polyoxyethylene nonylphenol ether, excipient comprises isopropyl alcohol, solvent naphtha, solvent naphtha, water, pyrrolidones, dimethyl formamide, dimethyl sulfoxide (DMSO), antifreezing agent (such as propane diols), deionized water etc.Above auxiliary agent, excipient and other auxiliary material can alone or and usefulness.
Above-mentioned Pesticidal combination can be prevented and treated application in the insecticidal materials of resistance Semiptera, coleopteran pest in preparation, and the control efficiency of the present composition is used apparently higher than its single dose, and described Semiptera insect refers in particular to plant hopper, aleyrodid, leafhopper and aphid.
Show through indoor synergism test mensuration: built agent all has significant synergistic insecticidal action; Field control effectiveness test shows that equally also all built agents of the present invention all are significantly higher than the effect of corresponding single dose agricultural chemicals to the insecticidal effect of water rice hopper and wheat aphid.
Pesticidal combination of the present invention compared with prior art, produce following beneficial effect: (1) is compared with single dose, and said composition has notable synergistic to insect, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests simultaneously, reduce control recruitment cost; (3) alternative high-toxic pesticide, and significantly reduce the field dosage, effective environmental contamination reduction and residue of pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with the MTI-446 single dose, produce and the use cost reduction; (6) suppress insect to the resistance enhancing of agricultural chemicals.
Embodiment
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.First by indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage; On this basis, carry out again field trial.
Embodiment 1:
Taking by weighing MTI-446, clothianidin, to adopt the conventional formulation method to be mixed with main effectively composition quality percentage composition by different proportion be 20% MTI-446 clothianidin missible oil, and the body ratio sees Table 1,2.
Adopt rice stem infusion process to carry out indoor synergy biologicall test, selecting the resistant rice plant hopper is target pest, and every processing repeats 3 times, and every concentration is processed 60, uses LC 50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
The toxicity test of the composite and single dose antagonism rice fulgorid of table 1 MTI-446 and clothianidin.
As shown in Table 1, MTI-446 and clothianidin are composite, and co-toxicity coefficient shows good synergistic function all greater than 120.
Selecting the resistance wheat aphid is that the worm leaf dipping method is soaked in the target pest employing, and every processing repeats 3 times, uses LC 50Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
The toxicity test of the composite and single dose antagonism wheat aphid of table 2 MTI-446 and clothianidin.
As shown in Table 2, the composite co-toxicity coefficient to wheat aphid of MTI-446 and clothianidin shows good synergistic function all greater than 120.
Adopt embodiment 2 and 3 sample product of embodiment to carry out the field trial of control in field Brown Planthopper, the contrast medicament is 10% clothianidin WP and 10% MTI-446 WP, and concrete consumption sees Table 3, and every mu of water consumption is 30kg, looked into behind the medicine 4 days, 10 days, 15 days, 20 days, 30 days results, result of the test sees Table 3:
Table 3: the composite and single dose of MTI-446 clothianidin is to the field control effectiveness test of brown planthopper
As can be known from the above table, 10.5% MTI-446 clothianidin missible oil and 11% MTI-446 clothianidin microemulsion are better than 10% clothianidin wetting powder, 10% MTI-446 WP to the water rice hopper drug effect, demonstrate the superiority of prescription.
Adopt embodiment 2 and 3 sample product of embodiment to carry out the field trial of control in field wheat aphid, the contrast medicament is 10% clothianidin WP and 10% MTI-446 WP, and concrete consumption sees Table 3, and every mu of water consumption is 30kg, looked into behind the medicine 4 days, 10 days, 15 days, 20 days, 30 days results, result of the test sees Table 4:
Table 4: the composite and single dose of MTI-446 clothianidin is to the field control effectiveness test of wheat aphid
As can be known from the above table, 10.5% MTI-446 clothianidin missible oil and 11% MTI-446 clothianidin microemulsion are better than 10% clothianidin wetting powder, 110% MTI-446 WP to the wheat aphid drug effect, demonstrate the superiority of prescription.
Embodiment 2:
Take by weighing 5g MTI-446,5g clothianidin, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, solvent naphtha to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and making main active ingredient weight percentage is 10% MTI-446 clothianidin missible oil.
Embodiment 3:
Take by weighing 2g MTI-446,8g clothianidin, emulsifier 1602 #4g, emulsifier 500 #2g, 1-METHYLPYRROLIDONE 4g, isopropyl alcohol 6g, solvent naphtha 3g, surplus is water, and the method that above raw material is prepared microemulsion routinely drops in the mixing kettle mixes, and making main active ingredient weight percentage is 10% MTI-446 clothianidin microemulsion.
Embodiment 4:
Take by weighing 60g MTI-446,5g clothianidin, 1g lauryl sodium sulfate, 0.5g dispersing agent NNO, kaolin to 100g, above raw material is prepared routinely the method for wetting powder and mixed, form 65% MTI-446 clothianidin wetting powder.
Embodiment 5:
Take by weighing 80g MTI-446,0.2g clothianidin, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and making main active ingredient weight percentage is 80.2% MTI-446 clothianidin missible oil.
Embodiment 6:
Take by weighing 20g MTI-446,2g clothianidin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared the method for suspending agent routinely, and making main active ingredient weight percentage is 22% MTI-446 clothianidin suspending agent.
Embodiment 7:
Take by weighing 30g MTI-446,0.5g clothianidin, calcium dodecyl benzene sulfonate 12g, phenethyl phenol polyethenoxy ether 8g, solvent naphtha to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and forms 30.5% MTI-446 clothianidin missible oil.
Embodiment 8:
Take by weighing 2g MTI-446,20g clothianidin, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin complements to 100g, and above raw material is made 22% MTI-446 clothianidin water dispersion granule by the method for water dispersion granule.
Embodiment 9:
Take by weighing 5g MTI-446,30g clothianidin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared the method for suspending agent routinely, make 35% MTI-446 clothianidin suspending agent.
Embodiment 10:
Take by weighing 0.1g MTI-446,70g clothianidin, alkylphenol polyoxyethylene 10g, phenethyl phenol polyethenoxy ether 10g, solvent naphtha to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and making main active ingredient weight percentage is 70.1% MTI-446 clothianidin missible oil.
Embodiment 11:
Take by weighing the 20g MTI-446, the 0.2g clothianidin is dissolved in the 8g solvent naphtha, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Mentioned solution is slowly poured in the excess water, and under fully stirring, making main active ingredient weight percentage is 20.2% MTI-446 clothianidin aqueous emulsion.

Claims (10)

1. Synergistic insecticidal compositions that contains MTI-446 and clothianidin is characterized in that it take MTI-446 and clothianidin as main active ingredient, and wherein, the weight ratio of MTI-446 and clothianidin is 1~80: 1~70.
2. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin according to claim 1 is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1~50: 1~60.
3. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin according to claim 2 is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1~20: 1~30.
4. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin according to claim 1 is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 1~80%.
5. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin according to claim 4 is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 5~50%.
6. the compound pesticide compositions that contains MTI-446 and clothianidin according to claim 5 is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 5~40%.
7. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin according to claim 1 is characterized in that it take MTI-446 and clothianidin as main active ingredient and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals.
8. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin according to claim 7 is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
9. the Synergistic insecticidal compositions that contains MTI-446 and clothianidin claimed in claim 1 is prevented and treated the application on the insecticidal materials of resistance Semiptera, coleopteran pest in preparation.
10. the application of Synergistic insecticidal compositions on the insecticidal materials of preparation control plant hopper, aleyrodid, leafhopper and aphid that contains MTI-446 and clothianidin claimed in claim 1.
CN2011103208830A 2011-10-20 2011-10-20 Synergistic insecticidal composition containing dinotefuran and clothianidin, and application thereof Pending CN103053585A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103141504A (en) * 2013-03-22 2013-06-12 青岛瀚生生物科技股份有限公司 Dinotefuran/Clothianidin compound insecticidal composition
CN112661574A (en) * 2021-02-04 2021-04-16 赤天化科技集团有限公司 High-tower pesticide-fertilizer containing clothianidin and dinotefuran and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101304659A (en) * 2005-11-10 2008-11-12 拜尔农作物科学股份公司 Synergistic insecticidal mixtures for seed treatment
CN102349505A (en) * 2011-09-13 2012-02-15 广西田园生化股份有限公司 Ultra-low-capacity liquid containing dinotefuran

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101304659A (en) * 2005-11-10 2008-11-12 拜尔农作物科学股份公司 Synergistic insecticidal mixtures for seed treatment
CN102349505A (en) * 2011-09-13 2012-02-15 广西田园生化股份有限公司 Ultra-low-capacity liquid containing dinotefuran

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103141504A (en) * 2013-03-22 2013-06-12 青岛瀚生生物科技股份有限公司 Dinotefuran/Clothianidin compound insecticidal composition
CN112661574A (en) * 2021-02-04 2021-04-16 赤天化科技集团有限公司 High-tower pesticide-fertilizer containing clothianidin and dinotefuran and preparation method thereof

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Application publication date: 20130424