CN102017984A

CN102017984A - Synergy disinfection composite containing nitenpyram and cypermethrin and application thereof

Info

Publication number: CN102017984A
Application number: CN2009101834847A
Authority: CN
Inventors: 杨寿海; 张永涛; 车文元; 包凌云; 李海东
Original assignee: Nanjing Huazhou Pharmaceutical Co Ltd
Current assignee: Nanjing Huazhou Pharmaceutical Co Ltd
Priority date: 2009-09-22
Filing date: 2009-09-22
Publication date: 2011-04-20

Abstract

The invention discloses a synergy disinfection composite containing nitenpyram and cypermethrin and application thereof. The main effective ingredients of the disinfection composite are nitenpyram and cypermethrin, wherein the weight ratio of nitenpyram to cypermethrin is 0.1-55:0.1-75. The disinfection composite of the invention can generate higher cooperative and synergistic action, overcomes and defers pest drug fastness, expands a prevention and cure spectrum, has high disinfection speed and lowers medicine application cost. The invention is especially suitable for preventing and curing Hemiptera insects with high drug fastness, such as cotton aphids, cabbage aphids and white flies, and the effect of the synergy disinfection composite is obviously superior to the single agent of synergist.

Description

Contain Synergistic insecticidal compositions of Nitenpyram and alpha-cypermethrin and uses thereof

Technical field

The invention belongs to pesticide field, relate to a kind of Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin and uses thereof.

Background technology

Nitenpyram (nitenpyram), chemical name are (E)-N-(6-chloro-3 pyridylmethyls)-N-ethyl-N '-methyl-2-nitro ethenylidene diamines.Structural formula is as follows:

This medicine insecticidal spectrum is wide, be widely used on agricultural and the gardening prevent eliminating aphis, leafhopper, thrips, Semiptera insect, toxicity is low, lasting medicine does not have poisoning, safe in utilization to crop; This medicine acts on nAChR, and the mode uniqueness remarkable interior suction and osmosis are arranged, but it costs an arm and a leg.

Alpha-cypermethrin (alphacypermethrin) chemical name: (RS)-cyano group (3-phenoxy phenyl) methyl (IRS) cis is trans-3-(2, the 2-dichloroethylene)-2,2-dimethyl cyclopropane carboxylic acid ester, it is the higher pyrethoid insecticides thing of a kind of biologically active, efficient isomer by cypermethrin is formed, and insecticidal activity is 1-3 a times of cypermethrin.Cypermethrin can be used the control of pest on crop such as cotton, vegetables, fruit tree, tea tree, soybean and beet.Alpha-cypermethrin belongs to the low toxicity insecticidal materials.Acute oral LD50:79～400mg/kg.Acute through skin LD ₅₀:＞2000mg/kg.But this composition is longer service time, and insect is increasing gradually to its pesticide resistance.

At present, the Semiptera insect, resistance as aphid, aleyrodid etc. increases gradually, the agent of agricultural chemicals list descends gradually to the effect of control of insect, control for the Semiptera insect does not still have effective preparation, and the inventor finds that after deliberation agriculture chemical compounding can obviously improve drug effect, and delay the generation of Semiptera pest resistance, still find no the Pesticidal combination that closes Nitenpyram and alpha-cypermethrin up to now.

Summary of the invention

The purpose of this invention is to provide a kind of Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin, this Pesticidal combination production cost is low, have quick-acting and the long-acting pesticidal effect.

Another object of the present invention provides this desinsection to be combined in preparation and prevents and treats application in the resistance Semiptera insect insecticidal materials.

For achieving the above object, the present invention is by the network analysis to Nitenpyram and alpha-cypermethrin insecticidal properties, make full use of both mutual supplement with each other's advantages, Nitenpyram and alpha-cypermethrin is composite according to certain ratio, obtain multifunctional insecticide composition of the present invention.The various pests that this insecticidal materials antagonism cotten aphid, vegetable aphid and aleyrodid etc. are easy to generate resistance has good preventive effect; And the inhibition insect is to the pesticide resistance generation of unitary agent (Nitenpyram or alpha-cypermethrin).

The objective of the invention is to realize in the following manner:

A kind of Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin, it is main active ingredient with Nitenpyram and alpha-cypermethrin, wherein, the weight ratio of Nitenpyram and alpha-cypermethrin is 0.1～55: 0.1～75, preferred 0.5～35: 0.5～50.

The optimum weight ratio of Nitenpyram and alpha-cypermethrin is 1～10: 5～25 in this Pesticidal combination.

Effective ingredient is present in the composition with the synergy effective dose in this Pesticidal combination.In the present composition, the two weight percentage that accounts for composition of Nitenpyram and alpha-cypermethrin is 1～70%.The preferred weight percentage composition is 5～55%." % " of the present invention is mass percent.

Above-mentioned Pesticidal combination is that main active ingredient (active component) and insecticides adjuvant, excipient are mixed with any one formulation that allows on the agricultural chemicals with Nitenpyram and alpha-cypermethrin.Preferred missible oil, aqueous emulsion, microemulsion or suspending agent.Auxiliary agent specifically can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, polyoxyethylene polyoxy third rare block compound (as farming breast 33 ^#), the one or more combinations in the polyoxyethylene nonylphenol ether, excipient comprises cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent, excipient can singly be used or mixed the use.

Above-mentioned Pesticidal combination is prevented and treated application in the insecticidal materials of resistance Semiptera insect in preparation, and this insecticidal materials is used on control cotten aphid, vegetable aphid and aleyrodid has significant especially effect, and effect is used apparently higher than its single agent.

Beneficial effect of the present invention: the invention provides the Pesticidal combination of a kind of Nitenpyram and alpha-cypermethrin, it compared with prior art can produce higher cooperative synergism, overcome and delayed pest resistance to insecticide, the expanding prevention spectrum, desinsection speed is fast, has reduced drug cost.

Embodiment

Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.Pass through indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage earlier; On this basis, carry out field trial again.

Embodiment 1:

Take by weighing alpha-cypermethrin, Nitenpyram employing conventional formulation method by 10: 1,15: 1, it was 40% alpha-cypermethrin Nitenpyram missible oil that 20: 1 weight ratio is mixed with main effectively composition quality percentage composition.

Employing is soaked the leaf dip method and is carried out indoor synergy biologicall test, and selecting the resistance cotten aphid is target pest, and every processing repeats 3 times, uses LC ₅₀Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

The Toxicity Determination of table 1. Nitenpyram and alpha-cypermethrin Synergistic insecticidal compositions and single agent antagonism cotten aphid thereof:

Data show in the table, and Nitenpyram and the alpha-cypermethrin back that is mixed has synergistic effect to cotten aphid, and three listed in table proportioning co-toxicity coefficients are all much larger than 120, so Nitenpyram and alpha-cypermethrin are mixed and have significant synergies.

Employing is soaked the leaf dip method and is carried out indoor synergy biologicall test, and selecting the resistance aleyrodid is target pest, and every processing repeats 3 times, uses LC ₅₀Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

The Toxicity Determination of table 2. Nitenpyram and alpha-cypermethrin Synergistic insecticidal compositions and single agent antagonism aleyrodid thereof:

Data show in the table, and Nitenpyram and the alpha-cypermethrin back that is mixed has synergistic effect to aleyrodid, and three listed in table proportioning co-toxicity coefficients are all much larger than 120, so Nitenpyram and alpha-cypermethrin are mixed and have significant synergies.

Adopt embodiment 2 and 3, according to every mu of ground difference medication 10g, 20g, 25g medicament, the contrast medicament is 10% alpha-cypermethrin WP 30g/ mu, 5% Nitenpyram AS30g/ mu, every mu of ground water 30kg control cotten aphid.4 days, 10 days, 15 days, 20 days, 30 days fruits that come to an end after the dispenser, and handle, the results are shown in Table 3:

Table 3: the composite field test results of Nitenpyram-alpha-cypermethrin to cotten aphid

As can be known from the above table, the Nitenpyram alpha-cypermethrin is composite to be better than 10% alpha-cypermethrin wetting powder, 5% Nitenpyram aqua to the cotten aphid drug effect, demonstrates the superiority of prescription.

Adopt embodiment 2 and 3, according to every mu of ground difference medication 10g, 20g, 25g medicament, the contrast medicament is 10% alpha-cypermethrin WP 30g/ mu, 5% Nitenpyram AS30g/ mu, every mu of ground water 30kg control vegetable aphid.4 days, 10 days, 15 days, 20 days, 30 days fruits that come to an end after the dispenser, and handle, the results are shown in Table 4:

Table 4: the composite field test results of Nitenpyram-alpha-cypermethrin to vegetable aphid

As can be known from the above table, the Nitenpyram alpha-cypermethrin is composite to be better than 10% alpha-cypermethrin wetting powder, 5% Nitenpyram aqua to the vegetable aphid drug effect, demonstrates the superiority of prescription.

Embodiment 2:

Take by weighing the 5g Nitenpyram, the 5g alpha-cypermethrin is dissolved in the 8g dimethylbenzene, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Above-mentioned solution is slowly poured in the excess water, fully stirred down, make 10% Nitenpyram aqueous emulsion of syn type cypermethrin.

Embodiment 3:

Take by weighing the 0.5g Nitenpyram, the 10g alpha-cypermethrin is dissolved in the 8g dimethylbenzene, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Above-mentioned solution is slowly poured in the excess water, fully stirred down, make 10.5% Nitenpyram aqueous emulsion of syn type cypermethrin.

Embodiment 4:

Take by weighing the 1g Nitenpyram, the 5g alpha-cypermethrin is dissolved in the 8g dimethylbenzene, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Above-mentioned solution is slowly poured in the excess water, fully stirred down, make 6% Nitenpyram aqueous emulsion of syn type cypermethrin.

Embodiment 5:

Take by weighing 50g Nitenpyram, 5g alpha-cypermethrin, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 4g, phenethyl phenol polyethenoxy ether 6g, N-Methyl pyrrolidone 4g, isopropyl alcohol 6g, dimethylbenzene 3g, surplus is a water, the method that above raw material is prepared microemulsion routinely drops in the mixing kettle mixes, and makes 55% Nitenpyram alpha-cypermethrin microemulsion.

Embodiment 6:

Take by weighing 5g Nitenpyram, 60g alpha-cypermethrin, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g makes 65% Nitenpyram pyridine worm, third water dispersible granules with above raw material by the method for water dispersion granule.

Embodiment 7:

Take by weighing 10g Nitenpyram, 20g alpha-cypermethrin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is a water, above raw material is prepared the method for suspending agent routinely, make 30% Nitenpyram alpha-cypermethrin suspending agent.

Embodiment 8:

Take by weighing 1g Nitenpyram, 4g alpha-cypermethrin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is a water, above raw material is prepared the method for suspending agent routinely, make 5% Nitenpyram alpha-cypermethrin suspending agent.

Embodiment 9:

Take by weighing 55g Nitenpyram, 1g alpha-cypermethrin, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 4g, phenethyl phenol polyethenoxy ether 5g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and makes 56% Nitenpyram alpha-cypermethrin missible oil.

Embodiment 10:

Take by weighing 0.1g Nitenpyram, 60g alpha-cypermethrin, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 2g, phenethyl phenol polyethenoxy ether 8g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and makes 60.1% Nitenpyram alpha-cypermethrin missible oil.

Embodiment 11:

Take by weighing 5g Nitenpyram, 25g alpha-cypermethrin, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 4g, phenethyl phenol polyethenoxy ether 5g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and makes 30% Nitenpyram alpha-cypermethrin missible oil.

Embodiment 12:

Take by weighing 5g Nitenpyram, 60g alpha-cypermethrin, 1g lauryl sodium sulfate, 0.5g dispersing agent NNO, kaolin to 100g, above raw material is prepared routinely the method for wetting powder and mixed, form 65% Nitenpyram alpha-cypermethrin wetting powder.

Claims

1. a Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin is characterized in that it is main active ingredient with Nitenpyram and alpha-cypermethrin, and wherein, the weight ratio of Nitenpyram and alpha-cypermethrin is 0.1～55: 0.1～75.

2. the Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin according to claim 1 is characterized in that in the said composition, and the weight ratio of Nitenpyram and alpha-cypermethrin is 0.5～35: 0.5～50.

3. the Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin according to claim 1 is characterized in that in the said composition, and the weight ratio of Nitenpyram and alpha-cypermethrin is 1～10: 5～25.

4. the Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin according to claim 1 is characterized in that the two weight percentage that accounts for composition of Nitenpyram and alpha-cypermethrin is 1～80%.

5. the Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin according to claim 4 is characterized in that the two weight percentage that accounts for composition of Nitenpyram and alpha-cypermethrin is 5～55%.

6. the Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin according to claim 1 is characterized in that it is that main active ingredient and insecticides adjuvant and excipients are mixed with any one formulation that allows on the agricultural chemicals with Nitenpyram and alpha-cypermethrin.

7. the Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin according to claim 6 is characterized in that described formulation is missible oil, aqueous emulsion, microemulsion or suspending agent.

8. the described Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin of claim 1 is prevented and treated application in the insecticidal materials of resistance Semiptera insect in preparation.

9. the described Synergistic insecticidal compositions that contains Nitenpyram and alpha-cypermethrin of claim 1 is prevented and treated application in resistance cotten aphid, vegetable aphid and the aleyrodid insecticidal materials in preparation.