CN102017948B

CN102017948B - Synergistic pesticide combination containing nitenpyram and pyridalyl and application of combination

Info

Publication number: CN102017948B
Application number: CN 200910183482
Authority: CN
Inventors: 杨寿海; 赵富明; 卢玉刚; 齐武; 姚明德; 陈文明
Original assignee: Nanjing Huazhou Pharmaceutical Co Ltd
Current assignee: Nanjing Huazhou Pharmaceutical Co Ltd
Priority date: 2009-09-22
Filing date: 2009-09-22
Publication date: 2013-09-18
Anticipated expiration: 2029-09-22
Also published as: CN102017948A

Abstract

The invention discloses a synergistic pesticide combination containing nitenpyram and pyridalyl and an application of the combination. The synergistic pesticide combination uses nitenpyram and pyridalyl as main active components, wherein the weight ratio of the nitenpyram to the pyridalyl is (0.1-80):(0.2-70). The pesticide combination can produce higher synergistic effect, overcomes and delays pesticide resistance of pests, has high pest control speed and long persisting efficacy and lowers the application cost. The invention can be used to prevent and control paddy delphacidae, aleyrodidae,aphides and other hemipteran pests generated on crops, and the resulting effect is apparently higher than that obtained by using a single agent.

Description

A kind of Synergistic insecticidal compositions and application thereof that contains Nitenpyram and pyridalyl

Technical field

The invention belongs to pesticide field, be specifically related to a kind of Synergistic insecticidal compositions and application thereof take Nitenpyram and pyridalyl as main active ingredient.

Background technology

Nitenpyram (nitenpyram) belongs to the anabasine insecticidal materials, and chemical name is (E)-N-(6-chloro-3 pyridylmethyls)-N-ethyl-N '-methyl-2-nitro ethenylidene diamines.Structural formula is as follows:

This medicine insecticidal spectrum is wide, be widely used in anti-ly on agricultural and the gardening eliminate aphis, the insects such as leafhopper, thrips, plant hopper, toxicity is low, lasting medicine to crop without poisoning, use safety; This medicine acts on nAChR, and mode is unique, and insect is difficult for producing resistance, and remarkable interior suction and osmosis are arranged.

Pyridalyl (pyridalyl), chemical name 2,6-two chloro-4-(3,3-, two chloroallyloxyaminos) phenyl 3-[5-(trifluoromethyl-2 hydroxy pyrimidine) propyl group] ether.Structural formula is as follows:

Pyridalyl has simultaneously tags and stomach poison function, and the larva of lepidoptera pest main in the agricultural production is had very high insecticidal activity.In addition, pyridalyl also demonstrates good insecticidal activity to thrips and dipterous insect, and is opposite with its high activity, and pyridalyl is very low to various useful arthropodan toxicity.

The Semiptera such as rice fulgorid, aphid insect is under the condition of present long-term prescription, and resistance increases gradually, and the agricultural chemicals single dose descends gradually to the effect of control of insect, there is no effective preparation for the control of Semiptera insect.The inventor finds after deliberation, and the composite of agricultural chemicals is expanding prevention spectrum and the effective measures that improve preventive effect, finds not yet that up to now the complex insecticidal composition of relevant Nitenpyram and pyridalyl is used for preventing and treating resistance Semiptera insect.

Summary of the invention

The purpose of this invention is to provide a kind of Synergistic insecticidal compositions that contains Nitenpyram and pyridalyl.

Another object of the present invention provides above-mentioned Synergistic insecticidal compositions and prevents and treats application in the resistance Semiptera insect insecticidal materials in preparation.

For achieving the above object, two kinds of insecticidal materials Nitenpyrams and pyridalyl that the present invention is different with controlling object are composite, obtain the new and effective multifunctional insecticide composition of a class.This Pesticidal combination has good preventive effect to the various pests that rice fulgorid, aphid, diamond-back moth easily produce resistance; And suppress insect to the pesticide resistance generation of unitary agent (Nitenpyram or pyridalyl).

The present invention adopts following technical scheme:

A kind of Synergistic insecticidal compositions that contains Nitenpyram and pyridalyl is characterized in that this Synergistic insecticidal compositions take Nitenpyram and pyridalyl as main active ingredient, and wherein, the weight ratio of Nitenpyram and pyridalyl is 0.1～80: 0.2～70.

The weight ratio of Nitenpyram and pyridalyl preferred 0.5～60 in this Synergistic insecticidal compositions: 2～50, more preferably 1～30: 4～20.

In the present composition, the two percentage by weight that accounts for composition of Nitenpyram and pyridalyl is 3～80%.Be preferably 5～50%, most preferably 5～20%." % " of the present invention is mass percent.

Above-mentioned Insecticidal combinations is take Nitenpyram and pyridalyl as main active ingredient (active component), and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals.Be preferably missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion and water dispersion granule.

Described auxiliary agent specifically can adopt calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, polyoxyethylene polyoxy third rare block compound (such as farming breast 33 ^#), polyoxyethylene nonylphenol ether etc., excipient can adopt cyclohexanone, dimethylbenzene, solvent naphtha, water, antifreezing agent (such as propane diols), deionized water etc.Auxiliary agent, excipient can alone or mixing and usefulness, also can add other auxiliary material that allows on the pesticidal preparations.

Above-mentioned Pesticidal combination can be prevented and treated application in the insecticidal materials of resistance Semiptera insect in preparation, and the control efficiency of the present composition is used apparently higher than its single dose, and described Semiptera insect refers in particular to rice fulgorid, aphid, aleyrodid.

Indoor bioassay and field control effectiveness test show that compound insecticidal medicine of the present invention has significant synergistic insecticidal action to the Semiptera insect, all is significantly higher than the effect of corresponding single dose agricultural chemicals especially to the insecticidal effect of water rice hopper, aphid, aleyrodid.

Beneficial effect of the present invention: the Nitenpyram that provides of the present invention and pyridalyl Pesticidal combination, can produce higher synergistic function, desinsection speed is fast, overcome and delayed pest resistance to insecticide, the expanding prevention spectrum has reduced drug cost simultaneously, and its successful is higher than its single dose to be used.

Embodiment

Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.First by indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage; On this basis, carry out again field trial.

Embodiment 1:

Take by weighing Nitenpyram, pyridalyl and adopt the conventional formulation method, being mixed with active ingredient quality percentage composition by different proportion respectively is 30% Nitenpyram pyridalyl missible oil, and concrete ratio sees Table 1,2.

Adopt rice stem infusion process to carry out indoor synergy biologicall test, selecting the resistant rice plant hopper is target pest, and every processing repeats 3 times, and every concentration is processed 60, uses LC ₅₀Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

The Toxicity Determination of table 1. Nitenpyram and pyridalyl composition and single dose antagonism rice fulgorid thereof:

Medicament	The toxicity regression curve	LC ₅₀(mg/L)	Actual measurement toxicity index ATI	Theoretical toxicity index TTI	Co-toxicity coefficient
						Pyridalyl A	Y＝1.83033+1.81687X	15.536	100	/	/
Nitenpyram B	Y＝4.56747+2.14270X	3.878	400.62	/	/
						A∶B＝10∶1	Y＝3.82390+1.49213X	4.140	302.26	127.3291	237.38
A∶B＝15∶1	Y＝3.23766+1.80134X	3.514	238.50	118.7888	200.78
						A∶B＝20∶1	Y＝3.19046+1.64086X	3.671	202.53	114.3152	177.17

Data show in the table, and Nitenpyram and pyridalyl are mixed and rear Brown Planthopper are had synergistic effect, and three listed in table proportioning co-toxicity coefficients are all much larger than 120, so Nitenpyram and pyridalyl are mixed and have significant synergies.

Employing is soaked the leaf dip method and is carried out indoor synergy biologicall test, and selecting the resistance aleyrodid is target pest, and every processing repeats 3 times, uses LC ₅₀Value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:

The Toxicity Determination of table 2. Nitenpyram and pyridalyl Synergistic insecticidal compositions and single dose antagonism aleyrodid thereof:

Medicament	The toxicity regression curve	LC ₅₀(mg/L)	Actual measurement toxicity index ATI	Theoretical toxicity index TTI	Co-toxicity coefficient
						Pyridalyl A	Y＝2.84968+1.75624X	10.536	100	/	/
Nitenpyram B	Y＝3.23546+2.21863X	2.850	369.68	/	/
						A∶B＝10∶1	Y＝3.48632+1.95624X	4.568	230.65	124.524	185.23
A∶B＝15∶1	Y＝3.53249+1.95103X	5.364	196.42	116.86	168.08
						A∶B＝20∶1	Y＝3.49046+2.34865X	6.159	171.07	112.84	151.60

Data show in the table, and Nitenpyram and pyridalyl are mixed and rear aleyrodid are had synergistic effect, and three listed in table proportioning co-toxicity coefficients are all much larger than 120, and Nitenpyram and pyridalyl are mixed and have significant synergies.

Adopt the sample of embodiment 2 and 3, according to every mu of ground medication 10g, 20g, 25g preparation, the contrast medicament is 10% pyridalyl WP30g/ mu, 5% Nitenpyram AS30g/ mu, every mu of ground water 30kg control Brown Planthopper.4 days, 10 days, 15 days, 20 days, 30 days fruits that come to an end after the dispenser, and carry out data and process, the results are shown in Table 3:

Table 3: Nitenpyram and pyridalyl Synergistic insecticidal compositions are to the field test results of Brown Planthopper

As can be known from the above table, the Nitenpyram pyridalyl is composite to be better than 10% pyridalyl wetting powder, 5% Nitenpyram aqua to the water rice hopper drug effect, demonstrates the superiority of prescription.

Adopt the sample of embodiment 2 and 3, according to every mu of ground medication 10g, 20g, 25g medicament, the contrast medicament is 10% pyridalyl WP30g/ mu, 5% Nitenpyram AS30g/ mu, every mu of ground water 30kg, the aleyrodid on the control cucumber.4 days, 10 days, 15 days, 20 days, 30 days fruits that come to an end after the dispenser, and process, the results are shown in Table 4:

Table 4: the composite field test results to aleyrodid of Nitenpyram-pyridalyl

As can be known from the above table, the Nitenpyram pyridalyl is composite to be better than 10% pyridalyl wetting powder, 5% Nitenpyram aqua to the aleyrodid drug effect, demonstrates the superiority of prescription.

Embodiment 2:

Take by weighing the 0.5g Nitenpyram, the 10g pyridalyl is dissolved in the 8g dimethylbenzene, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Mentioned solution is slowly poured in the excess water to gross weight 100g, fully stirred down, make 10.5% Nitenpyram pyridalyl aqueous emulsion.

Embodiment 3:

Take by weighing the 1g Nitenpyram, the 10g pyridalyl is dissolved in the 8g dimethylbenzene, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Mentioned solution is slowly poured in the excess water, under fully stirring, made 11% Nitenpyram pyridalyl aqueous emulsion.

Embodiment 4:

Take by weighing the 45g Nitenpyram, the 5g pyridalyl is dissolved in the 8g dimethylbenzene, adds 1g ethylene glycol and 5g alkylphenol polyoxyethylene disodium sulfosuccinate again, stir.Mentioned solution is slowly poured in the excess water, under fully stirring, made 50% Nitenpyram pyridalyl aqueous emulsion.

Embodiment 5:

Take by weighing 2g Nitenpyram, 20g pyridalyl, alkylphenol polyoxyethylene 5g, phenethyl phenol polyethenoxy ether 6g, 1-METHYLPYRROLIDONE 4g, isopropyl alcohol 6g, dimethylbenzene 3g, surplus is water, the method that above raw material is prepared microemulsion routinely drops in the mixing kettle mixes, and makes 22% Nitenpyram pyridalyl microemulsion.

Embodiment 6:

Take by weighing 5g Nitenpyram, 45g pyridalyl, the 8g of wooden sodium sulfonate, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g makes 50% Nitenpyram pyridalyl water dispersion granule with above raw material by the method for water dispersion granule.

Embodiment 7:

Take by weighing 75g Nitenpyram, 0.2g pyridalyl, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared routinely the method for suspending agent, made 75.2% Nitenpyram pyridalyl suspending agent.

Embodiment 8:

Take by weighing 10g Nitenpyram, 15g pyridalyl, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared routinely the method for suspending agent, made 25% Nitenpyram pyridalyl suspending agent.

Embodiment 9:

Take by weighing 5g Nitenpyram, 70g pyridalyl, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 4g, phenethyl phenol polyethenoxy ether 5g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and makes 75% Nitenpyram pyridalyl missible oil.

Embodiment 10:

Take by weighing 0.1g Nitenpyram, 30g pyridalyl, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 4g, phenethyl phenol polyethenoxy ether 6g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and makes 30.1% Nitenpyram pyridalyl missible oil.

Embodiment 11:

Take by weighing 30g Nitenpyram, 20g pyridalyl, calcium dodecyl benzene sulfonate 4g, alkylphenol polyoxyethylene 5g, phenethyl phenol polyethenoxy ether 6g, dimethylbenzene to 100g, the method that above raw material is prepared missible oil routinely drops in the mixing kettle mixes, and makes 50% Nitenpyram pyridalyl missible oil.

Embodiment 12:

Take by weighing 60g Nitenpyram, 5g pyridalyl, 1g lauryl sodium sulfate, 0.5g dispersing agent NNO, kaolin to 100g, above raw material is prepared routinely the method for wetting powder and mixed, form 65% Nitenpyram pyridalyl wetting powder.

Claims

1. Synergistic insecticidal compositions that contains Nitenpyram and pyridalyl, it is characterized in that this Synergistic insecticidal compositions is take Nitenpyram and pyridalyl as active ingredient, wherein, the weight ratio of Nitenpyram and pyridalyl is 1 ~ 30:4 ~ 20, and the two weight percentage that accounts for composition of Nitenpyram and pyridalyl is 5 ~ 20%.

2. the Synergistic insecticidal compositions that contains Nitenpyram and pyridalyl according to claim 1 is characterized in that it take Nitenpyram and pyridalyl as active ingredient and insecticides adjuvant, excipients are mixed with any one formulation that allows on the agricultural chemicals.

3. the Synergistic insecticidal compositions that contains Nitenpyram and pyridalyl according to claim 2 is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.

4. the Synergistic insecticidal compositions that contains Nitenpyram and pyridalyl claimed in claim 1 is prevented and treated application in the insecticidal materials of resistance Semiptera insect in preparation.

5. the application of Synergistic insecticidal compositions in the insecticidal materials of preparation control water rice hopper, aleyrodid, aphid that contains Nitenpyram and pyridalyl claimed in claim 1.