CN103621543A - Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof - Google Patents
Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof Download PDFInfo
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- CN103621543A CN103621543A CN201210312346.6A CN201210312346A CN103621543A CN 103621543 A CN103621543 A CN 103621543A CN 201210312346 A CN201210312346 A CN 201210312346A CN 103621543 A CN103621543 A CN 103621543A
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- clothianidin
- mti
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- PGOOBECODWQEAB-UHFFFAOYSA-N Clothianidin Chemical compound [O-][N+](=O)\N=C(/NC)NCC1=CN=C(Cl)S1 PGOOBECODWQEAB-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 239000005888 Clothianidin Substances 0.000 title claims abstract description 76
- YKBZOVFACRVRJN-UHFFFAOYSA-N Dinotefuran Chemical compound [O-][N+](=O)\N=C(/NC)NCC1CCOC1 YKBZOVFACRVRJN-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000749 insecticidal Effects 0.000 title claims abstract description 42
- 230000002195 synergetic Effects 0.000 title claims abstract description 28
- 241001124076 Aphididae Species 0.000 claims abstract description 5
- 241001498622 Cixius wagneri Species 0.000 claims abstract description 5
- 241001414720 Cicadellidae Species 0.000 claims abstract description 4
- 239000004480 active ingredient Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 241000607479 Yersinia pestis Species 0.000 claims description 9
- 239000002917 insecticide Substances 0.000 claims description 9
- 239000003905 agrochemical Substances 0.000 claims description 8
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 230000000361 pesticidal Effects 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000009736 wetting Methods 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000000240 adjuvant Effects 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 241000238631 Hexapoda Species 0.000 abstract description 10
- 239000003814 drug Substances 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 229940079593 drugs Drugs 0.000 abstract description 2
- 241000258937 Hemiptera Species 0.000 abstract 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 230000001934 delay Effects 0.000 abstract 1
- 230000002085 persistent Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 239000002994 raw material Substances 0.000 description 10
- -1 chloro thiazolyl Chemical group 0.000 description 9
- 241000209094 Oryza Species 0.000 description 8
- 239000002131 composite material Substances 0.000 description 8
- 235000007164 Oryza sativa Nutrition 0.000 description 7
- 241000125167 Rhopalosiphum padi Species 0.000 description 7
- 235000009566 rice Nutrition 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 6
- 241000437063 Phyllotreta striolata Species 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 5
- 235000006008 Brassica napus var napus Nutrition 0.000 description 5
- 241001674939 Caulanthus Species 0.000 description 5
- HCWYXKWQOMTBKY-UHFFFAOYSA-N calcium;dodecyl benzenesulfonate Chemical compound [Ca].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 HCWYXKWQOMTBKY-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000000575 pesticide Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 235000013311 vegetables Nutrition 0.000 description 4
- 241000283073 Equus caballus Species 0.000 description 3
- 241000578422 Graphosoma lineatum Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 235000018519 Scolymus Nutrition 0.000 description 3
- 240000005687 Scolymus hispanicus Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- MTXSIJUGVMTTMU-JTQLQIEISA-N (S)-anabasine Chemical compound N1CCCC[C@H]1C1=CC=CN=C1 MTXSIJUGVMTTMU-JTQLQIEISA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- PZZYQPZGQPZBDN-UHFFFAOYSA-N Aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 2
- 241000675108 Citrus tangerina Species 0.000 description 2
- 241000270322 Lepidosauria Species 0.000 description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- 229960002715 Nicotine Drugs 0.000 description 2
- CFRPSFYHXJZSBI-DHZHZOJOSA-N Nitenpyram Chemical compound [O-][N+](=O)/C=C(\NC)N(CC)CC1=CC=C(Cl)N=C1 CFRPSFYHXJZSBI-DHZHZOJOSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 241000176086 Sogatella furcifera Species 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- STCOOQWBFONSKY-UHFFFAOYSA-N Tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 229930014345 anabasine Natural products 0.000 description 2
- 230000003042 antagnostic Effects 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- XUZHLZDRCCUWEV-UHFFFAOYSA-N formaldehyde;methyl naphthalene-1-sulfonate Chemical compound O=C.C1=CC=C2C(S(=O)(=O)OC)=CC=CC2=C1 XUZHLZDRCCUWEV-UHFFFAOYSA-N 0.000 description 2
- 230000002045 lasting Effects 0.000 description 2
- 239000000391 magnesium silicate Substances 0.000 description 2
- 229910052919 magnesium silicate Inorganic materials 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 229930015196 nicotine Natural products 0.000 description 2
- 229940079888 nitenpyram Drugs 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 230000003449 preventive Effects 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- OKDGRDCXVWSXDC-UHFFFAOYSA-N 2-Chloropyridine Chemical compound ClC1=CC=CC=N1 OKDGRDCXVWSXDC-UHFFFAOYSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N Ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 241000239290 Araneae Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 210000000481 Breast Anatomy 0.000 description 1
- 241001347511 Carposina sasakii Species 0.000 description 1
- 241001465828 Cecidomyiidae Species 0.000 description 1
- 241000426497 Chilo suppressalis Species 0.000 description 1
- 241001364569 Cofana spectra Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 240000007842 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 241000258916 Leptinotarsa decemlineata Species 0.000 description 1
- 241000661348 Leptocorisa acuta Species 0.000 description 1
- 241000594036 Liriomyza Species 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001556089 Nilaparvata lugens Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 240000005158 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 241000517946 Phyllotreta nemorum Species 0.000 description 1
- 241000500437 Plutella xylostella Species 0.000 description 1
- 231100000614 Poison Toxicity 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 210000002784 Stomach Anatomy 0.000 description 1
- 241000339374 Thrips tabaci Species 0.000 description 1
- 241000669245 Unaspis Species 0.000 description 1
- 235000005042 Zier Kohl Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 102000015296 acetylcholine-gated cation-selective channel activity proteins Human genes 0.000 description 1
- 108040006409 acetylcholine-gated cation-selective channel activity proteins Proteins 0.000 description 1
- 231100000460 acute oral toxicity Toxicity 0.000 description 1
- 231100000293 acute skin toxicity Toxicity 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 235000021329 brown rice Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2R)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N n-heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 1
- SECXISVLQFMRJM-UHFFFAOYSA-N n-methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 1
- 230000001537 neural Effects 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N o-xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000000607 poisoning Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 210000004894 snout Anatomy 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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Abstract
The invention discloses a synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof. The synergistic insecticidal composition employs dinotefuran and clothianidin as main effective components, wherein, the weight ratio of dinotefuran to clothianidin is 0.1-70:0.2-70. The composition has high synergistic effects and delays drug resistance of insects. The insecticidal speed is fast, the persistent period is long and the drug cost is lowered. The composition can control hemiptera and coleopteran insects with resistance on crops, and especially can be used for control of plant hopper, whitefly, leafhopper and aphid. The effects of the composition are obviously higher than that of single usage.
Description
Technical field
The invention belongs to the pesticide field that contains heterocyclic compound, be specifically related to a kind of Synergistic insecticidal compositions and application thereof that MTI-446 and clothianidin be main active ingredient of take.
Background technology
MTI-446 (dinotefuran) is the third generation nicotinic insecticide of Mitsui chemical company exploitation, the chemical constitution of itself and existing nicotinic insecticide is far from each other, chloro-pyridine base, chloro thiazolyl before its tetrahydrofuran base has replaced, containing halogen.Meanwhile, also different with nicotine at aspect of performance.So people are referred to as " furans nicotine " at present.MTI-446 chemical name: 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine, structural formula is as follows:
A new generation's anabasine insecticide MTI-446 Main Function, in insect neurotransmission system, makes insect paralysis dead.This medicament insecticidal spectrum is wide, has remarkable interior suction osmosis, and has shown very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, and crop, without poisoning, be can be used for to numerous crops such as paddy rice, fruit tree, vegetables.To rice grub brown planthopper, white-backed planthopper, small brown rice planthopper, rice leafhopper, rice spider rafter stinkbug, star stinkbug, green rice bug resemble, red must fleahopper, the negative mixed worm of rice, rice cylinder water snout moth's larva be efficient.Effective to striped rice borer, oryza chinensis class.Efficient to vegetables, fruit insect Phytophthira, aleyrodid class, a red-spotted lizard class, unaspis shield kuwana, the green stinkbug of Zhu, peach fruit borer, tangerine lyonetid, the thin moth of tea, striped flea-beetle, the beans fly of diving.The cured a red-spotted lizard in diagonal angle, diamond-back moth, two secret notes are chrysomelid, tea golden thistle horse, onion thrips, golden thistle horse, oranges and tangerines golden thistle horse, soybean pod gall-midge, tomato Liriomyza are effective.MTI-446 has very wide insecticidal spectrum, and fool proof again to crop, people and animals and environment, then is equipped with the using method of various uses, this agricultural chemicals large-tonnage agricultural chemicals that is expected to become international.
Clothianidin (Clothianidin), chemical name: E)-1-(the chloro-1,3-thiazoles-5-of 2-ylmethyl)-3-methyl-2-nitroguanidine; Chemical molecular formula: C
6h
8clN
5o
2s; Sterling outward appearance is white crystals, 176.8 ℃ of fusing points, vapour pressure (20 ℃) 3.8 * 10-11Pa, solvability (g/L, 25 ℃): 0.327 (20 ℃) in water, in ethyl acetate 2.03, <0.00104 in normal heptane, in dimethylbenzene 0.0128, in carrene 1.32, in octanol 0.938, in acetone 15.2, in methyl alcohol 6.26.Structural formula is:
Clothianidin acute oral toxicity, rat male and female: LD50 > 5000mg/kg, acute dermal toxicity: rat male and female: LD50 > 2000mg/kg, inhales people's toxicity: rat male and female, 6.1mg/L.
Clothianidin belongs to anabasine insecticide, be a kind of activity high, there is interior absorption, tag and the broad spectrum pesticide of stomach poison function.Shi Wu field company is after Nitenpyram (nitenpyram), and another nicotinic insecticide of discovery, belongs to the second generation.The mechanism of action is in conjunction with the nAChR that is positioned at neural post-synapse.Be applicable to foliar spray, soil treatment effect, show good quick-acting, the lasting period is about 7 days.Be mainly used in paddy rice, vegetables, fruit tree and other crop, control Semiptera, coleoptera, diptera and some lepidoptera pest.
Rice fulgorid and aphid are under the condition of current long-term prescription, resistance increases gradually, agricultural chemicals single dose declines gradually to the effect of control of insect, through inventor, study discovery, the synergistic complex of agricultural chemicals is expanding prevention spectrum and the effective measures that improve preventive effect, not yet finds up to now the Synergistic insecticidal compositions of relevant MTI-446 and clothianidin.
Summary of the invention
The object of this invention is to provide a kind of Synergistic insecticidal compositions containing MTI-446 and clothianidin.
Another object of the present invention is to provide said composition and in preparation, prevents and treats the application on the insecticidal materials of resistance Semiptera, coleopteran pest.
For achieving the above object, the present invention is composite by MTI-446 and the clothianidin of lasting period length, obtains new and effective multifunctional insecticide composition.Semiptera and coleopteran pest that this insecticidal materials easily produces resistance to plant hopper, aleyrodid, leafhopper and aphid etc. have good preventive effect; And suppress insect the pesticide resistance of unitary agent (MTI-446 or clothianidin are arbitrary) is produced.
The object of the invention is to be achieved through the following technical solutions:
Containing a Synergistic insecticidal compositions for MTI-446 and clothianidin, it is characterized in that it take MTI-446 and clothianidin is main active ingredient, wherein, the weight ratio of MTI-446 and clothianidin is 0.1 ~ 70:0.2 ~ 70.Preferred 1 ~ 50:1 ~ 50 of the weight ratio of MTI-446 and clothianidin in this Synergistic insecticidal compositions, 1 ~ 20:1 ~ 20 more preferably, more further preferred weight ratio is 1 ~ 8:1 ~ 8, most preferably the weight ratio of MTI-446 and clothianidin is 1:2 ~ 8.
In the present composition, the two percentage by weight that accounts for composition of MTI-446 and clothianidin is 1 ~ 80%.Be preferably 5 ~ 50%, most preferably 5 ~ 40%.This Synergistic insecticidal compositions can only contain active ingredient MTI-446 and clothianidin, also can when using or prepare, in active component, add other components, and the effective ingredient of above-mentioned Insecticidal combinations is present in composition with synergy effective dose." % " of the present invention is mass percent.
It is main active ingredient (active component) that above-mentioned Insecticidal combinations be take MTI-446 and clothianidin, and insecticides adjuvant, excipients are mixed with any one formulation allowing on agricultural chemicals.Be preferably missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion and water dispersion granule.
Aforementionedly can be applicable to the not special restriction of insecticides adjuvant of the present invention, include, but are not limited to calcium dodecyl benzene sulfonate, emulsifier 600 #, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33
#), the one or more combinations in polyoxyethylene nonylphenol ether, aforementionedly can be applicable to excipient of the present invention and be also not particularly limited, include, but are not limited to isopropyl alcohol, solvent naphtha, water, dimethyl formamide, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent and excipient all can be used one or more.
Above-mentioned Pesticidal combination can be prevented and treated the application in the insecticidal materials of resistance Semiptera, coleopteran pest in preparation, and the control efficiency of the present composition is used apparently higher than its single dose, and described Semiptera insect refers in particular to plant hopper, aleyrodid, leafhopper and aphid; Coleopteran pest refers in particular to colorado potato beetles, brassicaceous vegetable phyllotreta striolata etc.
Through indoor synergism test, measure and show: built agent all has significant synergistic insecticidal action; Field control effectiveness test equally also shows that all built agents of the present invention are all significantly higher than the effect of corresponding single dose agricultural chemicals to the insecticidal effect of water rice hopper and wheat aphid.
Pesticidal combination of the present invention compared with prior art, produces following beneficial effect: (1) is compared with single dose, and said composition has notable synergistic to insect, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests simultaneously, reduce control recruitment cost; (3) alternative high-toxic pesticide, and significantly reduce field dosage, effectively reduce environmental pollution and residue of pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with MTI-446 single dose, produce and use cost reduction; (6) suppressing insect strengthens the resistance of agricultural chemicals.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but do not limit the present invention in any way.
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.First by indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage; On this basis, then carry out field trial.
Embodiment 1:
Take 30g MTI-446 clothianidin, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, vegetable oil to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the MTI-446 clothianidin missible oil that main active ingredient weight percentage is 30%.The concrete ratio of MTI-446 clothianidin is in Table 1,2.
Adopt cabbage leaves infusion process to carry out indoor synergy biologicall test, selecting resistance wild cabbage phyllotreta striolata is target pest, and every processing repeats 3 times, and every concentration is processed 60, uses LC
50value is calculated co-toxicity coefficient by the Y-factor method Y of majoring in of the abundant method introduction of Sun Yun, determines whether mixture has synergistic function:
The toxicity test of the composite and single dose antagonism wild cabbage phyllotreta striolata of table 1 MTI-446 and clothianidin.
As shown in Table 1, MTI-446 and clothianidin are composite, and co-toxicity coefficient is all greater than 120, show good synergistic function.
Selecting resistance wheat aphid is that worm leaf dipping method is soaked in target pest employing, and every processing repeats 3 times, uses LC
50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
The toxicity test of the composite and single dose antagonism wheat aphid of table 2 MTI-446 and clothianidin.
As shown in Table 2, MTI-446 and clothianidin are composite is all greater than 120 to the co-toxicity coefficient of wheat aphid, shows good synergistic function.Wherein, when MTI-446 and clothianidin 1:5, synergistic effect is the most obvious.
Adopt 3 sample product of embodiment to carry out the field trial of control in field wild cabbage phyllotreta striolata, contrast medicament is 10% clothianidin WDG and 10% MTI-446 WP, and concrete consumption is in Table 3, every mu of water consumption is 30kg, looks into 7 days after medicine 3 days, 14 days, the result of 28 days, result of the test is in Table 3:
Table 3: the composite and field control effectiveness test of single dose to wild cabbage phyllotreta striolata of MTI-446 clothianidin
As can be known from the above table, 10% MTI-446 clothianidin microemulsion is better than 10% clothianidin WDG, 10% MTI-446 WP to the drug effect of wild cabbage phyllotreta striolata, demonstrates the superiority of formula.
Adopt 3 sample product of embodiment to carry out the field trial of control in field wheat aphid, contrast medicament is 10% clothianidin WDG and 10% MTI-446 WP, and concrete consumption is in Table 4, every mu of water consumption is 30kg, looks into 7 days after medicine 3 days, 14 days, the result of 28 days, result of the test is in Table 4:
Table 4: the composite and field control effectiveness test of single dose to wheat aphid of MTI-446 clothianidin
As can be known from the above table, 10% MTI-446 clothianidin microemulsion is better than 10% clothianidin WDG, 10% MTI-446 WP to wheat aphid drug effect, demonstrates the superiority of formula.
Embodiment 2:
Take 20g MTI-446,2g clothianidin, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 22% MTI-446 clothianidin missible oil.
Embodiment 3:
Take 2g MTI-446,8g clothianidin, emulsifier 1602
#4g, emulsifier 500
#2g, 1-METHYLPYRROLIDONE 4g, isopropyl alcohol 6g, solvent naphtha 3g, surplus is water, and the method that above raw material is prepared to microemulsion routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 10% MTI-446 clothianidin microemulsion.
Embodiment 4:
Take 60g MTI-446,5g clothianidin, 1g lauryl sodium sulfate, 0.5g dispersing agent NNO, kaolin to 100g, above raw material is prepared routinely to the method for wetting powder and mixed, making main active ingredient weight percentage is 65% MTI-446 clothianidin wetting powder.
Embodiment 5:
Take 80g MTI-446,0.2g clothianidin, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 80.2% MTI-446 clothianidin missible oil.
Embodiment 6:
Take 20g MTI-446,2g clothianidin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared routinely to the method for suspending agent, making main active ingredient weight percentage is 22% MTI-446 clothianidin suspending agent.
Embodiment 7:
Take 30g MTI-446,0.5g clothianidin, calcium dodecyl benzene sulfonate 12g, phenethyl phenol polyethenoxy ether 8g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 30.5% MTI-446 clothianidin missible oil.
Embodiment 8:
Take 2g MTI-446,20g clothianidin, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g, it is 22% MTI-446 clothianidin water dispersion granule that above raw material is made to main active ingredient weight percentage by the method for water dispersion granule.
Embodiment 9:
Take 5g MTI-446,30g clothianidin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared routinely to the method for suspending agent, making main active ingredient weight percentage is 35% MTI-446 clothianidin suspending agent.
Embodiment 10:
Take 0.1g MTI-446,70g clothianidin, emulsifier 600 #10g, phenethyl phenol polyethenoxy ether 10g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 70.1% MTI-446 clothianidin missible oil.
Embodiment 11:
Take 20g MTI-446,0.2g clothianidin is dissolved in 8g solvent naphtha, add again 1g ethylene glycol and 5g emulsifier 600 #, stir, above-mentioned solution is slowly poured in excess water, under fully stirring, making main active ingredient weight percentage is 20.2% MTI-446 clothianidin aqueous emulsion.
Claims (10)
1. containing a Synergistic insecticidal compositions for MTI-446 and clothianidin, it is characterized in that it take MTI-446 and clothianidin is main active ingredient, wherein, the weight ratio of MTI-446 and clothianidin is 0.1 ~ 70:0.2 ~ 70.
2. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 1, is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1 ~ 50:1 ~ 50.
3. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 2, is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1 ~ 20:1 ~ 20.
4. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 3, is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1 ~ 8:1 ~ 8.
5. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 1, is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 1 ~ 80%.
6. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 5, is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 5 ~ 50%.
7. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 1, is characterized in that it take MTI-446 and clothianidin and be mixed with any one formulation allowing on agricultural chemicals as main active ingredient and insecticides adjuvant, excipients.
8. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 7, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
9. the Synergistic insecticidal compositions containing MTI-446 and clothianidin claimed in claim 1 is prevented and treated the application on the insecticidal materials of resistance Semiptera, coleopteran pest in preparation.
10. the application of the Synergistic insecticidal compositions containing MTI-446 and clothianidin claimed in claim 1 on the insecticidal materials of preparation control plant hopper, aleyrodid, leafhopper or aphid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210312346.6A CN103621543A (en) | 2012-08-29 | 2012-08-29 | Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof |
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| CN201210312346.6A CN103621543A (en) | 2012-08-29 | 2012-08-29 | Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112661574A (en) * | 2021-02-04 | 2021-04-16 | 赤天化科技集团有限公司 | High-tower pesticide-fertilizer containing clothianidin and dinotefuran and preparation method thereof |
| CN113475535A (en) * | 2018-03-02 | 2021-10-08 | 中国农业科学院棉花研究所 | Method for extracting castor-containing insecticidal active substance and combined application of castor-containing insecticidal active substance and neonicotinoid insecticide |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349505A (en) * | 2011-09-13 | 2012-02-15 | 广西田园生化股份有限公司 | Ultra-low-capacity liquid containing dinotefuran |
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- 2012-08-29 CN CN201210312346.6A patent/CN103621543A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349505A (en) * | 2011-09-13 | 2012-02-15 | 广西田园生化股份有限公司 | Ultra-low-capacity liquid containing dinotefuran |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113475535A (en) * | 2018-03-02 | 2021-10-08 | 中国农业科学院棉花研究所 | Method for extracting castor-containing insecticidal active substance and combined application of castor-containing insecticidal active substance and neonicotinoid insecticide |
| CN112661574A (en) * | 2021-02-04 | 2021-04-16 | 赤天化科技集团有限公司 | High-tower pesticide-fertilizer containing clothianidin and dinotefuran and preparation method thereof |
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