CN103621543A - Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof - Google Patents

Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof Download PDF

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Publication number
CN103621543A
CN103621543A CN201210312346.6A CN201210312346A CN103621543A CN 103621543 A CN103621543 A CN 103621543A CN 201210312346 A CN201210312346 A CN 201210312346A CN 103621543 A CN103621543 A CN 103621543A
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China
Prior art keywords
clothianidin
mti
synergistic insecticidal
compositions containing
insecticidal compositions
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CN201210312346.6A
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Chinese (zh)
Inventor
陈文明
袁竹青
彭永强
沈海峰
郭崇友
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Nanjing Huazhou Pharmaceutical Co Ltd
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Nanjing Huazhou Pharmaceutical Co Ltd
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Priority to CN201210312346.6A priority Critical patent/CN103621543A/en
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Abstract

The invention discloses a synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof. The synergistic insecticidal composition employs dinotefuran and clothianidin as main effective components, wherein, the weight ratio of dinotefuran to clothianidin is 0.1-70:0.2-70. The composition has high synergistic effects and delays drug resistance of insects. The insecticidal speed is fast, the persistent period is long and the drug cost is lowered. The composition can control hemiptera and coleopteran insects with resistance on crops, and especially can be used for control of plant hopper, whitefly, leafhopper and aphid. The effects of the composition are obviously higher than that of single usage.

Description

A kind of Synergistic insecticidal compositions and application thereof containing MTI-446 and clothianidin
Technical field
The invention belongs to the pesticide field that contains heterocyclic compound, be specifically related to a kind of Synergistic insecticidal compositions and application thereof that MTI-446 and clothianidin be main active ingredient of take.
Background technology
MTI-446 (dinotefuran) is the third generation nicotinic insecticide of Mitsui chemical company exploitation, the chemical constitution of itself and existing nicotinic insecticide is far from each other, chloro-pyridine base, chloro thiazolyl before its tetrahydrofuran base has replaced, containing halogen.Meanwhile, also different with nicotine at aspect of performance.So people are referred to as " furans nicotine " at present.MTI-446 chemical name: 1-methyl-2-nitro-3-(tetrahydrochysene-3-furfuryl) guanidine, structural formula is as follows:
A new generation's anabasine insecticide MTI-446 Main Function, in insect neurotransmission system, makes insect paralysis dead.This medicament insecticidal spectrum is wide, has remarkable interior suction osmosis, and has shown very high insecticidal activity at very low dosage.This medicament is fool proof to mammal, birds and aquatile, and crop, without poisoning, be can be used for to numerous crops such as paddy rice, fruit tree, vegetables.To rice grub brown planthopper, white-backed planthopper, small brown rice planthopper, rice leafhopper, rice spider rafter stinkbug, star stinkbug, green rice bug resemble, red must fleahopper, the negative mixed worm of rice, rice cylinder water snout moth's larva be efficient.Effective to striped rice borer, oryza chinensis class.Efficient to vegetables, fruit insect Phytophthira, aleyrodid class, a red-spotted lizard class, unaspis shield kuwana, the green stinkbug of Zhu, peach fruit borer, tangerine lyonetid, the thin moth of tea, striped flea-beetle, the beans fly of diving.The cured a red-spotted lizard in diagonal angle, diamond-back moth, two secret notes are chrysomelid, tea golden thistle horse, onion thrips, golden thistle horse, oranges and tangerines golden thistle horse, soybean pod gall-midge, tomato Liriomyza are effective.MTI-446 has very wide insecticidal spectrum, and fool proof again to crop, people and animals and environment, then is equipped with the using method of various uses, this agricultural chemicals large-tonnage agricultural chemicals that is expected to become international.
Clothianidin (Clothianidin), chemical name: E)-1-(the chloro-1,3-thiazoles-5-of 2-ylmethyl)-3-methyl-2-nitroguanidine; Chemical molecular formula: C 6h 8clN 5o 2s; Sterling outward appearance is white crystals, 176.8 ℃ of fusing points, vapour pressure (20 ℃) 3.8 * 10-11Pa, solvability (g/L, 25 ℃): 0.327 (20 ℃) in water, in ethyl acetate 2.03, <0.00104 in normal heptane, in dimethylbenzene 0.0128, in carrene 1.32, in octanol 0.938, in acetone 15.2, in methyl alcohol 6.26.Structural formula is:
Clothianidin acute oral toxicity, rat male and female: LD50 > 5000mg/kg, acute dermal toxicity: rat male and female: LD50 > 2000mg/kg, inhales people's toxicity: rat male and female, 6.1mg/L.
Clothianidin belongs to anabasine insecticide, be a kind of activity high, there is interior absorption, tag and the broad spectrum pesticide of stomach poison function.Shi Wu field company is after Nitenpyram (nitenpyram), and another nicotinic insecticide of discovery, belongs to the second generation.The mechanism of action is in conjunction with the nAChR that is positioned at neural post-synapse.Be applicable to foliar spray, soil treatment effect, show good quick-acting, the lasting period is about 7 days.Be mainly used in paddy rice, vegetables, fruit tree and other crop, control Semiptera, coleoptera, diptera and some lepidoptera pest.
Rice fulgorid and aphid are under the condition of current long-term prescription, resistance increases gradually, agricultural chemicals single dose declines gradually to the effect of control of insect, through inventor, study discovery, the synergistic complex of agricultural chemicals is expanding prevention spectrum and the effective measures that improve preventive effect, not yet finds up to now the Synergistic insecticidal compositions of relevant MTI-446 and clothianidin.
Summary of the invention
The object of this invention is to provide a kind of Synergistic insecticidal compositions containing MTI-446 and clothianidin.
Another object of the present invention is to provide said composition and in preparation, prevents and treats the application on the insecticidal materials of resistance Semiptera, coleopteran pest.
For achieving the above object, the present invention is composite by MTI-446 and the clothianidin of lasting period length, obtains new and effective multifunctional insecticide composition.Semiptera and coleopteran pest that this insecticidal materials easily produces resistance to plant hopper, aleyrodid, leafhopper and aphid etc. have good preventive effect; And suppress insect the pesticide resistance of unitary agent (MTI-446 or clothianidin are arbitrary) is produced.
The object of the invention is to be achieved through the following technical solutions:
Containing a Synergistic insecticidal compositions for MTI-446 and clothianidin, it is characterized in that it take MTI-446 and clothianidin is main active ingredient, wherein, the weight ratio of MTI-446 and clothianidin is 0.1 ~ 70:0.2 ~ 70.Preferred 1 ~ 50:1 ~ 50 of the weight ratio of MTI-446 and clothianidin in this Synergistic insecticidal compositions, 1 ~ 20:1 ~ 20 more preferably, more further preferred weight ratio is 1 ~ 8:1 ~ 8, most preferably the weight ratio of MTI-446 and clothianidin is 1:2 ~ 8.
In the present composition, the two percentage by weight that accounts for composition of MTI-446 and clothianidin is 1 ~ 80%.Be preferably 5 ~ 50%, most preferably 5 ~ 40%.This Synergistic insecticidal compositions can only contain active ingredient MTI-446 and clothianidin, also can when using or prepare, in active component, add other components, and the effective ingredient of above-mentioned Insecticidal combinations is present in composition with synergy effective dose." % " of the present invention is mass percent.
It is main active ingredient (active component) that above-mentioned Insecticidal combinations be take MTI-446 and clothianidin, and insecticides adjuvant, excipients are mixed with any one formulation allowing on agricultural chemicals.Be preferably missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion and water dispersion granule.
Aforementionedly can be applicable to the not special restriction of insecticides adjuvant of the present invention, include, but are not limited to calcium dodecyl benzene sulfonate, emulsifier 600 #, the rare block compound of polyoxyethylene polyoxy third (as agriculture breast 33 #), the one or more combinations in polyoxyethylene nonylphenol ether, aforementionedly can be applicable to excipient of the present invention and be also not particularly limited, include, but are not limited to isopropyl alcohol, solvent naphtha, water, dimethyl formamide, antifreezing agent (as propane diols), deionized water etc.Above auxiliary agent and excipient all can be used one or more.
Above-mentioned Pesticidal combination can be prevented and treated the application in the insecticidal materials of resistance Semiptera, coleopteran pest in preparation, and the control efficiency of the present composition is used apparently higher than its single dose, and described Semiptera insect refers in particular to plant hopper, aleyrodid, leafhopper and aphid; Coleopteran pest refers in particular to colorado potato beetles, brassicaceous vegetable phyllotreta striolata etc.
Through indoor synergism test, measure and show: built agent all has significant synergistic insecticidal action; Field control effectiveness test equally also shows that all built agents of the present invention are all significantly higher than the effect of corresponding single dose agricultural chemicals to the insecticidal effect of water rice hopper and wheat aphid.
Pesticidal combination of the present invention compared with prior art, produces following beneficial effect: (1) is compared with single dose, and said composition has notable synergistic to insect, has obviously improved control efficiency; (2) one medicines are controlled more, and a dispenser can prevent and treat various pests simultaneously, reduce control recruitment cost; (3) alternative high-toxic pesticide, and significantly reduce field dosage, effectively reduce environmental pollution and residue of pesticide; (4) have concurrently quick-acting and long-acting; (5) compare with MTI-446 single dose, produce and use cost reduction; (6) suppressing insect strengthens the resistance of agricultural chemicals.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but do not limit the present invention in any way.
Embodiments of the invention are the methods that adopt indoor bioassay and field trial to combine.First by indoor bioassay, the co-toxicity coefficient after clear and definite two kinds of medicaments are composite by a certain percentage; On this basis, then carry out field trial.
Embodiment 1:
Take 30g MTI-446 clothianidin, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, vegetable oil to 100g.The method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and makes the MTI-446 clothianidin missible oil that main active ingredient weight percentage is 30%.The concrete ratio of MTI-446 clothianidin is in Table 1,2.
Adopt cabbage leaves infusion process to carry out indoor synergy biologicall test, selecting resistance wild cabbage phyllotreta striolata is target pest, and every processing repeats 3 times, and every concentration is processed 60, uses LC 50value is calculated co-toxicity coefficient by the Y-factor method Y of majoring in of the abundant method introduction of Sun Yun, determines whether mixture has synergistic function:
The toxicity test of the composite and single dose antagonism wild cabbage phyllotreta striolata of table 1 MTI-446 and clothianidin.
As shown in Table 1, MTI-446 and clothianidin are composite, and co-toxicity coefficient is all greater than 120, show good synergistic function.
Selecting resistance wheat aphid is that worm leaf dipping method is soaked in target pest employing, and every processing repeats 3 times, uses LC 50value is pressed the abundant method of Sun Yun and is calculated co-toxicity coefficient:
The toxicity test of the composite and single dose antagonism wheat aphid of table 2 MTI-446 and clothianidin.
As shown in Table 2, MTI-446 and clothianidin are composite is all greater than 120 to the co-toxicity coefficient of wheat aphid, shows good synergistic function.Wherein, when MTI-446 and clothianidin 1:5, synergistic effect is the most obvious.
Adopt 3 sample product of embodiment to carry out the field trial of control in field wild cabbage phyllotreta striolata, contrast medicament is 10% clothianidin WDG and 10% MTI-446 WP, and concrete consumption is in Table 3, every mu of water consumption is 30kg, looks into 7 days after medicine 3 days, 14 days, the result of 28 days, result of the test is in Table 3:
Table 3: the composite and field control effectiveness test of single dose to wild cabbage phyllotreta striolata of MTI-446 clothianidin
As can be known from the above table, 10% MTI-446 clothianidin microemulsion is better than 10% clothianidin WDG, 10% MTI-446 WP to the drug effect of wild cabbage phyllotreta striolata, demonstrates the superiority of formula.
Adopt 3 sample product of embodiment to carry out the field trial of control in field wheat aphid, contrast medicament is 10% clothianidin WDG and 10% MTI-446 WP, and concrete consumption is in Table 4, every mu of water consumption is 30kg, looks into 7 days after medicine 3 days, 14 days, the result of 28 days, result of the test is in Table 4:
Table 4: the composite and field control effectiveness test of single dose to wheat aphid of MTI-446 clothianidin
As can be known from the above table, 10% MTI-446 clothianidin microemulsion is better than 10% clothianidin WDG, 10% MTI-446 WP to wheat aphid drug effect, demonstrates the superiority of formula.
Embodiment 2:
Take 20g MTI-446,2g clothianidin, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 3g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 22% MTI-446 clothianidin missible oil.
Embodiment 3:
Take 2g MTI-446,8g clothianidin, emulsifier 1602 #4g, emulsifier 500 #2g, 1-METHYLPYRROLIDONE 4g, isopropyl alcohol 6g, solvent naphtha 3g, surplus is water, and the method that above raw material is prepared to microemulsion routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 10% MTI-446 clothianidin microemulsion.
Embodiment 4:
Take 60g MTI-446,5g clothianidin, 1g lauryl sodium sulfate, 0.5g dispersing agent NNO, kaolin to 100g, above raw material is prepared routinely to the method for wetting powder and mixed, making main active ingredient weight percentage is 65% MTI-446 clothianidin wetting powder.
Embodiment 5:
Take 80g MTI-446,0.2g clothianidin, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 80.2% MTI-446 clothianidin missible oil.
Embodiment 6:
Take 20g MTI-446,2g clothianidin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared routinely to the method for suspending agent, making main active ingredient weight percentage is 22% MTI-446 clothianidin suspending agent.
Embodiment 7:
Take 30g MTI-446,0.5g clothianidin, calcium dodecyl benzene sulfonate 12g, phenethyl phenol polyethenoxy ether 8g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 30.5% MTI-446 clothianidin missible oil.
Embodiment 8:
Take 2g MTI-446,20g clothianidin, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, borax 2g, kaolin 28g, it is 22% MTI-446 clothianidin water dispersion granule that above raw material is made to main active ingredient weight percentage by the method for water dispersion granule.
Embodiment 9:
Take 5g MTI-446,30g clothianidin, methyl naphthalene sulfonate formaldehyde condensate 6g, polyoxyethylene nonylphenol ether 3g, aluminium-magnesium silicate 0.5g, ethylene glycol 7g, tributyl phosphate 2g, silicone oil 0.2g, surplus is water, above raw material is prepared routinely to the method for suspending agent, making main active ingredient weight percentage is 35% MTI-446 clothianidin suspending agent.
Embodiment 10:
Take 0.1g MTI-446,70g clothianidin, emulsifier 600 #10g, phenethyl phenol polyethenoxy ether 10g, solvent naphtha to 100g, the method that above raw material is prepared to missible oil routinely drops in mixing kettle mixes, and making main active ingredient weight percentage is 70.1% MTI-446 clothianidin missible oil.
Embodiment 11:
Take 20g MTI-446,0.2g clothianidin is dissolved in 8g solvent naphtha, add again 1g ethylene glycol and 5g emulsifier 600 #, stir, above-mentioned solution is slowly poured in excess water, under fully stirring, making main active ingredient weight percentage is 20.2% MTI-446 clothianidin aqueous emulsion.

Claims (10)

1. containing a Synergistic insecticidal compositions for MTI-446 and clothianidin, it is characterized in that it take MTI-446 and clothianidin is main active ingredient, wherein, the weight ratio of MTI-446 and clothianidin is 0.1 ~ 70:0.2 ~ 70.
2. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 1, is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1 ~ 50:1 ~ 50.
3. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 2, is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1 ~ 20:1 ~ 20.
4. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 3, is characterized in that the effective ingredient MTI-446 of this Pesticidal combination and the weight ratio of clothianidin are 1 ~ 8:1 ~ 8.
5. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 1, is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 1 ~ 80%.
6. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 5, is characterized in that the two weight percentage that accounts for composition of MTI-446 and clothianidin is 5 ~ 50%.
7. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 1, is characterized in that it take MTI-446 and clothianidin and be mixed with any one formulation allowing on agricultural chemicals as main active ingredient and insecticides adjuvant, excipients.
8. the Synergistic insecticidal compositions containing MTI-446 and clothianidin according to claim 7, is characterized in that described formulation is missible oil, suspending agent, aqueous emulsion, wetting powder, microemulsion or water dispersion granule.
9. the Synergistic insecticidal compositions containing MTI-446 and clothianidin claimed in claim 1 is prevented and treated the application on the insecticidal materials of resistance Semiptera, coleopteran pest in preparation.
10. the application of the Synergistic insecticidal compositions containing MTI-446 and clothianidin claimed in claim 1 on the insecticidal materials of preparation control plant hopper, aleyrodid, leafhopper or aphid.
CN201210312346.6A 2012-08-29 2012-08-29 Synergistic insecticidal composition containing dinotefuran and clothianidin and applications thereof Pending CN103621543A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112661574A (en) * 2021-02-04 2021-04-16 赤天化科技集团有限公司 High-tower pesticide-fertilizer containing clothianidin and dinotefuran and preparation method thereof
CN113475535A (en) * 2018-03-02 2021-10-08 中国农业科学院棉花研究所 Method for extracting castor-containing insecticidal active substance and combined application of castor-containing insecticidal active substance and neonicotinoid insecticide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102349505A (en) * 2011-09-13 2012-02-15 广西田园生化股份有限公司 Ultra-low-capacity liquid containing dinotefuran

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102349505A (en) * 2011-09-13 2012-02-15 广西田园生化股份有限公司 Ultra-low-capacity liquid containing dinotefuran

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113475535A (en) * 2018-03-02 2021-10-08 中国农业科学院棉花研究所 Method for extracting castor-containing insecticidal active substance and combined application of castor-containing insecticidal active substance and neonicotinoid insecticide
CN112661574A (en) * 2021-02-04 2021-04-16 赤天化科技集团有限公司 High-tower pesticide-fertilizer containing clothianidin and dinotefuran and preparation method thereof

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Application publication date: 20140312