CN103027875A - Composition for reducing skin irritation comprising prunus mume extracts - Google Patents
Composition for reducing skin irritation comprising prunus mume extracts Download PDFInfo
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- CN103027875A CN103027875A CN2012103654323A CN201210365432A CN103027875A CN 103027875 A CN103027875 A CN 103027875A CN 2012103654323 A CN2012103654323 A CN 2012103654323A CN 201210365432 A CN201210365432 A CN 201210365432A CN 103027875 A CN103027875 A CN 103027875A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention discloses a composition for reducing skin irritation comprising prunus mume extracts as an effective content. In addition, the present invention also discloses a cosmetic material composition used for sensitive skin and comprising the composition for reducing skin irritation and a composition used for hair of sensitive scalp.
Description
Technical field
The present invention relates to contain the alleviation skin irritation compositions of Fructus Mume extract.
Background technology
Biostearin, by acting on keratinocyte and promoting cell differentiation, increase the generation of collagen protein and elastin laminin and form thick rete malpighii, suppress the elasticity that keratinization increases skin, have outstanding anti-wrinkle effect, therefore be applicable to variousization make-up feed composition.But, be coated in biostearin on the skin after, Diazolidinyl Urea causes drying, erythema, cutin, pruritus or the side effect such as scorching hot of skin, this is called retinoid dermatitis (retinoid dermatitis).In addition, for the dosage form of cosmetic composition etc. and the surfactant that adds also is the main cause material that causes skin problem.
Particularly, for the people of sensitive skin, more often produce the skin problem that biostearin or surfactant cause, therefore, when these people will utilize the change make-up feed composition that contains mentioned component, more be added with problem.
The prior art document
Patent documentation
Korean Patent discloses 10-2010-0042414 description (on April 26th, 2010 is open)
Korean Patent discloses 10-2003-0015654 description (on February 25th, 2003 is open).
Summary of the invention
Technical problem
The object of the invention is to, provide and to alleviate skin irritant compositions.
Another object of the present invention is to, not change make-up feed composition and the hair grooming compositions of chafe are provided.
Technical scheme
One embodiment of the present invention provides the alleviation skin irritation compositions that contains as the Fructus Mume extract of effective ingredient.
Another embodiment of the present invention provides and contains the sensitive skin usefulnessization make-up feed composition that described alleviation skin irritation is used compositions.
Another embodiment of the present invention provides and contains the hair grooming compositions that is used for sensitive scalp that described alleviation skin irritation is used compositions.
Beneficial effect
Compositions of the present invention contains the Fructus Mume extract as effective ingredient, can alleviate drying, erythema, cutin, pruritus or the skin irritation such as scorching hot of skin, particularly, can alleviate the skin irritation that biostearin or surfactant cause.In addition, of the present inventionization make-up feed composition and hair grooming compositions contain the alleviation skin irritation compositions of Fructus Mume extract, and the people of not chafe, so sensitive skin or sensitive scalp also can use free of a burdenly.
Description of drawings
Fig. 1 is the chart of the inhibition of each Fructus Mume extract concentration of expression IL-6 secretion corresponding, that retinoic acid or sodium lauryl sulfate (SLS) are caused.
Fig. 2 is the chart of the inhibition of each Fructus Mume extract concentration of expression IL-8 secretion corresponding, that retinoic acid or sodium lauryl sulfate (SLS) are caused.
The chart of the inhibition of the cell death that Fig. 3 causes retinoic acid for the expression Fructus Mume extract.
The chart of the inhibition of the cell death that Fig. 4 causes sodium lauryl sulfate for the expression Fructus Mume extract.
The specific embodiment
In this manual, " skin " refers to cover the tissue of the body surface of animal, is the tissue that not only comprises the body surface that covers face or body etc., also refers to comprise the concept of the broad sense of scalp and hair.
Below, describe the present invention in detail.
Cytokine (cytokine) is the semiochemicals of the system of defense of control, stimulation health, the inflammatory mediator of the reaction of participation skin irritation or inflammatory reaction.Particularly, IL-8(Interleukin-8) participate in the skin irritation reaction that biostearin causes, IL-6(Interleukin-6) participate in skin irritation and scytitis reaction that surfactant causes.Therefore, the material that suppresses the secretion of these inflammatory mediators can be alleviated skin irritation.
One embodiment of the present invention provides and contains with the alleviation skin irritation compositions of Fructus Mume extract as effective ingredient.Fructus Mume extract can inflammation-inhibiting medium IL-6 and the secretion of IL-8, alleviates skin irritation, and therefore, the compositions that contains this Fructus Mume extract has outstanding alleviation skin irritation effect.
In this manual, " Fructus Mume " refers to the immature fruit of the drying of prunus mume (sieb.) sieb.et zucc. (Prunus mume)." extract " just pays no attention to the form of extracting solvent, extracting method, the composition that extracts or extract so long as extract the material of composition gained wherein from natural goods, and it is the concept that comprises all broad sense.In one embodiment of the present invention, Fructus Mume extract comprises the Fructus Mume extract that extracts by the conventional process of the industry.In another embodiment of the present invention, Fructus Mume extract comprises hot water extract or the solvent extractable matter of Fructus Mume, and described solvent comprises organic solvent, specifically comprises C
1～C
5Alcohol or polyhydric alcohol.
The alleviation skin irritation of one embodiment of the present invention can be alleviated drying, erythema, cutin, the pruritus or scorching hot of the skin that skin irritation causes with compositions.In another embodiment of the present invention, skin irritation comprises the skin irritation that skin preparations for extenal use causes, specifically comprises the skin irritation that biostearin in the skin preparations for extenal use or surfactant cause.The compositions of one embodiment of the present invention when the skin irritation of the sensitive skin of alleviating acceptant stimulation, easily this stimulation being reacted, can demonstrate better effect.
In this manual, biostearin refers to comprise the concept of vitamin A derivative, specifically including but not limited to, at least a material of selecting from vitamin A, axerophthal and retinoic acid.In one embodiment of the present invention, surfactant is including but not limited to sodium lauryl sulfate (Sodium Lauryl Sulfate, SLS).In this manual, sensitive skin refers to acceptant stimulation, and this is stimulated aitiogenic skin.
The alleviation skin irritation compositions of one embodiment of the present invention, can comprise take composition total weight as benchmark account for 0.001～20 % by weight, specifically account for 0.01～10 % by weight, more specifically account for 0.01～5 % by weight, specifically account for the Fructus Mume extract of 0.01～2 % by weight again.When using, not only being suitable for embodying Expected Results of the present invention in above-mentioned scope, and can satisfying simultaneously the stability of compositions and the requirement of safety, also is appropriate using in above-mentioned scope aspect cost performance.Specifically, during Fructus Mume extract less than 0.001 % by weight, can not obtain enough alleviation skin irritation effects; When surpassing 20 % by weight, can reduce safety and dosage form stability.
One embodiment of the present invention provides and contains the sensitive skin usefulnessization make-up feed composition of using compositions with described Fructus Mume extract as the alleviation skin irritation of effective ingredient.Describedization make-up feed composition can be skin whitening with or improve the wrinkle of skin compositions.Specifically, describedization make-up feed composition can be the compositions that contains biostearin or surfactant.The acceptant stimulation of sensitive skin also produces reaction, therefore is more prone to the compositions such as the contained biostearin of cosmetic combination or surfactant are produced reaction.The change make-up feed composition of one embodiment of the present invention contains with the alleviation skin irritation compositions of Fructus Mume extract as effective ingredient, and the people of sensitive skin also can use.
Cosmetic combination of the present invention can be to be suitable for local all dosage forms of using.For example, can be the dosage forms such as emulsion, suspension, solid, colloid, powder, ointment, foam (foam) or spray composite that emulsion, water that solution, oil phase are scattered in the water gained are scattered in the oil phase gained.The compositions of such dosage form can be according to the conventional process preparation in this field.
Of the present inventionization make-up feed composition in the scope of not destroying main effect, preferably contains other composition that can give to main effect synergy except above-mentioned material.In addition, cosmetic combination of the present invention can also comprise wetting agent, emollient, UV absorbent, antiseptic, antibacterial, antioxidant, pH adjusting agent, organic and inorganic pigment, spice, creeping chill agent or antiperspirant.Those skilled in the art can be in the scope of not destroying purpose of the present invention and effect the proportioning of selected mentioned component easily, its proportioning can be take composition total weight as benchmark 0.01～5 % by weight, specifically can be 0.01～3 % by weight.
One embodiment of the present invention provides and contains the hair grooming compositions that is used for sensitive scalp of using compositions with described Fructus Mume extract as the alleviation skin irritation of effective ingredient.The acceptant stimulation of sensitive scalp also produces reaction, therefore more the contained compositions such as biostearin or surfactant of hair grooming compositions is produced reaction.The hair grooming compositions of one embodiment of the present invention contains with the alleviation skin irritation compositions of Fructus Mume extract as effective ingredient, and the people of sensitive scalp also can use.
The dosage form of hair grooming compositions of the present invention is not particularly limited, and can select according to demand suitable dosage form.For example, described hair grooming compositions can be made by at least a dosage form of selecting from shampoo, hair conditioner, hairdressing gel, daily hair treatment, a tail oil, hair lotion, suppurative mastitis, additional issue hair care scalp liquid, scalp essence, scalp cream, hair jelly, hair spray and a film, but is not limited to these.In addition, described dosage form can contain the adding ingredient commonly used of the industry, can make by conventional process.
Below by embodiment and experimental example, specify structure of the present invention and effect.But the following example and experimental example only supply in the example of understanding the present invention, and category of the present invention and scope are not limited to this.
Embodiment
The preparation of Fructus Mume extract
Utilize Fructus Mume to adopt the conventional process of the industry to prepare Fructus Mume extract.Specifically, utilize 30% 1,3 butylene glycol (1,3-buthylene glycol) that Fructus Mume was flooded 3 days at normal temperatures.Then, filter with the filter of 250 orders, 3 μ m, 1 μ m, 0.5 μ m size successively.Then, 0～4 ℃ of lower placement 3 days, filter with the filter of 0.5 μ m, 0.3 μ m, 0.2 μ m size successively again, obtain Fructus Mume 1,3 butylene glycol extract.
Experimental example 1
The evaluation of the inhibition of the inflammatory mediator secretion that stimulation is caused
At 96 orifice plates (96-well plate) with about 4 * 10
4The density dispensing test cell in cell number/hole is keratinocyte (cell strain title: HaCaT, acquisition mode: Dr. N.E. Fusenig, Deutsches Krebsforschungszentrum, Heidelberg, Germany) after, utilization contains 10% fetal bovine serum (Fetal bovine sereum, FBS, source: Gibco, USA) and the DMEM(Dulbecco ' s Modified Eagle Medium of 1% penicillin-streptomycin (Penicillin-Streptomycin, source: Gibco, USA), source: Lonza, USA) culture medium is at 37 ℃, 5%CO
2Condition under cultivated 24 hours.After removing culture medium, with 200 μ L phosphate buffers (Phosphate buffered saline, PBS) washing 1 time, add the DMEM culture medium culturing 6 hours that 200 μ L do not contain fetal bovine serum.Afterwards, in containing the DMEM of 1% fetal bovine serum, after according to the described concentration of following table the Fructus Mume extract by above-described embodiment preparation being carried out processing in 30 minutes, process retinoic acid (the retinoic acid of 10 μ M concentration, source: Sigma-Aldrich, USA) or the sodium lauryl sulfate of 10ppM concentration (Sodium Lauryl Sulfate, SLS), cultivated 24 hours.Get 50 μ L culture fluid, utilize the ELISA method, utilize IL-6, IL-8 ELISA test kit (ELISA kit) (source: BD pharmigen, USA) to estimate the free inhibition of these inflammatory mediators.Suppressing can, be with standard substance be rhIL-6, rhIL-8(the source: BD pharmigen, USA) absorbance be benchmark drawing standard curve and obtain absorbance and standard substance between reaction equation after, the absorbance of substitution treated substance draws the secretory volume of these inflammatory mediators, and the result as shown in Figures 1 and 2.In addition, namely stimulate remission rate (%) by following formula assess inflammation medium suppression ratio (%), the result is as shown in table 1.
Inflammatory mediator secretory volume/retinoic acid (retinoic acid) in inflammatory mediator suppression ratio (%)=100 × ﹛ 1-(mass treatment group or the inflammatory mediator secretory volume) ﹜ in sodium lauryl sulfate (Sodium Lauryl Sulfate, SLS) the individual processing group
Table 1
Such as table 1, Figure 1 and Figure 2, Fructus Mume extract can suppress the secretion of the inflammatory mediator that retinoic acid and sodium lauryl sulfate cause, its effect increases with concentration.The stimulation that hence one can see that Fructus Mume extract can alleviate biostearin and surfactant causes.
Experimental example 2
The evaluation of the inhibition of the cell death that stimulation is caused
With processing keratinocyte with the practically identical method of experimental example 1, with 1% Fructus Mume extract this treated keratinocyte is carried out processing in 30 minutes.Afterwards, process respectively the retinoic acid and 0,100 of 0,10,100,500 and 1,000 ppm, the sodium lauryl sulfate of 500 and 1,000 ppm.Cultivate after 24 hours, measure absorbance based on the WST-1 analytic process at 450nm, estimate the cell death degree.With the result of non-processor group contrast as shown in Figures 3 and 4.
As shown in Figures 3 and 4, Fructus Mume extract can suppress the cell death that retinoic acid and sodium lauryl sulfate cause, its effect increases with the increase of concentration.The stimulation that hence one can see that Fructus Mume extract can alleviate biostearin and surfactant causes.
The following describes the dosage form example of the compositions of one embodiment of the present invention, also can be applied as other multiple dosage form except following illustration, following illustration only for specifying usefulness, is not used in restriction the present invention.
Dosage form example 1
Astringent
According to the described formation of following table, adopt conventional process to make astringent.
Table 2
| ? | Content (% by weight) |
| Fructus Mume extract | 2.0 |
| Retinoic acid | 0.5 |
| Glycerol | 3.0 |
| Butanediol | 2.0 |
| Propylene glycol | 2.0 |
| CVP Carbopol ETD2050 | 0.1 |
| The PEG-12 Nonoxynol | 0.2 |
| Polysorbate80 | 0.4 |
| Ethanol | 10.0 |
| Triethanolamine | 0.1 |
| Antiseptic, pigment, spice | In right amount |
| Purified Water | Surplus |
Dosage form example 2
Nourishing cream
According to the described formation of following table, adopt conventional process to make nourishing cream.
Table 3
| ? | Content (% by weight) |
| Fructus Mume extract | 1.0 |
| Biostearin | 0.5 |
| Polysorbate60 | 1.5 |
| Sorbitan sesquioleate | 0.5 |
| The PEG-60 castor oil hydrogenated | 2.0 |
| Liquid paraffin | 10.0 |
| Squalane | 5.0 |
| Caprylic/capric triglyceride | 5.0 |
| Glycerol | 5.0 |
| Butanediol | 3.0 |
| Propylene glycol | 3.0 |
| Triethanolamine | 0.2 |
| Antiseptic, pigment, spice | In right amount |
| Purified Water | Surplus |
Dosage form example 3
Shampoo
According to the described formation of following table, adopt conventional process to make shampoo.
Table 4
| ? | Content (% by weight) |
| Fructus Mume extract | 2.5 |
| Sodium lauryl sulfate | 5.0 |
| The carboxylate of 12-hydroxy octadecadienoic acid and Glycerin | 0.3 |
| Hexadecanol | 0.6 |
| Coconut oleoyl amine MEA | 1.0 |
| Guar hydroxypropyltrimonium chloride | 0.2 |
| Citric acid | 0.05 |
| Antiseptic, spice | In right amount |
| Purified Water | Surplus |
Dosage form example 4
Ointment
According to the described formation of following table, adopt conventional process to make ointment.
Table 5
| ? | Content (% by weight) |
| Fructus Mume extract | 0.1 |
| Vitamin A | 0.5 |
| Glycerol | 8.0 |
| Butanediol | 4.0 |
| Liquid paraffin | 15.0 |
| Beta glucan | 7.0 |
| Carbomer | 0.1 |
| Caprylic/capric triglyceride | 3.0 |
| Squalane | 1.0 |
| Cetearyl glucoside | 1.5 |
| Sorbitan stearate | 0.4 |
| Cetearyl alcohol | 1.0 |
| Cera Flava | 4.0 |
| Antiseptic, pigment, spice | In right amount |
| Purified Water | Surplus |
Claims (10)
1. alleviation skin irritation compositions that contains as the Fructus Mume extract of effective ingredient.
2. alleviation skin irritation compositions according to claim 1 is characterized in that, compositions can be alleviated drying, erythema, cutin, the pruritus or scorching hot of the skin that skin irritation causes.
3. alleviation skin irritation compositions according to claim 1 is characterized in that skin irritation comprises the skin irritation that skin preparations for extenal use causes.
4. alleviation skin irritation compositions according to claim 3 is characterized in that, the skin irritation that skin preparations for extenal use causes comprises the skin irritation that biostearin in the skin preparations for extenal use or surfactant cause.
5. alleviation skin irritation compositions according to claim 4 is characterized in that, biostearin is at least a material of selecting from vitamin A, axerophthal and retinoic acid.
6. alleviation skin irritation compositions according to claim 1 is characterized in that skin comprises sensitive skin.
7. alleviation skin irritation compositions according to claim 1 is characterized in that, Fructus Mume extract accounts for 0.001～20 % by weight take composition total weight as benchmark.
8. sensitive skin cosmetic combination that comprises each described compositions of claim 1～7.
9. cosmetic combination according to claim 8 is characterized in that, cosmetic combination is skin whitening usefulness or improves the cosmetic combination that wrinkle of skin is used.
10. hair grooming compositions that is used for sensitive scalp that comprises each described compositions of claim 1～7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0099693 | 2011-09-30 | ||
| KR1020110099693A KR20130035408A (en) | 2011-09-30 | 2011-09-30 | Composition for reducing skin irritation comprising prunus mume extracts |
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| Publication Number | Publication Date |
|---|---|
| CN103027875A true CN103027875A (en) | 2013-04-10 |
| CN103027875B CN103027875B (en) | 2017-10-27 |
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| CN201210365432.3A Active CN103027875B (en) | 2011-09-30 | 2012-09-27 | Alleviation skin irritatin composition containing smoked plum extractive |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6232180B2 (en) |
| KR (1) | KR20130035408A (en) |
| CN (1) | CN103027875B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250428A (en) * | 2015-11-09 | 2016-01-20 | 广州丹奇日用化工厂有限公司 | Plant extract and application thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6859428B2 (en) * | 2017-03-30 | 2021-04-14 | 株式会社マンダム | TRPA1 activity inhibitor |
| KR102087188B1 (en) * | 2017-09-21 | 2020-03-11 | (주)아모레퍼시픽 | Composition comprising Prunus mume flower extract for caring damages of skin cells by microdust |
| KR102350141B1 (en) * | 2020-03-05 | 2022-01-11 | 주식회사 현대바이오랜드 | A Cosmetic Composition for Skin protection and Alleviation of skin irritation Comprising Extract of Portulaca oleracea, Artemisia argyi and Rhodiola rosea |
| CN113181089B (en) * | 2021-03-23 | 2022-10-11 | 太和康美(北京)中医研究院有限公司 | Soothing and repairing composition and preparation method and application thereof |
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| JP2002284648A (en) * | 2001-03-27 | 2002-10-03 | National Institute Of Advanced Industrial & Technology | Composition for hair restorer |
| CN1394568A (en) * | 2001-07-06 | 2003-02-05 | 陈辉年 | Plant additive for shampoo |
| CN1397294A (en) * | 2001-07-13 | 2003-02-19 | 金蕙芬 | Process for preparing externally-applied Chiense medicine as liniment containing red jujube and black plum |
| KR20090009559A (en) * | 2007-07-20 | 2009-01-23 | 주식회사 코리아나화장품 | Cosmetic composition for preventing skin aging comprising the seven flowers extract consisting of camellia japonica, lonicera japonica, prunus mume, sophora japonica, nelumbo nucifera, carthamus tinctorius and pyrus serotina |
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| KR101519649B1 (en) * | 2008-06-24 | 2015-05-13 | (주)아모레퍼시픽 | Neurocosmetic Skin Care Method, Method For Screening Skin Cosmetic Material, and Skin Cosmetic Material |
| KR101736979B1 (en) * | 2010-09-08 | 2017-05-19 | (주)아모레퍼시픽 | Composition for external application to the skin containing prunus mume extract |
-
2011
- 2011-09-30 KR KR1020110099693A patent/KR20130035408A/en active Search and Examination
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2012
- 2012-09-25 JP JP2012211041A patent/JP6232180B2/en active Active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2002284648A (en) * | 2001-03-27 | 2002-10-03 | National Institute Of Advanced Industrial & Technology | Composition for hair restorer |
| CN1394568A (en) * | 2001-07-06 | 2003-02-05 | 陈辉年 | Plant additive for shampoo |
| CN1397294A (en) * | 2001-07-13 | 2003-02-19 | 金蕙芬 | Process for preparing externally-applied Chiense medicine as liniment containing red jujube and black plum |
| KR20090009559A (en) * | 2007-07-20 | 2009-01-23 | 주식회사 코리아나화장품 | Cosmetic composition for preventing skin aging comprising the seven flowers extract consisting of camellia japonica, lonicera japonica, prunus mume, sophora japonica, nelumbo nucifera, carthamus tinctorius and pyrus serotina |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250428A (en) * | 2015-11-09 | 2016-01-20 | 广州丹奇日用化工厂有限公司 | Plant extract and application thereof |
Also Published As
| Publication number | Publication date |
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| KR20130035408A (en) | 2013-04-09 |
| CN103027875B (en) | 2017-10-27 |
| JP2013079233A (en) | 2013-05-02 |
| JP6232180B2 (en) | 2017-11-15 |
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