CN103027875B - Alleviation skin irritatin composition containing smoked plum extractive - Google Patents
Alleviation skin irritatin composition containing smoked plum extractive Download PDFInfo
- Publication number
- CN103027875B CN103027875B CN201210365432.3A CN201210365432A CN103027875B CN 103027875 B CN103027875 B CN 103027875B CN 201210365432 A CN201210365432 A CN 201210365432A CN 103027875 B CN103027875 B CN 103027875B
- Authority
- CN
- China
- Prior art keywords
- composition
- skin
- smoked plum
- plum extractive
- skin irritatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses the alleviation skin irritatin composition containing the smoked plum extractive as active ingredient.In addition, the invention discloses the sensitive cosmetic combination containing the alleviation skin irritatin composition and the hair grooming compositions for sensitive scalp.
Description
Technical field
The present invention relates to the alleviation skin irritatin composition containing smoked plum extractive.
Background technology
Biostearin, by acting on keratinocyte and promoting cell differentiation, increase collagen and elastin laminin
Generation and form the rete malpighii of thickness, suppressing keratinization increases the elasticity of skin, with outstanding anti-wrinkle effect, therefore is applicable
In variousization make-up feed composition.But, after biostearin is coated on skin, skin can be stimulated to cause the drying, red of skin
Spot, cutin, itch or the side effect such as scorching hot, this is referred to as retinoid dermatitis（retinoid dermatitis）.In addition,
The surfactant added for the formulation of cosmetic composition etc. is also the main cause material for causing skin problem.
Particularly, for the people of sensitive, more often produce caused by biostearin or surfactant
Skin problem, it is therefore, more problematic when these people will utilize the change make-up feed composition containing mentioned component.
Prior art literature
Patent document
Korean Patent Publication No. 10-2010-0042414 specifications（On April 26th, 2010 is open）
Korean Patent Publication No. 10-2003-0015654 specifications（On 2 25th, 2003 open）.
The content of the invention
Technical problem
It is an object of the present invention to provide the composition of skin irritatin can be alleviated.
Another object of the present invention is to there is provided the change make-up feed composition and hair grooming compositions for not stimulating skin.
Technical scheme
One embodiment of the present invention provides the alleviation skin irritatin group containing the smoked plum extractive as active ingredient
Compound.
Another embodiment of the present invention provides the sensitive containing the alleviation skin irritatin composition
Make-up feed composition.
Another embodiment of the present invention is provided is used for sensitive scalp containing the alleviation skin irritatin composition
Hair grooming compositions.
Beneficial effect
The composition of the present invention contains smoked plum extractive as active ingredient, can alleviate the drying of skin, erythema, angle
Matter, itch or the skin irritatin such as scorching hot, particularly, can alleviate skin irritatin caused by biostearin or surfactant.This
Outside, change make-up feed composition and hair grooming compositions of the invention, containing the alleviation skin irritatin composition containing smoked plum extractive,
Skin is not stimulated, therefore the people of sensitive or sensitive scalp can also use free of a burdenly.
Brief description of the drawings
Fig. 1 for represent each smoked plum extractive concentration it is corresponding, to vitamin A acid or NaLS（SLS）It is caused
The chart of the inhibition of IL-6 secretions.
Fig. 2 for represent each smoked plum extractive concentration it is corresponding, to vitamin A acid or NaLS（SLS）It is caused
The chart of the inhibition of IL-8 secretions.
Fig. 3 is chart of the expression smoked plum extractive to the inhibition of cell death caused by vitamin A acid.
Fig. 4 is chart of the expression smoked plum extractive to the inhibition of cell death caused by NaLS.
Embodiment
In this manual, " skin ", refers to the tissue for covering the body surface of animal, is not only to include covering face or body
The tissue of the body surface of body etc., also refers to the broadest concept including scalp and hair.
Below, the present invention is described in detail.
Cell factor（cytokine）It is the semiochemicals for the system of defense for controlling, stimulating body, participates in skin irritatin anti-
Should or inflammatory reaction inflammatory mediator.Particularly, IL-8（Interleukin-8）Participate in skin irritatin caused by biostearin
Reaction, IL-6（Interleukin-6）Participate in skin irritatin caused by surfactant and scytitis reaction.Therefore, suppress
The material of the secretion of these inflammatory mediators can alleviate skin irritatin.
One embodiment of the present invention provides the alleviation skin irritatin group contained using smoked plum extractive as active ingredient
Compound.Smoked plum extractive can suppress inflammatory mediator IL-6 and IL-8 secretion, alleviate skin irritatin, therefore, contain the dark plum
The composition of extract has outstanding alleviation skin irritation effect.
In this manual, " dark plum ", refers to plum（Prunus mume）Drying immature fruit." extract "
If from the material obtained by Nature inorganic bone composition therein, just paying no attention to Extraction solvent, extracting method, the composition extracted or carrying
The form of thing is taken, it is to include the concept of all broad sense.In one embodiment of the present invention, smoked plum extractive includes passing through
The smoked plum extractive that the conventional process of the industry is extracted.In another embodiment of the present invention, smoked plum extractive includes crow
The hot water extract of plum or solvent extractable matter, the solvent include organic solvent, specifically include C1~C5Alcohol or polyalcohol.
The alleviation skin irritatin composition of one embodiment of the present invention can alleviate skin caused by skin irritatin
Drying, erythema, cutin, itch or scorching hot.In another embodiment of the present invention, skin irritatin causes including skin preparations for extenal use
Skin irritatin, specifically include skin irritatin caused by the biostearin or surfactant in skin preparations for extenal use.The present invention's
The composition of one embodiment, in the acceptant stimulation of alleviation, the skin of the sensitive easily reacted to the stimulation
During stimulation, more preferable effect can show that.
In this manual, biostearin, refers to the concept for including vitamin A derivatives, specifically includes but do not limit
In at least one material selected from vitamin A, axerophthal and vitamin A acid.In one embodiment of the present invention,
Surfactant is including but not limited to NaLS（Sodium Lauryl Sulfate, SLS）.In this manual,
Sensitive, refers to acceptant stimulation, to the aitiogenic skin of the stimulation.
The alleviation skin irritatin composition of one embodiment of the present invention, can be included on the basis of composition total weight
Account for 0.001~20 weight %, be specifically account for 0.01~10 weight %, more specifically account for 0.01~5 weight %, again be specifically account for
0.01~2 weight % smoked plum extractive.Within the above range in use, being not only adapted to the Expected Results for embodying the present invention, and
The requirement of the stability and security of composition can be met simultaneously, be also for using within the above range in terms of the cost performance
Appropriate.Specifically, when smoked plum extractive is less than 0.001 weight %, it is impossible to obtain enough alleviation skin irritation effects；Exceed
During 20 weight %, security and dosage form stability can be reduced.
There is provided the alleviation skin irritatin contained using the smoked plum extractive as active ingredient for one embodiment of the present invention
With the sensitive useization make-up feed composition of composition.Describedization make-up feed composition can be that skin is used or improved to skin whitening
Wrinkle composition.Specifically, describedization make-up feed composition can be the composition containing biostearin or surfactant.
Sensitive is acceptant to stimulate and produces reaction, therefore is more prone to the biostearin contained by cosmetic combination
Or the composition such as surfactant produces reaction.The change make-up feed composition of one embodiment of the present invention contains to be made with smoked plum extractive
For the alleviation skin irritatin composition of active ingredient, the people of sensitive can also use.
The cosmetic combination of the present invention can be suitable for the local all formulations used.For example, it may be solution, oil
Emulsion obtained by aqueous phase, Aqueous dispersions are mutually scattered in the emulsion obtained by oil phase, suspension, solid, colloid, powder, ointment, bubble
Foam（foam）Or the formulation such as spray composite.The composition of such formulation can be prepared according to the conventional process in the field.
The present invention change make-up feed composition in addition to the materials described above, in the range of main efficacy results are not destroyed, preferably
Be containing can to main efficacy results assign synergy other compositions.In addition, the cosmetic combination of the present invention can also be wrapped
Containing NMF, emollient, ultra-violet absorber, preservative, bactericide, antioxidant, pH adjusting agent, organic and inorganic pigment,
Spices, cooling agent or antiperspirant.Those skilled in the art can be light in the range of the purpose of the present invention and effect is not destroyed
Change places the proportioning of selected mentioned component, it can be 0.01~5 weight % on the basis of composition total weight that it, which is matched, specifically may be used
To be 0.01~3 weight %.
One embodiment of the present invention provides the alleviation skin irritatin contained using the smoked plum extractive as active ingredient
With the hair grooming compositions for sensitive scalp of composition.Sensitive scalp is acceptant to stimulate and produces reaction, therefore
Reaction more is produced to the composition such as biostearin or surfactant contained by hair grooming compositions.The one of the present invention
The hair grooming compositions of embodiment contain the alleviation skin irritatin composition using smoked plum extractive as active ingredient, sensitive
The people of property scalp can also use.
The formulation of the hair grooming compositions of the present invention is not particularly limited, and suitable formulation can be selected according to demand.Example
Such as, the hair grooming compositions can be by washing from shampoo, hair conditioner, treatment waxes, daily hair treatment, hair tail oil, hair
Selected at least in agent, hair-cream, additional issue hair care scalp liquid, scalp Essence, scalp creams, hair jelly, hair spray and hair film
A kind of formulation makes, but is not limited to these.In addition, the formulation can the conventional adding ingredient containing the industry, can pass through
Conventional process makes.
Below by embodiment and experimental example, the structure and effect of the present invention is illustrated.But, the following example and reality
Example is tested only for the example for understanding the present invention, and scope of the invention and scope are not limited thereto.
Embodiment
The preparation of smoked plum extractive
Smoked plum extractive is prepared using the conventional process of the industry using dark plum.Specifically, using 30% 1,3-BDO
（1,3-buthylene glycol）Dark plum is impregnated at normal temperatures 3 days.Then, successively with 250 mesh, 3 μm, 1 μm, it is 0.5 μm big
Small filter is filtered.Then, placed 3 days at 0~4 DEG C, then successively with the filtering of 0.5 μm, 0.3 μm, 0.2 μm size
Device is filtered, and obtains dark plum 1,3-BDO extract.
Experimental example 1
To the evaluation for the inhibition for stimulating caused inflammatory mediator secretion
In 96 orifice plates（96-well plate）With about 4 × 104The density dispensing experiment cell in cell number/hole is cutin
Form cell（Cell line title：HaCaT, acquisition mode：Dr. N.E. Fusenig,Deutsches
Krebsforschungszentrum, Heidelberg, Germany）Afterwards, using containing 10% fetal bovine serum（Fetal
Bovine sereum, FBS, source：Gibco,USA）With 1% Pen .- Strep（Penicillin-Streptomycin,
Source：Gibco, USA）DMEM（Dulbecco ' s Modified Eagle Medium, source：Lonza, USA）Culture
Base is in 37 DEG C, 5%CO2Under conditions of cultivate 24 hours.Remove after culture medium, with 200 μ L phosphate buffers（Phosphate
buffered saline, PBS）Washing 1 time, adds the DMEM medium cultures 6 hours that 200 μ L do not contain fetal bovine serum.
Afterwards, in the DMEM containing 1% fetal bovine serum, according to the concentration described in following table to the dark plum that is prepared by above-described embodiment
Extract is carried out after processing in 30 minutes, handles the vitamin A acid of 10 μM of concentration（Retinoic acid, source：Sigma-
Aldrich, USA）Or the NaLS of 10ppM concentration（Sodium Lauryl Sulfate、SLS）, cultivate 24 hours.
50 μ L nutrient solutions are taken, using ELISA method, IL-6, IL-8 ELISA kit are utilized（ELISA kit）（Source：BD
pharmigen,USA）Evaluate the free inhibition of these inflammatory mediators.Suppress can, be with standard substance i.e. rhIL-6,
rhIL-8（Source：BD pharmigen, USA）Absorbance on the basis of draw standard curve and obtain absorbance and reference material
After reaction equation between matter, the absorbance for substituting into treated substance draws the secretory volume of these inflammatory mediators, as a result such as Fig. 1 and Fig. 2
It is shown.In addition, evaluating inflammatory mediator inhibiting rate by following formula（%）Stimulate remission rate（%）, as a result as shown in table 1.
Inflammatory mediator inhibiting rate（%）=100 × ﹛ 1-（Inflammatory mediator secretory volume/vitamin A acid in material treatment group
（retinoic acid）Or NaLS（Sodium Lauryl Sulfate, SLS）Inflammation in independent treatment group is situated between
Matter secretory volume）﹜
Table 1
As shown in table 1, Fig. 1 and Fig. 2, smoked plum extractive can suppress scorching caused by vitamin A acid and NaLS
The secretion of disease medium, its effect increases and increased with concentration.It can thus be appreciated that smoked plum extractive can alleviate biostearin and surface
Stimulated caused by activating agent.
Experimental example 2
To the evaluation for the inhibition for stimulating caused cell death
Keratinocyte is handled with the practically identical method of experimental example 1, with 1% smoked plum extractive to this through processing
Keratinocyte carry out 30 minutes handle.Afterwards, 0,10,100,500 and 1,000 ppm vitamin A acid are handled respectively
And 0,100,500 and 1,000 ppm NaLS.After culture 24 hours, determined based on WST-1 analytic approach in 450nm
Absorbance, evaluates cell death degree.With the result that is contrasted without treatment group as shown in Figures 3 and 4.
As shown in Figures 3 and 4, can to suppress cell caused by vitamin A acid and NaLS dead for smoked plum extractive
Die, its effect increases with the increase of concentration.Draw it can thus be appreciated that smoked plum extractive can alleviate biostearin with surfactant
The stimulation risen.
Illustrate the formulation example of the composition of one embodiment of the present invention below, also can be using being in addition to following illustrations
Other a variety of formulations, following illustrations are only to illustrate use, are not used in the restriction present invention.
Formulation example 1
Toner
According to the composition described in following table, toner is made using conventional process.
Table 2
| Content（Weight %） | |
| Smoked plum extractive | 2.0 |
| Vitamin A acid | 0.5 |
| Glycerine | 3.0 |
| Butanediol | 2.0 |
| Propane diols | 2.0 |
| Carboxyl vinyl polymer | 0.1 |
| PEG-12 Nonoxynols | 0.2 |
| Polysorbate80 | 0.4 |
| Ethanol | 10.0 |
| Triethanolamine | 0.1 |
| Preservative, pigment, spices | In right amount |
| Purified Water | Surplus |
Formulation example 2
Nourishing cream
According to the composition described in following table, nourishing cream is made using conventional process.
Table 3
| Content（Weight %） | |
| Smoked plum extractive | 1.0 |
| Biostearin | 0.5 |
| Polysorbate60 | 1.5 |
| Sorbitan sesquioleate | 0.5 |
| PEG-60 rilanit specials | 2.0 |
| Atoleine | 10.0 |
| Saualane | 5.0 |
| Caprylic/capric triglyceride | 5.0 |
| Glycerine | 5.0 |
| Butanediol | 3.0 |
| Propane diols | 3.0 |
| Triethanolamine | 0.2 |
| Preservative, pigment, spices | In right amount |
| Purified Water | Surplus |
Formulation example 3
Shampoo
According to the composition described in following table, shampoo is made using conventional process.
Table 4
| Content（Weight %） | |
| Smoked plum extractive | 2.5 |
| NaLS | 5.0 |
| The carboxylate of 12- hydroxy octadecadienoic acids and 1,2,3- glycerine | 0.3 |
| Hexadecanol | 0.6 |
| Coconut oleoyl amine MEA | 1.0 |
| Guar hydroxypropyltrimonium chloride | 0.2 |
| Citric acid | 0.05 |
| Preservative, spices | In right amount |
| Purified Water | Surplus |
Formulation example 4
Ointment
According to the composition described in following table, ointment is made using conventional process.
Table 5
| Content（Weight %） | |
| Smoked plum extractive | 0.1 |
| Vitamin A | 0.5 |
| Glycerine | 8.0 |
| Butanediol | 4.0 |
| Atoleine | 15.0 |
| Beta glucan | 7.0 |
| Carbomer | 0.1 |
| Caprylic/capric triglyceride | 3.0 |
| Saualane | 1.0 |
| Cetearyl glucoside | 1.5 |
| Sorbitan stearate | 0.4 |
| Cetostearyl alcohol | 1.0 |
| Beeswax | 4.0 |
| Preservative, pigment, spices | In right amount |
| Purified Water | Surplus |
Claims (5)
1. application of the smoked plum extractive in the composition for preparing the external application for being used for alleviating skin irritatin, it is characterised in that described
Skin irritatin is caused by the vitamin A acid or NaLS in coating skin preparations for extenal use,
Wherein, the skin preparations for extenal use includes the vitamin A acid or the NaLS.
2. application according to claim 1, it is characterised in that composition can alleviate the dry of skin caused by skin irritatin
Dry, erythema, cutin, itch or scorching hot.
3. application according to claim 1, it is characterised in that skin includes sensitive.
4. application according to claim 1, it is characterised in that smoked plum extractive is accounted on the basis of composition total weight
0.001~20 weight %.
5. application according to claim 1, the composition is the hair grooming compositions for sensitive scalp.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2011-0099693 | 2011-09-30 | ||
| KR1020110099693A KR20130035408A (en) | 2011-09-30 | 2011-09-30 | Composition for reducing skin irritation comprising prunus mume extracts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103027875A CN103027875A (en) | 2013-04-10 |
| CN103027875B true CN103027875B (en) | 2017-10-27 |
Family
ID=48015609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210365432.3A Active CN103027875B (en) | 2011-09-30 | 2012-09-27 | Alleviation skin irritatin composition containing smoked plum extractive |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP6232180B2 (en) |
| KR (1) | KR20130035408A (en) |
| CN (1) | CN103027875B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105250428A (en) * | 2015-11-09 | 2016-01-20 | 广州丹奇日用化工厂有限公司 | Plant extract and application thereof |
| JP6859428B2 (en) * | 2017-03-30 | 2021-04-14 | 株式会社マンダム | TRPA1 activity inhibitor |
| KR102087188B1 (en) * | 2017-09-21 | 2020-03-11 | (주)아모레퍼시픽 | Composition comprising Prunus mume flower extract for caring damages of skin cells by microdust |
| KR102350141B1 (en) * | 2020-03-05 | 2022-01-11 | 주식회사 현대바이오랜드 | A Cosmetic Composition for Skin protection and Alleviation of skin irritation Comprising Extract of Portulaca oleracea, Artemisia argyi and Rhodiola rosea |
| CN113181089B (en) * | 2021-03-23 | 2022-10-11 | 太和康美(北京)中医研究院有限公司 | Soothing and repairing composition and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002284648A (en) * | 2001-03-27 | 2002-10-03 | National Institute Of Advanced Industrial & Technology | Composition for hair restorer |
| CN1394568A (en) * | 2001-07-06 | 2003-02-05 | 陈辉年 | Plant additive for shampoo |
| CN1397294A (en) * | 2001-07-13 | 2003-02-19 | 金蕙芬 | Process for preparing externally-applied Chiense medicine as liniment containing red jujube and black plum |
| KR100937339B1 (en) * | 2007-07-20 | 2010-01-20 | 주식회사 코리아나화장품 | Cosmetic Composition for Preventing Skin Aging Comprising the Seven Flowers Extract Consisting of Camellia japonica, Lonicera japonica, Prunus mume, Sophora japonica, Nelumbo nucifera, Carthamus tinctorius and Pyrus serotina |
| KR101519649B1 (en) * | 2008-06-24 | 2015-05-13 | (주)아모레퍼시픽 | Neurocosmetic Skin Care Method, Method For Screening Skin Cosmetic Material, and Skin Cosmetic Material |
| KR101736979B1 (en) * | 2010-09-08 | 2017-05-19 | (주)아모레퍼시픽 | Composition for external application to the skin containing prunus mume extract |
-
2011
- 2011-09-30 KR KR1020110099693A patent/KR20130035408A/en active Search and Examination
-
2012
- 2012-09-25 JP JP2012211041A patent/JP6232180B2/en active Active
- 2012-09-27 CN CN201210365432.3A patent/CN103027875B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130035408A (en) | 2013-04-09 |
| JP2013079233A (en) | 2013-05-02 |
| JP6232180B2 (en) | 2017-11-15 |
| CN103027875A (en) | 2013-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103393581B (en) | Natural anti-wrinkling anti-aging skin care composition and application thereof in cosmetic | |
| EP2793833B1 (en) | Topical oil composition for the treatment of fungal infections | |
| KR101219520B1 (en) | Anti-inflammatory, anti-oxidative or anti-bacterial compositions | |
| CN103027875B (en) | Alleviation skin irritatin composition containing smoked plum extractive | |
| WO2019166521A1 (en) | Dermatological product | |
| CN102421412B (en) | Composition containing chamaecyparis obtusa polysaccharides to be externally applied to skin | |
| CN106389171A (en) | Purely-botanic natural-component-compounded hydrolat-series toner and making method thereof | |
| JP6077560B2 (en) | Skin external preparation composition containing white-bellied extract | |
| JP2008100943A (en) | External preparation for skin having action to promote secretion of insulin-like growth factor 1 | |
| KR102300581B1 (en) | Compositions for improving skin conditions comprising plant extracts or fractions thereof | |
| JP2009242311A (en) | Scf secretion inhibitor and skin care preparation for external use for making skin pore inconspicuous | |
| KR101477959B1 (en) | Anti-irritating cosmetic compositions for skin comprising extracts of Aloe Aborescens | |
| KR102214985B1 (en) | Compositions for improving skin conditions comprising plant extracts or fractions thereof | |
| EP2722075B1 (en) | Prevention of conditions arising from an impaired skin barrier function | |
| KR101578908B1 (en) | Extract of fermentative Zizyphus jujuba Fructus by Laetiporus sulphureus having lifespan extention of C. elegans via stress response and increasing collegen synthesis, and its cosmetic and therapeutic agent for wrinkle containing the same | |
| US9486397B2 (en) | Dermocosmetic compositions based on a synergistic combination of colloidal silver and deoxyribonucleic acid | |
| CN106924057B (en) | Small micelle water cosmetic for promoting rapid transdermal absorption of water-soluble substances | |
| TW201601774A (en) | Composition containing natural plant extracts, external skin preparation comprising the same, cosmetic preparation comprising the same and pharmaceutical preparation comprising the same | |
| KR102333132B1 (en) | Cosmetic Composition containing Frangipani Oil or Fermented Frangipani Oil | |
| JP5972732B2 (en) | Antibacterial agent and external preparation for skin | |
| KR102034436B1 (en) | Composition For Treating And Preventing Atopic Dermatitis Comprising Ternstroemia kwangtungensis Merr. Extracts | |
| KR20090075281A (en) | Cosmetic composition with the effect of atopy skins | |
| KR101145814B1 (en) | Composition for improving skin wrinkle | |
| KR20120056225A (en) | Composition for external application comprising fine bubble | |
| KR102420354B1 (en) | Lotion composition having circulation and vitality and the manufacturing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |