CN105250428A - Plant extract and application thereof - Google Patents
Plant extract and application thereof Download PDFInfo
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- CN105250428A CN105250428A CN201510761083.0A CN201510761083A CN105250428A CN 105250428 A CN105250428 A CN 105250428A CN 201510761083 A CN201510761083 A CN 201510761083A CN 105250428 A CN105250428 A CN 105250428A
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Abstract
The invention discloses a plant extract and application thereof. The plant extract is an extract of a mixture comprising, by weight, 30-40 parts of smoked plums, 30-40 parts of ligusticum wallichii, 10-20 parts of mistletoe and 10-20 parts of teasel. The plant extract has the effects of removing old keratin, activating blood, nourishing skin, diminishing inflammation and alleviating pain, the process of adding the plant extract into cosmetics is simple, and an effect assessment and determination result shows that the plant extract has a prevention or improvement or removal effect on skin dryness, calluses and heel pain.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a Plant Extracts and application thereof.
Background technology
Fructus Mume has the dry almost ripe fruit of rose department plant plum to process, and its sour in the mouth, property is put down nontoxic.Containing abundant fruit acid, the mainly citric acid that content is higher and malic acid.Fruit acid can reduce the coagulability between epidermal keratinocyte, can remove aging cutin, improves coarse, obscure, conditioning skin quality.
Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong, and it is warm in nature, acrid in the mouth, micro-hardship, has blood-activating and qi-promoting, goes effect of wind pain relieving.Blood viscosity can be effectively reduced and expand blood vessel, to the rheological characteristic of blood, there is good improvement effect.
Herba Visci is the dry stem and branch with leaf of Loranthaceae mistletoe Herba Visci, and its bitter in the mouth is put down, and has curing rheumatism, invigorating the liver and kidney, bone and muscle strengthening, nourishes blood, relaxing muscles and tendons and activating QI and blood in the collateral, the effects such as promoting blood circulation to remove blood stasis.
Radix Dipsaci is the root of Dipsacus plant Radix Dipsaci, has the effects such as invigorating the liver and kidney, bone and muscle strengthening, continuous injured.Show to have significantly antibacterial, anti-inflammatory efficacy through zoopery.
Callus is the infringement of limitation flat hyperkeratosis, also known as callosity.The multiple position being born in long-term pressurized and friction, as the palm, tramples outstanding position, also shows in other pressurized positions.Infringement thickens for local skin cutin, in flat or mound shape swell, central authorities are thicker, and edge is thinner, indefinite border; In faint yellow or wax yellow, translucent, smooth surface, that touches is hard.Local sweat secretion reduces, insensitive, or has and slightly press pain.Its cause of disease traditional Chinese medical science is thought that brothers rub for a long time, is oppressed, QI-blood circulation is smooth, and failure of skin and muscle to be nourished forms.
Talalgia is heel one or both sides pain, not red pneumonedema, walking disorder.Also known as relieving heel pain.Chinese medicine is thought, talalgia many genus hepatic and renal YIN deficiency, phlegm-damp, heat in blood etc. because of caused by.Liver governing tendons, kidney governing bones, caused by liver and kidney deficiency, muscles and bones mistake is supported, and sense wind-cold damp pathogen or chronic strain just cause meridian stasis stagnant again, and QI-blood circulation is obstructed, and muscles and bones muscle is lost and supports and fall ill.Talalgia is the common a kind of disease of old people, present sickness rate in young woman rises year by year, particularly as white collar clan, the cooling slippers of fashion style is worn in working, and the heel minister phase exposes, attacked by the cold and evil is subject in air-conditioned room, After Hours be busy with going window-shopping, jumping slimnastics, foot fails again well to be had a rest, due to the long-term pressurized of heel, hyperkinesia with have a cold, cause heel soft tissue inflammation, final Provocative pain.
Cause because talalgia and callus are all obstructed due to QI-blood circulation, these two kinds of symptoms foot hold concurrently send out be more common.
Finding market does not also occur in the process of invention can simultaneously for the product of callus and talalgia problem.
Summary of the invention
Technical problem to be solved by this invention is to solve foot callus and talalgia simultaneously.One Plant Extracts and application thereof are provided, invent described plant extract with theory of Chinese medical science be according to, be means with modern technologies, mainly through the mode of nourishing of invigorating blood circulation, and then reach the object improved or eliminate callus and talalgia.
One object of the present invention is to provide a Plant Extracts, and described plant extract extracts gained by following weight parts raw material:
Fructus Mume 30-40 part, Rhizoma Chuanxiong 30-40 part, Herba Visci 10-20 part, Radix Dipsaci 10-20 part.
Theory of Chinese medical science is thought, callus be brothers for a long time by squeezing mill, QI and blood is smooth, and skin loses to support and causes.Ferritic deficient qi and blood, QI-blood circulation evil hyperamization liquid that is sluggish and limbs place sense cold-damp coagulates puckery, the mistake of hematogenous blockage skin all can be made to support and cause skin limitation keratinization hypertrophy.Talalgia is because of caused by liver and kidney deficiency, and muscles and bones mistake is supported, and sense wind-cold damp pathogen or chronic strain just cause meridian stasis stagnant again, and QI-blood circulation is obstructed, and muscles and bones muscle is lost and supports and fall ill.Fruit acid in Fructus Mume can reduce the coagulability between epidermal keratinocyte, can remove old cutin, has stronger moisture-keeping function simultaneously, can softening skin, prevent xerosis cutis, make the cutin on callus be easy to come off, improve skin absorptance; Utilize Rhizoma Chuanxiong simultaneously, the promoting blood circulation to remove obstruction in the collateral of Herba Visci is used for improving the nutrition supply of skin, recover the normal metabolism of skin; Be aided with the curing rheumatism of Radix Dipsaci, invigorating the liver and kidney, bone and muscle strengthening effect, alleviate further or eliminate talalgia problem.
One of them performance of invigorating blood circulation is the quickening of microcirculqtory system, and blood capillary diastole, blood capillary crossing net increase the object accelerating with velocity of blood flow all can realize invigorating blood circulation.Micro-circulation speed is accelerated, keratinocyte etc. for skin provides sufficient oxygen and nutrient substance, and the metabolite of cell and various harmful substance is removed in time, the old cell of metabolism, reduce the oxidation of collagen fiber, and make the various cells of skin maintain good function.
In some embodiments, described plant extract is extracted by ethanol, water or its combination and obtains.
Utilize various composition deliquescent difference in the solvent of opposed polarity in plant, use solvent to be dissolved out in plant tissue by effective ingredient.Above-mentioned solvent or its combination can not play chemical change with plant component, price economy, be easy to get, low to skin irritation, be easy to recycle.
In some embodiments, described plant extract is extracted by immersion, decoction, backflow, percolation or its combination and obtains.
When solvent is added in plant material, solvent due to diffusion, osmosis penetrates in cell by cell wall, dissolve solable matter, and cause the concentration difference of intraor extracellular, intracellular concentrated solution is constantly to external diffusion, solvent constantly enters again in medical material histiocyte, repeatedly come and go, until when intraor extracellular solution concentration reaches dynamic equilibrium, this saturated solution is leached, add novel solvent again, can the stripping of required composition major part.Suitable heating can be spread by acceleration molecular, improves extraction efficiency.Can also utilize the extraction means that this area is conventional, such as the means such as supercritical extraction, ultrasonic extraction improve extraction efficiency.
Another object of the present invention is to provide a Plant Extracts for prevention, improve or eliminate callus.
In some embodiments, described plant extract is also for prevention, alleviation or elimination talalgia.
In some embodiments, described plant extract is added in foodcare cosmetics as effective ingredient.
Above-mentioned plant extract proves through long-term experiment, to no skin irritation, can directly directly add in cosmetics as effective ingredient.
Carrier in cosmetics can enumerate excipient, filming agent, bonding agent, extender, disintegrating agent, stabilizing agent, antioxidant, lubricant, diluent, dispersant, buffer agent, osmotic pressure regulator, pH adjusting agent, emulsifying agent, antiseptic, surfactant, coloring agent, UV absorbent, wetting agent, thickening agent, active reinforcing agent, anti-inflammatory agent, antibacterial, spice, correctives, flavoring agent etc.
A Plant Extracts of the present invention and application thereof have following beneficial effect and advantage:
1, effectively remove old cutin, promote that skin absorbs.
2, there is effect of invigorating blood circulation significantly, for skin provides sufficient nutrition, fundamentally solve callus problem.
3, there is anti-inflammatory analgesic effect, strong muscles and bones simultaneously, can effectively releive or eliminate talalgia.
4, gentle to skin, can directly add in cosmetics, adapt to suitability for industrialized production.
Detailed description of the invention
Below with reference to specific embodiment, the present invention will be further described.
Embodiment 1
Fructus Mume 300g, Rhizoma Chuanxiong 400g, Herba Visci 100g, river are continued 200g and break by proportioning weighing, and pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 10 hours, refluxes 4 hours at 70 DEG C, collects extracting solution.Extracting solution is carried out distilling under reduced pressure, and vapo(u)rizing temperature is 60 DEG C, be distilled to that filtrate volume is original volume 50%, obtain plant extract A1.
Embodiment 2
Fructus Mume 350g, Rhizoma Chuanxiong 350g, Herba Visci 150g, river are continued 150g and break by proportioning weighing, and pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Filtrate is carried out distilling under reduced pressure, and vapo(u)rizing temperature is 60 DEG C, be distilled to that filtrate volume is original volume 50%, obtain plant extract A2.
Embodiment 3
Fructus Mume 400g, Rhizoma Chuanxiong 300g, Herba Visci 200g, river are continued 100g and break by proportioning weighing, and pulverize, mixing, obtains plant mixture.In plant mixture, add water, wherein the solid-liquid ratio g/ml of plant mixture and water is 1:10, soaks after 2 hours, decocts 2 hours, filters, and collects decoction liquor.Decoction liquor is carried out distilling under reduced pressure, and vapo(u)rizing temperature is 90 DEG C, be distilled to that filtrate volume is original volume 50%, obtain plant extract A3.
Embodiment 4
Fructus Mume 350g, Rhizoma Chuanxiong 350g, Herba Visci 150g, river are continued 150g is disconnected to be weighed by proportioning, pulverize, mixing, obtains plant mixture, joins in percolator, add layer by layer, and often adding one deck all will compacting gently, makes powder body even, fine and close.Constantly add 10L water on percolator top, allow solvent flood powder body 4-5cm before solvent adds all the time, controlling percolation speed is 10mL/min.Collect percolate, percolate is carried out distilling under reduced pressure, and vapo(u)rizing temperature is 90 DEG C, be distilled to that filtrate volume is original volume 50%, obtain plant extract A4.
Comparative example 1
Fructus Mume 200g, Rhizoma Chuanxiong 500g, Herba Visci 250g, river are continued 50g and break by proportioning weighing, and pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 50%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Filtrate is carried out distilling under reduced pressure, and vapo(u)rizing temperature is 60 DEG C, be distilled to that filtrate volume is original volume 50%, obtain plant extract A5.
Comparative example 2
Fructus Mume 250g, Rhizoma Chuanxiong 250g, Herba Visci 250g, river are continued 250g and break by proportioning weighing, and pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 50%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 60 DEG C, filters, and collects filtrate.Filtrate is carried out distilling under reduced pressure, and vapo(u)rizing temperature is 60 DEG C, be distilled to that filtrate volume is original volume 50%, obtain plant extract A6.
Embodiment 5 is invigorated blood circulation efficacy validation
(1) test specimen: according to the plant extract that embodiment 1-4 and comparative example 1-2 is obtained, be divided into tested material a1, a2, a3, a4, a5, a6 with after normal saline dilution 10 times respectively; Embodiment 1 gained plant extract A1 dilutes tested material a1, embodiment 2 gained plant extract A2 dilute tested material a2, embodiment 3 gained plant extract A3 dilute tested material a3, embodiment 4 gained plant extract A4 dilute tested material a4, comparative example 1 gained plant extract A5 dilute to obtain tested material a5, comparative example 2 gained plant extract A6 dilutes to obtain tested material a6, take normal saline as blank reagent;
(2) experimental animal: the adult mice of health, skin zero damage, regular grade, totally 70, body weight is 20 ± 2g, is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, the temperature of Animal House is 23 DEG C, and humidity is 52%RH, and drinking water is tap water, carry out random packet before experiment, often organize 10; Test prospective adaptation raises 7 days, feed of freely drinking water.
(3) test reagent and instrument:
Urethane, purchased from Sichuan Ke Long chemical reagent factory.
Normal saline, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
Microscope MoticBA300 and Moticimageadvanced3.2 work station, Microcirculation observation platform.
(4) test procedure:
1. 5 groups of mices use different tested material 0.5mL gavage respectively, and 1 group of mice is as blank group 0.5mL normal saline gavage, and every day, gavage twice, separated 8 hours during twice gavage at least, continuous gastric infusion 8 days, feed of freely drinking water.
2. the fine hair that front Medical adhesive plaster pastes mice two ear is tested, warm water cleaning.
3. after last administration, use urethane to carry out intraperitoneal anesthesia, back of the body position is fixed on observation platform, makes auricle open and flat in ear holder, drips a little liquid paraffin at Er Tuo and auricle surface.
4. the change upon administration of cold light source basis of microscopic observation Mice Auricle microcirculation is placed in, to record after last administration 10 respectively, 20,30min auricle capillary open amount, use blood capillary Point of intersection count method to measure capillary open amount, measure the bore of auricle arteriole, venule with micrometer.
(5) experimental result
The open number of variations of table 1 Mice Auricle blood capillary crossing net
The change of the fine motion of table 2 Mice Auricle, vein blood vessel bore
(6) interpretation of result:
From table 1,2, after administration 10,20,30min, compare with blank group, each tested material has significant expansion effect to Mice Auricle arteriole caliber; After administration 10,20,30min, each tested material has significant expansion effect to Mice Auricle venule diamater; Find that the open number of Mice Auricle blood capillary crossing net is significantly increased simultaneously.Point out plant extract of the present invention to improve significantly to Mice Auricle microcirculation, there is the effect of invigorating blood circulation.Wherein tested material a1-6 all has effect of significantly invigorating blood circulation, and its difference is little, and wherein the effect of invigorating blood circulation of tested material a5 is for optimum, and the effect of invigorating blood circulation of tested material a6 is the poorest.
Embodiment 6 anti-inflammatory effect is verified
(1) test specimen: according to the plant extract that embodiment 1-4 and comparative example 1-2 is obtained, be divided into tested material b1, b2, b3, b4, b5, b6 with after normal saline dilution 10 times respectively; Embodiment 1 gained plant extract A1 dilutes tested material b1, embodiment 2 gained plant extract A2 dilute tested material b2, embodiment 3 gained plant extract A3 dilute tested material b3, embodiment 4 gained plant extract A4 dilute tested material b4, comparative example 1 gained plant extract A5 dilute to obtain tested material b5, comparative example 2 gained plant extract A6 dilutes to obtain tested material b6, take normal saline as blank reagent, with 0.01g/kg acetyl salicylic acid solution for positive control;
(2) experimental animal: the adult mice of health, skin zero damage, regular grade, totally 80, body weight is 20 ± 2g, is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, the temperature of Animal House is 23 DEG C, and humidity is 52%RH, and drinking water is tap water, carry out random packet before experiment, often organize 10; Test prospective adaptation raises 7 days, feed of freely drinking water.
(3) test reagent:
Dimethylbenzene, purchased from Sichuan Ke Long chemical reagent factory.
Normal saline, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
Aspirin, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
(4) experimental procedure:
1. mice is weighed respectively, labelling.
2. 6 groups of mices use different tested material 0.5mL gavage respectively, 1 group of mice is as blank group 0.5mL normal saline gavage, 1 group of mice as positive controls with the acetyl salicylic acid solution gavage of 0.5mL, every day gavage twice, at least 8 hours are separated during twice gavage, continuous gastric infusion 8 days, feed of freely drinking water.
3. after last administration 30 minutes, namely 50 μ L caused by dimethylbenzene xylene are coated with at the left ear positive and negative of mice scorching.
4. put to death mice after 1 hour after last administration, cut ears.
5. lay auricle with the card punch of diameter 7mm at the symmetrical position of left and right ear, weigh in the balance heavily, record its quality, calculate its swelling rate.
(5) experimental result
Table 3 mice ear method measures the antiinflammation result of plant extract
* swelling rate=[(left ear quality-auris dextra quality)/auris dextra quality] × 100%
(6) interpretation of result
From table 3, compare with blank group, each tested material has obvious inhibitory action to mice auricle swelling, points out plant extract provided by the present invention to have the effect of antiinflammatory.Wherein tested material b1,2,3,4, the anti-inflammatory effects of 6 is all better than positive control, the anti-inflammatory effects of tested material b5 is relatively not obvious.
Embodiment 7 analgesic effect is verified
(1) test specimen: according to the plant extract that embodiment 1-4 and comparative example 1-2 is obtained, be divided into tested material c1, c2, c3, c4, c5, c6 with after normal saline dilution 10 times respectively; Embodiment 1 gained plant extract A1 dilutes tested material c1, embodiment 2 gained plant extract A2 dilute tested material c2, embodiment 3 gained plant extract A3 dilute tested material c3, embodiment 4 gained plant extract A4 dilute tested material c4, comparative example 1 gained plant extract A5 dilute to obtain tested material c5, comparative example 2 gained plant extract A6 dilutes to obtain tested material c6, take normal saline as blank reagent, with 2% tetrahydropalmatine solution for positive control;
(2) experimental animal: the adult mice of health, skin zero damage, female, regular grade, totally 80, body weight is 20 ± 2g, thered is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, and the temperature of Animal House is 23 DEG C, humidity is 52%RH, drinking water is tap water, carries out random packet before experiment, often organizes 10; Test prospective adaptation raises 7 days, feed of freely drinking water.
(3) test reagent:
Normal saline, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
Tetrahydropalmatine, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.
(4) test procedure:
1. temperature control hot-plate instrument is regulated at 55 ± 0.5 DEG C, puts large beaker and fixing, after putting into mice to the time of licking between metapedes be pain sensation response time (namely bitterly threshold values).
2. before administration, first test the pain sensation response time of mice, get the mice of pain sensation response time within 10-30 second and do following test, and the pain sensation response time of each mice got well in record.
3. 6 groups of mices use different tested material 0.5mL gavage respectively, 1 group of mice as blank group 0.5mL normal saline gavage, 1 group of mice as positive controls with the 2% tetrahydropalmatine solution gavage of 0.5mL.
4. administration is after 30 minutes, the pain sensation reaction of test mice, and records its pain sensation response time, and before calculating its Average administration, after pain threshold values, average medicine, 30 minutes pain threshold values, average pain valves improve percentage rate.
(5) result of the test:
Table 4 hot plate method measures the analgesic activity result of plant extract
Pain valve improves percentage rate=[before (after medicine 30 minutes pains threshold values-administration front pain threshold values)/administration pain threshold values] × 100%
(6) interpretation of result:
From table 4, compare with blank group, each tested material has analgesic activity in various degree to mice, points out plant extract provided by the present invention to have analgesic effect.Wherein tested material c1,2, the analgesic effect of 4 is all little with positive control difference, wherein the analgesic effect of tested material c6 is better than positive control, and the analgesic effect of tested material c3 is relatively not obvious, and the analgesic activity of tested material c5 is the poorest.
5-7 in conjunction with the embodiments, the plant extract A5 that comparative example 1 provides has the good effect of invigorating blood circulation and does not but possess obvious antiinflammatory and analgesic activity, otherwise the plant extract A6 that comparative example 2 provides, neither meets the requirement that the present invention will solve callus and talalgia simultaneously.The plant extract A1-4 that embodiment 1-4 provides have all simultaneously significantly invigorate blood circulation, antiinflammatory and analgesic activity.
Embodiment more than 8 irritation test
(1) test specimen: according to the plant extract obtained by embodiment 1-4, is divided into tested material d1, d2, d3, d4 respectively after waiting water gaging dilution; Embodiment 1 gained plant extract A1 dilutes tested material d1, embodiment 2 gained plant extract A2 dilute tested material d2, embodiment 3 gained plant extract d3 dilute tested material a3, embodiment 4 gained plant extract A4 dilute to obtain tested material d4, take clear water as blank reagent;
(2) experimental animal: the adult white new zealand rabbit of health, skin zero damage, regular grade, totally 32, body weight is 2.2-2.5kg, thered is provided (animal productiong credit number: SCXK (Guangdong) 2003-0002) by Guangdong Medical Lab Animal Center, the experimental animal quality certification is numbered: 0003296, laboratory animal occupancy permit number: SYXK (Guangdong) 2003-0011, the temperature of Animal House is 23 DEG C, humidity is 52%RH, drinking water is tap water, carries out random packet before experiment, often organizes 4;
(3) test procedure:
1. cut by hair spinal column both sides, laboratory animal back before test, unhairing scope is respectively 3cmX3cm, application area 2.5cmX2.5cm;
2. O.5g get tested material spreads upon on the skin of side, and opposite side, as blank, smears 1 every day, smears 14 days continuously.From second day, smear front cropping at every turn, remain tested material, observed result after a hour with water or nonirritant solvent cleaning, the standards of grading specified according to " cosmetics health specification " (2007 editions) are marked.
(4) experimental result:
Table 5 tested material d1, d2, d3 many skin irritation reaction results
Table 6 tested material d4, blank be skin irritation reaction result repeatedly
(5) evaluation of result
Every day every, animal average integral=Σ erythema and edema integration/animal subject number/14, judged skin irritation intensity with table 7;
Table 7 skin irritation strength grading
| Integral mean value | Intensity |
| 0～<0.5 | Nonirritant |
| 0.5～<2.0 | Subexcite |
| 2.0～<6.0 | Moderate stimulation |
| 6.0～8.0 | Strong and stimulating |
The equal nonirritant of the tested material d1-4 of experimental group can be found out from table 6-7, prove thus to use raw material of the present invention, solvent and preparation method to extract and the plant extract that obtains to the comparatively safe nonirritant of skin.
The preparation of embodiment 9 foot frost
The plant extract provided by embodiment 1-4 is that effective ingredient makes foot frost, and blank is the foot frost containing same excipient not containing plant extract.
The preparation method of table 8 foot frost
Embodiment 10 efficacy assessments
(1) experiment purpose
Evaluated by relative analysis, the foot frost obtained by Evaluation operation example 9 solves the effect of xerosis cutis, callus, talalgia.
(2) experimental technique
Collection wears high-heel shoes for a long time, xerosis cutis and women 150 people of existing callus and talalgia symptom in various degree, and be divided into 5 groups at random, often organize 30 people, 36.4 years old mean age, experimenter is healthy, without heredity or passing medical history, without bad life habits etc.For embodiment 9 gained foot frost carry out observation of curative effect, observe trier before testing and test in test process area skin moisture, callus place, heel pain improve situation.
In the left and right sides, experimenter's sole callus affected part selected about 5 × 5cm size skin moisture content is tested as test zone in region, callus place improves effect, use sufficient frost to smear, applying amount is about 5g, sooner or later each once, use 8 weeks continuously.
Selected experimenter's heel improves effect as test zone test heel pain, and use sufficient frost to smear, applying amount is about 5g, sooner or later respectively once, uses 8 weeks continuously.
(3) evaluation methodology
Trier's callus improves the Standardization of diagnosis and curative effect of degree with reference to traditional Chinese medical science callus.Cure: callus disappears completely; Take a turn for the better: callus deliquescing is thinning.Trier's subjective assessment talalgia improves situation.Trier's skin moisture content utilize moisture of skin scatter and disappear tester (TM210Tewameter) measure, not yet start the water loss amount first measuring recipient site skin before trying out, start to measure a moisture of skin windage in latter every two weeks on probation, recipient site measures after cleaning up 2 hours, the each repetition of each mensuration 5 times, calculates its TEWL average.
(4) experimental result
Table 9 foot frost on probation improves situation to callus
The white area skin water loss amount measured value of table 10 foot on probation
Table 11 foot frost on probation improves situation to talalgia
(4) interpretation of result:
The white e1-4 of foot all has improvement result in various degree to trier's callus as can be seen from Table 9, and effect is all better than blank, points out plant extract provided by the present invention to improve significantly effect to callus, wherein remarkable with the effect of the white e2 of foot; The white e1-4 of foot to scatter and disappear the improvement all had in various degree to trier's moisture of skin as can be seen from Table 10, effect is all better than blank, the water holding capacity pointing out vegetable composition provided by the present invention to contribute to repairing skin barrier, improve skin self, continues use and just can significantly improve skin moisturizing ability in one month.
The white e1-4 of foot all has improvement result in various degree to trier's talalgia as can be seen from Table 11, and effect is all better than blank, points out plant extract provided by the present invention to improve significantly effect to talalgia, wherein remarkable with the effect of the white e2 of foot;
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (6)
1. a Plant Extracts, is characterized in that, described plant extract extracts gained by following weight parts raw material:
Fructus Mume 30-40 part, Rhizoma Chuanxiong 30-40 part, Herba Visci 10-20 part, Radix Dipsaci 10-20 part.
2. plant extract according to claim 1, is characterized in that, described plant extract is extracted by ethanol, water or its combination and obtains.
3. plant extract according to claim 1 and 2, is characterized in that, described plant extract is extracted by immersion, decoction, backflow, percolation or its combination and obtains.
4. the plant extract according to any one of claim 1-3 is used for prevention, improves or eliminates callus.
5. application according to claim 4, is characterized in that, described plant extract is also for prevention, alleviation or elimination talalgia.
6. the application according to claim 4 or 5, is characterized in that, described plant extract is added in foodcare cosmetics as effective ingredient.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109549862A (en) * | 2019-01-30 | 2019-04-02 | 廖敏超 | Cosmetics and preparation method thereof containing growth factor |
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| CN102475646A (en) * | 2010-11-23 | 2012-05-30 | 刘世超 | Dark plum lemon whitening skin care liquid |
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| 高学敏等: "《中医美容学》", 31 January 2000, 中国科学技术出版社 * |
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|---|---|---|---|---|
| CN109549862A (en) * | 2019-01-30 | 2019-04-02 | 廖敏超 | Cosmetics and preparation method thereof containing growth factor |
| CN109549862B (en) * | 2019-01-30 | 2021-07-06 | 芭芭多芦荟生物科技研究(广州)院 | Cosmetic containing growth factor and preparation method thereof |
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