CN102993265B - 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 - Google Patents
免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 Download PDFInfo
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- CN102993265B CN102993265B CN201210382202.8A CN201210382202A CN102993265B CN 102993265 B CN102993265 B CN 102993265B CN 201210382202 A CN201210382202 A CN 201210382202A CN 102993265 B CN102993265 B CN 102993265B
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Abstract
Description
Claims (7)
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CN201210382202.8A CN102993265B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN202010160582.5A CN111420045B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN202010160581.0A CN111375056B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN201510253948.2A CN105061567B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
EP13845289.1A EP2918596A4 (en) | 2012-10-10 | 2013-06-26 | IMMUNE RECEIVER-MODIFIER CONJUGATE AND PREPARATION METHOD AND USE THEREOF, COUPLING PRECURSOR FOR PREPARING THE SAME, AND COMPOUND FOR SYNTHESIZING COUPLING PRECURSOR |
US14/434,743 US10030066B2 (en) | 2012-10-10 | 2013-06-26 | Immune receptor modifier conjugate and preparation method and use thereof, coupling precursor for preparing same, and compound for synthesizing coupling precursor |
PCT/CN2013/077972 WO2014056333A1 (zh) | 2012-10-10 | 2013-06-26 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
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CN202010160582.5A Division CN111420045B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN201510253948.2A Division CN105061567B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
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CN202010160581.0A Active CN111375056B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN201510253948.2A Active CN105061567B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN202010160582.5A Active CN111420045B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
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CN202010160581.0A Active CN111375056B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN201510253948.2A Active CN105061567B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN202010160582.5A Active CN111420045B (zh) | 2012-10-10 | 2012-10-10 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
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CN102993265B (zh) * | 2012-10-10 | 2015-05-13 | 深圳大学 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
CN105315281B (zh) | 2015-11-16 | 2017-04-19 | 深圳大学 | 化合物i和化合物ii及其制备方法和应用 |
CN105327345A (zh) * | 2015-11-19 | 2016-02-17 | 深圳大学 | 一种疫苗佐剂以及包含该佐剂的疫苗 |
CN106267188A (zh) * | 2016-08-15 | 2017-01-04 | 深圳大学 | 小分子免疫激动剂偶联pd‑1抗体的新型抗体及其在抗肿瘤中的应用 |
CN106692982A (zh) * | 2016-11-28 | 2017-05-24 | 吴福勤 | 一种tsh免疫活性配体复活固本疗法 |
CN106632338B (zh) * | 2016-12-16 | 2018-11-27 | 温州医科大学 | 一种9-取代-n-(2-氯苄基)嘌呤-6-胺类衍生物及其制备方法和应用 |
CN107281483A (zh) * | 2017-04-25 | 2017-10-24 | 深圳大学 | 免疫激动剂和组合物及其应用以及组合物的制备方法 |
CN107281484A (zh) * | 2017-05-31 | 2017-10-24 | 深圳大学 | 用于制备乙肝疫苗的组合物及其制备方法和应用 |
CN115192726A (zh) * | 2018-04-03 | 2022-10-18 | 深圳大学 | 免疫激动剂靶向化合物的合成及其应用 |
CN111704614B (zh) * | 2020-04-15 | 2021-10-22 | 深圳大学 | 一种系列免疫激动剂 |
KR20230157385A (ko) * | 2021-03-08 | 2023-11-16 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 항 her2 항체 면역 작용제 접합체 및 이의 적용 |
JP2024508976A (ja) * | 2021-03-08 | 2024-02-28 | ジーンクアンタム ヘルスケア (スーチョウ) シーオー., エルティーディー. | 抗体-免疫アゴニストコンジュゲート及びその使用 |
CN115068625B (zh) * | 2021-03-16 | 2024-07-02 | 中国科学院上海药物研究所 | Pd-l1和tlr7双靶向纳米抗体偶联药物及其在抗肿瘤中的应用 |
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CN102993265A (zh) * | 2012-10-10 | 2013-03-27 | 靳广毅 | 免疫受体调节剂偶联体及其制备方法和应用、制备其的偶联前体以及合成偶联前体的化合物 |
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JPWO2007034817A1 (ja) * | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
CN101230064A (zh) * | 2007-01-22 | 2008-07-30 | 靳广毅 | 9位亚甲基芳基上取代的嘌呤类衍生物 |
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CN111375056B (zh) | 2023-06-27 |
CN105061567A (zh) | 2015-11-18 |
EP2918596A4 (en) | 2016-08-31 |
CN111420045B (zh) | 2023-03-31 |
WO2014056333A9 (zh) | 2015-04-30 |
WO2014056333A1 (zh) | 2014-04-17 |
CN111375056A (zh) | 2020-07-07 |
US10030066B2 (en) | 2018-07-24 |
US20150284445A1 (en) | 2015-10-08 |
CN111420045A (zh) | 2020-07-17 |
EP2918596A1 (en) | 2015-09-16 |
CN102993265A (zh) | 2013-03-27 |
CN105061567B (zh) | 2021-07-20 |
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