CN102985440B - 包含额外的二硫键的胰岛素衍生物 - Google Patents

包含额外的二硫键的胰岛素衍生物 Download PDF

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Publication number
CN102985440B
CN102985440B CN201180031021.4A CN201180031021A CN102985440B CN 102985440 B CN102985440 B CN 102985440B CN 201180031021 A CN201180031021 A CN 201180031021A CN 102985440 B CN102985440 B CN 102985440B
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CN
China
Prior art keywords
insulin
gglu
desb30
human
insulin human
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Expired - Fee Related
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CN201180031021.4A
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English (en)
Chinese (zh)
Other versions
CN102985440A (zh
Inventor
P·马德森
F·胡巴莱克
T·B·克杰尔德森
S·卢德维格森
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Novo Nordisk AS
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Novo Nordisk AS
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201180031021.4A 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素衍生物 Expired - Fee Related CN102985440B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP10167046 2010-06-23
EP10167033.9 2010-06-23
EP10167033 2010-06-23
EP10167046.1 2010-06-23
US35915010P 2010-06-28 2010-06-28
US61/359150 2010-06-28
US35950010P 2010-06-29 2010-06-29
US61/359500 2010-06-29
PCT/EP2011/060383 WO2011161125A1 (en) 2010-06-23 2011-06-21 Insulin derivatives containing additional disulfide bonds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201510007033.3A Division CN104693302A (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素衍生物

Publications (2)

Publication Number Publication Date
CN102985440A CN102985440A (zh) 2013-03-20
CN102985440B true CN102985440B (zh) 2016-10-26

Family

ID=44508482

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201180031021.4A Expired - Fee Related CN102985440B (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素衍生物
CN201510007033.3A Pending CN104693302A (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素衍生物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201510007033.3A Pending CN104693302A (zh) 2010-06-23 2011-06-21 包含额外的二硫键的胰岛素衍生物

Country Status (13)

Country Link
US (2) US8853155B2 (cg-RX-API-DMAC7.html)
EP (1) EP2585485A1 (cg-RX-API-DMAC7.html)
JP (1) JP5931857B2 (cg-RX-API-DMAC7.html)
KR (1) KR20130036290A (cg-RX-API-DMAC7.html)
CN (2) CN102985440B (cg-RX-API-DMAC7.html)
AU (1) AU2011269000C1 (cg-RX-API-DMAC7.html)
BR (1) BR112012033107A2 (cg-RX-API-DMAC7.html)
CA (1) CA2802510A1 (cg-RX-API-DMAC7.html)
IL (1) IL223288A0 (cg-RX-API-DMAC7.html)
MX (1) MX337549B (cg-RX-API-DMAC7.html)
RU (1) RU2598273C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011161125A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201209345B (cg-RX-API-DMAC7.html)

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HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
CN103533952B (zh) * 2011-03-15 2017-02-15 诺沃—诺迪斯克有限公司 包含半胱氨酸置换的人胰岛素类似物和衍生物
WO2013093009A1 (en) * 2011-12-21 2013-06-27 Novo Nordisk A/S N -terminally modified insulin derivatives
EP2836508B1 (en) 2012-04-11 2016-06-29 Novo Nordisk A/S Insulin formulations
WO2014009316A1 (en) 2012-07-09 2014-01-16 Novo Nordisk A/S Novel use of insulin derivatives
CA2926701A1 (en) * 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
JP6737793B2 (ja) * 2015-01-29 2020-08-12 ノヴォ ノルディスク アー／エス 錠剤コアとポリビニルアルコールコーティングとを含む経口インスリン投与のための医薬組成物
HK1255634A1 (zh) 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
CN107436311B (zh) * 2016-05-25 2021-11-19 正大天晴药业集团股份有限公司 一种鉴别胰岛素单体或胰岛素多聚体的方法
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
CN113121649B (zh) * 2019-12-26 2022-10-04 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN116789801B (zh) * 2023-08-21 2023-11-14 南京赛诺生物技术有限公司 新型胰岛素衍生物及其用途
WO2025104600A1 (en) * 2023-11-15 2025-05-22 Ambio, Inc. Insulin analogs for the treatment of human metabolic disorder and disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
CN101541830A (zh) * 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物

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IE50892B1 (en) 1980-02-11 1986-08-06 Novo Industri As Process for preparing insulin esters
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
ZA954983B (en) 1994-06-17 1996-02-14 Novo Nordisk As N-terminally extended proteins expressed in yeast
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
HUP0004169A3 (en) * 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
CA2361830A1 (en) 1999-03-17 2000-09-21 Novo Nordisk A/S Method for acylating peptides and novel acylating agents
RU2283846C2 (ru) 1999-12-29 2006-09-20 Ново Нордиск А/С Предшественник инсулина, способ его получения и применение
JP4468174B2 (ja) 2002-09-25 2010-05-26 ノボ ノルディスク アクティーゼルスカブ ペプチドをアシル化するための方法
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
AU2004261353B2 (en) * 2003-08-05 2009-12-10 Novo Nordisk A/S Novel insulin derivatives
ES2369895T3 (es) 2003-12-03 2011-12-07 Novo Nordisk A/S Insulina monocatenaria.
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
US8343914B2 (en) * 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
WO2007096332A1 (en) 2006-02-21 2007-08-30 Novo Nordisk A/S Single-chain insulin analogues and pharmaceutical formulations thereof
EP2074140B8 (en) 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
AU2008288413B2 (en) * 2007-08-15 2013-09-26 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
RU2524423C2 (ru) * 2008-01-09 2014-07-27 Санофи-Авентис Дойчланд Гмбх Новые производные инсулина с чрезвычайно замедленным профилем время/действие
CN101970477B (zh) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
HUE032284T2 (en) 2008-03-18 2017-09-28 Novo Nordisk As Protease-stabilized, acylated insulin analogues
CN102149411A (zh) 2008-09-12 2011-08-10 诺沃—诺迪斯克有限公司 酰化肽或蛋白的方法
EP2376531A1 (en) 2008-12-09 2011-10-19 Novo Nordisk A/S Novel insulin analogues
US20120184488A1 (en) 2009-09-01 2012-07-19 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
EP2585483A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds
EP2585484A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000321A1 (en) * 1990-06-28 1992-01-09 Novo Nordisk A/S Novel, protracted insulin analogues
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
CN101541830A (zh) * 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物

Also Published As

Publication number Publication date
BR112012033107A2 (pt) 2016-10-11
KR20130036290A (ko) 2013-04-11
CN102985440A (zh) 2013-03-20
CN104693302A (zh) 2015-06-10
RU2012157683A (ru) 2014-07-27
IL223288A0 (en) 2013-02-03
US20130157938A1 (en) 2013-06-20
JP5931857B2 (ja) 2016-06-08
ZA201209345B (en) 2013-08-28
MX2012014641A (es) 2013-02-07
EP2585485A1 (en) 2013-05-01
AU2011269000C1 (en) 2015-10-08
JP2013530974A (ja) 2013-08-01
US20140371140A1 (en) 2014-12-18
US8853155B2 (en) 2014-10-07
AU2011269000A1 (en) 2012-12-13
US9512195B2 (en) 2016-12-06
AU2011269000B2 (en) 2015-04-23
MX337549B (es) 2016-03-10
WO2011161125A1 (en) 2011-12-29
RU2598273C2 (ru) 2016-09-20
CA2802510A1 (en) 2011-12-29

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