IL223288A0 - Insulin derivatives containing additional disulfide bonds - Google Patents

Insulin derivatives containing additional disulfide bonds

Info

Publication number
IL223288A0
IL223288A0 IL223288A IL22328812A IL223288A0 IL 223288 A0 IL223288 A0 IL 223288A0 IL 223288 A IL223288 A IL 223288A IL 22328812 A IL22328812 A IL 22328812A IL 223288 A0 IL223288 A0 IL 223288A0
Authority
IL
Israel
Prior art keywords
disulfide bonds
derivatives containing
containing additional
insulin derivatives
additional disulfide
Prior art date
Application number
IL223288A
Other languages
English (en)
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL223288A0 publication Critical patent/IL223288A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL223288A 2010-06-23 2012-11-27 Insulin derivatives containing additional disulfide bonds IL223288A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP10167033 2010-06-23
EP10167046 2010-06-23
US35915010P 2010-06-28 2010-06-28
US35950010P 2010-06-29 2010-06-29
PCT/EP2011/060383 WO2011161125A1 (en) 2010-06-23 2011-06-21 Insulin derivatives containing additional disulfide bonds

Publications (1)

Publication Number Publication Date
IL223288A0 true IL223288A0 (en) 2013-02-03

Family

ID=44508482

Family Applications (1)

Application Number Title Priority Date Filing Date
IL223288A IL223288A0 (en) 2010-06-23 2012-11-27 Insulin derivatives containing additional disulfide bonds

Country Status (13)

Country Link
US (2) US8853155B2 (cg-RX-API-DMAC7.html)
EP (1) EP2585485A1 (cg-RX-API-DMAC7.html)
JP (1) JP5931857B2 (cg-RX-API-DMAC7.html)
KR (1) KR20130036290A (cg-RX-API-DMAC7.html)
CN (2) CN104693302A (cg-RX-API-DMAC7.html)
AU (1) AU2011269000C1 (cg-RX-API-DMAC7.html)
BR (1) BR112012033107A2 (cg-RX-API-DMAC7.html)
CA (1) CA2802510A1 (cg-RX-API-DMAC7.html)
IL (1) IL223288A0 (cg-RX-API-DMAC7.html)
MX (1) MX337549B (cg-RX-API-DMAC7.html)
RU (1) RU2598273C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011161125A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201209345B (cg-RX-API-DMAC7.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2910570T3 (en) 2008-03-18 2017-01-30 Novo Nordisk As Protease-stabilized acylated insulin analogues.
WO2012123519A2 (en) * 2011-03-15 2012-09-20 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
US20140357838A1 (en) * 2011-12-21 2014-12-04 Novo Nordisk A/S N-Terminally Modified Insulin Derivatives
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
WO2014009316A1 (en) 2012-07-09 2014-01-16 Novo Nordisk A/S Novel use of insulin derivatives
MX366636B (es) 2013-10-07 2019-07-17 Novo Nordisk As Nuevo derivado de un análogo de insulina.
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
WO2016119854A1 (en) * 2015-01-29 2016-08-04 Novo Nordisk A/S Pharmaceutical composition for oral insulin administration comprising a tablet core and a polyvinyl alcohol coating
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
CN107436311B (zh) * 2016-05-25 2021-11-19 正大天晴药业集团股份有限公司 一种鉴别胰岛素单体或胰岛素多聚体的方法
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
CN113121649B (zh) * 2019-12-26 2022-10-04 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN116789801B (zh) * 2023-08-21 2023-11-14 南京赛诺生物技术有限公司 新型胰岛素衍生物及其用途
US20250154220A1 (en) * 2023-11-15 2025-05-15 Ambio, Inc. Insulin analogs for the treatment of human metabolic disorder and disease

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343898A (en) 1980-02-11 1982-08-10 Novo Industri A/S Process for preparing esters of human insulin
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
IL114160A (en) 1994-06-17 2006-12-31 Novo Nordisk As Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
CA2306905A1 (en) * 1997-10-24 1999-05-06 Eli Lilly And Company Fatty acid-acylated insulin analogs
HUP0200297A3 (en) 1999-03-17 2002-09-30 Novo Nordisk As Method for acylating peptides and the glutaminic acid derivatives as acylating agents
KR20030004317A (ko) 1999-12-29 2003-01-14 노보 노르디스크 에이/에스 인슐린 선구물질 및 인슐린 선구물질 유사체의 제조 방법
KR101131783B1 (ko) 2002-09-25 2012-03-30 노보 노르디스크 에이/에스 아실화된 펩타이드의 제조방법
AU2003903124A0 (en) * 2003-06-20 2003-07-10 Mark Del Borgo Analogues of heteromeric proteins
BRPI0413276B8 (pt) * 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
AU2004295023A1 (en) 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
US8343914B2 (en) * 2006-01-06 2013-01-01 Case Western Reserve University Fibrillation resistant proteins
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
WO2007135117A2 (en) * 2006-05-24 2007-11-29 Novo Nordisk A/S Soluble, stable insulin-containing formulations
KR101729986B1 (ko) 2006-09-22 2017-04-25 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
EP2178912B1 (en) * 2007-08-15 2015-07-08 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
MY152979A (en) 2008-01-09 2014-12-15 Sanofi Aventis Deutschland Novel insulin derivatives having an extremely delayed time-action profile
WO2009112583A2 (en) 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
DK2910570T3 (en) 2008-03-18 2017-01-30 Novo Nordisk As Protease-stabilized acylated insulin analogues.
ES2561208T3 (es) 2008-09-12 2016-02-25 Novo Nordisk A/S Método de acilación de un péptido o una proteína
EP2376531A1 (en) 2008-12-09 2011-10-19 Novo Nordisk A/S Novel insulin analogues
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
JP5973427B2 (ja) 2010-06-23 2016-08-23 ノヴォ ノルディスク アー／エス 追加のジスルフィド結合を含有するインスリン類似体
EP2585483A1 (en) 2010-06-23 2013-05-01 Novo Nordisk A/S Human insulin containing additional disulfide bonds

Also Published As

Publication number Publication date
EP2585485A1 (en) 2013-05-01
KR20130036290A (ko) 2013-04-11
WO2011161125A1 (en) 2011-12-29
US9512195B2 (en) 2016-12-06
BR112012033107A2 (pt) 2016-10-11
RU2598273C2 (ru) 2016-09-20
US20140371140A1 (en) 2014-12-18
AU2011269000A1 (en) 2012-12-13
MX337549B (es) 2016-03-10
MX2012014641A (es) 2013-02-07
US8853155B2 (en) 2014-10-07
US20130157938A1 (en) 2013-06-20
AU2011269000B2 (en) 2015-04-23
JP5931857B2 (ja) 2016-06-08
CN104693302A (zh) 2015-06-10
CA2802510A1 (en) 2011-12-29
ZA201209345B (en) 2013-08-28
CN102985440B (zh) 2016-10-26
JP2013530974A (ja) 2013-08-01
CN102985440A (zh) 2013-03-20
RU2012157683A (ru) 2014-07-27
AU2011269000C1 (en) 2015-10-08

Similar Documents

Publication Publication Date Title
ZA201209345B (en) Insulin derivatives containing additional disulfide bonds
IL246205A0 (en) History of heteroarylpiperidine and piperazine as fungicides
IL226245A0 (en) History
IL222646A0 (en) N3-substituted -n1-sulfonyl-5-fluoropyrimidinone derivatives
IL224690A (en) History of heteroarylpipridine and piperazine as fungicides
ZA201209117B (en) Tetrahydro-pyrido-pyrimidine derivatives
SG10201507079WA (en) Syringe
EP2654872A4 (en) AUTODILATION CANNULA
GB2490849B (en) Di-aspirin derivatives
HU1000243D0 (en) 8-hidroxy-quinoline derivatives
HUE070784T2 (hu) Terápiás készítmények diabéteszes szimmetrikus polineuropátia kezelésére
PT2600881T (pt) Composto medicinal natural
PL2558470T3 (pl) Pochodne ditiinopirydazynodionu jako środki grzybobójcze
GB201001048D0 (en) Antiseptic gum
GB201110460D0 (en) Cavity closer
IL267880A (en) History of heteroarylpiperidine and piperazine as fungicides
GB201004177D0 (en) Syringe
GB201000942D0 (en) Syringe
ZA201209248B (en) Amido-tropane derivatives
IL220983A0 (en) 2-aldoximino-5-fluoropyrimidine derivatives
PL391402A1 (pl) Kaniula dezintegrująco-ssąca
GB201007934D0 (en) Syringes
GB201004368D0 (en) Blood coaggulation factors
GB201010012D0 (en) Cavity closer
GB201002154D0 (en) Packaging thirty