CN102961519B - Compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof - Google Patents
Compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of compound bee-glue composition for the treatment of mammitis of cow, by following component by weight mixed preparing form: propolis 15 ~ 35 parts, Fructus Forsythiae 15 ~ 35 parts, Fructus Crataegi 15 ~ 35 parts, Sargassum 15 ~ 35 parts, Fructus Chebulae 15 ~ 45 parts, 15 ~ 35 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 15 ~ 35 parts, Herba Lysimachiae 15 ~ 45 parts, Semen Plantaginis 15 ~ 35 parts, Medulla Junci 15 ~ 45 parts.The present invention adopts the pure Chinese medicine ingredients of multi-flavor, has the unique advantage not available for Western medicine; Reasonable recipe, preparation is simple, and pollution-free, cost is low, drug residue free, has no side effect, evident in efficacy.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof, belong to field of animal, particularly relate to a kind of compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof.
Background technology
Mammitis of cow is that milch cow is before just before giving birth or the common a kind of multiple diseases of pregnancy duration, the multiple lactation period being born in breast use milch cow, primary disease is the commonly encountered diseases frequently-occurring disease in milk cattle cultivating process, sometimes even jeopardizing the life security of female animal and newborn animal thereof, is cause one of disease that milch cow economic loss is the most serious.
Chinese veterinarian thinks that heat is stopped up because of female animal Jiao in antenatal puerperal three by this disease system, pyretic toxicity multiple abscess breast and swell swollen, or the inaccessible milk accumulation of mammary gland, or polygalactia and the young stock amount of sucking is few, or puerperal, young stock was dead, and milk can not dissipate, accumulate within breast, pent-up forms primary disease.
Current medicine effect is outstanding not, can produce drug resistance again, constitute a serious threat to environment and human health with the existing drug residue of western medicine.Therefore researching and developing a kind of specific medicament for the treatment of mammitis of cow is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, drug residue free, to have no side effect, effectively compound bee-glue composition and preparation method thereof for the treatment of mammitis of cow.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of mammitis of cow, by following component by weight mixed preparing form: propolis 15 ~ 35 parts, Fructus Forsythiae 15 ~ 35 parts, Fructus Crataegi 15 ~ 35 parts, Sargassum 15 ~ 35 parts, Fructus Chebulae 15 ~ 45 parts, 15 ~ 35 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 15 ~ 35 parts, Herba Lysimachiae 15 ~ 45 parts, Semen Plantaginis 15 ~ 35 parts, Medulla Junci 15 ~ 45 parts.
Described various component optimum ratio amount is: propolis 25 parts, Fructus Forsythiae 25 parts, Fructus Crataegi 25 parts, Sargassum 25 parts, Fructus Chebulae 30 parts, 25 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 25 parts, Herba Lysimachiae 30 parts, Semen Plantaginis 25 parts, Medulla Junci 30 parts.
Treating a preparation method for the compound bee-glue composition of mammitis of cow, is carry out as follows:
(1) 700 mesh sieves are crossed after the various compositions in prescription being carried out respectively micronizing;
(2) proportioning takes propolis 15 ~ 35 parts, Fructus Forsythiae 15 ~ 35 parts, Fructus Crataegi 15 ~ 35 parts, Sargassum 15 ~ 35 parts, Fructus Chebulae 15 ~ 45 parts by weight, mixes 5 ~ 10 minutes;
(3) proportioning takes 15 ~ 35 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 15 ~ 35 parts, Herba Lysimachiae 15 ~ 45 parts, Semen Plantaginis 15 ~ 35 parts, Medulla Junci 15 ~ 45 parts by weight, mixes 5 ~ 10 minutes;
(4) merge the obtained compositions of above-mentioned steps (2) and (3), remix 10 ~ 15 minutes, mix homogeneously.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, lung, stomach warp, has anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improves that immunity, antiallergic are oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Fructus Forsythiae: bitter, cold, returns lung, the heart, small intestine meridian, has the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Fructus Crataegi: sour, sweet, tepor, returns stomach, spleen, Liver Channel, has the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.
Sargassum: bitter, salty, cold, returns liver, stomach, kidney channel, has the function of hard masses softening and resolving, inducing diuresis to remove edema; Cure mainly phlegm retention edema, painful and swollen testis etc.
Fructus Chebulae: bitter, sour, puckery, flat, returns lung, large intestine channel, the function of have astringing intestine to stop diarrhea, astringing the lung; Cure mainly chronic diarrhea chronic dysentery, have blood in stool, proctoptosis, cough and asthma due to lung deficiency etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Herba Artemisiae Scopariae: bitter, pungent, be slightly cold, returns spleen, stomach, liver, gallbladder meridian, has the function of eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice; Cure mainly jaundice, oliguria, eczema pruritus etc.
Herba Lysimachiae: sweet, salty, be slightly cold, returns liver, gallbladder, kidney, urinary bladder channel, has the function of clearing away heat-damp and promoting diuresis, diuretic relieving constipation, calculus pain relieving, removing toxic substances and promoting subsidence of swelling; Cure mainly jaundice due to damp-heat, pyretic stranguria, stranguria caused by urinary stone, edema, toxic swelling etc.
Semen Plantaginis: sweet, be slightly cold, returns liver, kidney, lung, small intestine meridian, has clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, the function of improving eyesight; Cure mainly pyretic stranguria hematuria, have loose bowels, conjunctival congestion and swelling pain, edema etc.
Medulla Junci: sweet, light, be slightly cold, GUIXIN, lung, small intestine meridian, have the function of clearing away heart-fire, diuresis; Cure mainly difficulty in urination, edema, aphtha of the mouth and tongue etc.
All taste Chinese medicine is according to tcm theory compatible combination above, for the various paathogenic factors causing mammitis of cow, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Pure Chinese medicine composition is pollution-free, no drug residue, and cost is low, draws materials wide, curative effect highly significant.Select multi-flavor pure Chinese medicinal preparation, there is the unique advantage not available for Western medicine.Theoretical according to motherland tradition Chinese veterinarian, optimize this ten herbal medicine, and make them form compound preparation according to optimum proportioning, clinical practice proves, has specially good effect to treatment mammitis of cow.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof, carries out: (every part by 10g) as follows
(1) 700 mesh sieves are crossed after the various compositions in prescription being carried out respectively micronizing;
(2) proportioning takes propolis 150 parts, Fructus Forsythiae 150 parts, Fructus Crataegi 150 parts, Sargassum 150 parts, Fructus Chebulae 150 parts by weight, mixes 5 ~ 10 minutes;
(3) proportioning takes 150 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 150 parts, Herba Lysimachiae 150 parts, Semen Plantaginis 150 parts, Medulla Junci 150 parts by weight, mixes 5 ~ 10 minutes;
(4) merge the obtained compositions of above-mentioned steps (2) and (3), remix 10 ~ 15 minutes, mix homogeneously.
Embodiment 2
A kind of compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof, carries out: (every part by 10g) as follows
(1) 700 mesh sieves are crossed after the various compositions in prescription being carried out respectively micronizing;
(2) proportioning takes propolis 250 parts, Fructus Forsythiae 250 parts, Fructus Crataegi 250 parts, Sargassum 250 parts, Fructus Chebulae 300 parts by weight, mixes 5 ~ 10 minutes;
(3) proportioning takes 250 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 250 parts, Herba Lysimachiae 300 parts, Semen Plantaginis 250 parts, Medulla Junci 300 parts by weight, mixes 5 ~ 10 minutes;
(4) merge the obtained compositions of above-mentioned steps (2) and (3), remix 10 ~ 15 minutes, mix homogeneously.
Embodiment 3
A kind of compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof, carries out: (every part by 10g) as follows
(1) 700 mesh sieves are crossed after the various compositions in prescription being carried out respectively micronizing;
(2) proportioning takes propolis 350 parts, Fructus Forsythiae 350 parts, Fructus Crataegi 350 parts, Sargassum 350 parts, Fructus Chebulae 450 parts by weight, mixes 5 ~ 10 minutes;
(3) proportioning takes 350 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 350 parts, Herba Lysimachiae 450 parts, Semen Plantaginis 350 parts, Medulla Junci 450 parts by weight, mixes 5 ~ 10 minutes;
(4) merge the obtained compositions of above-mentioned steps (2) and (3), remix 10 ~ 15 minutes, mix homogeneously.
Clinical trial:
Clinical experiment animal selects 380-450 age in days, and Laboratory Diagnosed is the milch cow of mammitis of cow, is isolated and raises separately, complete feed of feeding, and be divided into 3 groups at random, and often organize 10,3 groups of feeding environments are identical, and test period is 7 days; Blank group is left intact, and drug control group " YIMUSHENGHUA SAN " by specification uses treatment; Product of the present invention (compositions obtained by the embodiment of the present invention 1) decocting can be got soup by Chinese medicine composition group of the present invention, wait temperature gavage ill milch cow, day dose be: by every 150g, every day 1 time, be used in conjunction 2-3 days.After decocting, Chinese medicinal liquor gavages, and is reached the object of disease therapy after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 7th day) at the end of experiment.
The situation of traditional Chinese medicine composition for treating mammitis of cow of the present invention applied clinically by table:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 10.0 | 60.0 | 30.0 |
| II | YIMUSHENGHUA SAN group | 0 | 80.0 | 20.0 |
| III | Present composition group | 0 | 90.0 | 10.0 |
This clinical effectiveness statistical analysis, present composition treatment group and YIMUSHENGHUA SAN group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 220 age in days healthy cow 10,5 times according to the made compositions recommended dose of the embodiment of the present invention 1 gavage 5 days, during medication, healthy cow is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and to compare difference not remarkable with blank group (i.e. health not administration group).
Above-mentioned detailed description of compound bee-glue composition of this treatment mammitis of cow and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for mammitis of cow, it is characterized in that by following component by weight mixed preparing form: propolis 15 ~ 35 parts, Fructus Forsythiae 15 ~ 35 parts, Fructus Crataegi 15 ~ 35 parts, Sargassum 15 ~ 35 parts, Fructus Chebulae 15 ~ 45 parts, 15 ~ 35 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 15 ~ 35 parts, Herba Lysimachiae 15 ~ 45 parts, Semen Plantaginis 15 ~ 35 parts, Medulla Junci 15 ~ 45 parts.
2. the compound bee-glue composition for the treatment of mammitis of cow according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, Fructus Forsythiae 25 parts, Fructus Crataegi 25 parts, Sargassum 25 parts, Fructus Chebulae 30 parts, 25 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 25 parts, Herba Lysimachiae 30 parts, Semen Plantaginis 25 parts, Medulla Junci 30 parts.
3. a preparation method for the compound bee-glue composition for the treatment of mammitis of cow according to claim 1, is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed after the various compositions in prescription being carried out respectively micronizing;
(2) proportioning takes propolis 15 ~ 35 parts, Fructus Forsythiae 15 ~ 35 parts, Fructus Crataegi 15 ~ 35 parts, Sargassum 15 ~ 35 parts, Fructus Chebulae 15 ~ 45 parts by weight, mixes 5 ~ 10 minutes;
(3) proportioning takes 15 ~ 35 parts, Radix Glycyrrhizae, Herba Artemisiae Scopariae 15 ~ 35 parts, Herba Lysimachiae 15 ~ 45 parts, Semen Plantaginis 15 ~ 35 parts, Medulla Junci 15 ~ 45 parts by weight, mixes 5 ~ 10 minutes;
(4) merge the obtained compositions of above-mentioned steps (2) and (3), remix 10 ~ 15 minutes, mix homogeneously.
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| CN201210516226.8A CN102961519B (en) | 2012-11-22 | 2012-11-22 | Compound bee-glue composition for the treatment of mammitis of cow and preparation method thereof |
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| CN102961519B true CN102961519B (en) | 2015-07-29 |
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| CN104288508A (en) * | 2014-09-27 | 2015-01-21 | 李保集 | Ointment for mastitis of dairy cows and preparation method thereof |
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| WO1989006955A1 (en) * | 1988-02-08 | 1989-08-10 | Unipharmart | Process for manufacturing veterinary products being suitable particularly for treatment of mastitis and the product thus obtained |
| CN1823903A (en) * | 2005-12-31 | 2006-08-30 | 天津生机集团 | Yinghuang breast filling liquid, its preparation method and use |
| CN101134074A (en) * | 2006-08-30 | 2008-03-05 | 天津市润拓生物技术有限公司 | Compound traditional Chinese powder medicine for treating chronic mastitis for cows |
| KR20110092509A (en) * | 2010-02-09 | 2011-08-18 | 주식회사 제일바이오 | Composition for treating bovine mastitis |
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Effective date of registration: 20191212 Address after: 243100 industrial concentration zone, Dalong Township, Dangtu County, Ma'anshan City, Anhui Province Patentee after: Anhui Shengda Sports Goods Co., Ltd. Address before: 266000 Shandong Province, Qingdao city Licang District Nanwang Industrial Park No. 66 Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |