CN102958934B - 稠合吡咯并咔唑衍生物的纯化方法 - Google Patents

稠合吡咯并咔唑衍生物的纯化方法 Download PDF

Info

Publication number
CN102958934B
CN102958934B CN201180024787.XA CN201180024787A CN102958934B CN 102958934 B CN102958934 B CN 102958934B CN 201180024787 A CN201180024787 A CN 201180024787A CN 102958934 B CN102958934 B CN 102958934B
Authority
CN
China
Prior art keywords
formula
compound
methyl
acid
butanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180024787.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN102958934A (zh
Inventor
肖恩·P·阿尔文
阿诺德·格兰德里
盖伊·皮亚琴扎
塞巴斯蒂安·罗斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
European Saifulun Co
Tiva Sant
Cephalon LLC
Original Assignee
Ladder Wa Sangte Co
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ladder Wa Sangte Co, Cephalon LLC filed Critical Ladder Wa Sangte Co
Publication of CN102958934A publication Critical patent/CN102958934A/zh
Application granted granted Critical
Publication of CN102958934B publication Critical patent/CN102958934B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201180024787.XA 2010-05-18 2011-05-17 稠合吡咯并咔唑衍生物的纯化方法 Active CN102958934B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34583110P 2010-05-18 2010-05-18
US61/345,831 2010-05-18
PCT/US2011/036814 WO2011146488A1 (en) 2010-05-18 2011-05-17 Method for purifying a fused pyrrolocarbazole derivative

Publications (2)

Publication Number Publication Date
CN102958934A CN102958934A (zh) 2013-03-06
CN102958934B true CN102958934B (zh) 2015-06-17

Family

ID=44168420

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180024787.XA Active CN102958934B (zh) 2010-05-18 2011-05-17 稠合吡咯并咔唑衍生物的纯化方法

Country Status (20)

Country Link
US (1) US8884014B2 (enExample)
EP (1) EP2571885B1 (enExample)
JP (2) JP5828594B2 (enExample)
KR (1) KR101815332B1 (enExample)
CN (1) CN102958934B (enExample)
AU (1) AU2011256264B2 (enExample)
BR (1) BR112012029374B1 (enExample)
CA (1) CA2799517C (enExample)
CL (1) CL2012003208A1 (enExample)
EA (1) EA021869B1 (enExample)
ES (1) ES2530015T3 (enExample)
IL (2) IL223016A0 (enExample)
MX (1) MX2012013304A (enExample)
MY (1) MY156830A (enExample)
NZ (1) NZ604135A (enExample)
PH (1) PH12012502250A1 (enExample)
SG (2) SG10201503541WA (enExample)
UA (1) UA108498C2 (enExample)
WO (1) WO2011146488A1 (enExample)
ZA (1) ZA201209305B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010059795A1 (en) 2008-11-19 2010-05-27 Cephalon, Inc. Novel forms of an indazolo [5,4-a] pyrrolo [3,4-c] carbazole compound

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050143442A1 (en) * 2003-12-23 2005-06-30 Hudkins Robert L. Novel fused pyrrolocarbazoles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2220811T3 (es) * 2000-09-29 2004-12-16 Eli Lilly And Company Procedimiento y compuestos para el tratamiento de enfermedades proliferativas.
JP2006241579A (ja) 2005-03-07 2006-09-14 Nippon Paint Co Ltd 化成処理剤及び表面処理金属
WO2010059795A1 (en) 2008-11-19 2010-05-27 Cephalon, Inc. Novel forms of an indazolo [5,4-a] pyrrolo [3,4-c] carbazole compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050143442A1 (en) * 2003-12-23 2005-06-30 Hudkins Robert L. Novel fused pyrrolocarbazoles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
4-哌啶醇的精致工艺研究;张惠等;《研发前沿》;20090106;第17卷(第1期);第26-27页 *
关于中药化学实验的几点思考;卢汝梅等;《广西中医学院学报》;19991231;第16卷(第4期);第23页 *

Also Published As

Publication number Publication date
ES2530015T3 (es) 2015-02-25
PH12012502250A1 (en) 2013-02-04
SG10201503541WA (en) 2015-06-29
KR20140095116A (ko) 2014-08-01
ZA201209305B (en) 2014-02-26
KR101815332B1 (ko) 2018-01-04
JP5828594B2 (ja) 2015-12-09
BR112012029374B1 (pt) 2021-05-25
IL242221B (en) 2018-06-28
AU2011256264A1 (en) 2013-01-10
SG185645A1 (en) 2012-12-28
CN102958934A (zh) 2013-03-06
CA2799517A1 (en) 2011-11-24
AU2011256264B2 (en) 2016-09-15
JP2016074668A (ja) 2016-05-12
JP2013526573A (ja) 2013-06-24
WO2011146488A1 (en) 2011-11-24
HK1182100A1 (en) 2013-11-22
IL242221A0 (en) 2015-11-30
UA108498C2 (en) 2015-05-12
BR112012029374A8 (pt) 2017-12-26
MY156830A (en) 2016-03-31
IL223016A0 (en) 2013-02-03
US20130123499A1 (en) 2013-05-16
CL2012003208A1 (es) 2013-05-17
NZ604135A (en) 2015-02-27
BR112012029374A2 (pt) 2016-07-26
EP2571885B1 (en) 2014-11-12
EP2571885A1 (en) 2013-03-27
US8884014B2 (en) 2014-11-11
EA021869B1 (ru) 2015-09-30
EA201291269A1 (ru) 2013-05-30
MX2012013304A (es) 2013-04-03
CA2799517C (en) 2019-01-22

Similar Documents

Publication Publication Date Title
ES2894262T3 (es) Procedimiento para preparar inhibidores de BTK
MC1921A1 (fr) Derives acyles
JP7236433B2 (ja) Ｌｆａ－１拮抗薬リフィテグラストを調製および精製するためのプロセス
EP3169692A1 (en) A new form of sofosbuvir and a method of its preparation
JPH0730018B2 (ja) 新規化合物の３−アミノ−２−オキソアゼチジン誘導体及びそれらの製造法
JP2023164476A (ja) ラパマイシン誘導体の精製
CN102958934B (zh) 稠合吡咯并咔唑衍生物的纯化方法
CN110612291A (zh) 2-([1,2,3]三唑-2-基)-苯甲酸衍生物的制备
US7776852B2 (en) Process for producing highly pure midazolam and salts thereof
CN111499640A (zh) 哌嗪并三唑类衍生物的手性拆分方法
JP2023526351A (ja) アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの製造方法
CN114436991A (zh) 一种2-氨基噻唑类化合物的合成方法
HK1182100B (en) Method for purifying a fused pyrrolocarbazole derivative
CN112062763A (zh) 羟基吡啶酮并[1,2-b][1,2,5]三氮卓平衍生物及制备和应用
CN102382115B (zh) 一种吲唑并酞嗪化合物的合成方法
JPS59216858A (ja) スレオ−３−（３，４−ジヒドロキシフエニル）セリンの製造法
TW202540077A (zh) 具有抗癌活性之ｍｄｍ２－ｐ５３交互作用的異吲哚啉酮抑制劑的中間體的製造方法
WO2016142173A1 (en) 4-(2-methyl-1h-imidazol-1-yl)-2,2-diphenylbutanenitrile solid form
WO2025105347A1 (ja) 組成物、フルチカゾンフランカルボン酸エステルの製造方法、フルチカゾンフランカルボン酸エステルの精製方法及び標識化合物の製造方法
EP2462144B1 (en) PROCESS FOR PREPARING A 2-ALKYNYL SUBSTITUTED 5-AMINO-PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE
CN101163699A (zh) 二氨甲酸酯化合物的合成方法及形成其的中间体
JP2022047504A (ja) ビスカルバゾール誘導体の製造方法
JPH0474175A (ja) ４―シアノキヌクリジン硫酸付加体の精製方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: TEVA SANTE SAS

Free format text: FORMER OWNER: CEPHALON EUROPE

Effective date: 20150520

Owner name: CEPHALON EUROPE

Free format text: FORMER OWNER: CEPHALON FRANCE

Effective date: 20150520

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20150520

Address after: American Pennsylvania

Applicant after: CEPHALON, Inc.

Applicant after: Tiva Sant

Address before: American Pennsylvania

Applicant before: Cephalon, INC.

Applicant before: The European Saifulun Co.

Effective date of registration: 20150520

Address after: American Pennsylvania

Applicant after: CEPHALON, Inc.

Applicant after: The European Saifulun Co.

Address before: American Pennsylvania

Applicant before: Cephalon, INC.

Applicant before: Safran

C14 Grant of patent or utility model
GR01 Patent grant