MX2012013304A - Metodo para purificar un derivado de pirrolocarbazol fusionado. - Google Patents

Metodo para purificar un derivado de pirrolocarbazol fusionado.

Info

Publication number
MX2012013304A
MX2012013304A MX2012013304A MX2012013304A MX2012013304A MX 2012013304 A MX2012013304 A MX 2012013304A MX 2012013304 A MX2012013304 A MX 2012013304A MX 2012013304 A MX2012013304 A MX 2012013304A MX 2012013304 A MX2012013304 A MX 2012013304A
Authority
MX
Mexico
Prior art keywords
purifying
fused pyrrolocarbazole
pyrrolocarbazole derivative
derivative
relates
Prior art date
Application number
MX2012013304A
Other languages
English (en)
Inventor
Sebastien Rose
Shawn P Allwein
Arnaud Grandeury
Guy Piacenza
Original Assignee
Cephalon France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon France filed Critical Cephalon France
Publication of MX2012013304A publication Critical patent/MX2012013304A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un método para purificar un compuesto de pirrolocarbazol fusionado conocido como 11-isobutil-2-metil-8-(2-pirimidinilamino)-2, 5, 6, 11, 12, l3-hexahidro-4Hindazolo [5, 4-a] pirrolo-[3, 4-c]carbazol-4-ona usando un complejo ácido del mismo. La presente invención también se refiere a una forma cristalina del complejo ácido.
MX2012013304A 2010-05-18 2011-05-17 Metodo para purificar un derivado de pirrolocarbazol fusionado. MX2012013304A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34583110P 2010-05-18 2010-05-18
PCT/US2011/036814 WO2011146488A1 (en) 2010-05-18 2011-05-17 Method for purifying a fused pyrrolocarbazole derivative

Publications (1)

Publication Number Publication Date
MX2012013304A true MX2012013304A (es) 2013-04-03

Family

ID=44168420

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012013304A MX2012013304A (es) 2010-05-18 2011-05-17 Metodo para purificar un derivado de pirrolocarbazol fusionado.

Country Status (20)

Country Link
US (1) US8884014B2 (es)
EP (1) EP2571885B1 (es)
JP (2) JP5828594B2 (es)
KR (1) KR101815332B1 (es)
CN (1) CN102958934B (es)
AU (1) AU2011256264B2 (es)
BR (1) BR112012029374B1 (es)
CA (1) CA2799517C (es)
CL (1) CL2012003208A1 (es)
EA (1) EA021869B1 (es)
ES (1) ES2530015T3 (es)
HK (1) HK1182100A1 (es)
IL (2) IL223016A0 (es)
MX (1) MX2012013304A (es)
MY (1) MY156830A (es)
NZ (1) NZ604135A (es)
SG (2) SG10201503541WA (es)
UA (1) UA108498C2 (es)
WO (1) WO2011146488A1 (es)
ZA (1) ZA201209305B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103965204B (zh) 2008-11-19 2016-09-07 赛福伦公司 吲唑并[5,4-a]吡咯并[3,4-c]咔唑化合物的新形式

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109229B2 (en) * 2000-09-29 2006-09-19 Eli Lilly And Company Methods and compounds for treating proliferative diseases
US7169802B2 (en) 2003-12-23 2007-01-30 Cephalon, Inc. Fused pyrrolocarbazoles
JP2006241579A (ja) 2005-03-07 2006-09-14 Nippon Paint Co Ltd 化成処理剤及び表面処理金属
CN103965204B (zh) * 2008-11-19 2016-09-07 赛福伦公司 吲唑并[5,4-a]吡咯并[3,4-c]咔唑化合物的新形式

Also Published As

Publication number Publication date
IL242221B (en) 2018-06-28
ES2530015T3 (es) 2015-02-25
CA2799517C (en) 2019-01-22
CA2799517A1 (en) 2011-11-24
AU2011256264A1 (en) 2013-01-10
CL2012003208A1 (es) 2013-05-17
JP2013526573A (ja) 2013-06-24
US20130123499A1 (en) 2013-05-16
IL242221A0 (en) 2015-11-30
KR20140095116A (ko) 2014-08-01
CN102958934B (zh) 2015-06-17
SG185645A1 (en) 2012-12-28
BR112012029374A8 (pt) 2017-12-26
EA021869B1 (ru) 2015-09-30
US8884014B2 (en) 2014-11-11
HK1182100A1 (en) 2013-11-22
EP2571885B1 (en) 2014-11-12
MY156830A (en) 2016-03-31
CN102958934A (zh) 2013-03-06
BR112012029374B1 (pt) 2021-05-25
KR101815332B1 (ko) 2018-01-04
EP2571885A1 (en) 2013-03-27
IL223016A0 (en) 2013-02-03
WO2011146488A1 (en) 2011-11-24
SG10201503541WA (en) 2015-06-29
JP5828594B2 (ja) 2015-12-09
UA108498C2 (en) 2015-05-12
JP2016074668A (ja) 2016-05-12
NZ604135A (en) 2015-02-27
EA201291269A1 (ru) 2013-05-30
BR112012029374A2 (pt) 2016-07-26
ZA201209305B (en) 2014-02-26
AU2011256264B2 (en) 2016-09-15

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GB Transfer or rights

Owner name: CEPHALON, INC.*

FG Grant or registration