CN102918038B - 新的多晶型物 - Google Patents

新的多晶型物 Download PDF

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Publication number
CN102918038B
CN102918038B CN201180026714.4A CN201180026714A CN102918038B CN 102918038 B CN102918038 B CN 102918038B CN 201180026714 A CN201180026714 A CN 201180026714A CN 102918038 B CN102918038 B CN 102918038B
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CN
China
Prior art keywords
proline
methyl
tetrahydrochysene
aza
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201180026714.4A
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English (en)
Chinese (zh)
Other versions
CN102918038A (zh
Inventor
约翰·亨里克·谢尔斯特伦
比约恩·埃里克·约翰松
托马斯·威廉森
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Vantia Ltd
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Vantia Ltd
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Publication date
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Publication of CN102918038A publication Critical patent/CN102918038A/zh
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Publication of CN102918038B publication Critical patent/CN102918038B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
CN201180026714.4A 2010-04-01 2011-03-31 新的多晶型物 Expired - Fee Related CN102918038B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1005623.2A GB201005623D0 (en) 2010-04-01 2010-04-01 New polymorph
GB1005623.2 2010-04-01
US34704810P 2010-05-21 2010-05-21
US61/347,048 2010-05-21
PCT/GB2011/000500 WO2011121308A1 (en) 2010-04-01 2011-03-31 New polymorph

Publications (2)

Publication Number Publication Date
CN102918038A CN102918038A (zh) 2013-02-06
CN102918038B true CN102918038B (zh) 2015-09-09

Family

ID=42228830

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180026714.4A Expired - Fee Related CN102918038B (zh) 2010-04-01 2011-03-31 新的多晶型物

Country Status (20)

Country Link
US (1) US9079881B2 (enExample)
EP (1) EP2552910B1 (enExample)
JP (1) JP5802737B2 (enExample)
KR (1) KR101792621B1 (enExample)
CN (1) CN102918038B (enExample)
CA (1) CA2795109C (enExample)
DK (1) DK2552910T3 (enExample)
ES (1) ES2538085T3 (enExample)
GB (1) GB201005623D0 (enExample)
HR (1) HRP20150513T1 (enExample)
HU (1) HUE026442T2 (enExample)
ME (1) ME02102B (enExample)
MX (1) MX2012011382A (enExample)
PL (1) PL2552910T3 (enExample)
PT (1) PT2552910E (enExample)
RS (1) RS53956B1 (enExample)
RU (1) RU2559633C2 (enExample)
SI (1) SI2552910T1 (enExample)
SM (1) SMT201500107B (enExample)
WO (1) WO2011121308A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
CN104059070B (zh) * 2013-09-17 2016-02-10 天津药物研究院有限公司 利希普坦晶型ⅰ及其制备方法和用途
CN103755707B (zh) * 2013-09-17 2015-11-18 天津药物研究院 利希普坦晶型ⅱ及其制备方法和用途
CN103694240B (zh) * 2013-09-18 2015-11-18 天津药物研究院 利希普坦的溶剂合物及其制备方法和用途
CN104140429B (zh) * 2014-07-25 2015-11-18 天津药物研究院 利希普坦晶型ⅴ及其制备方法和用途
WO2017013498A2 (en) * 2015-07-22 2017-01-26 Anavex Life Sciences Corp. Crystal forms of tetra-hydro-n, n-dimethyl-2, 2-diphenyl-3-furanmethanamine hydrochloride, processes for making such forms, and their pharmaceutical compositions
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049682A1 (en) * 2000-01-05 2001-07-12 Ferring Bv Condensed azepines as vasopressin agonists
CN1462269A (zh) * 2000-06-26 2003-12-17 费林股份公司 稠合的氮杂䓬衍生物及其作为抗利尿剂的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
DK1000059T3 (da) 1997-07-30 2005-01-10 Wyeth Corp Tricycliske vasopressin-agonister
ES2229525T3 (es) 1997-07-30 2005-04-16 Wyeth Agonistas triciclicos de la vasopresina.
CN1339036A (zh) 1999-02-04 2002-03-06 美国家用产品公司 作为血管加压素激动剂的噻吩基苯甲酰基苯并吖庚因
WO2000046228A2 (en) 1999-02-04 2000-08-10 American Home Products Corporation Pyrrolobenzodiazepine carboxyamide vasopressin agonists
DE60001054T2 (de) 1999-02-04 2003-07-24 Wyeth, Madison Trizyclische pyridin n-oxide vasopressin agonisten
EP1149097A2 (en) 1999-02-04 2001-10-31 American Home Products Corporation Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049682A1 (en) * 2000-01-05 2001-07-12 Ferring Bv Condensed azepines as vasopressin agonists
CN1462269A (zh) * 2000-06-26 2003-12-17 费林股份公司 稠合的氮杂䓬衍生物及其作为抗利尿剂的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists;Christopher M. Yea，等;《J. Med. Chem.》;20081124;第51卷(第24期);第8124-8134页 *

Also Published As

Publication number Publication date
DK2552910T3 (en) 2015-04-07
CN102918038A (zh) 2013-02-06
JP2013523706A (ja) 2013-06-17
KR101792621B1 (ko) 2017-11-02
US20140296213A1 (en) 2014-10-02
CA2795109A1 (en) 2011-10-06
RU2012146544A (ru) 2014-05-10
RU2559633C2 (ru) 2015-08-10
KR20130023218A (ko) 2013-03-07
GB201005623D0 (en) 2010-05-19
SI2552910T1 (sl) 2015-06-30
SMT201500107B (it) 2015-07-09
CA2795109C (en) 2018-04-17
HRP20150513T1 (hr) 2015-06-05
PL2552910T3 (pl) 2015-07-31
ES2538085T3 (es) 2015-06-17
JP5802737B2 (ja) 2015-11-04
PT2552910E (pt) 2015-05-13
EP2552910A1 (en) 2013-02-06
US9079881B2 (en) 2015-07-14
WO2011121308A1 (en) 2011-10-06
MX2012011382A (es) 2013-01-29
HUE026442T2 (en) 2016-06-28
RS53956B1 (sr) 2015-08-31
ME02102B (me) 2015-10-20
EP2552910B1 (en) 2015-03-11

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Granted publication date: 20150909

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