KR101792621B1 - 새로운 다형체 - Google Patents

새로운 다형체 Download PDF

Info

Publication number
KR101792621B1
KR101792621B1 KR1020127028111A KR20127028111A KR101792621B1 KR 101792621 B1 KR101792621 B1 KR 101792621B1 KR 1020127028111 A KR1020127028111 A KR 1020127028111A KR 20127028111 A KR20127028111 A KR 20127028111A KR 101792621 B1 KR101792621 B1 KR 101792621B1
Authority
KR
South Korea
Prior art keywords
tetrahydro
methyl
proline
benzylcarbamoyl
ylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020127028111A
Other languages
English (en)
Korean (ko)
Other versions
KR20130023218A (ko
Inventor
요한 헨릭 첼스트롬
비요른 에릭 요한슨
토마스 빌헬름센
Original Assignee
밴티아 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 밴티아 리미티드 filed Critical 밴티아 리미티드
Publication of KR20130023218A publication Critical patent/KR20130023218A/ko
Application granted granted Critical
Publication of KR101792621B1 publication Critical patent/KR101792621B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
KR1020127028111A 2010-04-01 2011-03-31 새로운 다형체 Expired - Fee Related KR101792621B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1005623.2 2010-04-01
GBGB1005623.2A GB201005623D0 (en) 2010-04-01 2010-04-01 New polymorph
US34704810P 2010-05-21 2010-05-21
US61/347,048 2010-05-21
PCT/GB2011/000500 WO2011121308A1 (en) 2010-04-01 2011-03-31 New polymorph

Publications (2)

Publication Number Publication Date
KR20130023218A KR20130023218A (ko) 2013-03-07
KR101792621B1 true KR101792621B1 (ko) 2017-11-02

Family

ID=42228830

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127028111A Expired - Fee Related KR101792621B1 (ko) 2010-04-01 2011-03-31 새로운 다형체

Country Status (20)

Country Link
US (1) US9079881B2 (enExample)
EP (1) EP2552910B1 (enExample)
JP (1) JP5802737B2 (enExample)
KR (1) KR101792621B1 (enExample)
CN (1) CN102918038B (enExample)
CA (1) CA2795109C (enExample)
DK (1) DK2552910T3 (enExample)
ES (1) ES2538085T3 (enExample)
GB (1) GB201005623D0 (enExample)
HR (1) HRP20150513T1 (enExample)
HU (1) HUE026442T2 (enExample)
ME (1) ME02102B (enExample)
MX (1) MX2012011382A (enExample)
PL (1) PL2552910T3 (enExample)
PT (1) PT2552910E (enExample)
RS (1) RS53956B1 (enExample)
RU (1) RU2559633C2 (enExample)
SI (1) SI2552910T1 (enExample)
SM (1) SMT201500107B (enExample)
WO (1) WO2011121308A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201105537D0 (en) * 2011-03-31 2011-05-18 Vantia Ltd New process
CN103755707B (zh) * 2013-09-17 2015-11-18 天津药物研究院 利希普坦晶型ⅱ及其制备方法和用途
CN104059070B (zh) * 2013-09-17 2016-02-10 天津药物研究院有限公司 利希普坦晶型ⅰ及其制备方法和用途
CN103694240B (zh) * 2013-09-18 2015-11-18 天津药物研究院 利希普坦的溶剂合物及其制备方法和用途
CN104140429B (zh) * 2014-07-25 2015-11-18 天津药物研究院 利希普坦晶型ⅴ及其制备方法和用途
US10413519B2 (en) * 2015-07-22 2019-09-17 Anavex Life Sciences Corp. Crystal forms of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hydrochloride, processes of making such forms, and their pharmaceutical compositions
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049682A1 (en) 2000-01-05 2001-07-12 Ferring Bv Condensed azepines as vasopressin agonists
WO2002000626A1 (en) 2000-06-26 2002-01-03 Ferring B.V. Fused azepine derivatives and their use as antidiuretic agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
PT1000059E (pt) 1997-07-30 2004-12-31 Wyeth Corp Agonistas triciclicos de vasopressina
ATE277050T1 (de) 1997-07-30 2004-10-15 Wyeth Corp Trizyclische vasopressin agoniste
CA2358892A1 (en) 1999-02-04 2000-08-10 Robert John Steffan Pyrrolobenzodiazepine carboxyamide vasopressin agonists
AU2849500A (en) 1999-02-04 2000-08-25 American Home Products Corporation Tricyclic pyridine n-oxides vasopressin agonists
AU2603000A (en) 1999-02-04 2000-08-25 American Home Products Corporation Thienylbenzoylbenzazepines as vasopressin agonists
EP1149097A2 (en) 1999-02-04 2001-10-31 American Home Products Corporation Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049682A1 (en) 2000-01-05 2001-07-12 Ferring Bv Condensed azepines as vasopressin agonists
WO2002000626A1 (en) 2000-06-26 2002-01-03 Ferring B.V. Fused azepine derivatives and their use as antidiuretic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry, 2008, 51(24), 8124-8134.

Also Published As

Publication number Publication date
GB201005623D0 (en) 2010-05-19
EP2552910A1 (en) 2013-02-06
CN102918038B (zh) 2015-09-09
HUE026442T2 (en) 2016-06-28
CA2795109C (en) 2018-04-17
PL2552910T3 (pl) 2015-07-31
CA2795109A1 (en) 2011-10-06
RS53956B1 (sr) 2015-08-31
JP2013523706A (ja) 2013-06-17
HRP20150513T1 (hr) 2015-06-05
ME02102B (me) 2015-10-20
SI2552910T1 (sl) 2015-06-30
SMT201500107B (it) 2015-07-09
MX2012011382A (es) 2013-01-29
PT2552910E (pt) 2015-05-13
KR20130023218A (ko) 2013-03-07
JP5802737B2 (ja) 2015-11-04
DK2552910T3 (en) 2015-04-07
ES2538085T3 (es) 2015-06-17
RU2012146544A (ru) 2014-05-10
RU2559633C2 (ru) 2015-08-10
EP2552910B1 (en) 2015-03-11
CN102918038A (zh) 2013-02-06
US20140296213A1 (en) 2014-10-02
US9079881B2 (en) 2015-07-14
WO2011121308A1 (en) 2011-10-06

Similar Documents

Publication Publication Date Title
KR101792621B1 (ko) 새로운 다형체
KR101791724B1 (ko) 결정질 날록솔-ｐｅｇ 접합체
CN117946011A (zh) 4-嘧啶磺酰胺衍生物的结晶形式
US20200317639A1 (en) Polymorphs of n-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1yl)methyl]phenyl}methyl)pyrazole-4-carboxamide
CA3059815C (en) Acid addition salts of an orally available gonadotropin-releasing hormone receptor antagonist, elagolix
JP2016509031A (ja) トレラグリプチンの固形形式及びその製造方法と用途
KR20240167881A (ko) 5-meo-dmt의 결정질 브롬화수소염
JP2022000451A (ja) ピリジノイルピペリジン５−ｈｔ１ｆアゴニストに関する組成物および方法
WO2019062854A1 (zh) 瑞博西林的共晶和瑞博西林单琥珀酸盐的共晶、其制备方法、组合物和用途
CN102414201B (zh) 溶剂化物晶体
CN109336881B (zh) 一种利伐沙班晶体
SK6182003A3 (en) Crystalline and solvated forms of ondansetrone hydrochloride and preparation thereof
CN104341343A (zh) 贝曲西班的晶型及其制备方法和用途
CN111683934B (zh) (r)-3-(1-(2,3-二氯-4-(吡嗪-2-基)苯基)-2,2,2-三氟乙基)-1-甲基-1-(1-甲基哌啶-4-基)脲的延胡索酸盐、制备方法及其用途
WO2013174035A1 (zh) 一种制备磷酸西他列汀无水晶型i的方法
CN115141132B (zh) 吡咯酰胺化合物的晶型及其制备方法和用途
KR101903641B1 (ko) 1-(2-메틸-4-(2,3,4,5-테트라하이드로-1-벤즈아제핀-1-일카보닐)벤질카르바모일)-l-프롤린-n,n-디메틸아미드의 제조 방법
US20050113410A1 (en) Pharmaceutical salts of zafirlukast
US20070208072A1 (en) Maleate salt of tegaserod and crystalline forms thereof
EP1626048A1 (en) Crystal of benzimidazole derivative and process for producing the same
SK280555B6 (sk) Kryštalické monohydráty hydrochloridu endo-2,3-dih
CN101316839B (zh) 二氢吡啶衍生物的酸加成盐
KR20250070110A (ko) 펙수프라잔 염산염의 결정형a 및 이의 제조 방법과 용도
JP2011510032A (ja) ６−フルオロ−１，２−ジヒドロ−２−オキソ−３ｈ−インドール−３−イリデン誘導体の塩形態、それらの製造方法及びそれらを含有する医薬組成物
HK1083340A (en) Crystal of benzimidazole derivative and process for producing the same

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20201027

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20201027