RU2559633C2 - Новый полиморф - Google Patents

Новый полиморф Download PDF

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Publication number
RU2559633C2
RU2559633C2 RU2012146544/04A RU2012146544A RU2559633C2 RU 2559633 C2 RU2559633 C2 RU 2559633C2 RU 2012146544/04 A RU2012146544/04 A RU 2012146544/04A RU 2012146544 A RU2012146544 A RU 2012146544A RU 2559633 C2 RU2559633 C2 RU 2559633C2
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RU
Russia
Prior art keywords
methyl
benzazepin
benzylcarbamoyl
ylcarbonyl
proline
Prior art date
Application number
RU2012146544/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2012146544A (ru
Inventor
Йохан Хенрик ЧЕЛЛЬСТРЕМ
Бьерн Эрик ЙОХАНСОН
Томас ВИЛЬХЕЛЬМСЕН
Original Assignee
Вантия Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Вантия Лимитед filed Critical Вантия Лимитед
Publication of RU2012146544A publication Critical patent/RU2012146544A/ru
Application granted granted Critical
Publication of RU2559633C2 publication Critical patent/RU2559633C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
RU2012146544/04A 2010-04-01 2011-03-31 Новый полиморф RU2559633C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1005623.2 2010-04-01
GBGB1005623.2A GB201005623D0 (en) 2010-04-01 2010-04-01 New polymorph
US34704810P 2010-05-21 2010-05-21
US61/347,048 2010-05-21
PCT/GB2011/000500 WO2011121308A1 (en) 2010-04-01 2011-03-31 New polymorph

Publications (2)

Publication Number Publication Date
RU2012146544A RU2012146544A (ru) 2014-05-10
RU2559633C2 true RU2559633C2 (ru) 2015-08-10

Family

ID=42228830

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012146544/04A RU2559633C2 (ru) 2010-04-01 2011-03-31 Новый полиморф

Country Status (20)

Country Link
US (1) US9079881B2 (enExample)
EP (1) EP2552910B1 (enExample)
JP (1) JP5802737B2 (enExample)
KR (1) KR101792621B1 (enExample)
CN (1) CN102918038B (enExample)
CA (1) CA2795109C (enExample)
DK (1) DK2552910T3 (enExample)
ES (1) ES2538085T3 (enExample)
GB (1) GB201005623D0 (enExample)
HR (1) HRP20150513T1 (enExample)
HU (1) HUE026442T2 (enExample)
ME (1) ME02102B (enExample)
MX (1) MX2012011382A (enExample)
PL (1) PL2552910T3 (enExample)
PT (1) PT2552910E (enExample)
RS (1) RS53956B1 (enExample)
RU (1) RU2559633C2 (enExample)
SI (1) SI2552910T1 (enExample)
SM (1) SMT201500107B (enExample)
WO (1) WO2011121308A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201105537D0 (en) 2011-03-31 2011-05-18 Vantia Ltd New process
CN104059070B (zh) * 2013-09-17 2016-02-10 天津药物研究院有限公司 利希普坦晶型ⅰ及其制备方法和用途
CN103755707B (zh) * 2013-09-17 2015-11-18 天津药物研究院 利希普坦晶型ⅱ及其制备方法和用途
CN103694240B (zh) * 2013-09-18 2015-11-18 天津药物研究院 利希普坦的溶剂合物及其制备方法和用途
CN104140429B (zh) * 2014-07-25 2015-11-18 天津药物研究院 利希普坦晶型ⅴ及其制备方法和用途
CN108026059A (zh) * 2015-07-22 2018-05-11 阿纳韦克斯生命科学公司 四氢-n，n-二甲基-2，2-二苯基-3-呋喃甲胺盐酸盐的晶型，制备这样晶型的方法，及其药物组合物
WO2020154581A1 (en) 2019-01-24 2020-07-30 Assia Chemical Industries Ltd Solid state forms of fedovapagon-salicyclic acid co-crystal

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049682A1 (en) * 2000-01-05 2001-07-12 Ferring Bv Condensed azepines as vasopressin agonists
WO2002000626A1 (en) * 2000-06-26 2002-01-03 Ferring B.V. Fused azepine derivatives and their use as antidiuretic agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW359669B (en) 1995-12-15 1999-06-01 Otsuka Pharma Co Ltd Benzazepine derivatives
DK1000062T3 (da) 1997-07-30 2004-11-22 Wyeth Corp Tricykliske vasopressinagonister
DE69826677T2 (de) 1997-07-30 2005-02-10 Wyeth Trizyclische Vasopressin-Agonisten
DK1149096T3 (da) 1999-02-04 2003-04-07 Wyeth Corp Tricykliske pyridin-N-oxider som vasopressinagonister
JP2002536377A (ja) 1999-02-04 2002-10-29 ワイス バソプレシンアゴニストとしてのチエエニルベンゾイルベンズアゼピン類
WO2000046225A2 (en) 1999-02-04 2000-08-10 American Home Products Corporation Pyridobenzodiazepine and pyridobenzoxazepine carboxyamide vasopressin agonists
CN1339037A (zh) 1999-02-04 2002-03-06 美国家用产品公司 吡咯并苯并二吖庚因酰胺血管加压素激动剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049682A1 (en) * 2000-01-05 2001-07-12 Ferring Bv Condensed azepines as vasopressin agonists
RU2259367C2 (ru) * 2000-01-05 2005-08-27 Ферринг Бв Конденсированные азепины, фармацевтическая композиция, содержащая их, способ лечения с использованием указанной композиции
WO2002000626A1 (en) * 2000-06-26 2002-01-03 Ferring B.V. Fused azepine derivatives and their use as antidiuretic agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cristopher M. Yea at al, New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Reteptor Agonists, J.Med. Chem., 2008,v.51,p.8124-8134. *

Also Published As

Publication number Publication date
JP5802737B2 (ja) 2015-11-04
CN102918038A (zh) 2013-02-06
RU2012146544A (ru) 2014-05-10
KR20130023218A (ko) 2013-03-07
US20140296213A1 (en) 2014-10-02
CN102918038B (zh) 2015-09-09
PT2552910E (pt) 2015-05-13
HUE026442T2 (en) 2016-06-28
RS53956B1 (sr) 2015-08-31
CA2795109C (en) 2018-04-17
PL2552910T3 (pl) 2015-07-31
EP2552910A1 (en) 2013-02-06
CA2795109A1 (en) 2011-10-06
KR101792621B1 (ko) 2017-11-02
EP2552910B1 (en) 2015-03-11
JP2013523706A (ja) 2013-06-17
DK2552910T3 (en) 2015-04-07
HRP20150513T1 (hr) 2015-06-05
ES2538085T3 (es) 2015-06-17
SI2552910T1 (sl) 2015-06-30
SMT201500107B (it) 2015-07-09
GB201005623D0 (en) 2010-05-19
MX2012011382A (es) 2013-01-29
US9079881B2 (en) 2015-07-14
WO2011121308A1 (en) 2011-10-06
ME02102B (me) 2015-10-20

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20200401