CN102906100A - 头孢匹胺钠水合物及其制备方法和用途 - Google Patents

头孢匹胺钠水合物及其制备方法和用途 Download PDF

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Publication number
CN102906100A
CN102906100A CN201180000250XA CN201180000250A CN102906100A CN 102906100 A CN102906100 A CN 102906100A CN 201180000250X A CN201180000250X A CN 201180000250XA CN 201180000250 A CN201180000250 A CN 201180000250A CN 102906100 A CN102906100 A CN 102906100A
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China
Prior art keywords
low molecule
sodium
low
molecule
cefpiramide
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Pending
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CN201180000250XA
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English (en)
Inventor
刘力
Original Assignee
胡梨芳
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Priority to CN201180000250XA priority Critical patent/CN102906100A/zh
Publication of CN102906100A publication Critical patent/CN102906100A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

本发明涉及头孢匹胺钠水合物及其制备方法和用途，该头孢匹胺钠水合物具有较好的存储稳定性，适用于制备对革兰氏阳性或阴性细菌敏感菌所致的人或动物的呼吸系统、肝胆系统、五官、尿路感染、腹腔感染、盆腔感染、败血症、皮肤软组织感染、骨和关节感染、心内膜炎、脑膜炎等疾病的治疗或预防的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201180000250XA 2010-05-17 2011-05-17 头孢匹胺钠水合物及其制备方法和用途 Pending CN102906100A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201180000250XA CN102906100A (zh) 2010-05-17 2011-05-17 头孢匹胺钠水合物及其制备方法和用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201010185294.1 2010-05-17
CN201010185294A CN101838276B (zh) 2010-05-17 2010-05-17 头孢匹胺钠水合物及其制备方法和用途
CN201180000250XA CN102906100A (zh) 2010-05-17 2011-05-17 头孢匹胺钠水合物及其制备方法和用途
PCT/CN2011/074207 WO2011144021A1 (zh) 2010-05-17 2011-05-17 头孢匹胺钠水合物及其制备方法和用途

Publications (1)

Publication Number Publication Date
CN102906100A true CN102906100A (zh) 2013-01-30

Family

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CN201010185294A Expired - Fee Related CN101838276B (zh) 2010-05-17 2010-05-17 头孢匹胺钠水合物及其制备方法和用途
CN201180000250XA Pending CN102906100A (zh) 2010-05-17 2011-05-17 头孢匹胺钠水合物及其制备方法和用途

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CN (2) CN101838276B (zh)
WO (1) WO2011144021A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101838276B (zh) * 2010-05-17 2012-10-10 胡梨芳 头孢匹胺钠水合物及其制备方法和用途
CN102973570A (zh) * 2012-12-17 2013-03-20 苏州二叶制药有限公司 注射用头孢匹胺钠
CN103319505B (zh) * 2013-06-07 2016-01-20 华北制药河北华民药业有限责任公司 结晶生产头孢匹胺钠晶体的方法
CN104327099A (zh) * 2014-09-29 2015-02-04 联合康兴（北京）医药科技有限公司 头孢哌酮钠化合物实体及组合物和用途
CN109721618A (zh) * 2017-10-30 2019-05-07 刘力 头孢匹胺新化合物及其组合物和用途
CN107951842B (zh) * 2017-12-21 2020-03-27 广州白云山天心制药股份有限公司 一种微粉头孢匹胺的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127403A1 (en) * 2002-09-06 2004-07-01 Francesco Parenti Methods for treating and preventing Gram-positive bacteremias
CN1594324A (zh) * 2004-07-07 2005-03-16 广州白云山医药科技发展有限公司 头孢匹胺钠的制备方法
CN1965838A (zh) * 2005-11-17 2007-05-23 李海超 含头孢匹胺和β－内酰胺酶抑制剂的药物组合物
CN101838276A (zh) * 2010-05-17 2010-09-22 胡梨芳 头孢匹胺钠水合物及其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5430197A (en) * 1977-08-10 1979-03-06 Yamanouchi Pharmaceut Co Ltd Novel antibiotic compound
CN100480251C (zh) * 2007-04-18 2009-04-22 武汉同源药业有限公司 化合物头孢匹胺钠的合成方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040127403A1 (en) * 2002-09-06 2004-07-01 Francesco Parenti Methods for treating and preventing Gram-positive bacteremias
CN1594324A (zh) * 2004-07-07 2005-03-16 广州白云山医药科技发展有限公司 头孢匹胺钠的制备方法
CN1965838A (zh) * 2005-11-17 2007-05-23 李海超 含头孢匹胺和β－内酰胺酶抑制剂的药物组合物
CN101838276A (zh) * 2010-05-17 2010-09-22 胡梨芳 头孢匹胺钠水合物及其制备方法和用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PACZKOWSKI,D.,GAWROHSKA-SZKLARZ: "Effect of hyperlipidaemia on the pharmacokinetics of mexilefine", 《EUROPEAN JOURNAL OF PHARMACOLOGY》, vol. 183, no. 6, 6 July 1990 (1990-07-06), pages 2299 - 2300 *

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CN101838276B (zh) 2012-10-10
CN101838276A (zh) 2010-09-22
WO2011144021A1 (zh) 2011-11-24

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