CN102885310B - Health care food composition capable of assisting in improving memory, and preparation method thereof - Google Patents
Health care food composition capable of assisting in improving memory, and preparation method thereof Download PDFInfo
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- CN102885310B CN102885310B CN201210399554.4A CN201210399554A CN102885310B CN 102885310 B CN102885310 B CN 102885310B CN 201210399554 A CN201210399554 A CN 201210399554A CN 102885310 B CN102885310 B CN 102885310B
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- 235000013305 food Nutrition 0.000 title claims abstract description 24
- 230000036541 health Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000015654 memory Effects 0.000 title abstract description 11
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 42
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 42
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Abstract
The invention discloses a health care food composition capable of assisting in improving memory, and a preparation method of the composition. The health care food composition contains docosahexenoic acid (DHA) algal oil, gamma-aminobutyric acid, phosphatidylserine, taurine, zinc gluconate, vitamin C and vitamin B12. The invention also discloses the preparation method of the health care food composition. The animal function test proves that the health care food composition has the function of assisting in improving memory, and is free from toxic and side effects.
Description
Technical field
The present invention relates to a kind of composition, be specifically related to health-care food composition of a kind of auxiliary improvement of memory and preparation method thereof.
Background technology
DHA, DHA, is commonly called as docosapentaenoic acid, is a kind of essential element that nervous system cell is grown and maintained, and is brain and amphiblestroid important composition composition, most important to infant's intelligence and visual acuity.
Existing research shows, DHA and taurine have facilitation to brain growth, and zoopery also proves, above-mentioned substance has the neural function of growing, strengthen learning and memory of little mouse of promotion.
It is logical that Gabanergic effectively improves brain blood flow, promotes the metabolic function of brain, and memory barrier, children ' s intelligence development that cerebrovascular disorder is caused be slow has good mitigation.
With age growth, in phosphatidylserine and other important brain, chemical substance can reduce gradually, thereby causes memory, cognitive power to weaken.Supplementary phosphatidylserine can increase the mobility of brain bur number, brain cell membrane and promote glucose metabolism in brain cell, thereby makes brain cell more active.
Zinc and man memory power are in close relations.Research shows ZD mouse brain cell DNA, RNA and the synthetic minimizing of protein, affect brain cell proliferation differentiation, cell cyclic adenosine monophosphate (cAMP) increases during zinc deficiency simultaneously, and cGMP reduces, cause suppressing brain cell DNA and DHA synthetic, and then affect brain cell proliferation and differentiation.
Vitamin C energy promotion health Growth of Cells, can promote the synthetic of collagen, carnitine, some neurotransmitter and peptide hormone, sound essential to safeguarding nervous system.
Cobastab
12can promote erythrocytic growth and maturation, make human body hematopoietic function in normal condition, safeguard that nervous system health is that nervous function perfects indispensable vitamin, participate in the formation of lipoprotein in nerve fiber.
Chinese patent (publication number 102000082A) discloses a kind of medicine or health food that strengthens memory effect that have, and the best proportioning of its each composition is 10000 parts of DHA, 300 parts of taurines, 800 parts of zinc gluconates, Cobastab
16 parts, Cobastab
26 parts and Cobastab
66 parts.Test shows takes after said composition for pointing to that memory, associative learning, image are freed recall, random shape is re-recognized with the test event score such as portrait feature contact memorys all higher than before test, shows that said composition can improve human body and remember function.Other have no relevant report.
Summary of the invention
For the problem lacking about the health food of auxiliary improvement of memory in prior art; the invention provides a kind of health-care food composition of new auxiliary improvement of memory, comprise DHA algae oil, GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C and Cobastab
12.
Preferably; the health-care food composition of above-mentioned auxiliary improvement of memory, each composition is counted by weight: DHA algae oil 350-410, GABA 50-100, phosphatidylserine 50-100, taurine 30-70, zinc gluconate 12-17, vitamin C 10-15 and Cobastab
120.0003-0.0004.
Preferably, the health-care food composition of above-mentioned auxiliary improvement of memory, each composition is counted by weight: DHA algae oil 382.4, GABA 70, phosphatidylserine 70, taurine 50, zinc gluconate 15, vitamin C 12.5 and Cobastab
120.00035.
The health-care food composition of above-mentioned auxiliary improvement of memory, the purity of described DHA algae oil is 40%, and the purity of GABA is 20%, and the purity of phosphatidylserine is 50 ~ 60%, and the zinc content of zinc gluconate is 14%.
The present invention also provides a kind of health products of auxiliary improvement of memory, health-care food composition and the pharmaceutically acceptable auxiliary material of above-mentioned auxiliary improvement of memory, consists of.Described pharmaceutically acceptable auxiliary material comprises food and the spendable auxiliary material of medicine field.
Preferably, the health products formulation of described auxiliary improvement of memory is soft capsule.
Preferably, when the health products formulation of described auxiliary improvement of memory is soft capsule, auxiliary material is gelatin, glycerine and purified water.
Preferably, each composition of the health products soft capsule of above-mentioned auxiliary improvement of memory is counted DHA algae oil 382.4, Cobastab by weight
120.00035, GABA 70, phosphatidylserine 70, taurine 50, zinc gluconate 15, vitamin C 12.5; Gelatin 150, glycerine 62 and purified water 150.
The preparation method of the health products of above-mentioned auxiliary improvement of memory, step is as follows:
(1) prepare capsule-core feed liquid: by GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C and Cobastab
12cross respectively after 80 mesh sieves, each composition that takes formula ratio adds in DHA algae oil, grinds to form pulpous state, and standing, 0.06-0.08Mpa is evacuated to without bubble, after 80 mesh sieves, obtains capsule-core feed liquid;
(2) prepare capsule hide glue gelatin: purified water adds gelatin and glycerine after being heated to 60 ℃, under sealing state, stir and be heated to 70 ℃, be stirred to and become even glue, standing, 0.06-0.08Mpa is evacuated to without bubble, crosses 80 mesh sieves, 60-70 ℃ of insulation deposited, and obtains capsule hide glue gelatin;
(3) pill: by capsule-core feed liquid and capsule cladding hydraulic pressure glue capsule; Through shaping, wash ball and dry, make finished product again.Washing ball, preferably to use concentration expressed in percentage by volume be 95% edible alcohol.
The present invention has following beneficial effect: health-care food composition of the present invention shows to have the function of auxiliary improvement of memory and without any side effects through animal function test.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described, can be implemented, but illustrated embodiment is not as a limitation of the invention so that those skilled in the art can better understand the present invention also.
In following examples, raw material: DHA algae oil (purity 40%) is purchased from Jia Kang source, Beijing development in science and technology Co., Ltd; GABA (purity 20%) is purchased from Shanghai Tong Yuan food technology Co., Ltd; Phosphatidylserine (purity 50-60%) is purchased from Shanghai Tong Yuan food technology Co., Ltd; Taurine, zinc gluconate, vitamin C, Cobastab
12purchased from Guangzhou Kang nutrition Science and Technology Ltd..
embodiment 1 soft capsule
Raw material consumption (meter by weight), content: DHA algae oil 382.4, Cobastab
120.00035, GABA 70, phosphatidylserine 70, taurine 50, zinc gluconate 15 and vitamin C 12.5; Capsule skin: gelatin 150, glycerine 62 and purified water 150.
(1) preparation of capsule-core feed liquid
1. GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C, Cobastab
12, cross respectively 80 mesh sieves.
2. by the described DHA algae oil that measures.
3. by formula rate, get GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C, the Cobastab after sieving
12, join in DHA algae oil, stir evenly, to cross colloid mill and grind to form pulpous state, standing vacuumizing (0.06-0.08Mpa) is extremely without bubble, and pressurization discharging, crosses 80 mesh sieves, obtains capsule-core feed liquid.
(2) preparation of capsule hide glue gelatin
Capsule skin feeds intake and can amplify by formula.Change in glue tank and add purified water, while being heated to 60 ℃, add gelatin, glycerine, seal, start stirring arm and stir, and be heated to 70 ℃, stir and make into even glue, then stop stirring, standing vacuumizing (0.06-0.08Mpa), to without bubble, adds extrudate, crosses 80 mesh sieves, 60-70 ℃ of insulation deposited, and obtains capsule hide glue gelatin.
(3) pill
By capsule-core feed liquid and capsule hide glue gelatin compacting capsule, note insulation (60-70 ℃).Capsule-core feed liquid 0.6g/ grain.
(4) sizing is dry
The capsule suppressing is with tape transport to rolling in cage, and capsule rolls with rolling cage, makes its cooling and the surperficial moisture that leaves, and through sizing and preliminarily dried, obtains sizing capsule.
(5) wash ball
The capsule of shaping washs with 95% edible alcohol.
(6) dry
Capsule after washing is sent into hothouse inner drying, and hothouse temperature is between 20-25 ℃, and humidity, below 40%, treats that the pliability of capsule is suitable, stops being dried.
(7) choose ball
After capsule is dried, manually sort out defective capsule, qualified capsule packing is finished product.
Specification is 0.6g/ grain.Oral, every day 2 times, each 2.
embodiment 2 soft capsules
Raw material consumption (meter by weight), content: DHA algae oil 350, Cobastab
120.00039, GABA 50, phosphatidylserine 100, taurine 30, zinc gluconate 17, vitamin C 10 and soybean oil 42; Capsule skin: gelatin 150, glycerine 62 and purified water 150.
(1) preparation of capsule-core feed liquid
1. GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C, Cobastab
12, cross respectively 80 mesh sieves.
2. by the described DHA algae oil that measures.
3. by formula rate, get GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C, the Cobastab after sieving
12, add in the mixture of DHA algae oil and soybean oil, stir evenly, to cross colloid mill and grind to form pulpous state, standing vacuumizing (0.06 ~ 0.08Mpa) is extremely without bubble, and pressurization discharging, crosses 80 mesh sieves, obtains capsule-core feed liquid.
(2) preparation of capsule hide glue gelatin
Capsule skin feeds intake and can amplify by formula.Change in glue tank and add purified water, while being heated to 60 ℃, add gelatin, glycerine, seal, start stirring arm and stir, and be heated to 70 ℃, stir and make into even glue, stop stirring, standing vacuumizing (0.06-0.08Mpa), to without bubble, adds extrudate, crosses 80 mesh sieves, 60-70 ℃ of insulation deposited, and obtains capsule hide glue gelatin.
(3) pill
By capsule-core feed liquid and capsule hide glue gelatin compacting capsule, note insulation (60-70 ℃).Capsule-core feed liquid 0.6g/ grain.
(4) sizing is dry
The capsule suppressing is with tape transport to rolling in cage, and capsule rolls with rolling cage, makes its cooling and the surperficial moisture that leaves, and through sizing and preliminarily dried, obtains sizing capsule.
(5) wash ball
The capsule of shaping washs with 95% edible alcohol.
(6) dry
Capsule after washing is sent into hothouse inner drying, and hothouse temperature is between 20-25 ℃, and humidity, below 40%, treats that the pliability of capsule is suitable, stops being dried.
(7) choose ball
After capsule is dried, manually sort out defective capsule, qualified capsule packing is finished product.
Specification is 0.6g/ grain.Every day 2 times, each 2.
embodiment 3 soft capsules
Raw material consumption (meter by weight), content: DHA algae oil 410, Cobastab
120.0003, GABA 100, phosphatidylserine 50, taurine 70, zinc gluconate 12, vitamin C 15 and soybean oil 42; Capsule skin: gelatin 150, glycerine 62 and purified water 150.
(1) preparation of capsule-core feed liquid
1. GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C, Cobastab
12, cross respectively 80 mesh sieves.
2. by the described DHA algae oil that measures.
3. by formula rate, get GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C, the Cobastab after sieving
12, add in the mixture of DHA algae oil and soybean oil, stir evenly, to cross colloid mill and grind to form pulpous state, standing vacuumizing (0.06-0.08Mpa) is extremely without bubble, and pressurization discharging, crosses 80 mesh sieves, obtains capsule-core feed liquid.
(2) preparation of capsule hide glue gelatin
Capsule skin feeds intake and can amplify by formula.In adding of purified water glue tank, while being heated to 60 ℃, add gelatin, glycerine, seal, start stirring arm and stir, and be heated to 70 ℃, stir and make into even glue, stop stirring, standing vacuumizing (0.06-0.08Mpa), to without bubble, adds extrudate, crosses 80 mesh sieves, 60-70 ℃ of insulation deposited, and obtains capsule hide glue gelatin.
(3) pill
By capsule-core feed liquid and capsule hide glue gelatin compacting capsule, note insulation (60-70 ℃).Capsule-core feed liquid 0.7g/ grain.
(4) sizing is dry
The capsule suppressing is with tape transport to rolling in cage, and capsule rolls with rolling cage, makes its cooling and the surperficial moisture that leaves, and through sizing and preliminarily dried, obtains sizing capsule.
(5) wash ball
The capsule of shaping washs with 95% edible alcohol.
(6) dry
Capsule after washing is sent into hothouse inner drying, and hothouse temperature is between 20-25 ℃, and humidity, below 40%, treats that the pliability of capsule is suitable, stops being dried.
(7) choose ball
After capsule is dried, manually sort out defective capsule, qualified capsule packing is finished product.
Specification is 0.7g/ grain, oral, every day 2 times, each 2.
embodiment 4?
security and functional verification
Below study auxiliary improving memory function and the edible safety (testing with assessment technique standard (2003 editions) > > content according to the check of < < health food) of health-care food composition of the present invention.
One, security detects
Acute toxicity test
1. sample: by the sample that described in embodiment 1 prepared by formula and technique.
2. animal used as test: SPF level Kunming mouse.
3. its mouse oral acute toxicity test (MTD): select 20 of 18-22g SPF level Kunming mouses, male and female half and half, with the dosage per os secondary gavage of 24g/kgBW, after administration, Continuous Observation is 14 days.Record poisoning manifestations and death condition.
4. result: with the mouse of two kinds of sexes of dosage gavage of 24g/kgBW, observe 14 days.Experimental session has no obvious poisoning manifestations, and in the observation period, nothing is dead.Tested material is all greater than 24g/kgBW to the acute oral toxicity of the mouse of two kinds of sexes (MTD), according to < < toxicological evaluation of food safety procedure and method > > (version in 2003) acute toxicity classification, belong to nontoxic level.
The acute toxicity tests of table 1 mouse
| Animal | Sex | Number of animals (only) | Dosage (g/kgBW) | Death condition (only) | MTD(g/kg·BW) |
| Mouse | Male | 10 | 24 | 0 | >24 |
| Mouse | Female | 10 | 24 | 0 | >24 |
30 days feeding trials
1. sample: by the sample that described in embodiment 1 prepared by formula and technique.It is 2.4g/60kgBW day that people intends with dosage.
2. animal used as test: select body weight 60-80g, 80 of SD rats, male and female half and half.
3. test method: rat is divided into three tested material groups and a control group, 20 every group, male and female half and half at random.Control group is fed and to be raised arm's length basis piece material, and tested material group is fed to raise and mixed various dose sample, and dosage is designed to: basic, normal, high dosage group is respectively 1,2,4g/kgBW(is equivalent to respectively people and intends 25 times, 50 times, 100 times with dosage).Continuous Observation 30 days.
4. observation index and result
4.1 ordinary circumstances are observed:
Observe performance, behavior, toxicity performance and the death condition of animal every day.Weigh weekly 1 time and food intake dose twice, calculate weekly food utilization and total food utilization.Each treated animal of result grows, activity is all normal, without poisoning manifestations and death, each treated animal weekly body weight, weekly body weight recruitment, food-intake and food utilization weekly, and TBW recruitment, total food-intake and the equal no difference of science of statistics of total foodstuff utilization rate weekly (
p>0.05).
4.2 hematological examinations:
Measuring hemoglobin content (Hgb), red blood cell (RBC) and leucocyte (WBC) counting, leukocyte differential count (lymph, monokaryon, neutral grain, have a liking for acid, basophilic).Experiment latter stage, hematological indices was all in range of normal value, each treated animal hemoglobin, red blood cell and white blood cell count(WBC), leukocyte differential count compare with control group equal no difference of science of statistics (
p>0.05).
4.3 Biochemical Indexes:
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN), cholesterol (CHO), triglycerides (TG), blood sugar (GLU), total protein (TP), albumin (ALB), creatinine (CRE).Experiment experimental animal in latter stage every biochemical indicator all in range of normal value, each treated animal blood biochemistry index compare with control group equal no difference of science of statistics (
p>0.05).
4.4 gross examination of skeletal muscle and pathologic diagnosis:
Animal is put to death in the dislocation of test cervical vertebra in latter stage, observes each main organs and chest, the change of abdominal cavity general pathology.Take out liver, kidney, spleen, the testis of all animals, weigh and calculate organ coefficient.Take out liver, kidney, spleen, testis (or ovary), stomach and the duodenum of control group and high dose group animal, with 12% formalin, fix, histological examination is carried out in FFPE, section, HE dyeing under light microscopic.Each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) is showed no significant pathological change.
Above-mentioned acute toxicity test and 30 days feeding trial results show that this product belongs to nontoxic level, can long-term taking.
Two, auxiliary improving memory function test
1. sample: by the sample that described in embodiment 1 prepared by formula and technique.It is 2.4g/60kgBW day that people intends with dosage.
2. Kunming mouse, body weight 18-23 g.Mouse is divided into 4 groups at random: control group, basic, normal, high (0.400g/kgBW, 0.800g/kgBW, 1.200g/kgBW) dosage group, every group of mouse male and female half and half.After gavage 30 d, start continuously experiment and observe, control animals gavage distilled water.Select diving tower experiment, keep away dark experiment as observation index.
3. diving tower experiment
Copper grid are housed at the bottom of reaction chamber, and its two ends connect 36V power supply.Normal reaction after animal is shocked by electricity is on the insulated platform jumping in case in order to avoid electric shock.Most animals may be again or is repeatedly skipped on copper grid, and the platform that snaps back again after being shocked by electricity, so trains 5 min, and records the number of times (or claiming errors number) that every mouse is shocked by electricity.Replication after 24 h, i.e. memory keeps test.
4 keep away dark experiment
Utilize mouse to have a liking for the device of dark habit design, half of this device is darkroom, second half is bright chamber, has a duck eye to communicate between light and shade chamber, and the copper grid of energising are equipped with in bottom, darkroom, and are connected with the timer that automatically records the time in incubation period.Mouse enters darkroom and is shocked by electricity, and timing stops automatically.After last administration, start to train next day.During experiment, mouse is put into bright chamber in hole dorsad, start timer simultaneously.Animal enters darkroom through hole and is shocked by electricity, and timer stops automatically, and experiment stops, and takes out mouse.Record every mouse from putting into bright chamber to the interval time that enters darkroom and shocked by electricity, i.e. incubation period.Replication after 24 h, records incubation period and the interior number of shocks that suffers of 5 min that every animal enters darkroom.
5 results
The impact that table 2 is tested mouse diving tower (
± S, n=10)
| Group | Training incubation period/s | Test incubation period/s | Training errors number/time | Test errors number/time |
| Control group | 40.5±31.2 | 98.2±53.4 | 3.2±1.0 | 1.8±1.2 |
| Low dose group | 43.2±20.0 | 135.4±50.9 | 3.3±1.1 | 1.1±1.1 |
| Middle dosage group | 41.1±16.9 | 156.4±31.8 | 3.3±1.2 | 0.6±0.7 |
| High dose group | 43.5±29.8 | 169.3±29.0* | 3.4±1.1 | 0.3±0.7* |
*
P＜0.05。
Table 3 on mouse keep away dark experiment impact (
± S, n=10)
| Group | Training incubation period/s | Test incubation period/s | Training errors number/time | Test errors number/time |
| Control group | 42.5±21.2 | 171.4±80.4 | 2.6±1.1 | 1.3±0.9 |
| Low dose group | 39.8±250 | 200.7±72.1 | 2.9±1.3 | 1.0±0.9 |
| Middle dosage group | 42.3±21.0 | 230.7±65.7 | 2.5±1.4 | 0.7±0.7 |
| High dose group | 40.3±17.5 | 264.2±51.8* | 2.7±1.3 | 0.2±0.5* |
*
P＜0.05。
Experimental result demonstration, the test result of experimental group is better than control group, and the every test result of high dose group is all better, shows that this product has the effect that improves memory.
The above embodiment is only the preferred embodiment for absolutely proving that the present invention lifts, and protection scope of the present invention is not limited to this.Being equal to that those skilled in the art do on basis of the present invention substitutes or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (7)
1. the health-care food composition of an auxiliary improvement of memory; it is characterized in that, constituent is counted by weight: DHA algae oil 350-410, GABA 50-100, phosphatidylserine 50-100, taurine 30-70, zinc gluconate 12-17, vitamin C 10-15 and Cobastab
120.0003-0.0004.
2. the health-care food composition of auxiliary improvement of memory according to claim 1; it is characterized in that, each composition is counted by weight: DHA algae oil 382.4, GABA 70, phosphatidylserine 70, taurine 50, zinc gluconate 15, vitamin C 12.5 and Cobastab
120.00035.
3. health products for auxiliary improvement of memory, is characterized in that being comprised of health-care food composition and the pharmaceutically acceptable auxiliary material of the arbitrary described auxiliary improvement of memory of claim 1-2.
4. the health products of auxiliary improvement of memory according to claim 3, is characterized in that formulation is soft capsule.
5. the health products of auxiliary improvement of memory according to claim 4, is characterized in that described auxiliary material is gelatin, glycerine and purified water.
6. the health products of auxiliary improvement of memory according to claim 5, is characterized in that each composition of soft capsule is counted DHA algae oil 382.4, Cobastab by weight
120.00035, GABA 70, phosphatidylserine 70, taurine 50, zinc gluconate 15, vitamin C 12.5; Gelatin 150, glycerine 62 and purified water 150.
7. the preparation method of the health products of auxiliary improvement of memory claimed in claim 6, is characterized in that step is as follows:
(1) prepare capsule-core feed liquid: by GABA, phosphatidylserine, taurine, zinc gluconate, vitamin C and Cobastab
12cross respectively after 80 mesh sieves, each composition that takes formula ratio adds in DHA algae oil, grinds to form pulpous state, and standing, 0.06-0.08Mpa is evacuated to without bubble, after 80 mesh sieves, obtains capsule-core feed liquid;
(2) prepare capsule hide glue gelatin: purified water adds gelatin and glycerine after being heated to 60 ℃, under sealing state, stir and be heated to 70 ℃, be stirred to and become even glue, standing, 0.06-0.08Mpa is evacuated to without bubble, crosses 80 mesh sieves, 60-70 ℃ of insulation deposited, and obtains capsule hide glue gelatin;
(3) pill: by capsule-core feed liquid and capsule cladding hydraulic pressure glue capsule; Through shaping, wash ball and dry, make finished product again.
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| CN111264873A (en) * | 2020-03-11 | 2020-06-12 | 北京康立生医药技术开发有限公司 | Composition with function of improving memory |
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| CN114601166A (en) * | 2022-03-02 | 2022-06-10 | 江苏盛世康禾生物技术有限公司 | Health food for strengthening brain and improving memory and preparation method thereof |
| CN115380956A (en) * | 2022-08-25 | 2022-11-25 | 北京斯利安健康科技有限公司 | Composition for assisting in improving memory and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1711859A (en) * | 2005-06-25 | 2005-12-28 | 苟春虎 | Fermented milk sheets with auxin |
| CN101766660B (en) * | 2008-12-30 | 2012-06-20 | 安琪酵母股份有限公司 | Preparation having function of improving memories and preparation method and application thereof |
| CN102000082B (en) * | 2010-10-12 | 2011-12-28 | 烟台大洋制药有限公司 | Medicament or health care food with memory strengthening effect |
| CN102578183A (en) * | 2011-01-13 | 2012-07-18 | 吕学栋 | Bread for enhancing memory and relieving brainfag |
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