CN103609752B - A kind of composition and method of making the same and application that improves brain cognitive function - Google Patents
A kind of composition and method of making the same and application that improves brain cognitive function Download PDFInfo
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Abstract
The invention provides a kind of composition and method of making the same and application that improves brain cognitive function. Said composition contains phosphatidylserine, DHA and vegetable oil, and wherein, the mass ratio of described phosphatidylserine, DHA and vegetable oil is (50-200): (5-150): (2500-10000). The food that the present invention also provides the preparation method of above-mentioned composition and contained said composition. The present invention is grouped together phosphatidylserine, DHA, vegetable oil to form a kind of composition, make phosphatidylserine, DHA, vegetable oil act synergistically on human brain, greatly reduce the effective clinical dosage of phosphatidylserine and fish oil, can prevent memory capability to reduce and learning ability reduction, can prevent senile dementia, improve brain cognitive ability, in improving human brain cognitive function, also there is the effect that promotes cardiovascular and cerebrovascular health. By regulating content and the ratio of ω-6, ω-3, ω-9 between different vegetable oil, can play better effect.
Description
Technical field
The present invention relates to a kind of composition and method of making the same and application that improves brain cognitive function, belong to food technologyField.
Background technology
Result of study finds that phosphatidylserine and fish oil improve and have important effect brain cognitive function, have at presentA certain amount of phosphatidylserine or DHA or both compositions improvement and the note for brain cognitive function found in researchThe raising of recalling power has important effect, and still, general clinical testing effective dose is all higher, the Crook, (Crook such as T.H.TH,TinklenbergJ,YesavageJ,PetrieW,NunziMG,MassariDC.Effectsofphpsphatidylserineinage-associatedmemoryimpairment.Neurology.1991,41(5):644-649) the clinical research age in 1991,149 people in 50-75 year, is taken 300mg phosphatidylserine every day, to improving noteRecall power and there is effect; Schreiber, (Schreiber, the ShaulViewProfile such as S.; Kampf-Sherf, Orli;Gorfine,MalkaViewProfile;Kelly,Dalia;etal.Anopentrialofplant-sourcederivedphosphatydilserinefortreatmentofage-relatedcognitivedecline.TheIsraelJournalofPsychiatryandRelatedSciences37.4 (2000): 302-7.) clinical research15 people of 65-78, take 300mg phosphatidylserine every day, have effect to improving memory.
And in the time taking compared with low dosage, there is no positive effect, meanwhile, DHA has fishlike smell, adds in a large number in food and goes backCan affect the taste of food, reduce effective period of food quality.
Studies have found that, the tissue that human brain cognitive function is played a major role is brain neuroblastoma system, and to nerveous systemThe material that system plays a major role has the many kinds of substance such as phosphatidylserine and polyunsaturated fatty acid, and polyunsaturated fatty acid isThe important component of central nervous system membrane phospholipid, to regulating the mobility of film to play an important role, therefore, many kinds of substance commonEffect just makes neural function be maintained.
Therefore, research and develop a kind of composition that comprises phosphatidylserine and DHA, improve its dissolubility in food, keep awayThe taste of exempting to affect food is one of this area problem demanding prompt solution.
Summary of the invention
For solving the problems of the technologies described above, the object of the present invention is to provide a kind of composition that improves brain cognitive function,Said composition contains phosphatidylserine, DHA and vegetable oil, can, in improving human brain cognitive function, have promotionThe effect of cardiovascular and cerebrovascular health has good dissolubility simultaneously, and taste to food etc. does not have adverse influence.
For achieving the above object, the invention provides a kind of composition that improves brain cognitive function, said composition containsPhosphatidylserine, DHA and vegetable oil, wherein, the mass ratio of described phosphatidylserine, DHA and vegetable oil is (50-200):(5-150): (2500-10000), be preferably (50-90): (5-150): (2500-10000).
In above-mentioned composition, preferably, described vegetable oil is soybean oil, corn oil, sunflower oil, rapeseed oil and oliveThe combination of one or more in wet goods. More preferably, the chief component of soybean oil comprises palmitic acid C16:0, palmitoleic acidC16:1, stearic acid C18:0, oleic acid C18:1, linoleic acid C18:2, leukotrienes C18:3, content be respectively 8.0wt%-13.5wt%,0.2wt%, 2.5wt%-5.4wt%, 17.7wt%-28wt%, 50wt%-57wt%, 5.5wt%-10wt%; The chief component of corn oilComprise palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acid C18:1, linoleic acid C18:2, leukotrienes C18:3,Content is respectively 8.6wt%-16.5wt%, 0.5wt%, 3.3wt%, 20wt%-42wt%, 34wt%-65.6wt%, 2wt%; Sunflower seedsThe chief component of oil comprise palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acid C18:1, linoleic acid C18:2,Leukotrienes C18:3, content is respectively 2.6wt%-5wt%, 0.1wt%, 2.9wt%-6.2wt%, 45wt%-65wt%, 5wt%-27wt%, 0.3wt%; The chief component of rapeseed oil comprises palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acidC18:1, linoleic acid C18:2, leukotrienes C18:3, content be respectively 2.5wt%-6.0wt%, 0.6wt%, 0.8wt%-3wt%,55wt%-66wt%, 18wt%-30wt%, 6wt%-14wt%; The chief component of olive oil comprises palmitic acid C16:0, palmitoleic acidC16:1, stearic acid C18:0, oleic acid C18:1, linoleic acid C18:2, leukotrienes C18:3, content be respectively 7.5wt%-20wt%,0.3wt%-3.5wt%, 0.5wt%-5.0wt%, 55.0wt%-83.0wt%, 3.5wt%-21.0wt%, 0.1wt%-1.0wt%; AboveContent be mass percent.
In above-mentioned composition, preferably, described vegetable oil comprise saturated fatty acid, omega 6 polyunsaturated fatty acid, ω-3 polyunsaturated fatty acids, ω-9 monounsaturated fatty acids.
In above-mentioned composition, preferably, the energy value of described saturated fatty acid accounts for the total energy value of described compositionBelow 30%, the energy value sum of described omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acids accounts for described compositionBelow 30% of total energy value, the energy value of described ω-9 monounsaturated fatty acids account for described composition total energy value 40% withOn. By the saturated fatty acid in control phosphatidylserine and the content of polyunsaturated fatty acid, can increase phosphatidyl silkPropylhomoserin is made the mobility of used time in cell membrane, impels phosphatidylserine efficiently to play a role, and can reduce its effect effectivelyContent. Phosphatidylserine is the main component of brain cell membrane, plays very important work to maintaining normal nervous systemWith, but phosphatidylserine has certain mobility in cell membrane, and within the specific limits, mobility is stronger, effect effectFruit is better, by increasing unrighted acid, can bring into play better the function of phosphatidylserine in cell membrane, reduces and sends outWave the amount of the needed phosphatidylserine of said function.
In above-mentioned composition, preferably, the energy of described omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acidsThe ratio of value is (3-12): 1. More preferably, the energy of described omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acidsThe ratio of value is (6-10): 1.
In above-mentioned composition, preferably, insatiable hunger more than the energy value of described ω-9 monounsaturated fatty acids and described ω-6With the ratio of the energy value sum of aliphatic acid and omega-3 polyunsaturated fatty acids be (2-15): 1. More preferably, described ω-9 are single notThe energy value sum of the energy value of saturated fatty acid and described omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acidsThan being (5-12): 1.
In above-mentioned composition, preferably, the primary raw material of DHA is fish oil or the algae oil of embedding form.
The present invention also provides the preparation method of the above-mentioned composition that improves brain cognitive function, and it comprises the following steps:
First vegetable oil is mixed, then phosphatidylserine and DHA powder are mixed, by the mass ratio of 1:5-15Mixed-powder is dissolved in vegetable oil, and temperature is controlled at 20-55 DEG C, obtains premix;
Premix is mixed completely with residue vegetable oil, obtain the described composition that improves brain cognitive function.
The present invention is by phosphatidylserine and DHA are dissolved in vegetable oil in advance, and then mixes with other raw materials,Can improve the dissolubility of phosphatidylserine, it still can be realized completely in the time adding in the products such as milk and dissolve. AndAnd, the embedding form that the present invention adopts DHA, and after mixing with vegetable oil, vegetable oil gets up DHA emulsification embedding, canFew the coming out so that the taste of DHA is tried one's best, to guarantee product quality.
The present invention also provides a kind of food, and it comprises the above-mentioned composition that improves brain cognitive function; Preferably, this foodProduct are sweets, dairy products or cereal preparation.
The present invention is grouped together phosphatidylserine, DHA, vegetable oil to form a kind of composition, makes phosphatidyl silk ammoniaAcid, DHA, vegetable oil act synergistically on human brain, greatly reduce the effective clinical dosage of phosphatidylserine and fish oil, canPrevention memory capability reduces and learning ability reduces, and can prevent senile dementia, improve brain cognitive ability, is improving human brainWhen portion cognitive function, also there is the effect that promotes cardiovascular and cerebrovascular health. By regulate ω-6 between different vegetable oil, ω-3, the content of ω-9 and ratio, can play better effect.
The above-mentioned composition that improves brain cognitive function provided by the invention can add in numerous food, for example sweetProduct, dairy products, special food (special diet), cereal preparation etc.
Detailed description of the invention
Understand for technical characterictic of the present invention, object and beneficial effect being had more clearly, existing to skill of the present inventionArt scheme is carried out following detailed description, but can not be interpreted as restriction that can practical range of the present invention.
Embodiment 1
The present embodiment provides a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine 50mg, fishOil (containing DHA150mg), sunflower oil 3g, rapeseed oil 7g;
Wherein, in vegetable oil, the content of saturated fatty acid is 2.6g, and the content of ω-6 and ω-3 is 2.5g, ω-6: ω-3The ratio of energy value be 12, ω-9 content is 4.9g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 2.
The composition of what the present embodiment provided improve brain cognitive function is prepared by following steps:
Sunflower oil and rapeseed oil are mixed, obtain vegetable oil mixt;
Phosphatidylserine and fish oil are mixed, then mix temperature according to the mass ratio of 1:5 with vegetable oil mixtDegree is controlled at 20 DEG C, obtains premix;
Premix is mixed with residue vegetable oil mixt, obtain this and improve the composition of brain cognitive function.
Embodiment 2
The present embodiment provides a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine 90mg, fishOil (containing DHA5mg), soybean oil 8g, rapeseed oil 2g;
Wherein, in vegetable oil, the content of saturated fatty acid is 0.5g, and the content of ω-6 and ω-3 is 2.9g, ω-6: ω-3The ratio of energy value be 3, ω-9 content is 6.6g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 15.
The composition of what the present embodiment provided improve brain cognitive function is prepared by following steps:
Soybean oil and rapeseed oil are mixed, obtain vegetable oil mixt;
Phosphatidylserine and fish oil are mixed, then mix with vegetable oil mixt according to the mass ratio of 1:15,Temperature is controlled at 55 DEG C, obtains premix;
Premix is mixed with residue vegetable oil mixt, obtain this and improve the composition of brain cognitive function.
Embodiment 3
The present embodiment provides a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine 70mg, algaeOil (containing DHA100mg), corn oil 6g, rapeseed oil 4g;
Wherein, in vegetable oil, the content of saturated fatty acid is 1.5g, and the content of ω-6 and ω-3 is 2.0g, ω-6: ω-3The ratio of energy value be 10, ω-9 content is 6.5g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 10.
The composition of what the present embodiment provided improve brain cognitive function is prepared by following steps:
Corn oil and rapeseed oil are mixed, obtain vegetable oil mixt;
Phosphatidylserine and algae oil are mixed, then mix with vegetable oil mixt according to the mass ratio of 1:10,Temperature is controlled at 35 DEG C, obtains premix;
Premix is mixed with residue vegetable oil mixt, obtain this and improve the composition of brain cognitive function.
Embodiment 4
The present embodiment provides a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine 200mg,Algae oil (containing DHA100mg), corn oil 6g, rapeseed oil 4g;
Wherein, in vegetable oil, the content of saturated fatty acid is 1.5g, and the content of ω-6 and ω-3 is 2.0g, ω-6: ω-3The ratio of energy value be 10, ω-9 content is 6.5g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 10.
The composition of what the present embodiment provided improve brain cognitive function is prepared by following steps:
Corn oil and rapeseed oil are mixed, obtain vegetable oil mixt;
Phosphatidylserine and algae oil are mixed, then mix with vegetable oil mixt according to the mass ratio of 1:10,Temperature is controlled at 35 DEG C, obtains premix;
Premix is mixed with residue vegetable oil mixt, obtain this and improve the composition of brain cognitive function.
Comparative example 5
This comparative example provides a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine 20mg, algaeOil (containing DHA100mg), corn oil 6g, rapeseed oil 4g;
Wherein, in vegetable oil, the content of saturated fatty acid is 1.5g, and the content of ω-6 and ω-3 is 2.0g, ω-6: ω-3The ratio of energy value be 10, ω-9 content is 6.5g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 10.
The composition of what this comparative example provided improve brain cognitive function is prepared by following steps:
Corn oil and rapeseed oil are mixed, obtain vegetable oil mixt; Phosphatidylserine and algae oil are mixed allEven, obtain mixture, two groups of mixtures no longer mix, and while use, join respectively food as the functional materials in foodIn.
Comparative example 6
This comparative example provides a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine 50mg, fishOil (containing DHA3mg), soybean oil 8g, rapeseed oil 2g;
Wherein, in vegetable oil, the content of saturated fatty acid is 0.5g, and the content of ω-6 and ω-3 is 2.9g, ω-6: ω-3The ratio of energy value be 10, ω-9 content is 6.6g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 10.
The composition of what this comparative example provided improve brain cognitive function is prepared by following steps:
Corn oil and rapeseed oil are mixed, obtain vegetable oil mixt;
Phosphatidylserine and algae oil are mixed, then mix temperature according to the mass ratio of 1:1 with vegetable oil mixtDegree is controlled at 15 DEG C, obtains premix;
Premix is mixed with residue vegetable oil mixt, obtain this and improve the composition of brain cognitive function.
7 comparative examples of comparative example provide a kind of composition that improves brain cognitive function, and it contains: phosphatidylserine50mg, fish oil (containing DHA100mg), sunflower oil 3g, rapeseed oil 7g;
Wherein, in vegetable oil, the content of saturated fatty acid is 2.6g, and the content of ω-6 and ω-3 is 2.5g, ω-6: ω-3The ratio of energy value be 0.5, ω-9 content is 4.9g, ω-9:(ω-6+ ω-3 simultaneously) the ratio of energy value be 1.0.
The composition of what this comparative example provided improve brain cognitive function is prepared by following steps:
Corn oil and rapeseed oil are mixed, obtain vegetable oil mixt;
Phosphatidylserine and algae oil are mixed, then mix with vegetable oil mixt according to the mass ratio of 1:25,Temperature is controlled at 70 DEG C, obtains premix;
Premix is mixed with residue vegetable oil mixt, obtain this and improve the composition of brain cognitive function.
Test case
Comparative example 5 and the composition that improves brain cognitive function of embodiment 2 are joined in dairy products, and final ratio is5g composition/50g milk powder, then arranges 15 trial test personnel to taste, and sample reconstitutes mode and is: 25g milk powder joinsIn the warm water of 180mL60 DEG C.
Marking standard is: 10 points of total scores, and milk fragrance and Flavor score value are more high better, but 6 points below for taste can notAccept, 6 points above for taste can be accepted; Oxidation of Fat and Oils taste score value is more low better, and 6 points is above that taste is unacceptable, 6 points withCan accept for taste down, the results are shown in following table 1.
Table 1
| Milk fragrance | Oxidation of Fat and Oils taste | Flavor | |
| Embodiment 2 | 110 | 30 | 107 |
| Comparative example 5 | 98 | 86 | 94 |
| P value | 0.01 | 0.002 | 0.008 |
Taste conclusion: totally 15 people participate in tasting, and wherein 11 people think the composition that improves brain cognitive function of comparative example 5Have a kind of oily fishy smell that is different from the peculiar taste smell of milk powder, hidden milk fragrance, but this taste can also be accepted; And it is realExecute the composition that improves brain cognitive function and the distinctive taste smell of the milk powder indifference of example 2, free from extraneous odour. Divide from tasting resultAnalyse, the overall local flavor of the composition that improves brain cognitive function of embodiment 2 will be significantly better than comparative example 4, is mainly due to rightThe phosphatidylserine of ratio 5 does not have and DHA fully mixes by certain condition with vegetable oil.
Comparative example 7 and the composition that improves brain cognitive function of embodiment 1 are joined in dairy products, and final ratio is5g/50g milk powder is placed 3 months at 42 DEG C, monthly samples one-time detection peroxide value and acid value, checking fat oxidation degree,Result is as following table 2.
The composition of comparative example 7 temperature in mixed process is higher, and Oxidation of Fat and Oils degree is also higher, therefore, is joiningWhile producing milk powder in dairy products, shelf life of products can shorten, so peroxide value and acid value comparative example result will be apparently higher than realitiesExecute the composition that improves brain cognitive function of example 1, therefore, the preparation method of composition can produce larger shadow to the quality of productRing.
Table 2
The correlated performance of what this test case provided embodiment the improve composition of brain cognitive function is tested.
Clinical research, joins the composition that improves brain cognitive function of embodiment 3 and comparative example 6 in dairy products,Final ratio is 10g composition/50g milk powder (skimmed milk power, whole milk powder, desalted whey powder, PURE WHEY, maltodextrinDeng), experimenter is 50 people (slight amnesia healthy old mens, the age is more than 55 years old), dosage is 50g milk powder every day, treatment12 weeks phases, mainly to remember, the recognition tests of attention, learning ability, test result is as shown in Table 3 and Table 4.
Table 3 experimenter tests the Cognitive Effects of the composition to embodiment 3
| Cognitive integrate score | Baseline | 6 weeks | 12 weeks | P-value * |
| Memory identification | 80.6±2.11 | 86.24±2.07 | 87.36±1.54 | 0.007 |
| Memory is looked back | 73.52±2.55 | 81.12±2.64 | 82.32±2.3 | 0.015 |
| Executive capability | 72.36±4.62 | 79.16±4.36 | 82.64±3.69 | 0.013 |
| Brain flexibility | 73.13±4.64 | 79.32±4.35 | 82.44±3.53 | 0.029 |
| Focus one's attention on | 85.2±2.46 | 88.24±2.45 | 90.28±1.91 | 0.076 |
| Sustained attention power | 82.04±3.18 | 86±2.52 | 87.76±1.8 | 0.100 |
Table 4 experimenter tests the Cognitive Effects of the composition to comparative example 6
| Cognitive integrate score | Baseline | 6 weeks | 12 weeks | P-value * |
| Memory identification | 79.6±2.11 | 82.24±2.07 | 84.36±1.54 | 0.070 |
| Memory is looked back | 75.52±2.55 | 77.12±2.64 | 78.32±2.3 | 0.090 |
| Executive capability | 70.36±4.62 | 72.16±4.36 | 73.64±3.69 | 0.100 |
| Brain flexibility | 71.13±4.64 | 73.32±4.35 | 75.44±3.53 | 0.180 |
| Focus one's attention on | 83.2±2.46 | 848.24±2.45 | 85.28±1.91 | 0.250 |
| Sustained attention power | 80.04±3.18 | 81±2.52 | 83.76±1.8 | 0.290 |
Although the test index of result also increases in table 4, effect is not remarkable, not representative, and contrast is describedThe composition of example can not promote the improvement of these cognitive functions.
Experimental design
This experimental design is single center and open label. All participants are according to baseline, by commenting after the treatment of 12 weeksDetermine cognitive performance and security. Assess cognitive performance by two kinds of diverse ways: the cognitive assessment tool (NexAde of computerTM, withThe NexSig nervous system detection technique company of Se Liehezi Leah) and Gordon Ray audio verbal learning test (Rey-AVLT).
Cognitive assessment
The content measurement of grouping comprises:
1, recognize plus sige, experimenter can be by arbitrary button, and "+" symbol there will be on screen.
2, determine odd mode, experimenter must identify from three kinds of patterns.
3, memory pattern, experimenter provides a pictures (being similar to odd mode identification), then from three kinds of picturesIdentify.
4, numerical chracter replacement test, experimenter must with the pattern match providing.
5, front and back digital span, it is (at every turn multiple that experimenter repeats a Serial No. according to front and back order or transposeNumeral).
6, delay memory pattern, experimenter must know the simple mode of informing that requirement is remembered, after 10 minutes, needs to be againExisting.
Before each test, every the tested task of need to be familiar with a brief training module problem, test is limited to30-45 minute, comprises the training stage.
The order that each item-dividing test increases progressively with difficulty carry out (as from input set of number by any key), each groupingTest is essentially the service of training below. All tests have multiple versions, to can eliminate the difference because of management organizationThe difference on effect causing. Score obtains by algorithm, in module, every group of result is separated and is settled. Based on module andThe quantity of collecting increases, and this software can provide the mark of test.
Based on the result of individual task, 8 comprehensive cognitive marks are calculated, and these total performances comprise: notice concentrate,Sustained attention power, memory identification and recovery, visual space learning ability, solid space short-term memory power, execution function and brainFlexibility.
Gordon Ray audio verbal learning test (Rey-AVLT) is made up of 15 common nouns, continuous by 5Test (test 1 by experiment 5) is read out. Read by a reminiscence freely at every turn and complete. In test 6,One has the interference inventory of 15 new terms to be presented out, then remembers freely these new terms. In test 7, need not readRead other content, experimenter requires to remember the content of first inventory again. After 20 minutes, need not read other content, testedPerson is required again to remember the content (test 8) of first inventory. 5 kinds of different marks are exported from test: directly noteRecalling power (test 1 mark), best learning ability (test 5), speech calculates learning ability (test 1 by experiment 5), postpones noteRecall (test 8) and memory identification (test 9).
Statistical method
The computer mark of collecting at baseline and after 6,12 weeks depends on duplicate measurements analytical model (RM-ANOVA). For learningThe tested conspicuousness of issuing after examination and approval in present duplicate measurements analysis of independent sample of raw t-test comparison analysis. Do is like this in order to determineThe significance difference opposite sex between baseline and 6 weeks and baseline and the computer mark between 12 weeks.
For the independent sample of student t test be used to test baseline and within 12 weeks, treat during Gordon Ray audio glossologyHabit test result changes, and the variation of somatic data (blood pressure and pulse). Because this test is exploratory, not to manyIndividual test is proofreaied and correct.
Cognitive result
In table 1, presented the cognitive result of assessment by computer, cognitive integrate score is not with baseline with take composition 6 weeks and 12After week, be as the criterion. Duplicate measurements analytical model (RM-ANOVA) has confirmed at memory identification (P=0.007), reminiscence (P=0.015), the aspect such as executive capability (P=0.013) and brain flexibility (P=0.029) significantly improves the effect of score. Also simultaneouslyFind that, sustained attention power aspect concentrated to notice increases.
The comparative analysis of the independent sample of testing according to duplicate measurements analytical model (RM-ANOVA) with for student t-is sent outNow along with the variation of Time of Administration, the cognitive integrate score effect (Fig. 1) that increases significantly. Find baseline and combining after 12 weeksClose score and have significant difference: memory cognitive ability 6.76 ± 2.13 (P=0.004), reminiscence 8.80 ± 2.92 (P=0.006), executive capability 10.28 ± 3.27 (P=0.004) and brain flexibility 9.32 ± 3.32 (P=0.01).
In addition, score has showing of remarkable result at baseline and after taking composition 6 weeks: (P=0.003) identified in memoryAnd reminiscence (P=0.01).
Can find out by above-mentioned test, the composition that improves brain cognitive function that adopts the application to provide is certainCan play the effect that improves brain cognitive function.
Claims (18)
1. improve a composition for brain cognitive function, said composition is made up of phosphatidylserine, DHA and vegetable oil, itsIn, the mass ratio of described phosphatidylserine, DHA and vegetable oil is (50-200): (5-150): (2500-10000).
2. composition according to claim 1, wherein, the mass ratio of described phosphatidylserine, DHA and vegetable oil is(50-90):(5-150):(2500-10000)。
3. composition according to claim 1 and 2, wherein, described vegetable oil is soybean oil, corn oil, sunflower oil, dishThe combination of one or more in seed oil and olive oil.
4. composition according to claim 3, wherein, the chief component of described soybean oil comprises palmitic acid C16:0, palmOleic acid C16:1, stearic acid C18:0, oleic acid C18:1, linoleic acid C18:2, leukotrienes C18:3, content is respectively 8.0wt%-13.5wt％、0.2wt％、2.5wt％-5.4wt％、17.7wt％-28wt％、50wt％-57wt％、5.5wt％-10wt％；
The chief component of described corn oil comprise palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acid C18:1,Linoleic acid C18:2, leukotrienes C18:3, content is respectively 8.6wt%-16.5wt%, 0.5wt%, 3.3wt%, 20wt%-42wt％、34wt％-65.6wt％、2wt％；
The chief component of described sunflower oil comprises palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acid C18:1, linoleic acid C18:2, leukotrienes C18:3, content be respectively 2.6wt%-5wt%, 0.1wt%, 2.9wt%-6.2wt%,45wt％-65wt％、5wt％-27wt％、0.3wt％；
The chief component of described rapeseed oil comprise palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acid C18:1,Linoleic acid C18:2, leukotrienes C18:3, content be respectively 2.5wt%-6.0wt%, 0.6wt%, 0.8wt%-3wt%,55wt％-66wt％、18wt％-30wt％、6wt％-14wt％；
The chief component of described olive oil comprise palmitic acid C16:0, palmitoleic acid C16:1, stearic acid C18:0, oleic acid C18:1,Linoleic acid C18:2, leukotrienes C18:3, content is respectively 7.5wt%-20wt%, 0.3wt%-3.5wt%, 0.5wt%-5.0wt％、55.0wt％-83.0wt％、3.5wt％-21.0wt％、0.1wt％-1.0wt％。
5. according to the composition described in claim 1,2 or 4, wherein, described vegetable oil comprises insatiable hunger more than saturated fatty acid, ω-6With aliphatic acid, omega-3 polyunsaturated fatty acids, ω-9 monounsaturated fatty acids.
6. composition according to claim 3, wherein, described vegetable oil comprises unsaturated lipid more than saturated fatty acid, ω-6Fat acid, omega-3 polyunsaturated fatty acids, ω-9 monounsaturated fatty acids.
7. composition according to claim 5, wherein, the energy value of described saturated fatty acid accounts for the total energy of described compositionBelow 30% of value, the energy value sum of described omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acids accounts for described groupBelow 30% of the total energy value of compound, the energy value of described ω-9 monounsaturated fatty acids accounts for the total energy value of described compositionMore than 40%.
8. composition according to claim 6, wherein, the energy value of described saturated fatty acid accounts for the total energy of described compositionBelow 30% of value, the energy value sum of described omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acids accounts for described groupBelow 30% of the total energy value of compound, the energy value of described ω-9 monounsaturated fatty acids accounts for the total energy value of described compositionMore than 40%.
9. composition according to claim 5, wherein, described omega 6 polyunsaturated fatty acid and ω-3 polyunsaturated fatThe ratio of the energy value of acid is (3-12): 1.
10. composition according to claim 6, wherein, unsaturated lipid more than described omega 6 polyunsaturated fatty acid and ω-3The ratio of the energy value of fat acid is (3-12): 1.
11. according to the composition described in claim 9 or 10, wherein, and insatiable hunger more than described omega 6 polyunsaturated fatty acid and ω-3With the ratio of the energy value of aliphatic acid be (6-10): 1.
12. compositions according to claim 5, wherein, the energy value of described ω-9 monounsaturated fatty acids and described ω-The ratio of the energy value sum of 6 polyunsaturated fatty acids and omega-3 polyunsaturated fatty acids is (2-15): 1.
13. compositions according to claim 6, wherein, the energy value of described ω-9 monounsaturated fatty acids and described ω-The ratio of the energy value sum of 6 polyunsaturated fatty acids and omega-3 polyunsaturated fatty acids is (2-15): 1.
14. according to the composition described in claim 12 or 13, wherein, and the energy value of described ω-9 monounsaturated fatty acids and instituteThe ratio of stating the energy value sum of omega 6 polyunsaturated fatty acid and omega-3 polyunsaturated fatty acids is (5-12): 1.
15. compositions according to claim 1, wherein, the primary raw material of described DHA is fish oil or the algae of embedding formOil.
The preparation method of the composition that improves brain cognitive function described in 16. claim 1-15 any one, it comprises followingStep:
First vegetable oil is mixed, then phosphatidylserine and DHA powder are mixed, will mix by the mass ratio of 1:5-15Close powder dissolution in vegetable oil, temperature is controlled at 20-55 DEG C, obtains premix;
Premix is mixed completely with residue vegetable oil, obtain the described composition that improves brain cognitive function.
17. 1 kinds of food, it comprises the composition that improves brain cognitive function described in claim 1-15 any one.
18. food according to claim 17, wherein, this food is sweets, dairy products or cereal preparation.
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| CN105311072A (en) * | 2015-08-25 | 2016-02-10 | 北京世纪合辉医药科技股份有限公司 | Healthcare product capable of improving memory and production method thereof |
| CN105341909A (en) * | 2015-11-09 | 2016-02-24 | 苏州泽达兴邦医药科技有限公司 | Health care food used for improving memory and preparation method therefor |
| CN106722978A (en) * | 2015-11-19 | 2017-05-31 | 徐州统食品工业有限公司 | A kind of health food for improving cognitive ability and memory |
| CN105497093B (en) * | 2015-12-30 | 2019-09-06 | 颐海产业控股有限公司 | A kind of composition with auxiliary improvement of memory power function, preparation method and the capsule containing the composition |
| CN106954859A (en) * | 2017-03-15 | 2017-07-18 | 天津市益倍建生物技术有限公司 | A kind of composition acted on auxiliary improvement of memory and its application |
| CN107125752B (en) * | 2017-06-14 | 2020-06-30 | 安徽省芬格欣生物药业有限公司 | Phosphatidylserine oral liquid for improving memory function and preparation method thereof |
| CN110038018B (en) * | 2019-04-25 | 2021-03-19 | 河北康睿达脂质有限公司 | A method for preparing brain neurotrophic therapeutic composition |
| GR20220100576A (en) * | 2022-07-13 | 2024-02-09 | Σταυρουλα Κωνσταντινου Μπασακιδου | Edible oils enriched with nutrients to boost brain function |
| CN115119939A (en) * | 2022-07-22 | 2022-09-30 | 上海攸伽健康科技(集团)有限公司 | Composition for improving brain function |
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