CN106954859A - A kind of composition acted on auxiliary improvement of memory and its application - Google Patents
A kind of composition acted on auxiliary improvement of memory and its application Download PDFInfo
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- CN106954859A CN106954859A CN201710154844.5A CN201710154844A CN106954859A CN 106954859 A CN106954859 A CN 106954859A CN 201710154844 A CN201710154844 A CN 201710154844A CN 106954859 A CN106954859 A CN 106954859A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
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- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides a kind of composition acted on auxiliary improvement of memory, includes the following component of parts by weight：100 200 parts of phosphatidylserine, 100 200 parts of walnut peptide, 100 200 parts of wolfberry fruit extract, 50 100 parts of fish oil powder, 10 50 parts of grape extract.The present invention is with phosphatidylserine, walnut peptide, wolfberry fruit extract, and fish oil powder, grape extract is primary raw material, makes various composition reasonable formula, cooperate with shared, composition, which can effectively reach, improves effect of memory.
Description
Technical field
The invention belongs to field of health care food, and in particular to a kind of to have the composition for improving memory effect.
Background technology
Memory is one kind of mankind's intellectual activities, belongs to the category of psychology or brain science, and memory represents a people
To past activity, impression, the impression accumulation of experience, in each stage of life, memory suffers from very important effect, but by
In either internally or externally reason, the people of all age group suffers from the puzzlement in terms of memory.Adolescents with learning task is heavy, memory
The quality of power directly influences the height of achievement；A middle-aged person's operating pressure is big, and the quality of memory directly influences operating efficiency
Height；The elderly is due to the decline of physical function, and the quality of memory is even more the quality of life for being related to old age, so improving
Memory suffers from very great meaning in each stage of life.
At present, many companies and scientific research institution are all being studied for how to improve memory, and have also issued phase
The achievement answered, wherein being no lack of the achievement of formula and composition.In existing document, patent CN106266239A discloses a kind of improvement
The composition of memory, the active ingredient of the composition is prepared from by the medicinal material of following parts by weight：2-6 parts of the fruit of Chinese magnoliavine, ginseng
3-9 parts, 1-3 parts of pseudo-ginseng, 6-12 parts of matrimony vine；Patent CN106138946A discloses a kind of health caring product prescription for improving and remembering, its
Constitute as the raw material of following quality proportioning：60-90 parts of fructus alpiniae oxyphyllae, 90-120 parts of American Ginseng, 40-80 parts of ginkgo leaf, fiveleaf akebia fruit 10-
50 parts, 40-60 parts of the root of Dahurain angelica, 10-30 parts of the achene of Siberian cocklebur, 20-40 parts of peppermint；As CN106213482A discloses a kind of improvement memory
Health food and preparation method thereof, it is described to improve the health food of memory, be according to the component of parts by weight：Ground beetle 18-24
Part, 12-20 parts of crucian, 10-15 parts of Radix Glycyrrhizae, 8-13 parts of the root of Dahurain angelica, 8-13 parts of prepared rhizome of rehmannia, 5-10 parts of dried orange peel, 5-10 parts of the coptis, Li Dou
5-10 parts, 5-8 parts of roundpod jute leaf, 2-4 parts of qualities of stevia extract, 2-4 parts of Millettia extract, 2-4 parts of agastache extract.
The health product of above-mentioned formula, plays the role of all to contain traditional Chinese medicine ingredients in auxiliary improvement of memory, but the said goods,
Can not continuously it take for a long time.
The content of the invention
The present invention mesh be overcome the deficiencies in the prior art there is provided it is a kind of with auxiliary improvement of memory act on composition and
It is applied.
The present invention, which is adopted the following technical scheme that, realizes above-mentioned purpose：
A kind of composition acted on auxiliary improvement of memory, includes the following component of parts by weight：
100-200 parts of phosphatidylserine, 100-200 parts of walnut peptide, 100-200 parts of wolfberry fruit extract, fish oil powder 50-
100 parts, 10-50 parts of grape extract.
Preferably, the active ingredient of the composition is composed of the following components in parts by weight：150 parts of phosphatidylserine,
130 parts of walnut peptide, 140 parts of wolfberry fruit extract, 50 parts of fish oil powder, 30 parts of grape extract.
The present invention another optimal technical scheme be：The active ingredient of the composition is by following parts by weight into packet
Into：100-200 parts of phosphatidylserine, 100-200 parts of walnut peptide, 100-200 parts of wolfberry fruit extract, 50-100 parts of fish oil powder,
10-50 parts of grape extract, 100-200 parts of prebiotics；
The composition of the prebiotics (Probiotics) includes one in isomalto-oligosaccharide, FOS and xylo-oligosaccharide
Plant or a variety of.Prebiotics is auxiliary material.
It is highly preferred that the active ingredient of the composition is composed of the following components in parts by weight：Phosphatidylserine 150
Part, 130 parts of walnut peptide, 140 parts of wolfberry fruit extract, 50 parts of fish oil powder, 30 parts of grape extract, 150 parts of prebiotics.
Wherein, the formulation of the composition is one kind in granule, pulvis, capsule, tablet.
A preferred technical solution of the present invention is：The formulation of the composition is granule, the preparation of the composition
Method includes step：
1) 40-80 of phosphatidylserine, walnut peptide, wolfberry fruit extract, fish oil powder, grape extract is weighed according to proportioning
Fine powder under mesh sieve, is well mixed；
2) fine powder mixed is added into adhesive, the particle of 20-60 mesh is made, under conditions of temperature is 40-60 DEG C
It is dried, drying time 30-90 minute, dispenses, produce；The consumption of the binding agent is remaining each component quality sum
2%-5%.
Wherein, the alcohol that the binding agent is water or volumetric concentration is 10-95%.
Wherein, the formulation of the composition is granule, and the preparation method of the composition includes step：
1) prebiotics is pulverized and sieved, chooses fine powder under 40-80 mesh sieves, phosphatidylserine, walnut are weighed according to proportioning
Peptide, wolfberry fruit extract, fish oil powder, grape extract, the lower fine powder of prebiotics sieve, are well mixed；
2) fine powder mixed is added into adhesive, the particle of 20-60 mesh is made, under conditions of temperature is 40-60 DEG C
It is dried, drying time 30-90 minute, dispenses, produce；The consumption of the binding agent is remaining each component quality sum
2%-5%.
Wherein, the alcohol that the binding agent is water or volumetric concentration is 10-95%.
Composition of the present invention is in the functional food and health food that are acted on auxiliary improvement of memory is prepared
Using.
The beneficial effects of the present invention are：
1st, the present invention is with phosphatidylserine, walnut peptide, wolfberry fruit extract, and fish oil powder, grape extract is primary raw material,
Make various composition reasonable formula, cooperate with shared, composition, which can effectively reach, improves effect of memory.
2nd, after the preparation that the present invention is provided is reconstituted, color coordination, mouthfeel is soft, and has the distinctive fragrance of plant extracts.
3rd, proved through animal experiment：The composition that the present invention is provided can improve the memory capability of mouse, show of the present invention group
Compound has effects that auxiliary improvement of memory.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
In embodiment, phosphatidylserine used is that crude soya bean oil expression residue is extracted, and biology is built again purchased from Tianjin benefit
Technology Co., Ltd.；
The Walnut extract is walnut peptide, and wherein content of peptides is more than 60%, and biotechnology is built again purchased from Tianjin benefit
Co., Ltd；
The wolfberry fruit extract is LBP-X, and wherein polyoses content builds biological skill again up to more than 50% purchased from Tianjin benefit
Art Co., Ltd；
The fish oil powder is DHA content more than 5%, purchased from dutch royal DSM group；
The grape extract be Resveratrol content up to more than 5%, purchased from Tianjin Yi Beijian Bioisystech Co., Ltd.
In embodiment, unless otherwise specified, used means are this area conventional technology.
Embodiment 1
Formula：Phosphatidylserine 15kg, walnut peptide 13kg, wolfberry fruit extract 14kg, fish oil powder 5kg, grape extract
3kg。
The composition of the present embodiment is granule, and preparation method is：
1) 80 mesh of phosphatidylserine, walnut peptide, wolfberry fruit extract, fish oil powder, grape extract are weighed according to proportioning
The lower fine powder of sieve, is well mixed；
2) fine powder mixed is added into adhesive, adhesive is the alcohol of mass concentration 80%, and the consumption of binding agent is
The 5% of remaining each component quality sum.The particle of 20-60 mesh is made, is dried under conditions of temperature is 60 DEG C, when drying
Between 60 minutes, packing, produce.
Embodiment 2：
Formula：Phosphatidylserine 12kg, walnut peptide 15kg, wolfberry fruit extract 13kg, fish oil powder 6kg, grape extract
4kg.Preparation method be the same as Example 1.
Embodiment 3：
Formula：Phosphatidylserine 17kg, walnut peptide 10kg, wolfberry fruit extract 12kg, fish oil powder 6kg, grape extract
5kg.Preparation method be the same as Example 1.
Embodiment 4：
Formula：Phosphatidylserine 14kg, walnut peptide 17kg, wolfberry fruit extract 10kg, fish oil powder 8kg, grape extract
1kg.Preparation method be the same as Example 1.
Zoopery：
In order to prove whether the composition in the present invention has effects that auxiliary improvement of memory, inventive samples selection is implemented
The sample of example 1 carries out zoometry, and test process is as follows.
Study subject：Kunming mouse 80 (male and female half and half), 10 monthly ages, body weight 30-35g.
Experimental method：Mouse adaptability is raised one week, 20-25 DEG C of feeding environment temperature, humidity 40%-60%, average mark
Into 4 groups, i.e. control group (physiological saline 20mL/kg) is medicine low dose group (150mg/kg), middle dose group (300mg/kg), high
Dosage group (600mg/kg), carries out gastric infusion using not damaged gastric perfusion needle, once a day, continues 5 weeks, every time by every group 20
Mouse ad lib is drunk water after gavage.
Water maze laboratory
Water maze orientation navigation：Mouse is put into water in fixed position towards Morris water maze pool walls and starts meter
When, if mouse finds platform in 60s and stops 10s, the time stopped after 10s is as incubation period, if mouse is in 60s
Do not find platform inside then to be led to platform and stop 10s, 60s will be designated as incubation periods, every group of time interval trained twice is long
In 10min.Mouse is continuously trained after 4d, observes and records platform incubation period and total distance, as shown in table 1.
Water maze space exploration：After orientation navigation experiment is completed, mouse rest 3h removes platform, will in fixed position
Mouse is put into water towards pool wall, is observed and is recorded the number of times that platform area is passed through in 60s and the platform quadrant residence time, such as table 2
It is shown.
Appeared on the stage to each group mouse influence in incubation period and total distance of the present composition of table 1 is compared (n=20)
| Packet | Dosage (mg/kg) | Appear on the stage incubation period (s) | Total distance (m) |
| Control group | 42.05±0.75 | 11.57±1.53 | |
| Low dose group | 150 | 39.15±1.21 | 10.03±1.26 |
| Middle dose group | 300 | 31.02±0.86 | 8.43±0.92 |
| High dose group | 600 | 26.13±0.92 | 6.97±0.99 |
(n=is compared in the influence that the present composition of table 2 passes through platform number of times and platform quadrant residence time to each group mouse
20)
| Packet | Dosage (mg/kg) | Pass through platform number of times (N/min) | The platform quadrant residence time (s) |
| Control group | 2.59±0.73 | 22.03±2.82 | |
| Low dose group | 150 | 3.01±0.90 | 25.61±1.66 |
| Middle dose group | 300 | 4.96±0.56 | 36.53±2.51 |
| High dose group | 600 | 5.82±0.82 | 40.39±1.86 |
Summary experimental result understands that after the gavage present composition, taking the mouse of middle and high dosage group can substantially contract
Total distance before short Morris water mazes platform incubation period and upper platform, shows to take the study energy of mouse after the present composition
Power strengthens；The space exploration result of the test of Morris water mazes shows, takes the mouse of middle and high dosage group and can substantially increase and passes through
Platform number of times, extends the platform quadrant residence time, shows that taking the present composition there is enhancing to make the memory capability of mouse
With.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of composition acted on auxiliary improvement of memory, it is characterised in that the following component including parts by weight：
100-200 parts of phosphatidylserine, 100-200 parts of walnut peptide, 100-200 parts of wolfberry fruit extract, 50-100 parts of fish oil powder,
10-50 parts of grape extract.
2. composition according to claim 1, it is characterised in that the active ingredient of the composition is by following parts by weight
Composition is constituted：150 parts of phosphatidylserine, 130 parts of walnut peptide, 140 parts of wolfberry fruit extract, 50 parts of fish oil powder, grape extract
30 parts.
3. composition according to claim 1, it is characterised in that the active ingredient of the composition is by following parts by weight
Composition is constituted：100-200 parts of phosphatidylserine, 100-200 parts of walnut peptide, 100-200 parts of wolfberry fruit extract, fish oil powder 50-
100 parts, 10-50 parts of grape extract, 100-200 parts of prebiotics；
The composition of the prebiotics includes the one or more in isomalto-oligosaccharide, FOS and xylo-oligosaccharide.
4. composition according to claim 3, it is characterised in that the active ingredient of the composition is by following parts by weight
Composition is constituted：150 parts of phosphatidylserine, 130 parts of walnut peptide, 140 parts of wolfberry fruit extract, 50 parts of fish oil powder, grape extract
30 parts, 150 parts of prebiotics.
5. composition according to claim 1, it is characterised in that the formulation of the composition is granule, pulvis, capsule
One kind in agent, tablet.
6. composition according to claim 1 or 2, it is characterised in that the formulation of the composition is granule, described group
The preparation method of compound includes step：
1) the 40-80 mesh sieves of phosphatidylserine, walnut peptide, wolfberry fruit extract, fish oil powder, grape extract are weighed according to proportioning
Lower fine powder, is well mixed；
2) fine powder mixed is added into adhesive, the particle of 20-60 mesh is made, carried out under conditions of temperature is 40-60 DEG C
Dry, drying time 30-90 minute, packing is produced；The consumption of the binding agent is the 2%- of remaining each component quality sum
5%.
7. composition according to claim 6, it is characterised in that the binding agent is water or volumetric concentration is 10-95%
Alcohol.
8. the composition according to claim 3 or 4, it is characterised in that the formulation of the composition is granule, described group
The preparation method of compound includes step：
1) prebiotics is pulverized and sieved, chooses fine powder under 40-80 mesh sieves, phosphatidylserine, walnut peptide, Chinese holly are weighed according to proportioning
Qi extract, fish oil powder, grape extract, the lower fine powder of prebiotics sieve, are well mixed；
2) fine powder mixed is added into adhesive, the particle of 20-60 mesh is made, carried out under conditions of temperature is 40-60 DEG C
Dry, drying time 30-90 minute, packing is produced；The consumption of the binding agent is the 2%- of remaining each component quality sum
5%.
9. composition according to claim 8, it is characterised in that the binding agent is water or volumetric concentration is 10-95%
Alcohol.
10. the composition described in any one of claim 1~9 is preparing the functional food acted on auxiliary improvement of memory and guarantor
Application in health food.
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Application publication date: 20170718 |