CN115380956A - Composition for assisting in improving memory and preparation method thereof - Google Patents
Composition for assisting in improving memory and preparation method thereof Download PDFInfo
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- CN115380956A CN115380956A CN202211028115.2A CN202211028115A CN115380956A CN 115380956 A CN115380956 A CN 115380956A CN 202211028115 A CN202211028115 A CN 202211028115A CN 115380956 A CN115380956 A CN 115380956A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
Abstract
The application provides a composition for assisting in improving memory, which comprises the following components in parts by weight: 180-210 parts of docosahexaenoic acid, 160-180 parts of milk mineral salt, 19-22 parts of phosphatidylserine, 13-16 parts of taurine, 170-210 parts of isomaltitol and 350-390 parts of whole milk powder. The product takes food raw materials as formula raw materials, has safe dosage, has exact auxiliary memory improving effect through animal experiments and human body experiments, and has convenient taking and good taste.
Description
Technical Field
The invention belongs to the field of health-care food, and particularly relates to a composition for assisting in improving memory and a preparation method thereof.
Background
Children and adolescents are in a stage of constantly learning, memorizing and receiving new knowledge, which is a period of time requiring intensive stimulation of brain cells. Brain cells are stimulated by proper nutrients, and the processes of the cells extend; only by supplementing the nutrients in time, the connection between nerve cells can be strengthened, and the information transmission can be fast and smooth, thereby achieving the function of assisting in improving memory. At present, few products for assisting in improving memory are applied to children and juvenile groups.
Docosahexaenoic acid is widely present in the form of phospholipids in brain cells and retina, and plays an important role in the normal functioning of the central nervous system and the structure and function of retina. Research in recent years shows that DHA can supplement a certain amount of DHA to benefit intelligence and strengthen brain, and has important roles in brain neural development and learning and memory behaviors. But the function of assisting to improve the memory of a human body cannot be achieved by singly taking the docosahexaenoic acid, and the docosahexaenoic acid serving as a new food raw material is regulated by the national health department that the daily dose of a pure product is less than 300mg.
The milk mineral salt is also called milk calcium, whey mineral concentrate and whey calcium, is prepared from whey by removing components such as protein, lactose and the like, has calcium content of about 23-28%, and has calcium-phosphorus ratio of about 2:1. The source and the specific calcium and phosphorus are more beneficial to the absorption and utilization of the calcium by the human body than the calcium in the calcium, and the calcium is widely used as a new calcium source for various foods. Calcium, as one of the minerals, has the potential to improve brain function in healthy children. The milk mineral salt is used as one of new food raw materials, and the daily dose of a pure product of the milk mineral salt is less than 200mg specified by the national health department.
Phosphatidylserine (PS) is one of cell membrane components, and it can affect the fluidity and permeability of cell membrane, and activate the metabolism and synthesis of various enzymes, and has effects of improving nerve cell function, regulating nerve pulse conduction and improving brain memory function. PS not only has a significant and positive effect on the recovery of physiological cognitive abilities and cognitive abilities of impaired people, but also may have the effect of improving cognitive abilities in non-impaired cognitive decline. When the content of acetylcholine in brain is increased, the information transmission speed between nerve cells of brain is increased, and the physiological functions of the brain include improving memory, enhancing intelligence, promoting brain development and the like. Phosphoesterylserine is used as one of new food raw materials, and the daily dose of a pure product of the phosphatidylserine is less than 600mg specified by the national health department.
Taurine is an important free amino acid in the mammalian nervous system and has a wide range of biological activities. Taurine may be helpful in enhancing learning and memory ability in mammals and humans.
Isomalt is a sweetener and has the characteristics of low hygroscopicity, high stability, high tolerance, low calorie, pure sweetness and the like. In the product, the addition of isomalt can mask the fishy smell of docosahexaenoic acid. The daily dosage of the product is large, so that the unpleasant odor of the raw materials is covered, the product can be taken after being mixed with water, and the convenience and the taste of the product are improved.
The whole milk powder not only has the function of regulating the mouthfeel in the product, but also has better mixing property of the raw materials. In addition, the protein in the whole milk powder is used as a carrier of human enzyme, and may be one of the reasons that the product has the function of assisting to improve the memory of children and teenagers.
Disclosure of Invention
The invention can realize that each raw material is in a safe dosage range by applying safe food raw materials in the form of composition powder, so that the food has the function of assisting in improving memory for children and teenagers; meanwhile, the composition has good taste, can well cover the serious fishy smell of the docosahexaenoic acid powder, is easy to realize achievement transformation and is convenient to take and carry by applying the modern powder formulation.
The method is realized by adopting the following technical scheme:
the composition for assisting in improving memory comprises the following components in parts by weight:
180-210 parts of docosahexaenoic acid
160-180 parts of milk mineral salt
19-22 parts of phosphatidyl serine
13-16 parts of taurine
170-210 parts of isomalt
350-390 parts of whole milk powder.
Optionally, the docosahexaenoic acid is docosahexaenoic acid embedded powder.
Optionally, the auxiliary memory improving composition is a powdered mixture.
Optionally, the auxiliary memory improving composition comprises the following components in parts by weight:
200 parts of docosahexaenoic acid powder
Milk mineral salt 174 parts
20 parts of phosphatidyl serine
Taurine 14 parts
Isomalt 206 parts
386 parts of full cream milk powder.
The application also provides a preparation method of the composition for assisting in improving the memory, which comprises the following steps:
and uniformly mixing phosphatidyl serine powder, taurine powder, milk mineral salt powder, docosahexenoic acid powder, whole milk powder and isomalt powder to obtain the composition for assisting in improving memory.
Optionally, the preparation method of the composition for assisting in improving memory comprises the following steps:
step 1), uniformly mixing phosphatidyl serine powder and taurine powder to obtain mixed powder 1;
step 2) mixing the milk mineral salt powder and the mixed powder 1 uniformly to obtain mixed powder 2;
and 3) mixing docosahexenoic acid powder, whole milk powder, isomaltitol powder and mixed powder 2 to obtain the composition for assisting in improving memory.
According to the preparation method, the uniformity of product mixing can be better ensured by adopting a gradient mixing mode, so that the quality of the product is ensured.
The application also provides a using method of the composition for assisting in improving the memory, and the composition is taken 2 times a day by being infused with water, and 5g of the composition is taken each time.
Optionally, the administration is continued for at least 30 days
The method of the application can obtain the following beneficial effects:
at present, aiming at children and young people, auxiliary memory improving products with good safety, exact effect, good taste and convenient taking are lacked in the market. The product takes food raw materials as formula raw materials, has safe dosage, has exact auxiliary memory improving effect through animal experiments and human body experiments, and has convenient taking and good taste.
Detailed Description
The technical solution of the present invention will be clearly and completely described below. The sources of the raw materials in the application are as follows: docosahexaenoic acid powder: jiabiyouh biotechnology (Wuhan) GmbH; milk mineral salt: denmark ala food company; phosphatidylserine: shanghai Tongyuan food technology, inc.; taurine: mingjiang Yongan pharmaceutical industry, inc.; isomalt: guangxi Uvo Biotechnology, inc.; whole milk powder: hengyuans Nyssaceae, N.Zealand.
Example 1
The formula (1000 g) of the composition for assisting in improving memory comprises the following components in parts by weight: 200g of docosahexaenoic acid powder, 174g of milk mineral salt, 20g of phosphatidylserine, 14g of taurine, 206g of isomaltulose and 386g of full-fat milk powder.
The preparation method of the composition for assisting in improving memory comprises the following steps:
1) And uniformly mixing the phosphatidylserine and the taurine to obtain mixed powder 1.
2) And (3) uniformly mixing the milk mineral salt and the mixed powder 1 to obtain mixed powder 2.
3) Mixing docosahexaenoic acid powder, whole milk powder, isomaltitol and mixed powder 2 to obtain total mixed powder.
4) Packaging the total mixed powder.
Comparative example 1:
formulation (1000 g): isomalt 300g, whole milk powder 700g
The preparation method comprises the following steps:
1) Mixing the whole milk powder and isomaltulose to obtain mixed powder.
2) And packaging the mixed powder.
Comparative example 2:
formulation (1000 g): 200g of docosahexaenoic acid powder, 174g of milk mineral salt, 20g of phosphatidylserine, 14g of taurine, 206g of xylitol and 386g of full-fat milk powder.
The preparation method comprises the following steps:
1) And uniformly mixing the phosphatidylserine and the taurine to obtain mixed powder 1.
2) And (3) uniformly mixing the milk mineral salt and the mixed powder 1 to obtain mixed powder 2.
3) Mixing docosahexenoic acid powder, whole milk powder, xylitol and the mixed powder 2 to obtain total mixed powder.
4) Packaging the total mixed powder.
Comparative example 3:
formulation (1000 g): 200g of docosahexaenoic acid powder, 174g of milk mineral salt, 20g of phosphatidylserine, 14g of taurine, 206g of white granulated sugar and 386g of whole milk powder
The preparation method comprises the following steps:
1) And uniformly mixing the phosphatidylserine and the taurine to obtain mixed powder 1.
2) And (3) uniformly mixing the milk mineral salt and the mixed powder 1 to obtain mixed powder 2.
3) Mixing docosahexenoic acid powder, whole milk powder, white granulated sugar and the mixed powder 2 to obtain total mixed powder.
4) Packaging the total mixed powder.
Comparative example 4:
formulation (1000 g): 200g of docosahexaenoic acid powder, 174g of milk mineral salt, 20g of phosphatidyl serine, 14g of taurine, 166g of isomalt and 426g of whole milk powder
The preparation method comprises the following steps:
1) And uniformly mixing the phosphatidylserine and the taurine to obtain mixed powder 1.
2) And (3) uniformly mixing the milk mineral salt and the mixed powder 1 to obtain mixed powder 2.
3) Mixing docosahexaenoic acid powder, whole milk powder, isomaltitol, and mixed powder 2 to obtain total mixed powder.
4) Packaging the total mixed powder.
Test example 1
The samples of example and comparative example 1 were provided to the subjects and divided into a test group and a control group. The dosage and the taking method are as follows: the medicine is taken twice a day with warm water 5g each time. The test basis is as follows: the technical Specification for testing and evaluating health food (2003 edition). Subject inclusion criteria: the students in middle school are healthy, have no intellectual disability, are informed and willing to cooperate, are aged between 10 and 15 years old, have not received similar tests (memory quotient and intelligence quotient tests), and have not taken medicines or health foods related to memory improvement within one year. Exclusion criteria: those with obvious physical defects, who have impaired hearing, speech expression and intellectual defects, and those with obvious mental, sleep and lifestyle abnormalities and lack of cooperation; taking articles related to the tested function in a short time affects the result judger; if the test sample is not met the inclusion standard, the test sample is not eaten according to the regulation, and the efficacy or the safety is not judged to be affected by the insufficiency of the efficacy or the data.
Voluntary subjects who met the inclusion criteria and were guaranteed to be matched were randomized into the test and control groups. The samples of example and comparative example 1 were administered to the test group and the control group for 30 consecutive days. The original diet habit is not changed during the test eating period, and the diet is normal.
The association study amount of the test group before taking the sample is compared with that of the control group, and the difference is not significant (P is more than 0.05); the association study amount of the test group after taking the sample is compared with that of the control group before taking the sample and after taking the sample, and the difference is significant (P is less than 0.05). The results are shown in Table 1 below:
TABLE 1 influence of examples and test examples 1 samples on associative learning scale scores
Note: control # P < 0.05 between self-control P < 0.05 groups
Comparing the meaningless graph reconsideration amount of the test food group with that of the control group before taking the sample, wherein the difference is not significant (P is more than 0.05); the meaningless pattern reconsideration amount of the test-eating group after the sample is taken is compared with that of the control group before the sample is taken and after the sample is taken, and the difference is significant (P is less than 0.05). The results are shown in Table 2 below:
TABLE 2 influence of examples and test example 1 samples on meaningless graphical recognizability of scores
Note: control # P < 0.05 between self-control P < 0.05 groups
Comparing the human image characteristics of the test food group before taking the sample with the recall scale and the control group, the difference is not significant (P is more than 0.05); the human image characteristics of the test food group after the sample is taken are related to the recall scale, and compared with the control group before the sample is taken and after the sample is taken, the difference is significant (P is less than 0.05). The results are given in Table 3 below:
table 3 effect of examples and test examples 1 samples on portrait trait in relation to recall scale scores
Note: control # P < 0.05 between self-control P < 0.05 groups
The difference is not significant (P is more than 0.05) when the memory quotient of the test food group before the sample is taken is compared with the control group; the difference between the memory quotient of the test-eating group after taking the sample and the memory quotient of the control group before taking the sample and after taking the sample is significant (P is less than 0.05). The results are given in Table 4 below:
TABLE 4 influence of the samples of example and test example 1 on memory quotient
Note: control # P < 0.05 between self-control P < 0.05 groups
By combining the data, after the test subject continuously takes the product for 30 days, the associative learning scale score, the meaningless figure recognizability scale score, the portrait character association recall scale and the memory quotient of the test food group are all higher than those of the control group before the test food and after the sample taking, the memory scale score is higher than those of the control group before the test food, the difference is significant (P is less than 0.05), and the product is proved to have the effect of assisting in improving the memory.
Test example 2
The samples of the examples, the comparative example 2, the comparative example 3 and the comparative example 4 are 100g, 25g of warm water with the temperature of 50 ℃ is added into 100ml each time, after the mixture is stirred evenly, about 20ml of drinking taste is obtained, and each sample can be tasted by not less than 3 people. In order to compare the mouthfeel of the inventive example with comparative examples 2, 3 and 4, a mouthfeel test was performed. The results are shown in Table 5:
TABLE 5 taste comparison of examples with comparative examples 2, 3 and 4
The test results show that the examples have excellent mouthfeel and can solve the fishy smell caused by the raw material of the docosahexenoic acid powder.
Test example 3
Acute oral toxicity test: the Maximum Tolerated Dose (MTD) of female and male mice of Kunming species is more than 20.00g/kg BW, and belongs to nontoxic grade.
Three genotoxicity tests: the Ames test, mouse marrow pleochromocyte micronucleus test and mouse sperm malformation test result are all negative.
Feeding test for 30 days: the product without auxiliary materials with the dosage of 2.50 g/kg-bw, 5.00 g/kg-bw and 10.00 g/kg-bw is used for gastric lavage of rats for 30 days, the animals grow well in the experimental period, and the weight, the weight gain, the food utilization rate, the blood conventional index, the blood biochemical index, the visceral organ weight and the ratio of the visceral organ weight to the body weight of each dosage group are compared with those of a control group, so that no significant difference exists (P is more than 0.05). Gross anatomy and histopathological examination revealed no obvious sample-related abnormal changes. The product is prompted to have no obvious toxic or side effect on rats after being fed for 30 days.
Although the present application has been described with reference to a few embodiments, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the application as defined by the appended claims.
Claims (8)
1. The composition for assisting in improving memory is characterized by comprising the following components in parts by weight:
docosahexaenoic acid 180-210 parts
160-180 parts of milk mineral salt
19-22 parts of phosphatidyl serine
13-16 parts of taurine
170-210 parts of isomaltitol
350-390 parts of full cream milk powder.
2. The composition for assisting in improving memory according to claim 1, wherein the docosahexaenoic acid is docosahexaenoic acid embedded powder.
3. The auxiliary memory-improving composition according to claim 1, wherein the auxiliary memory-improving composition is a powdered mixture.
4. The composition for assisting in improving memory according to claim 1,
the composition for assisting in improving memory comprises the following components in parts by weight:
195-205 parts of docosahexaenoic acid powder
170 to 175 portions of milk mineral salt
20 to 21 portions of phosphatidyl serine
13 to 14 portions of taurine
195-205 parts of isomalt
380-390 parts of whole milk powder;
preferably, the auxiliary memory improving composition comprises the following components in parts by weight:
200 parts of docosahexaenoic acid powder
Milk mineral salt 174 parts
20 parts of phosphatidyl serine
Taurine 14 parts
Isomalt 206 parts
386 parts of full cream milk powder.
5. The method for preparing a composition for improving memory as auxiliary in any one of claims 1 to 4, comprising the steps of:
and uniformly mixing the phosphatidylserine powder, the taurine powder, the milk mineral salt powder, the docosahexenoic acid powder, the whole milk powder and the isomaltitol powder to obtain the composition for assisting in improving the memory.
6. The method for preparing a composition for improving memory as claimed in claim 5, comprising the steps of:
step 1) mixing phosphatidyl serine powder and taurine powder uniformly to obtain mixed powder 1;
step 2) mixing the milk mineral salt powder and the mixed powder 1 uniformly to obtain mixed powder 2;
and 3) mixing docosahexenoic acid powder, whole milk powder, isomaltitol powder and mixed powder 2 to obtain the composition for assisting in improving memory.
7. The method for using the composition for assisting in improving memory according to any one of claims 1 to 4, wherein the composition is administered 2 times a day with 5g of water.
8. The method of use of claim 7, wherein the administration is continued for at least 30 consecutive days.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211028115.2A CN115380956A (en) | 2022-08-25 | 2022-08-25 | Composition for assisting in improving memory and preparation method thereof |
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| CN202211028115.2A CN115380956A (en) | 2022-08-25 | 2022-08-25 | Composition for assisting in improving memory and preparation method thereof |
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Citations (7)
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2022
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