CN107495335A - One kind chelating calcium composition and preparation method thereof - Google Patents
One kind chelating calcium composition and preparation method thereof Download PDFInfo
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- CN107495335A CN107495335A CN201710598314.XA CN201710598314A CN107495335A CN 107495335 A CN107495335 A CN 107495335A CN 201710598314 A CN201710598314 A CN 201710598314A CN 107495335 A CN107495335 A CN 107495335A
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- calcium
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- chelating calcium
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 64
- 239000011575 calcium Substances 0.000 title claims abstract description 64
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title description 6
- 240000002234 Allium sativum Species 0.000 claims abstract description 19
- 235000004611 garlic Nutrition 0.000 claims abstract description 19
- 102000008186 Collagen Human genes 0.000 claims abstract description 16
- 108010035532 Collagen Proteins 0.000 claims abstract description 16
- 150000004676 glycans Chemical class 0.000 claims abstract description 16
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 16
- 239000005017 polysaccharide Substances 0.000 claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 8
- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 claims description 16
- 240000001008 Dimocarpus longan Species 0.000 claims description 10
- 235000000235 Euphoria longan Nutrition 0.000 claims description 10
- 235000001855 Portulaca oleracea Nutrition 0.000 claims description 10
- 241000219784 Sophora Species 0.000 claims description 10
- 239000007962 solid dispersion Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 230000033228 biological regulation Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 244000234609 Portulaca oleracea Species 0.000 claims 3
- 244000126002 Ziziphus vulgaris Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 abstract description 7
- 239000013522 chelant Substances 0.000 abstract description 3
- 230000001988 toxicity Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 239000013589 supplement Substances 0.000 abstract description 2
- 235000001465 calcium Nutrition 0.000 abstract 6
- 241000234427 Asparagus Species 0.000 abstract 3
- 235000005340 Asparagus officinalis Nutrition 0.000 abstract 3
- 229960005069 calcium Drugs 0.000 description 54
- 241000219304 Portulacaceae Species 0.000 description 7
- 241000700159 Rattus Species 0.000 description 7
- 235000001014 amino acid Nutrition 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010006956 Calcium deficiency Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000001132 Osteoporosis Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010017076 Fracture Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- JPIJQSOTBSSVTP-STHAYSLISA-N L-threonic acid Chemical compound OC[C@H](O)[C@@H](O)C(O)=O JPIJQSOTBSSVTP-STHAYSLISA-N 0.000 description 1
- 206010034464 Periarthritis Diseases 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- HLBIGQDEEVNODU-RGMNGODLSA-N [Ca].C(CC)N[C@@H](CCO)C(=O)O Chemical compound [Ca].C(CC)N[C@@H](CCO)C(=O)O HLBIGQDEEVNODU-RGMNGODLSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009056 active transport Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 238000001479 atomic absorption spectroscopy Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229960004256 calcium citrate Drugs 0.000 description 1
- 239000004227 calcium gluconate Substances 0.000 description 1
- 229960004494 calcium gluconate Drugs 0.000 description 1
- 235000013927 calcium gluconate Nutrition 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- -1 compound amino acid Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 229940056902 l- threonic acid Drugs 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses one kind to chelate calcium composition, is made of the raw material of following parts by weight：12 parts of 1 part of L asparagus amino-acid calciums, 0.2 0.4 parts of ultra micro composition, 0.1 0.3 parts of garlic polysaccharide and collagen protein powder.Present invention chelating calcium composition can effectively supplement the calcareous of needed by human body, the absorptivity of calcium in L asparagus amino-acid calciums can not only be promoted, and the toxicity of L asparagus amino-acid calciums can be reduced, there is Synergy and attenuation, is adapted to the elderly, women and children taking.
Description
Technical field
The present invention relates to a kind of health food, and in particular to one kind chelating calcium composition and preparation method thereof.
Background technology
At present, calcium is that people's in-vivo content is most and most active metallic element, after occupying oxygen, carbon, hydrogen, nitrogen in vivo, row
At the 5th.The 2% of body weight is accounted for, total amount has the good reputation of human body " biological element " more than 1 kilogram.Calcium is most rich in human body
Rich mineral matter, the whole life process of human body is participated in, from the think of of bone formation, contraction of muscle, heartbeat, nerve and brain
Dimension activity, until the growing of human body, dispelling fatigue, brain tonic and intelligence development and anti-aging etc., it may be said that all motions of life
All it be unable to do without calcium.Thus " calcium is human life sheet ".
Calcium deficiency is to the resistance of human body, endurance, immunity, memory, comprehension, creativity, respond and anti-aging
Ability has different degrees of influence.Furtherly, osteoproliferation, osteoporosis, fracture, rickets, dental caries, scapulohumeral periarthritis,
The diseases such as arthritis, juvenile are retarded, senile dementia, hypertension, heart disease, diabetes, anemia, apositia all with calcium deficiency
There is direct or indirect relation.
At present, Oral Calcium Preparations are various in style on domestic market, but are generally divided into three types.First type is inorganic
Calcium, such as calcium oxide, calcium chloride, calcium carbonate, calcium phosphate, or come from animal shell bone by processing etc.；Second species
Type is calcium of organic acid, such as calcium gluconate, calcium lactate, calcium acetate, calcium citrate；The third type is organic calcium, such as amino
Acid chelating calcium, compound amino acid chelate calcium, l threonic acid etc..The general indissoluble solution of first kind calcium agent, stronger pair of some alkalescence
Stomach and intestine produce strong impulse, and the absorptivity of calcium is low；Second class calcium agent is easy to phytic acid, oxalic acid in hydrochloric acid in gastric juice and food in stomach
The absorption of precipitation obstruction calcium is combined to form Deng acidic materials, after calcium ion enters small intestine, also easily combines to form hydrogen-oxygen with hydroxyl
Change calcium precipitate and hinder the absorption of calcium.And the 3rd class calcium agent amino acid chelated calcium is dissolved in pH with the form stable of chelate and is more than
In 7.0 alkaline small intestine, and Epithelium of intestinal villus cell can be participated in the active transport process of amino acid is completely absorbed, made
The absorptivity of calcium greatly improves, and research shows that it all improves significantly to osteoporosis, acalcicosis, to body without pair
Effect, and bioavilability is higher than in general calcium-supplementing preparation.But such calcium agent is amino acid to be formed with inorganic salts chelating, pass through
Chemical reaction, it is artificial synthesized obtain, security is troubling.
The content of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of chelating calcium composition, and the chelating calcium composition can be effective
The calcareous of needed by human body is supplemented, the absorptivity of calcium in ASPARTIC ACID calcium can not only be promoted, and L- Tianmens can be reduced
The toxicity of winter propylhomoserin calcium, has the function that Synergy and attenuation.
Present invention also offers the preparation method of the chelating calcium composition.
The purpose of the present invention is achieved by the following technical solution：
One kind chelating calcium composition, is made of the raw material of following parts by weight：1 part of ASPARTIC ACID calcium, ultra micro composition
0.2-0.4 parts, garlic polysaccharide 0.1-0.3 parts and collagen protein powder 1-2 parts；
The ultra micro composition is according to 1 by purslane, spina date seed, arillus longan and sophora flower：0.2-0.4：0.8-1.2：0.1-0.3
Weight ratio made from.
Preferably, a kind of chelating calcium composition, is made of the raw material of following parts by weight：1 part of ASPARTIC ACID calcium,
1.5 parts of 0.3 part of ultra micro composition, 0.2 part of garlic polysaccharide and collagen protein powder.
The molecular weight of the collagen protein powder is 3000-4000 dalton.
Preferably, ultra micro composition is according to 1 by purslane, spina date seed, arillus longan and sophora flower：0.3：1：0.2 weight
Than obtained.
One kind chelating calcium composition, is prepared by following steps：
1）Purslane, spina date seed, arillus longan and sophora flower are distinguished into ultramicro grinding, are well mixed after crossing 800 mesh sieves, obtains ultra micro combination
Thing；
2）It will be codissolved under garlic polysaccharide and collagen protein powder stirring in water, regulation density is to 1.3g/mL, in air velocity
It is spray-dried under the conditions of 1.0m/min, pressure 0.6MPa, 180 DEG C of intake air temperature to water content≤5.0%, it is more obtains garlic
Sugared solid dispersions；
3）Ultra micro composition, garlic polysaccharide solid dispersions and ASPARTIC ACID calcium are well mixed, you can chelating calcium is made
Composition.
Beneficial effects of the present invention：Present invention chelating calcium composition can effectively supplement the calcareous of needed by human body, can not only
Promote the absorptivity of calcium in ASPARTIC ACID calcium, and the toxicity of ASPARTIC ACID calcium can be reduced, there is Synergy and attenuation
Effect, be adapted to the elderly, women and children taking.
Embodiment
With reference to embodiment, the present invention is described further.
Embodiment 1
One kind chelating calcium composition, is made of the raw material of following parts by weight：1 part of ASPARTIC ACID calcium, ultra micro composition
1 part of 0.2 part, 0.3 part of garlic polysaccharide and collagen protein powder；
The ultra micro composition is according to 1 by purslane, spina date seed, arillus longan and sophora flower： 0.4： 1.2：0.1 weight is than system
.
The molecular weight of the collagen protein powder is 3000-4000 dalton.
One kind chelating calcium composition, is prepared by following steps：
1）Purslane, spina date seed, arillus longan and sophora flower are distinguished into ultramicro grinding, are well mixed after crossing 800 mesh sieves, obtains ultra micro combination
Thing；
2）It will be codissolved under garlic polysaccharide and collagen protein powder stirring in water, regulation density is to 1.3g/mL, in air velocity
It is spray-dried under the conditions of 1.0m/min, pressure 0.6MPa, 180 DEG C of intake air temperature to water content≤5.0%, it is more obtains garlic
Sugared solid dispersions；
3）Ultra micro composition, garlic polysaccharide solid dispersions and ASPARTIC ACID calcium are well mixed, you can chelating calcium is made
Composition.
Embodiment 2
One kind chelating calcium composition, is made of the raw material of following parts by weight：1 part of ASPARTIC ACID calcium, ultra micro composition
1.5 parts of 0.3 part, 0.2 part of garlic polysaccharide and collagen protein powder.
The ultra micro composition is according to 1 by purslane, spina date seed, arillus longan and sophora flower：0.3：1：0.2 weight is than system
.
Remaining is the same as embodiment 1.
Embodiment 3
One kind chelating calcium composition, is made of the raw material of following parts by weight：1 part of ASPARTIC ACID calcium, ultra micro composition
2 parts of 0.4 part, 0.1 part of garlic polysaccharide and collagen protein powder；
The ultra micro composition is according to 1 by purslane, spina date seed, arillus longan and sophora flower：0.2：0.8：0.3 weight is than system
.
Remaining is the same as embodiment 1.
Comparative example
One kind chelating calcium, is made of the ASPARTIC ACID calcium of 1 parts by weight.
The absorptivity research of calcium in rat body
Experimental animal：SD rats, body weight is in 120g-250g.
Test method：Rat is randomly divided into 4 groups, every group 30, each group general information comparing difference is counted without Tong and learns Yi Yi ﹙
P>0.05 ﹚, there is comparativity.Animal is placed in stainless steel metabolic cage word material and fed 3 days after packet, then start administration by gavage to
Medicine 7 days；The obtained chelating calcium of control group administration comparative example（Calculating calcium content is 70mg）, embodiment is administered in experimental group 1-3 respectively
Chelating calcium composition prepared by 1-3（Calculating calcium content is 70mg）；Excrement and urine in 7 days are collected simultaneously, to determine calcium content.Experiment
After end, by Animal Anesthesia, through heart extracting blood 5-6ml, centrifugation, serum is taken to determine calcium content, blood calcium, excrement calcium, urinary calcium, feed calcium
Press atomic absorption spectroscopy determination.Result of the test is as shown in table 1.
The rat calcium absorptivity testing result of table 1
Note：Compared with control group, * P ＜ 0.05.
Result of the test：As shown in Table 1, embodiment 1-3 prepare chelating calcium composition in ultra micro composition, garlic polysaccharide,
Collagen has facilitation to ASPARTIC ACID calcium rat calcium uptake, meanwhile, experimental group 1-3 rats blood calcium is than control
Group rat blood calcium dramatically increases（P ＜ 0.05）.
Safety testing
Product prepared by comparative example and embodiment 1-3 is subjected to toxicology test, measure decimal single oral administration acute toxicity
LD50, it is 70mg that each group, which calculates calcium content, and result of the test is as shown in table 2.
The LD of 2 different groups of table50Value
| Group | LD50Value（g/kg） |
| Control group | 11.52 |
| Experimental group 1 | 18.56 |
| Experimental group 2 | -- |
| Experimental group 3 | -- |
Note：-- expression can not measure LD50Value.
Result of the test：As shown in Table 2, ultra micro composition, garlic polysaccharide, collagen and the combination of ASPARTIC ACID calcium
Afterwards, LD50Value significantly reduces.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (5)
1. one kind chelating calcium composition, it is characterised in that be made of the raw material of following parts by weight：ASPARTIC ACID calcium 1
Part, ultra micro composition 0.2-0.4 parts, garlic polysaccharide 0.1-0.3 parts and collagen protein powder 1-2 parts；
The ultra micro composition is according to 1 by purslane, spina date seed, arillus longan and sophora flower：0.2-0.4：0.8-1.2：0.1-0.3
Weight ratio made from.
2. chelating calcium composition according to claim 1, it is characterised in that be made of the raw material of following parts by weight：
1.5 parts of 1 part of ASPARTIC ACID calcium, 0.3 part of ultra micro composition, 0.2 part of garlic polysaccharide and collagen protein powder.
3. chelating calcium composition according to claim 1, it is characterised in that the molecular weight of the collagen protein powder is
3000-4000 dalton.
4. chelating calcium composition according to claim 1, it is characterised in that the ultra micro composition is by purslane, acid
Jujube kernel, arillus longan and sophora flower are according to 1：0.3：1：Made from 0.2 weight ratio.
5. the chelating calcium composition any one of a kind of claim 1-4, it is characterised in that be prepared into by following steps
Arrive：
1）Purslane, spina date seed, arillus longan and sophora flower are distinguished into ultramicro grinding, are well mixed after crossing 800 mesh sieves, obtains ultra micro combination
Thing；
2）It will be codissolved under garlic polysaccharide and collagen protein powder stirring in water, regulation density is to 1.3g/mL, in air velocity
It is spray-dried under the conditions of 1.0m/min, pressure 0.6MPa, 180 DEG C of intake air temperature to water content≤5.0%, it is more obtains garlic
Sugared solid dispersions；
3）Ultra micro composition, garlic polysaccharide solid dispersions and ASPARTIC ACID calcium are well mixed, you can chelating calcium is made
Composition.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112471519A (en) * | 2020-12-02 | 2021-03-12 | 聊城美之健医药科技有限公司 | Chelated calcium collagen superfine powder and processing technology thereof |
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